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Shikimic Acid Sigma CAS 138-59-0

Molecular Formula: C7H10O5

Formula Weight: 174.15

ZSpharmac: Shikimic Acid Sigma Supplement

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Product Name: Shikimic Acid Sigma
CAS No: 138-59-0
Purity: 99%

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Basic Info

Product Name:Shikimic Acid Sigma
Other Names:Shikimic Acid
CAS:138-59-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Light Beige or Light Gray Powder
EINECS No.:205-334-2
Storage:2-8°C
Provide:Shikimic Acid Sigma MSDS;
Shikimic Acid Sigma COA

What is Shikimic Acid Sigma?

Shikimic Acid Sigma is present in the dry ripe fruit of the Magnoliaceae plant star anise. Star anise is an evergreen tree that expands in moist, cozy semi-shade conditions and can get to a height of 30 meters. Generally dispersed in the mountains with loosened dirt in Fujian, Guangdong, Guangxi, Yunnan, Guizhou as well as various other districts. The bark is grey to red brown. The leaves are oblong, whole as well as single, lanceolate, leathery, short-stalked, 6-12 cm long as well as 2-5 centimeters vast, with transparent oil areas noticeable on the top surface area. Flowers in springtime and autumn. Flowers solitary in fallen leave axils. There are 3 yellow-green sepals; 6-9 perianth, pink to dark red. Autumn to second springtime outcomes. Aggregate fruit is star-shaped octagonal, 1-2 centimeters long, 3-5 centimeters wide, <1 cm high. Turn from eco-friendly to yellow when mature. Follicles are blunt or blunt-pointed at the top, each including a seed 6 mm long. The fruit is selected in autumn as well as wintertime as well as is reddish-brown or yellow-brown after drying out. The smell is fragrant and also wonderful.

Shikimic Acid Sigma Properties:

Melting point 185-187 °C (lit.)
alpha -180 º (c=4, H2O 25 ºC)
Boiling point 225.11°C (rough estimate)
density 1.52 g/cm3 (27.2℃)
refractive index -180 ° (C=1, H2O)
storage temp. 2-8°C
solubility 180g/l
form Powder
pkapK (14.1°) 5.19
color White to light beige or light gray
optical activity[α]/D -180.0±5.0°, c = 4 in H2O
Water Solubility 18 g/100 mL (20 ºC)

 

Shikimic Acid Sigma Uses

  1. Shikimic Acid Sigma is an anti-tumor medicine, and also it is additionally an artificial basic material for anti-tumor drugs such as dioxin and glyoxalase inhibitors.
  2. Shikimic Acid Sigma is a key precursor for the synthesis of several alkaloids, arylamine acids, indole derivatives as well as chiral medicines. Much more recently, shikimic acid was made use of as the starting product for oseltamivir (the active ingredient in Tamiflu), a neuraminidase inhibitor that can be made use of to treat and also stop flu An as well as flu B.
  3. Shikimic Acid Sigma was made use of as a requirement for quantitative determination of shikimic acid content in the apical parts of roots. Likewise utilized as a substratum for shikimate kinase assays.

Pharmacological Effects of Shikimic Acid Sigma

1. Anti-bacterial and antitumor effects

In 1987, it was reported that Japanese scholars located that a compound of Shikimic Acid had a considerable inhibitory effect on HeLacells and Ehrlichascitescarcinoma, as well as can extend the inoculation of mice with leukemia cells L1210. survival time, and also suggested that the repressive impact was generally due to the response of this shikimic acid compound with hydrosulfide. Another substance had no incongruity versus leukemia cell L1210, but had some enmity versus Trichophytonmentagrophytes ATCC9972. In 1988, Sunlight Kuailin et al. carried out initial artificial insemination anti-bacterial and also antitumor experiments on a manufactured shikimic acid derivative, and showed that this compound has a similar artificial insemination inhibitory effect to leukemia cell L1210 as dimycin.

2. Effects on the cardio system

Sunlight Jianning from Beijing University of Standard Chinese Medication examined the impacts of shikimic acid as well as its derivatives triacetylshikimic acid and isopropylidene Shikimic Acid Sigma on the cardio system, and also found that all three compounds have antithrombotic and platelet aggregation restraint impacts, and also their mechanism of activity was researched.

