Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical

Sclareol CAS 515-03-7

Molecular Formula: C20H36O2

Formula Weight: 308.51

ZSpharmac: Sclareol Supplier

Product Name: Sclareol
CAS No: 515-03-7
Purity: 99%

Navigation Bar

Basic Info

Product Name:Sclareol
Other Names:Stearyl Alcohol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Neat
EINECS No.:208-194-0
Provide:Sclareol MSDS;
Sclareol COA

What is Sclareol?

Sclareol (English Sclareol) is a white crystalline powder drawn out from the stems and leaves of the all-natural Labiatae plant– Salvia Sclare L., with a melting point of 95-105 ° C as well as a pale amber (Ambergris) scent, delicate aroma, strong diffusion and durable odor can provide the significance a dazzling, harmonious as well as resilient scent. It is an ideal resources for the synthesis of ambergris items. It is generally made use of as a substitute for all-natural ambergris such as sclareolactone and also ambroxol It is utilized in the synthesis of materials, and also in a percentage is additionally utilized in the release of significances. In the field of medication, it is used for anti-bacterial and anti-inflammatory, choleretic as well as anticancer. In the field of pesticides, it is used to prevent as well as regulate crop rust, powdery mold, kill pests, moderate plant development task, as well as plant protection feature task.

Sclareol Property

Melting point 

95-100 °C (lit.)


-13 º (c=4, in carbon tetrachloride)

Boiling point 

218-220 °C/19 mmHg (lit.)


0.954±0.06 g/cm3(Predicted)

storage temp. 



Chlorform, Ethyl Acetate (Slightly)






White to Off-White


Sclareol Uses

  1. Sclareol is mostly used in the synthesis of ambergris-amber fragrances. It is better for usage in fragrance significances when its fragrance-fixing buildings are utilized straight for flavoring.
  2. Sclareol is used in flavors, seasonings, cigarettes, cosmetics, organic food, preservative, and so on.
  3. Sclareol is a ditertiary alcohol of the helanane type, which was first found in the southerly European salvia sage (Clary sage Salvia sclarea), and is commonly made use of as a fragrance active ingredient in cosmetics and fragrances and as a food flavor product. Because of its strong antibacterial task and managing effect on fungal development as well as plant development, sclareol can also be utilized in the field of pesticides. In addition, sclareol is cytotoxic to human leukemia cells, colon cancer cells, and xenografts. Presently, the majority of the inflorescences, stems as well as leaves of the plant Sclareus are used as raw materials to extract Sclareus remove, and additionally purification is used to acquire Sclareol.

Separation Method of Sclareol

At present, the approach generally used in this industry is: make use of the crude extract of Clary Perilla as resources, and also different it by vacuum distillation or solvent extraction. The solvent extraction approach requires to use a huge amount of solvent for duplicated condensation, as well as the retreat and leakage of the solvent It is not only a harmful variable for secure production, yet additionally triggers excellent pressure on the atmosphere. Although vacuum cleaner purification can reduce environmental pollution, it additionally has the adhering to problems: 1. Low production effectiveness: the home heating procedure in vacuum distillation needs at the very least 12 hrs; 2. Low return: the product components are easily destroyed by warm, so the product yield can only get to around 70%; 3. High energy consumption and high price: a big amount of heat energy is eaten during vacuum distillation, so the power consumption is huge, also increases the production cost. Invention web content:
Today creation will give a sort of splitting up approach of sclareol, to get rid of the issues of low production performance, reduced return, large energy intake and also high cost in the previous art.
For getting rid of the trouble that previous art exists, technical system of the here and now innovation is: a type of splitting up technique of sclareol, consists of the complying with actions successively:
( 1) Pre-treatment: warming the unrefined remove of Clary Perilla, the temperature level is managed at 80 ~ 250 ° C up until completely
Thaw, be transferred in the centrifugal extractor of band insulation system, at 135 ~ 150 ℃, perform centrifugal removal with the turning rate of 500-6000 rev/min, eliminate heavy stage;
( 2) One-stage purification: the unrefined essence of Clarissa is sent to a molecular still, the stress is regulated at 100 Pa-150 , the temperature level is 190 ° C to 230 ° C, and the unrefined remove is separated right into hefty phase and also light stage after continuous distillation, the heavy phase is directly discharged with a special pipe as well as thrown out, and also the light stage enters the additional purification;
( 3) Additional distillation: the light stage obtained in step (2) is sent to the molecular still once again, with a pressure of 30 Pa to 70 , as well as a temperature level of 260 ° C to 300 ° C, to obtain a fragrance with a purity of 90% -98%. perillyl alcohol.
In the above-mentioned steps (1 ): the unrefined essence of Clary Perilla is warmed, as well as the temperature is regulated at 80 ~ 100 ° C, totally melted. Power usage is reduced.
Compared to prior art, the present development has the following advantages:
1. High production effectiveness: the whole thermal splitting up process does not exceed 10 seconds;
2. High return: because of the brief home heating time, the item components are well protected, so that the total return of the system can reach greater than 95%;.
3. Low power consumption and low cost: the home heating time is short, so the power intake is considerably lowered.

Biotransformation Process of Sclareol

Sclareol is a vital starting material for the synthesis of high-value ambromide, a sustainable alternative to ambergris in high-end perfumes, with significant market value. Sclareol can be obtained by biotransformation of sclareol, a radane-type diterpene, using Hyphozyma roseonigra. Nevertheless, the path as well as device of sclareol biosynthesis remain unclear. In this study, the dynamic time course of sclareol biotransformation was explored by resting cell assays and also numerous intermediates created during the biotransformation were taken a look at. The outcomes indicated that (1) sclareol and sclareolide are not interconvertible and might be manufactured via various metabolic pathways; (2) numerous accepted intermediates created by the biotransformation have a Laudan carbon skeletal system, including isomerization and oxidized analogues. A probable change path for sclareol in H. roseonigra was proposed based on the identified metabolites. This study illuminates the biosynthetic mechanism of sclareol as well as leads the way for future biotechnological production of this encouraging substance.

About That Product:
If you need Sclareol as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Sclareol, ZSpharmac will provide Sclareol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Sclareol Quotation