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Silk Fibroin Protein CAS 96690-41-4

Molecular Formula: Null

Formula Weight: 0

ZSpharmac: Silk Fibroin Protein Supplier

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Product Name: Silk Fibroin Protein
CAS No: 96690-41-4
Purity: 99%

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Basic Info

Product Name:Silk Fibroin Protein
Other Names:Protein Hydrolyzates, Silk
CAS:96690-41-4
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:306-235-8
Storage:2-8°C
Provide:Silk Fibroin Protein MSDS;
Silk Fibroin Protein COA

What is Silk Fibroin Protein?

Silk is coagulated from the silk fluid produced by the silk glands in the body of silkworms. It contains two components: silk fibroin (SF for brief) as well as silk sericin (Silk Sericin). Silk fibroin is the text of silk, bookkeeping for around 70% to 80% of silk mass. It is an all-natural biological macromolecule without physiological task. It is created by attaching several shrinkage bonds, and also its molecular weight is typically considered to be about 3.7 × 105.

Compared with other all-natural polymers, silk fibroin healthy protein has noticeable benefits. Studies have shown that it has excellent biocompatibility, non-toxic, non-polluting, non-irritating, and naturally degradable. Therefore, lots of scholars are committed to research as well as open up new areas of silk fibroin application. Silk fibers have actually been utilized as textile fibers for hundreds of years, as well as have actually been used medically for decades as surgical sutures. Given that the discovery that Silk Fibroin Healthy protein has unique physical and also chemical residential properties as well as good compatibility with the human body, it has actually been extensively researched as a preservative and in cosmetics. Recently, it has actually gradually been found that silk fibroin has more potentials, such as applications in biosensing, biomedical materials, soft tissue compatibility products, cells design and other areas, and brand-new progression has likewise been made in traditional fields.

Silk Fibroin Protein Property

density 0.622[at 20℃]
Odorat 100.00?%. bland
Water Solubility 462g/L at 30℃

 

Silk Fibroin Protein Application

1. Study on the application of Silk Fibroin Protein in the field of biosensors
Biosensors are analytical systems that use bioactive materials as delicate aspects and also are geared up with suitable transducers. The immobilization of naturally energetic enzymes is an important step in the preparation of nearly all sorts of biosensors. The silk membrane layer prepared from silk fibroin is a superb paralyzed enzyme service provider, and also there are lots of study records on its application in biosensors. Silk membrane as an incapacitated provider of enzymes started in 1978.

In 1989, the silk membrane-immobilized sugar oxidase biosensor was first related to the analysis system. Now, as an exceptional enzyme immobilizer, silk fibroin film has been commonly used in biosensors as well as other detectors. The reported enzymes immobilized with silk fibroin membranes consist of glucose oxidase (GOD), peroxidase (COVERING), urease, lipase, pectinase, catalase, glucoamylase, superoxide dismutase, penicillin acylase, papain, phenylalanine lyase, β-glucosidase, etc.

Furthermore, making use of Silk Fibroin Healthy protein in natural chemical sensing units has actually also been reported. The billing characteristics of silk fibroin movie were researched, and the study showed that silk fibroin film is a polyamino acid film with amphoteric billing effect, and its fee generally originates from the charged teams on the side chains of basic amino acids and also acidic amino acids, and the isoelectric factor is pH = around 4.5. Making use of the amphoteric billing characteristics of silk membrane around the isoelectric factor as well as the electrostatic communication in between costs, it can be made use of to change electrodes. Under the physical problem pH value = 7.4, the silk membrane has the qualities of a packed electric membrane Efficiently remove the disturbance of anionic substances.

The electrode was made use of in the decision of neurotransmitter substance system, the natural chemical DA and also 5-HT were established, and the pH value charge choice effect of the modified electrode was validated, and also due to the fact that the silk membrane is safe and compatible with the body The advantages such as high stability totally show its wide potential customers for the determination of organic substances and also life science study.

2. Organic enzyme protectant
Organophosphorus pesticides can integrate with cholinesterase in the body to create secure phosphorylated cholinesterase with natural phosphate, consequently inhibiting the task of cholinesterase in the body, to make sure that the acetylcholine generated by typical nerve activities can not be decomposed immediately and also trigger Individuals are infected and die. Therefore, it is a reliable anti-virus technique to utilize enzymes to respond with poisonous substances artificial insemination, so that they lose the ability to enter the body and destroy them. With acetylcholinesterase as the detoxing enzyme as well as Silk Fibroin Healthy protein remedy as the enzyme carrier, the treated textile has an excellent anti-virus effect, as well as can be stored for a long time at an appropriate temperature. When pure water is utilized as the enzyme carrier, it can likewise be The fabric has a good anti-virus effect, yet its anti-virus result worsens with time.

It reveals that when Silk Fibroin Healthy protein option is made use of as the artificial organic enzyme protective agent, it can straight respond with poisonous compounds (organic phosphates) as well as incorporate to develop a stable phosphorylated cholinesterase to block the dangerous agent from invading the human body. Researches have revealed that it is feasible to utilize silk fibroin service as a biological enzyme safety representative, which has a much better anti-virus result and also can make the enzyme have a longer storage space life.

