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Zhishang Chemical

Rhodiolin CAS 86831-54-1

Molecular Formula: C27H30O16

Formula Weight: 610.52

ZSpharmac: Rhodiolin Supplement

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Product Name: Rhodiolin
CAS No: 86831-54-1
Purity: 99%

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Basic Info

Product Name:Rhodiolin
Other Names:Rhamnoside
CAS:86831-54-1
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystal Powder
EINECS No.:0
Storage:2-8°C
Provide:Rhodiolin MSDS;
Rhodiolin COA

What is Rhodiolin?

Rhodiola grows on plateaus above 4,000 meters above sea level. It can show tenacious and lush vitality under extremely harsh natural conditions such as strong solar ultraviolet radiation, great temperature difference between day and night, and very dry weather under wind and sun, indicating that its internal storage There are special living substances. In the process of research on Rhodiola on the Tibetan Plateau, it was found that when the rhizomes of Rhodiola with dry epidermis were cut open, rich colloidal liquid immediately exuded inside, indicating that its moisturizing function was very strong. On the skin, it has rapid anti-inflammatory, wound closure and obvious moisturizing effect.

In research and production, the skin of hands frequently dipped in Rhodiola rosea extract is visibly fair, smooth and delicate. Practice has proved that Rhodiola has a good skin care effect and can be used as a natural cosmetic component without pollution in the snow. After years of scientific research, it has been confirmed that Rhodiola contains unique salidroside and aglycone tyrosol, which can activate the metabolism of skin cells and maintain youthful vitality; natural SOD scavenges free radicals and resists skin aging; rich in polyphenols The ingredients can absorb ultraviolet rays in various bands respectively, and have good anti-radiation and anti-photoaging functions; polysaccharide ingredients have good moisturizing function; Rhodiola contains 18 kinds of amino acids, 35 kinds of trace elements and vitamins A, C, D , E, can provide natural nourishment to human cells. Known water extraction method and alcohol extraction method, the Rhodiolin obtained not only has a low content of active ingredients, but also contains many complex ingredients that are not absorbed by human skin and are not beneficial to skin care, such as soluble starch, sugar, fiber. Su et al. Using supercritical extraction method, the above-mentioned beneficial ingredients for skin cells in Rhodiola can be fully selectively extracted and separated, and the content of effective skin care active ingredients is more than double that of water extraction method. The glycoside content is 1-2.5%, the SOD is 0.3%, the polyphenol is 3%, and the polysaccharide is 4.5%. In the supercritical extraction Rhodiolin, salidroside is 5-6%, SOD is 2%, polyphenol is 6%, polysaccharide is 10%, and the supercritical extraction Rhodiolin is easier to penetrate and absorb by the skin, and its moisturizing , astringent, antibacterial, anti-ultraviolet light, whitening, freckle, anti-aging and other effects are twice as high as the water extraction Rhodiolin.

Rhodiolin Properties

Melting point 195-199 °C
Boiling point 994.3±65.0 °C(Predicted)
density 1.82±0.1 g/cm3(Predicted)
storage temp. 2-8°C

 

