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Zhishang Chemical

Rosmarinic Acid Extract CAS 20283-92-5

Molecular Formula: C18H16O8

Formula Weight: 360.31

ZSpharmac: Rosmarinic Acid Extract Supplement

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Product Name: Rosmarinic Acid Extract
CAS No: 20283-92-5
Purity: 99%

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Basic Info

Product Name:Rosmarinic Acid Extract
Other Names:Rosmarinic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Faintly Beige Powder
EINECS No.:606-487-1
Provide:Rosmarinic Acid Extract MSDS;
Rosmarinic Acid Extract COA

What is Rosmarinic Acid Extract?

Rosmarinic Acid Extract is a water-soluble all-natural phenolic acid substance separated from rosemary, a plant of the Lamiaceae household. Among the various plants of the Phytophthaceae, the highest possible web content is especially in the Lamiaceae and also Limperaceae plants.

Rosmarinic Acid Remove is a natural antioxidant with strong antioxidant task, its antioxidant activity is more powerful than vitamin E, caffeic acid, chlorogenic acid, folic acid, etc. It aids prevent cell damages triggered by complimentary radicals, so Reduced risk of cancer cells as well as arteriosclerosis.

Rosmarinic Acid Essence has strong anti-inflammatory task, and Rosmarinic Acid Essence likewise has antibacterial, antiviral, as well as antitumor tasks, and has the homes of hindering severe as well as persistent infections, anti-ultraviolet rays, as well as hindering elastin degradation, which has made Rosmarinic Acid Extract a cosmetic item of ingredients.

Main application areas:
1. Food area: Rosmarinic Acid Essence, as a natural as well as efficient antioxidant, can replace BHA as well as BHT in animal as well as vegetable oils, milk products, oil-rich food, sweet as well as baked food; it can additionally be used as a flavor in numerous soups and also In skilled food; as well as both antibacterial as well as anti-bacterial effects. In Japan, rosmarinic acid-rich shiso extract is utilized as a garnish to boost the shelf life of fresh seafood.
2. The area of healthcare products: anti-tumor, anti-hepatitis and defense of liver damages, anti-nephritis, anti-thrombotic and also anti-platelet gathering impacts, in addition to rejuvenating, enhancing memory, boosting tension and drowsiness.
3. Cosmetics field: utilized in skin care products to eliminate blemishes, anti-oxidation, rise skin elasticity, delay aging, etc; utilized in hair shampoos and also hair care items, can promote scalp blood flow, enhance loss of hair, decrease scalp The event of dandruff as well as promote hair growth, hydrating hair. Therefore, rosmarinic acid can be used as an exceptional additive in cosmetics.

Rosmarinic Acid Extract Properties:

Melting point 171-175 °C (lit.)
alpha +102~+110°(D/20℃)(c=0.2,C2H5OH)
Boiling point 694.7±55.0 °C(Predicted)
density 1.33
storage temp. 2-8°C
solubility H2O: soluble1mg/mL, clear, colorless
form powder
color white to faintly beige


Effects of Rosmarinic Acid Extract

Rosmarinic Acid Remove has broad-spectrum antimicrobial task, preventing both microorganisms as well as fungi. Rosmarinic acid has evident inhibitory result on bacteria such as Bacillus subtilis, Bacillus luteus, Escherichia coli, Staphylococcus aureus and also Rhizococcus solani. Neusa et al. discovered that rosmarinic acid can hinder the growth and also biofilm development of Streptococcus cavities and Streptococcus mutans, as well as lower their glucosyltransferase task, showing that rosmarinic acid can be utilized for the avoidance as well as treatment of oral diseases. Research on the antibacterial mechanism of rosmarinic acid reveals that: on the one hand, rosmarinic acid can raise the permeability of bacterial cell membrane layers, leading to a huge quantity of sugar and protein leakage, impacting the typical metabolic rate of microorganisms; on the other hand, it can additionally affect microbial healthy protein. It additionally hinders TaqDNA polymerase.

Guo Daosen et al. examined the repressive activity of rosmarinic acid on mycelial growth and spore germination of different phytopathogenic fungis, and found that rosmarinic acid hindered Botrytis cinerea of tomato, Botrytis cinerea of mango, Penicillium citrus and Black area of pear. The mycelial growth repressive impact was strong, and the inhibitory effect on the spore germination of black place Pear was the toughest. Rosmarinic acid has anti-bacterial task versus Gram-negative microorganisms Escherichia coli and also Gram-positive bacteria Staphylococcus aureus, however Staphylococcus aureus is dramatically more sensitive to rosmarinic acid than Escherichia coli. The experimental outcomes likewise reveal that rosmarinic acid can considerably raise the leaks in the structure of bacterial cell membrane layers, increase the leak of sugars and healthy proteins, and interrupt cell metabolic rate; rosmarinic acid can additionally impact bacterial healthy protein metabolic process, compared to Rosmarinic Acid Extract therapy The total protein of Staphylococcus aureus cells before as well as after showed that the treatment of rosmarinic acid advertised the degradation of some proteins throughout bacterial metabolic rate, or advertised the synthesis of some stress and anxiety proteins in a short amount of time. As for which particular protein rosmarinic acid acts on, it remains to be more determined. From the experimental outcomes of the interaction in between rosmarinic acid and plasmid DNA, it can be seen that rosmarinic acid does not connect with DNA, so it can be guessed that it can not bind to the guides in the polymerase chain reaction system. Restraint of the enzyme chain reaction is due to the fact that the substance inhibits the activity of DNA polymerase binding, thereby hindering DNA duplication. In recap, rosmarinic acid has particular results on the permeability of microbial cell membrane, protein metabolic process and also DNA duplication, thus exerting its antibacterial effect.

