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Rosmarinic Acid For Skin CAS 20283-92-5

Molecular Formula: C18H16O8

Formula Weight: 360.31

ZSpharmac: Rosmarinic Acid For Skin Supplier

Product Name: Rosmarinic Acid For Skin
CAS No: 20283-92-5
Purity: 99%

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Basic Info

Product Name:Rosmarinic Acid For Skin
Other Names:Rosmarinic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Faintly Beige Powder
EINECS No.:606-487-1
Provide:Rosmarinic Acid For Skin MSDS;
Rosmarinic Acid For Skin COA

What is Rosmarinic Acid For Skin?

The rosemary plant comes from the family members Lamiaceae and belongs to the genus Rosmarinus. Little evergreen shrub. Worrying 1 meter high, young branches with 4 edges, arranged carefully, with thick hairs; leaves in contrast, sessile, hard, straight, surface area dark environmentally friendly, smooth, back gray-white great hair; blossoms bisexual, expanding in pairs on short pedicels, Axillary, calyx bell-shaped, 2-lipped, top lip entire, lower lip bilobed, corolla 3 times longer than calyx, 2-lipped, top lip deeply scooped bilobed, minimized lip trilobed concave to center of wattles, productive stamens 2-extended Outside the flowers, the blossoms are light blue, sometimes pink or white, and also bloom in spring with a strong scent.
The rosemary plant originated from North Africa. After Zhang Qian travelled to the Western Areas, it was presented to China from the Western Regions. It was a standard property traded between the Roman Realm, the Eastern Roman Realm along with China, so the Chinese in addition called it “Great Qin Scent”.
This product is a medical as well as edible natural herb with an oleosome, which can be taken advantage of for enjoying and drawing out aroma. The twigs as well as additionally buds of rosemary can also be used to extract great smelling oil. This aromatic oil can be used to readjust the scent of food, to adjust seasoning, to make Shaosi, and more. Rosemary is hardly ever used as a food flavoring by Chinese people. It is mainly utilized in Western food along with is relatively regular in Europe. Currently, rosemary is still a very popular cooking flavor in Europe.

Rosmarinic Acid For Skin Property

Melting point 171-175 °C (lit.)
alpha +102~+110°(D/20℃)(c=0.2,C2H5OH)
Boiling point 694.7±55.0 °C(Predicted)
density 1.33
storage temp. 2-8°C
solubility Soluble in ethanol, DMSO or dimethyl formamide to approximately 25 mg/mL.
form powder
color white to faintly beige


Rosmarinic Acid For Skin Action

Anti-bacterial impact
Rosmarinic acid has broad-spectrum antimicrobial activity as well as has inhibitory influence on both germs in addition to fungis. Rosmarinic acid has noticeable inhibitory effect on bacteria such as Bacillus subtilis, Bacillus luteus, Escherichia coli, Staphylococcus aureus as well as Rhizococcus solani. Neusa situated that rosmarinic acid can prevent the advancement and additionally biofilm development of Streptococcus dental caries as well as Streptococcus mutans, and also reduced their glucosyltransferase activity, recommending that rosmarinic acid can be used for the evasion and likewise therapy of dental diseases. Study on the anti-bacterial gadget of rosmarinic acid shows that: on the one hand, rosmarinic acid can raise the leaks in the structure of bacterial cell membrane layers, activating a large amount of leakage of sugars and likewise healthy proteins, affecting the regular metabolic procedure of microbes; on the other hand, it can in addition influence microbial healthy and balanced protein. Metabolic price, likewise inhibits TaqDNA polymerase.
Guo Daosen et al. looked into the repressive task of rosmarinic acid on the mycelium growth and spore germination of different plant pathogenic fungi, as well as additionally located that rosmarinic acid has the impact on Botrytis cinerea, Mango grey area, Penicillium citrus and likewise Black area of pear. The mycelium development repressive outcome is a lot more effective, as well as the repressive impact on the spore germination of Pyrella black location is the greatest.
Rosmarinic acid has anti-bacterial task against Gram-negative microbes Escherichia coli in addition to Gram-positive bacteria Staphylococcus aureus, yet the sensitivity of Staphylococcus aureus to rosmarinic acid is considerably more than that of Escherichia coli. The speculative end results likewise expose that rosmarinic acid can significantly increase the leaks in the framework of bacterial cell membrane layer layers, speed up the leakage of carbohydrates and likewise healthy proteins, as well as also make cell metabolic price condition; rosmarinic acid can likewise influence microbial healthy protein metabolic rate. The full healthy protein of Staphylococcus aureus prior to in addition to after therapy exposed that the therapy of rosmarinic acid promoted the degeneration of certain healthy proteins in the process of bacterial metabolic price, or advertised the synthesis of some tension and also anxiety proteins in a short period of time. As for which certain healthy and balanced protein rosmarinic acid acts on, it remains to be to be additional established. From the speculative outcomes of the communication in between rosmarinic acid and also plasmid DNA, it can be seen that rosmarinic acid has no communication with DNA, so it can be thought that it can not be incorporated with the overviews in the polymerase chain reaction system, as well as also rosmarinic acid has no impact on the polymerization. The inhibition of enzyme domino effect is due to the reality that the compound inhibits the binding task of DNA polymerase, therefore hindering the replication of DNA. In wrap-up, rosmarinic acid has specific results on the permeability of microbial cell membrane layer, healthy protein metabolic price as well as DNA duplication, hence applying its anti-bacterial influence

Anti-oxidize effect
Rosmarinic Acid For Skin has a strong activity of scavenging cost-free radicals in the body and additionally anti-oxidation. Research study studies have in fact shown that its system of task is: rosmarinic acid takes on unsaturated fats to include with lipid peroxyl to end the domino effect of lipid peroxidation as well as also reduced the price of lipid peroxidation, while rosmarinic acid is oxidized to Quinoid; Rosmarinic Acid For Skin can avoid the respiratory system ruptured of neutrophils and also avoid the release of lysosomes by decreasing the focus of intracellular calcium ions; avoid the oxidation of low-density lipoprotein managed by endothelial cells.
The antioxidant effect of Rosmarinic Acid For Skin is connected with its framework. Nakamura et al. thought that the o-diphenolic hydroxyl group is the item basis for scavenging absolutely free radicals. Furthermore, the conjugated twin bond at C3 has a collaborating impact.

