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SesaMolin CAS 526-07-8

Molecular Formula: C20H18O7

Formula Weight: 370.35

ZSpharmac: SesaMolin Supplier

Product Name: SesaMolin
CAS No: 526-07-8
Purity: 99%

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Basic Info

Product Name:SesaMolin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
Provide:SesaMolin MSDS;
SesaMolin COA

What is SesaMolin?

Sesame is an important oil crop in my country, its planting area ranks fourth in the world, and its output ranks first. Sesame contains a class of compounds called lignans, which are characteristic components of sesame, and the content in sesame is 0.5%~1.0%. The lignans in sesame are mainly sesamin, sesamolin, sesamol and sesamol. Among them, the content of sesamin and sesamolin is more, the content of sesamin in sesame is 0.2%~0.5%, the content in sesame oil is 0.4%~0.8%; Medium is 0.2%~0.6%. Although sesame oil contains more unsaturated fatty acids such as oleic acid and linoleic acid, it can still maintain high stability, which is largely due to the fact that it contains these endogenous lignan antioxidant components . The antioxidant components of sesame lignans can not only prevent oil from oxidative rancidity, but also have high physiological activity in the human body. It can eliminate free radicals in the body, reduce serum cholesterol, enhance the body’s immunity, resist high blood pressure, and resist thrombosis , Relieve atherosclerosis, and promote alcohol metabolism, strengthen detoxification activity, resist liver poisoning, and inhibit breast cancer. Therefore, sesamin and sesamolin can not only be used as preservatives in the food industry to maintain the flavor of food, but also can be used as health food additives to enhance the health of the body, and can also be developed into natural medicines for disease prevention and treatment.

SesaMolin Property

Melting point 94-95℃
alpha D20 +212° (chloroform)
Boiling point 520.8±50.0 °C(Predicted)
density 1.418
solubility Soluble in chloroform
form powder
color White


Applications of SesaMolin

Sesamin and sesamolin are lignans (lignans, also called lignans) compounds with strong physical task. Our country has had the behavior of eating sesame as well as sesame oil considering that old times, not just due to its distinct aromatic flavor, but also because of its strong healthcare feature. The Chinese Medication Dictionary documents: “Revitalize the liver and kidney, moisten the 5 internal body organs; boost energy, vitality and also muscle mass toughness; anti-inflammatory, discomfort alleviating, hair development” and so forth. The reason that sesame oil has distinct physical functions is due to the fact that it includes lignans, fat-soluble phenolic anti-oxidants, sesamin, sesamolin, etc. In the past 10 years, study on the physical functions of sesame essences has actually made wonderful progress. Research studies have actually revealed that lignans such as sesamin as well as sesamolin in sesame have physical features such as lowering cholesterol, anti-oxidation, as well as protecting the liver., has repressive result on influenza virus, Sendai infection as well as Mycobacterium consumption, and has a particular effect on bronchitis in clinical monitoring, so it has a wide range of uses in medicine, health and wellness items, aesthetic raw materials and also preservative.

On top of that, sesamolin can likewise be catalyzed to prepare sesamol. Sesamol, with molecular formula C20H18O7, is among the all-natural antioxidant active ingredients of sesame lignans. Compared to other antioxidant energetic ingredients in sesame oil such as sesamol, sesamin and also sesamolin, its antioxidant ability is the toughest, but additionally the most stable. Sesamol not only has anti-oxidation homes, but likewise can be used as an all-natural antioxidant. It additionally has a large range of biological activities. It can not only protect and enhance liver function, control blood pressure, as well as lower cholesterol, but also directly act on cells as well as body organs to apply its outstanding anti-inflammatory properties. oxidation capability. The prep work method is: take 80 mg (0.216 mmol) of pure sesamolin (purity 98%) and 20 mL of ethylbenzene right into a 50 mL three-necked flask (initial focus of sesamolin is 10.8 mmol L-1), mix as well as preheat to 90 ° C, then include 3 g of molybdosilicic acid heteropolyacid triggered at 200 ° C for 3h (about the first sesamolin is 13.89 g · mmol-1), continue to stir and also keep at 90 ° C for 1.5 h, HPLC identifies the reaction time of 1.5 h The return of the reaction service converted to sesaminol was 87.9%. Suction purification after cooling down, the driver was washed two times with ethyl acetate, the washings acquired two times were incorporated and along with the natural phase obtained by suction filtration, the solvent was vaporized under decreased pressure to acquire a yellow-brown paste solid, which was cleansed by silica gel column chromatography. Elute with n-hexane and ethyl acetate at a proportion of 5:1, spot by TLC, collect sesamol components, vaporize the solvent under lowered stress to acquire 58.6 mg of yellow-brown sesamol solid, and also the overall sesamol material is 98.8% as identified by HPLC. The return was 73.2%.

Preparation of SesaMolin

A method for continuously separating sesamin and sesamolin from sesame: comprises the following steps:

(1) Sesame is used as raw material, after ultrafine pulverization, ultrasonic-assisted reflux extraction is performed using a halogenated alkane solvent to obtain an extract containing sesamin and sesamolin;

(2) Decolorize and concentrate the extract, recycle the organic solvent to obtain a concentrate, absorb it with a macroporous resin, elute with ethanol, and collect the eluate;

(3) Concentrate the eluate, and separate the concentrate by using simulated moving bed chromatography to obtain sesamin and sesamolin in sesame, with a purity of over 99.90%.

Determination Method of SesaMolin

A method for measuring sesamolin content in sesame, comprising the following steps:

(1) To make a standard working curve: use methanol solutions of sesamolin standard substances with gradient concentrations of 200, 100, 50, 25, 12.5, and 6.25 μg/mL, and use anhydrous methanol as a blank control to measure the absorbance at a wavelength of 287 nm , with the concentration as the abscissa and the absorbance as the ordinate, draw a standard working curve, and the corresponding fitting equation is y=457.729323x-3.3962015, where y is the peak area, and x is the sesamolin content;

(2) Sample treatment: crush the sesame sample, pass it through a 0.35 μm sieve, weigh 0.2000 g of the obtained powder, add 7 mL of absolute ethanol, and use ultrasonic waves (ultrasonic power: 80 W) and oscillator for 25 min intermittently at 60 ° C (Sonication for 5 minutes, shaking for 1 minute, and so on cycle), then, centrifuge at 5000rpm for 2min, take the supernatant in a syringe, and filter it with a 0.45μm nylon membrane filter head; this step uses a digitally controlled ultrasonic cleaner for ultrasonic treatment. Maximum frequency: 40KHZ, maximum power: 150W;

(3) HPLC determination, determination conditions: chromatographic column: Agilent L1260, Eclipse XDB-C18-USP L1 analytical column, specification: 4.6 mm×250 mm, particle size: 5 μm, original product number: 990967-202, column temperature: 30 ℃; mobile phase is methanol: water = 80:20 (V/V), flow rate: 1mL/min, detection wavelength: 287nm, injection volume: 9μL, retention time: 15min; search or calculate according to the prepared standard working curve, That is, the content of sesamolin in the sesame sample was obtained.

About Products:
If you need SesaMolin as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced SesaMolin manufacturer and supplier, ZSpharmac will provide SesaMolin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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