The Shikimic Acid path is a crucial metabolic pathway in plants, fungis and microorganisms, which has seven enzymatic processes. Dehydroquinate (DHQ) and shikimate dehydrogenase (SDH) advertise stages 3 as well as 4 in the shikimate pathway. In most microorganisms, DHQ and also SDH are monofunctional, but in plants DHQ as well as SDH can fuse to create an enzyme with two features. The benefit of the DHQ-SDH bifunctional enzyme is that it raises the effectiveness of metabolite traffic in the shikimate pathway by restricting the mass of intermediates in completing pathways. Christendat’s group at the College of Toronto recently examined the DHQ-SDH structure of Arabidopsis thaliana, a herbaceous plant. The researchers first completed the co-crystallization of DHQ-SDH enzyme and also shikimic acid by the gas-phase hanging decrease method, and then added nicotinamide adenine dinucleotide phosphate (NADP+) to the crystal to form a three-way complicated. The manufacturing of dehydroshikimate item at the DHQ website suggests that SDH-shikimate-NADP(H) is an energetic complex that is favorable for shikimate oxidation, and there is an active website in the concave structure of DHQ-SDH. DHQ-SDH healthy proteins can distinguish metabolites in the Shikimic Acid pathway by face-to-face localization, and also can increase the transfer efficiency of metabolites from DHQ to SDH domains. This design has been validated by the existing kinetic data as well as recommends that SDH contributes in the shikimate pathway to deposit metabolites.

Currently, there are three resources of Shikimic Acid: one is removal from plants, which is the major resource of shikimic acid; the second is biosynthesis by microbes; the 3rd is chemical synthesis. After getting in touch with the literary works, it is reported that ache needles contain shikimic acid. Among them, the ache fallen leaves of Masson want have the highest web content of shikimic acid, with a web content of 37.70 mg/g. Consequently, want has a remarkable result on the health and wellness and security of cardiovascular and also cerebrovascular.

Preparation of Shikimic Acid Sigma

1500kg star anise dried fruit (the shikimic acid content is 3.69%) is pulverized to a particle size of over 20~30 meshes and placed in a percolation tank. According to the mass ratio of material: water=1:3, water is passed into the material and heated under normal pressure. The water temperature reaches 75°C to soak the material for 1 hour, turn on the motor for 15 minutes, and then soak for 1 hour. Repeat this for 5 times. After soaking and extracting for 7 hours, after concentrating the leachate in the inner circulation concentration tank, the specific gravity is 1.15, and the weight is 1.15. It is 45.7kg of crude shikimic acid extract.

2 Mix the crude extract of Shikimic Acid according to the ratio of material: silica gel = 1:1 while it is still hot, stir evenly, cool to dryness, and use it to load the sample and pass it through the chromatographic column.

3. Put the cooled, dried and stirred silica gel samples on the upper ends of 6 chromatographic columns with an inner diameter of 40 cm, and the sample thickness is about 15 cm. The upper Shikimic Acid Sigma sample was rinsed at a flow rate of about 800ml/min.

4. Detect the eluent that flows out with a high-performance liquid phase detector, and start collecting when it is detected that the eluent contains shikimic acid. After 5 hours of collecting, it is specially noted that the ethyl acetate pipeline is realized in this process, Loop operation. The detection conditions of Shikimic Acid Sigma are mobile phase: double distilled water adjusted to pH 2 with phosphoric acid; flow rate: 0.6ml/min; wavelength: 213nm; column temperature 25℃; column C18; Concentration 20 μg/ml.

5. Concentrate the collected liquid to dryness, add 15L of methanol to dissolve, then add 45L of water, stand for refrigerated crystallisation, filter the crystals the next day to obtain 18kg of dry pure shikimic acid, and the detected content is 92%.

6. Recrystallize once by the same crystallization method in step 5 to obtain 16kg of fine shikimic acid with a content of 98%, and the final extraction rate of Shikimic Acid is 85%.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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