Antidepressant effect
Rosmarinic acid has antidepressant outcomes on family pet versions of depression. ItoN et al. executed experiments on cell dispersing in the hippocampal gyrus of computer system mice, carried out immunohistochemical analysis with bromodeoxyuridine antibody, in addition to discovered its device of task. They located that the recognized proliferating cells boosted in the rosmarinic acid treatment team, integrated with the stress and anxiety animal model. The forced swim exam showed that rosmarinic acid generated an antidepressant-like effect at least partially via hippocampal neonatal cell expansion.

The research results on the safety and security of rosmarinic acid show that the security of rosmarinic acid is better. Salt as well as additionally sucrose have no effect on the security of rosmarinic acid; pH as well as additionally temperature have little impact on the protection of rosmarinic acid, the results reveal that rosmarinic acid is much better for storage along with use under acidic as well as likewise minimized temperature level conditions; light has no outcome on the safety and security of rosmarinic acid. The impact of marinic acid is higher, so it should be avoided light as high as practical when using it; Ca2+ as well as also Mg2+ have a much better result on the safety and security of rosmarinic acid, and various other steel ions have little effect on rosmarinic acid, so they should be stayed clear of when using Contact with calcium as well as magnesium; lowered emphasis of salt benzoate as well as potassium sorbate have little influence on the stability of rosmarinic acid, and also should certainly be consisted of an ideal quantity according to the hygienic needs for making use of preservative; ascorbic acid has a particular result on rosmarinic acid, the effect of reduced emphasis is little; the oxidant hydrogen peroxide has an excellent impact on rosmarinic acid; the reducing agent sodium metabisulfite has a tiny impact on rosmarinic acid.

Application of Rosmarinic Acid For Skin

1. Food field: As an all-natural and efficient anti-oxidant, rosmarinic acid can replace BHA and also BHT in animal and veggie oils, dairy items, oil-rich foods, sweets and baked foods; it can likewise be utilized as a seasoning in numerous soups And also spices food; and also both disinfectant and antibacterial impact. In Japan, perilla extract rich in rosmarinic acid is used as a garnish to improve the service life of fresh seafood.
2. Healthcare products area: anti-tumor, anti-hepatitis as well as liver damage defense, anti-nephritis, anti-thrombosis as well as anti-platelet aggregation results, and so on, as well as rejuvenating, memory improvement, tension and sleepiness and also various other impacts.
3. Cosmetics area: Rosmarinic Acid For Skin can be used in skin treatment products to remove areas, resist oxidation, rise skin elasticity, and also hold-up aging; it can be made use of in hair shampoo and hair treatment items to promote scalp blood circulation as well as improve Loss of hair, lower the event of dandruff and also boost hair growth, hydrate hair. Therefore, rosmarinic acid can be used as a superb additive in cosmetics.

Ecological Information on Rosmarinic Acid For Skin

The production as well as use of rosmarinic acid in herbal supplements, food tastes, beverages, food chemicals, as well as cosmetics might result in its launch into the environment with different waste streams. Rosmarinic acid is located in lots of typical herbs in the Lamiaceae family members, consisting of rosemary, sage, Spanish sage, oregano, basil, marjoram, thyme, mint group, lavender, perilla, as well as lemon balm. If released to air, the estimated vapor stress at 25 ° C is 1.1X10-13 mm Hg, suggesting that rosmarinic acid will exist in the feel only in the particulate stage. The particulate phase rosmarinic acid will definitely be removed from the ambience by damp along with completely dry deposition. If launched into dust, rosmarinic acid is expected to be very mobile based on an approximated Koc of 60. Rosmarinic acid has a pKa of 3.57, carbon as well as clay than their neutral matchings. Volatilization from wet dirt location is not planned for to be a substantial destiny procedure based upon an approximated Henry’s regulation constant of 2.7X10-27 atm-cu m/mole. Based upon its vapor stress and anxiety, rosmarinic acid is not expected to volatilize from completely dry dust area. Rosmarinic acid has an optimum UV absorption at 332 nm: therefore, it might most likely to threat to route photolysis on dirt area based on sunshine. No biodegradation details in dust or water. If released right into water, rosmarinic acid is not anticipated to adsorb to postpone solids as well as likewise debris based upon the approximated Koc. Volatilization from the surface is not anticipated to be a vital fate procedure based upon the estimated Henry’s law constant for this compound. An approximated BCF of 3 reveals a low bioconcentration possibility in water organisms.Rosmarinic acid is expected to take on hydrolysis in the setting, with half-lives of 26 and also 2.6 years at pH 7 as well as also 8, respectively. Sensitized photooxidation could be a crucial destiny procedure of rosmarinic acid in natural waters exposed to sunshine. Work-related straight exposure to rosmarinic acid might develop from skin straight exposure to this compound in offices where rosmarinic acid is produced or used. The fundamental people undergoes rosmarinic acid via consumption of nutritional supplements in addition to foods (natural solutions) having rosmarinic acid for skin, and dermal exposure to this substance in consumer things including rosmarinic acid.

About Products:
If you need Rosmarinic Acid For Skin cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Rosmarinic Acid For Skin, ZSpharmac will provide Rosmarinic Acid For Skin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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