3. Drug launch products
Silk fibroin movie was used to install 5-fluorouracil (5-FU), and also the medicine release from silk fibroin 5-FU composite movie was determined at various pH values. The results revealed that the silk movie could be utilized as a 5-FU service provider to install 5-FU evenly. As a result of the defense of the silk fibroin finishing, the dissolution as well as launch price of 5-FU in the composite film became slower as well as the launch time was prolonged.

When the covered composite membrane layer is close to the isoelectric factor of silk fibroin (pH= 4.5), the release price of 5-FU in the service is slower and also the launch time is much longer, which indicates that readjusting the pH worth of the exterior remedy can manage the 5-FU release speed. The silk membrane layer with a permeable framework is prepared by freeze-drying technique. The presence of a multitude of blood vessels in the membrane greatly boosts the air leaks in the structure as well as wetness permeability of the silk membrane. The medicine is applied in the porous silk membrane. The presence of pores is handy for the controlled launch of the medication.

4. Bionic materials
The “man-made skin” wound defense movie constructed from Silk Fibroin Healthy protein as well as fresh pigskin were checked on bunnies, and the results revealed that the performance of silk fibroin film was far better than that of pigskin. In the medical tests of deep second-degree injuries as well as shallow second-degree injuries, it has great wetness leaks in the structure and bond to the injury, which advertises wound recovery. In regards to organic efficiency, it has solid bactericidal residential properties, good bond in between the drug silk movie as well as the body surface, satisfies the demands of wound coverings and is non-toxic, has no revitalizing effect on the skin, as well as has a cytotoxicity of the initial level. It appropriates for deep second-degree burns and also The security and also treatment of skin injury wounds such as cosmetic surgery locations can generally satisfy the application of scaffold materials, yet they are far inferior to all-natural polymers in regards to biocompatibility and cell attachment.

The biocompatibility and cell adhesion capability of scaffold products are crucial. Silk Fibroin Healthy protein is favored as an all-natural polymer material with exceptional biocompatibility. Recently, making use of silk healthy protein to customize some biopolymer products has likewise attracted considerable interest of scientists.

Composition of Silk Fibroin Protein

Silk Fibroin Protein contains 18 kinds of amino acids, of which glycine, alanine, and serine account for about 85% of the total amino acids. The diameter of the protein molecule is 10 25 μm, which includes heavy chain (H chain, about 390 kD) and light chain (L chain, about 26 kD) natural polymer fibrin, as shown in the figure:

The 20th cysteine residue at the C-terminal of the H chain and the 172nd cysteine residue of the L chain form a disulfide bond to combine the two. In addition, there is a glycoprotein (P25) with a molecular mass of about 30 kD that combines with the complex of the H chain and the L chain through hydrophobic forces, and the molar ratio of the H chain, the L chain, and P25 is 6 : 6 : 1 . In the H chain, 94% of the sequences are highly repetitive crystalline regions, and the rest include the N-terminal sequence (signal peptide), the junction between the crystalline regions, and the C-terminal sequence.

The amino acid sequence in the crystalline region is mainly composed of a hexapeptide repeat sequence (Gly-Ser-Gly-Ala-Gly-Ala), forming an anti-parallel β-sheet structure. Silk fibroin is composed of crystalline state and amorphous state in the polymerized state, and the crystalline state can be divided into silkⅠ and silkⅡ. The antiparallel β-fold sheet structure belongs to silk II, which is an orthorhombic crystal system; silk I is an intermediate form between α-helix and β-sheet, and the three-dimensional conformation is crank-shaped, and the shear force and temperature , change of solvent may make silkⅠ into silkⅡ.

In addition, there is a crystalline silk III, which is found in the silk fibroin film formed between the Silk Fibroin Protein solution and the air interface, and is an intermediate form between silk I and silk II. The above-mentioned unique structure of silk fibroin makes it have a variety of special properties. Silk fibroin not only has good biocompatibility and degradation performance, but also has the characteristics of easy processing and modification, non-toxic degradation products and low immunogenicity, and the mechanical strength of silk fibroin materials is also significantly better than other biological materials.

Extraction of Silk Fibroin Protein

Because sericin in silk can cause allergic reactions in the human body, when silk fibroin is used in tissue engineering, it is necessary to remove the immunogenic sericin first. Utilizing the difference in solubility between silk fibroin and sericin in the aqueous solution system, the silk can be treated with acid, alkali, soap, enzymes, etc., so that the sericin can be dissolved in the solution system, and the silk can be separated by centrifugation, filtration, dialysis, etc. Protein, to achieve the purpose of removing sericin. The commonly used degumming methods are as follows: ①sodium carbonate degumming; ②neutral soap degumming; ③tartaric acid degumming; ④high temperature and high pressure water degumming; ⑤alkaline protease degumming.

About Products:
If you need Silk Fibroin Protein as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced producer and supplier of Silk Fibroin Protein, our company,
ZSpharmac will provide Silk Fibroin Protein raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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