Zhishang Chemical

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Zhishang Chemical

Sesamin CAS 526-07-8

Molecular Formula: C20H18O7

Formula Weight: 370.35

ZSpharmac: Sesamin Supplier

Product Name: Sesamin
CAS No: 526-07-8
Purity: 99%

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Basic Info

Product Name:Sesamin
Other Names:SesaMolin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
Provide:Sesamin MSDS;
Sesamin COA

What is Sesamin?

Sesame is an important oil crop in my country, its planting location rankings 4th on the planet, and its output ranks initially. Sesame includes a course of substances called lignans, which are particular elements of sesame, as well as the content in sesame is 0.5%~ 1.0%. The lignans in sesame are mainly Sesamin, sesamolin, sesamol and sesamol. Wherein Sesamin as well as sesamolin material are much more, the content of sesamin in sesame is 0.2%~ 0.5%, the web content in sesame oil is 0.4%~ 0.8%; Sesamin in sesame 0.1%~ 0.3%, in sesame oil It is 0.2%~ 0.6%. Although sesame oil includes much more unsaturated fatty acids such as oleic acid as well as linoleic acid, it can still keep high stability, which is mostly because of the fact that it consists of these endogenous lignan antioxidant elements. The antioxidant components of sesame lignans can not only avoid oil from oxidative rancidity, yet additionally have high physical task in the body. It can get rid of cost-free radicals in the body, decrease serum cholesterol, boost the body’s immunity, resist hypertension, and also resist apoplexy, Alleviate atherosclerosis, as well as advertise alcohol metabolism, reinforce detoxification activity, withstand liver poisoning, and prevent breast cancer. For that reason, Sesamin as well as sesamolin can not just be utilized as preservatives in the food industry to keep food taste, yet also can be made use of as health food ingredients to enhance the health of the body, and can also be become alternative medicines for illness avoidance and therapy.

Sesamin Property

Melting point 94-95℃
alpha D20 +212° (chloroform)
Boiling point 520.8±50.0 °C(Predicted)


Application of Sesamin

Sesamin as well as sesamolin are lignans (lignans, likewise known as lignans) substances with strong physical task. Our nation has actually had the practice of consuming sesame and sesame oil because ancient times, not only because of its unique aromatic taste, but also as a result of its strong health care feature. The Chinese Medication Thesaurus records: “Invigorate the liver and also kidney, moisten the 5 inner organs; rise energy, vigor and muscle mass toughness; anti-inflammatory, discomfort soothing, hair development” and so on. The reason sesame oil has unique physiological features is due to the fact that it has lignans, fat-soluble phenolic anti-oxidants, sesamin, sesamolin, etc. In the past 10 years, study on the physical features of sesame removes has made excellent development. Researches have shown that lignans such as sesamin and also sesamolin in sesame have physiological features such as lowering cholesterol, anti-oxidation, and securing the liver., has inhibitory impact on flu infection, Sendai virus and also Mycobacterium tuberculosis, and has a certain result on respiratory disease in professional monitoring, so it has a large range of uses in medication, health and wellness products, cosmetic raw materials and preservative.
In addition, sesamolin can additionally be militarized to prepare sesamol. Sesamol, with molecular formula C20H18O7, is among the natural antioxidant active components of sesame lignans. Compared with various other antioxidant active ingredients in sesame oil such as sesamol, sesamin and sesamolin, its antioxidant capability is the toughest, but likewise the most secure. Sesamol not only has anti-oxidation buildings, but likewise can be used as a natural antioxidant. It also has a large range of organic tasks. It can not only secure as well as enhance liver feature, regulate high blood pressure, and reduced cholesterol, but likewise straight act upon tissues and body organs to apply its superb anti-inflammatory buildings. oxidation capability. The prep work approach is: take 80 mg (0.216 mmol) of pure sesamolin (purity 98%) and also 20 mL of ethylbenzene into a 50 mL three-necked flask (first concentration of sesamolin is 10.8 mmol L-1), mix and preheat to 90 ° C, then add 3 g of molybdosilicic acid heteropolyacid activated at 200 ° C for 3h (relative to the first sesamolin is 13.89 g · mmol-1), remain to mix and maintain 90 ° C for 1.5 h, HPLC figures out the response time of 1.5 h The yield of the reaction service transformed to sesaminol was 87.9%. Suction filtration after cooling down, the catalyst was cleaned twice with ethyl acetate, the washings acquired twice were incorporated and also together with the organic phase gotten by suction purification, the solvent was vaporized under lowered stress to acquire a yellow-brown paste strong, which was cleansed by silica gel column chromatography. Elute with n-hexane as well as ethyl acetate at a ratio of 5:1, discover by tender loving care, accumulate sesamol components, vaporize the solvent under reduced pressure to obtain 58.6 mg of yellow-brown sesamol solid, as well as the total sesamol content is 98.8% as identified by HPLC. The return was 73.2%.

Preparation of Sesamin

A technique for constantly dividing sesamin and also sesamolin from sesame: consists of the complying with actions:
( 1) Sesame is made use of as basic material, after ultrafine pulverization, ultrasonic-assisted reflux extraction is done using a halogenated alkane solvent to obtain an essence having sesamin and sesamolin;
( 2) Decolorize and focus the essence, reuse the organic solvent to acquire a concentrate, absorb it with a macroporous material, elute with ethanol, as well as collect the eluate;
( 3) Focus the eluate, and divide the concentrate by utilizing simulated moving bed chromatography to get sesamin and also sesamolin in sesame, with a pureness of over 99.90%.

Determination Method of Sesamin

An approach for measuring Sesamin web content in sesame, comprising the adhering to steps:
( 1) To make a standard working curve: use methanol services of sesamolin conventional materials with slope concentrations of 200, 100, 50, 25, 12.5, and also 6.25 μg/ mL, and utilize anhydrous methanol as a blank control to measure the absorbance at a wavelength of 287 nm, with the focus as the abscissa and the absorbance as the ordinate, attract a typical working curve, as well as the equivalent suitable formula is y= 457.729323x-3.3962015, where y is the peak location, and x is the sesamolin web content;
( 2) Example treatment: crush the sesame example, pass it via a 0.35 μm screen, evaluate 0.2000 g of the gotten powder, include 7 mL of absolute ethanol, and also make use of ultrasonic waves (ultrasonic power: 80 W) and also oscillator for 25 min periodically at 60 ° C (Sonication for 5 minutes, shaking for 1 min, and so on cycle), then, centrifuge at 5000rpm for 2min, take the supernatant in a syringe, and filter it with a 0.45 μm nylon membrane filter head; this action uses an electronically controlled ultrasonic cleaner for ultrasonic therapy. Optimum regularity: 40KHZ, maximum power: 150W;
( 3) HPLC determination, resolution conditions: chromatographic column: Agilent L1260, Eclipse XDB-C18-USP L1 logical column, requirements: 4.6 mm × 250 mm, particle dimension: 5 μm, initial item number: 990967-202, column temperature: 30 ℃; mobile stage is methanol: water = 80:20 (V/V), circulation rate: 1mL/min, detection wavelength: 287nm, shot volume: 9μL, retention time: 15min; search or calculate according to the ready common functioning curve, That is the web content of Sesamin in the sesame example.

About That Product:
If you need Sesamin, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Sesamin manufacturer and supplier, ZSpharmac will provide Sesamin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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