Zhishang Chemical

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Zhishang Chemical

Sericin CAS 60650-88-6

Molecular Formula:  

Formula Weight: 60650-88-6

ZSpharmac: Sericin Cosmetic Raw Material Suppliers

Product Name: Sericin
CAS No: 60650-88-6
Purity: 99%

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Basic Info

Product Name:Sericin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colorless Liquid
EINECS No.:1806241-263-5
Provide:Sericin MSDS;
Sericin COA

What is Sericin?

Sericin is an all-natural macromolecular protein covered externally of silk fibroin fibers. It is mostly secreted by the silk glands of silkworms and is among the primary healthy proteins that compose silkworm cocoons. Sericin is commonly utilized in the pharmaceutical market due to its excellent water solubility, cell attachment and spreading task, lower immunogenicity, distinct in situ fluorescence, antioxidant activity and tyrosinase restraint. Fabric ending up finishes, aesthetic additives, along with food, medication, and useful organic materials.

Sericin Property

1. Amphoteric buildings and isoelectric factor of sericin Sericin consists of cost-free carboxyl groups and amino teams, which can engage to create bipolar ions and has amphoteric properties. In solutions with a smaller sized pH well worth, sericin exists in the form of favorable ions; in solutions with a bigger pH worth, sericin exists in the form of adverse ions. The isoelectric element of sericin is: 3.8-4.5.

2. Colloidal residential or business residential properties of sericin Sericin is a polymer compound with a huge molecular weight and a piece diameter of 1-100nm. Thinking about that the piece size is within the selection of colloidal fragments, it discloses the distinctive homes of dialysis, communication, and coagulation of sol. Gelling and peptizing homes.

3. Sericin denatured sericin particles generally change their homes when impacted by some outside physical or chemical aspects, yet these alterations do not involve changes in the key framework. The covalent bonds of the peptide chain are not harmed, nevertheless just Adjustments in molecular conformation take place, causing changes in structures. Its major symptoms are adjustments in physical properties, chemical properties and loss of biological task. The most famous sign is a decrease in solubility, which will considerably reduce its use worth. The main aspects that develop sericin denaturation contain temperature degree, pH worth and natural solvents.

4. Swelling and dissolution of sericin Sericin is a type of polymer. When it participates in contact with a perfect fluid, it will automatically take in the fluid and swell and become soft. After unrestricted swelling, it can liquify in the liquid. Under normal conditions, silk fibroin can only swell yet not liquify in water, yet sericin can dissolve in hot water. This is among the most vital home of sericin, and it is also the basis for people to use water to make silk, refining and degumming.

Sericin Structure

Sericin is a water-soluble globular protein with a molecular weight of around 10-300kDa. The molecular weight of sericin in solution is affected by temperature level, pH, and so on. Sericin is made up of 18 amino acid residues, of which the main amino acid deposits are serine (Ser), aspartic acid (Asp), and glycine (Gly). Their contents are roughly 33%, 20%, and 14% respectively. Amino acid deposits have a multitude of solid polar groups such as hydroxyl, carboxyl, and amino teams, and polar side chain amino acids account for greater than 70% of sericin. The second framework of sericin is mainly arbitrary coils, and consists of part of the β-sheet framework and nearly no α-helical framework, and the content is close to the β-sheet framework of silk fibroin, but now regarding the particles of sericin There is still some debate over the conformation. Since sericin consists of a lot of carboxyl and amino teams, it exhibits amphoteric properties by incorporating with hydrogen ions or hydroxide ions. The isoelectric factor of the healthy protein is a reflection of the amphoteric residential or commercial properties. The isoelectric point of sericin is 3.8 ~ 4.5.

When the hydrogen ions and hydroxide ions bound to the protein reach equilibrium and the net charge on the protein is no, the pH of the service at this time is the isoelectric point of the healthy protein. When the pH worth in the solution is low, sericin exists in the form of favorable ions; when the pH value in the option is high, sericin exists in the form of adverse ions. Sericin is a globular protein whose polypeptide chain is tightly folded. The hydrophobic amino acid side chains are located inside the molecule, and the hydrophilic amino acid side chains are exposed to the water solvent on the outside. As a result, the globular protein has great solubility in water solvents. Nevertheless, the molecular weight of sericin has a terrific impact on its solubility. Small-molecule sericin can be liquified in cold water, while large-molecule sericin can be dissolved in hot water. Sericin is an all-natural biopolymer with a huge molecular weight. As a result, the fragment size of sericin is usually in between 1 and 100nm, which belongs to the series of colloidal fragments. For that reason, the sericin solution will also reveal dialysis, coagulation, and coagulation. Attributes of colloidal solutions such as gelation and peptization.