Rosmarinic Acid Remove has a strong scavenging task of totally free radicals in the body and an antioxidant result. Researches have actually shown that its system of activity is: rosmarinic acid takes on unsaturated fatty acids to incorporate with lipid peroxy teams to terminate the domino effect of lipid peroxidation as well as minimize the rate of lipid peroxidation, while rosmarinic acid is oxidized to Quinoid; marinic acid prevents neutrophil respiratory ruptured as well as hinders lysosome release by lowering intracellular calcium ion focus; hinders endothelial cell-mediated low-density lipoprotein oxidation. The antioxidant effect of Rosmarinic Acid Remove is related to its structure, and Nakamura et al. believed that the hydroxyl group of ortho-diphenol is the product basis of totally free radical scavenging task. As well as the conjugated double bond at the C3 placement has a synergistic result.

Rosmarinic Acid Extract has antidepressant effects in animal versions of clinical depression. ItoN et al. carried out experiments on cell spreading in the hippocampus of mice, done immunohistochemical analysis with bromodeoxyuridine antibody, as well as explored its system of action. They found that the rosmarinic acid treatment team boosted the labeled proliferative cells. Integrated with the expression of clinical depression animal designs Required swim examination, showing that Rosmarinic Acid Remove at least partially multiplies as well as creates an antidepressant-like result on brand-new cells in the hippocampus.

The results of the research study on the stability of Rosmarinic Acid Extract show that the stability of rosmarinic acid is better. Salt and also sucrose have no result on the stability of rosmarinic acid; pH and temperature have little result on the security of rosmarinic acid, the results show that Rosmarinic Acid Remove is preferable for storage and usage under acidic and reduced temperature problems; Aromaic acid has a terrific influence, so it needs to be prevented as much as possible when using it; Ca2+ and Mg2+ have a fantastic influence on the stability of rosmarinic acid, as well as various other steel ions have little impact on rosmarinic acid. Contact with calcium and also magnesium; low focus of sodium benzoate as well as potassium sorbate have little effect on the stability of rosmarinic acid, as well as need to be included a proper amount according to the hygiene criteria for preservative; ascorbic acid has a specific influence on rosmarinic acid, Reduced focus has less effect; oxidant hydrogen peroxide has fantastic effect on rosmarinic acid; reducing representative sodium metabisulfite has much less effect on Rosmarinic Acid Extract.

Effects of Rosmarinic Acid Ecological Information

The production as well as use Rosmarinic Acid Essence in natural supplements and also food flavorings, beverages, food chemicals as well as cosmetics can lead to its launch right into the atmosphere with different waste streams. Rosmarinic acid is located in numerous usual herbs in the Lamiaceae household, consisting of rosemary, sage, Spanish sage, oregano, basil, marjoram, thyme, mint group, lavender, basil, as well as lemon balm. If launched right into air, the approximated vapor stress at 25 ° C is 1.1X10-13 mm Hg, which indicates that Rosmarinic Acid Essence will just exist in the particle phase in the atmosphere. Particle phase rosmarinic acid will certainly be eliminated from the atmosphere by damp and also dry deposition. Rosmarinic Acid Essence is expected to have high movement with an approximated Koc of 60 if released into dirt. Rosmarinic acid has a pKa of 3.57, as well as carbon and also clay are more powerful than their neutral counterparts. Based upon the estimated Henry’s Regulation constant of 2.7X10-27 atm-cu m/mole, volatilization from damp soil surfaces is not anticipated to be a considerable fate procedure. Based on its vapor stress, rosmarinic acid is not anticipated to vaporize from dry soil surface areas. Rosmarinic Acid Essence has optimum UV absorption at 332 nm: consequently, it might be at risk to guide photolysis on dirt surface areas revealed to sunlight. Biodegradation information in dirt or water are not readily available. If released right into water, Rosmarinic Acid Remove is not expected to adsorb into put on hold solids and also debris based on the approximated Koc. Volatilization from water is not expected to be an important fate process on the surface based upon estimated Henry’s law constants for this substance. An estimated BCF of 3 suggests a reduced capacity for bioconcentration in marine organisms. Rosmarinic acid is anticipated to hydrolyze in the environment with half-lives of 26 and also 2.6 years, specifically, at pH 7 and also 8. Sensitized photo-oxidation might be an essential destiny procedure for rosmarinic acid in all-natural water revealed to sunshine. In work environments where rosmarinic acid is produced or used, dermal direct exposure to this substance may result in work exposure to Rosmarinic Acid Essence. The basic population is subjected to Rosmarinic Acid Extract with intake of nutritional supplements and foods (natural herbs) consisting of rosmarinic acid as well as via skin contact with this compound in consumer products including rosmarinic acid.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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