Sericin Application

1. Application in the field of cosmetics Generally chatting, normal skin stratum corneum should certainly maintain 10% to 20% wetness to make the skin adaptable, plump and shiny without breaking. The reason the stratum corneum maintains a specific amount of wetness is, on the one hand, the ability of the sebum flick to stop water evaporation, and on the other hand, the stratum corneum includes all-natural moisturizing factors (NMF) with wetness absorption and hydrating functions; sericin is abundant in Consisting of polar amino acids, it includes polar teams such as -OH, -COOH, -NH2, and so forth, and has components and features comparable to moisturizing elements. There are currently cosmetics containing sericin in Japan, such as creams, facial cleansers, and facial cleansers. hold-up. Researches have actually revealed that skin dimming is as a result of the oxidative outcome of tyrosinase in melanocytes. Hideyuki Yamada’s research discovered that sericin can prevent the task of this enzyme and still preserves this ability after boiling. In sericin, tyrosine (Tyr), tryptophan (Trp) and phenylalanine (Phe) can soak up ultraviolet rays and prevent the skin from tanning and sunburn.

2. Application in the edible field: Above 90% of the amino acids included in sericin can be taken in by the body, and higher than 17% of the amino acids consisted of in sericin are necessary for the human body. Among them, serine, glycine, and aspartic acid have unique pharmacological outcomes: serine can efficiently impede the increase in blood cholesterol and can prevent and deal with high blood pressure; impede tuberculosis microorganisms and can be made use of to manage lung disease. Glycine can at the same time decrease cholesterol, minimized blood glucose level, stay clear of and treat apoplexy, blood coagulation, and treat diabetics concerns. Aspartic acid can reduce blood ammonia, safeguard myocardium, deal with angina pectoris, and additionally has a protective outcome on the liver. Serine and glycine are dietary aspects for glial cells. The consumed sericin (serine and glycine represent concerning half) can increase memory and avoid dementia. As an antioxidant, sericin can be made use of in the food area. Sericin can efficiently prevent fat peroxidation (food oxidation generally entails fat oxidation) and inhibit polyphenol oxidase, consequently hindering food browning. The study additionally found that sericin can advertise the absorption of zinc, iron, calcium and various other aspects in computer mice. Sericin with a bigger molecular weight can not be soaked up by the stomach system and is produced with the feces, which has the feature of quiting irregularity.

3. In the field of fiber alteration, sericin is chosen the surface of the fiber material with a cross-linking representative, to make certain that the fiber has both the first efficiency and the sensible qualities of sericin, which enhances the wearability and well worth of the material. Polyester has high endurance and great toughness, however has insufficient dampness absorption and breathability and inadequate using convenience, so it can not be utilized as a far better product for utilizing. Surface area alteration of polyester with sericin can enhance the benefit of polyester.

4. Biomaterials Numerous researches have in fact disclosed that sericin has the capacity to work as a medical apparel. The water-absorbing residential or commercial homes of sericin help maintain a rather wet ambience on the skin surface and take in exudate from injuries. Two-dimensional membrane layers, three-dimensional hydrogels, and permeable scaffolds prepared from sericin have actually been reported. In computer mouse experiments, not equally as a clothing, yet likewise as a sericin significance, it additionally revealed excellent injury recovery buildings and did not create allergies. Injuries treated with sericin showed a lot less inflammatory feedback than controls. The injuries were treated with collagen and sericin, and the skin of the sericin-treated experimental team grew a lot faster.

Sericin Separation Method

1. High temperature warm water technique: by saturating silk in hot water, sericin is liquified in hot water but silk fibroin is insoluble. Then utilize filtering or centrifugation to get rid of the silk fibroin to obtain a sericin aqueous service. The sericin remedy is after that dried out to obtain sericin powder. The sericin gotten by this technique does not introduce various other chemicals, but the yield is reduced.

2. Sodium carbonate method: submerse silk in sodium carbonate aqueous option. At a certain temperature level, sericin liquifies in sodium carbonate liquid option but silk fibroin does not dissolve. Silk fibroin is gotten rid of by filtering or centrifugation; the acquired sodium carbonate sericin aqueous remedy is after that dialyzed, concentrated or dried to acquire sericin.

3. Acid rainfall approach: Taking advantage of the minimized solubility of sericin at the isoelectric point (pH 3.8-4.5), sericin is sped up from the aqueous service and then reused and utilized. This approach is one of one of the most usual approaches used in industry to isolate healthy proteins.

4. Citric acid technique: Making the most of the reality that sericin can be liquified in boiling water of citric acid liquid option but silk fibroin is insoluble, sericin protein can be gotten by dialyzing and concentrating the liquified sericin citric acid solution. Nevertheless, in this technique, the healthy protein is sped up from the solution throughout the dialysis process, and the precipitated sericin is challenging to redissolve.

5. Urea method: A technique that uses urea liquid remedy to dissolve sericin, and afterwards dialyzes and focuses to obtain sericin healthy protein. This approach has a much lighter impact on the molecular weight of sericin than the high-temperature hot water technique and sodium carbonate method. Nonetheless, the sericin obtained by this technique has noticeable cytotoxicity.

6. Lithium bromide approach This method utilizes lithium bromide liquid service to liquify sericin at a reduced temperature, and then dialyzes and focuses to get a liquid sericin healthy protein option of excellent concentration. This method is a relatively mild method that has actually been reported to divide sericin from silk.

About Products:
If you need the cosmetic raw material Egg Yolk Oil, please contact our service staff directly, we will provide you with high-quality products at the best price.
Our company, as an experienced Egg Yolk Oil manufacturer and supplier, ZSpharmac will provide Egg Yolk Oil raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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