Rhodiolin Uses

  1. Rhodiolin has better skin care effect and can be used as a natural cosmetic component without pollution in snow. After years of scientific research, it has been confirmed that Rhodiola contains unique salidroside and aglycone tyrosol, which can activate the metabolism of skin cells and maintain youthful vitality; natural SOD scavenges free radicals and resists skin aging; rich in polyphenols The ingredients can absorb ultraviolet rays in various bands respectively, and have good anti-radiation and anti-photoaging functions; polysaccharide ingredients have good moisturizing function; Rhodiola contains 18 kinds of amino acids, 35 kinds of trace elements and vitamins A, C, D , E, can provide natural nourishment to human cells. Known water extraction method and alcohol extraction method, the Rhodiolin obtained not only has a low content of active ingredients, but also contains many complex ingredients that are not absorbed by human skin and are not beneficial to skin care, such as soluble starch, sugar, fiber. Su et al. Using supercritical extraction method, the above-mentioned beneficial ingredients for skin cells in Rhodiola can be fully selectively extracted and separated, and the content of effective skin care active ingredients is more than double that of water extraction method. The glycoside content is 1-2.5%, the SOD is 0.3%, the polyphenol is 3%, and the polysaccharide is 4.5%. The content of salidroside in supercritical extraction Rhodiolin is 5-6%, SOD is 2%, polyphenol is 6%, polysaccharide is 10%, and supercritical extraction Rhodiolin is easier to penetrate and absorb into the skin, and its moisturizing, astringent, Antibacterial, anti-ultraviolet light, whitening, freckle removal, anti-aging and other effects are twice as high as that of water-extracted rhodiola.
  2. Rhodiolin has anti-hypoxia, anti-fatigue, anti-myocardial aging, and anti-tumor effects.

Rhodiolin Application

1) Anti-aging: Using the combination of in vivo and in vitro research methods, the effect of the medicinal plant Rhodiola rosea extract – rhodiola on in vitro cultured human embryonic lung diploid fibroblasts (2BS) and rat liver was discussed. , observed the effect of Rhodiolin on the growth and proliferation of 2BS cells, as well as on the morphological and histochemical changes of rat liver cells and the changes of lipid peroxide (LPO) and liver serum superoxide dismutase (SOD) in liver tissue. The experimental results are that Rhodiolin can promote the growth and proliferation of 2BS cells, and reduce the content of LPO and lipofuscin in liver tissue and the activity of acid phosphatase (ACPase) in rat liver tissue. The results show that Rhodiolin has the effect of delaying cell aging and anti-degeneration.

2) Anti-senile dementia: In experiments, D-galactose was injected intraperitoneally for 6 consecutive weeks, and Aβ140 was injected into the bilateral hippocampus to create AD rat model. The learning and memory behaviors of rats were detected by Y-shaped maze and one-time passive avoidance test. The content of lipofuscin in cerebral cortex, the fluidity of hippocampal mitochondrial membrane, SOD activity and MDA content were measured, and the ultrastructure of hippocampus was observed by electron microscope. Results Rhodiolin could significantly improve the learning and memory impairment of dementia rats, significantly reduce SOD activity, MDA content and cortical lipofuscin content in the hippocampus of dementia rats, and inhibit the degeneration and apoptosis of hippocampal neurons. Therefore, Rhodiolin may have a certain preventive effect on senile dementia rats by affecting the level of free radicals

3) The effect of Rhodiolin on biochemical indicators such as blood sugar in diabetic rats. Of 25 SD rats, 5 were randomly selected as blank control group, and the remaining 20 rats were treated with alloxan-induced diabetes. After successful modeling, they were randomly divided into experimental group (10 rats) and control group (10 rats). The experimental group was treated with Rhodiola angustifolia extract – rhodiola, which was injected into the experimental group by tail vein injection every 3 days, and the blood was taken by decapitation on the 32nd day, and the blood glucose, transaminase, urea nitrogen and blood routine indexes of each rat were measured. . Results Rhodiolin had no significant effect (P>0.05) on blood glucose, BUN, MCV, MCH, MCHC, and PLT in diabetic rats; however, GPT, RBC, HCT, HGB, RDW, and WBC had significant effects compared with the control group. sex (P<0.05) increased. Therefore, Rhodiolin can change the normal physiological function of the liver.

4) Anti-tumor: To explore the effect of Rhodiolin on liver cancer by combining in vitro cultured liver cancer cells (7721) and mouse transplanted liver cancer (H22). The experimental results show that salidroside can inhibit the growth and proliferation of 7721 and H22 hepatoma cells, reduce DNA synthesis, increase glycogen content, improve the quality of life and prolong the survival period of tumor-bearing mice. The results of flow cytometry showed that Rhodiolin could inhibit the S phase (DNA synthesis phase) of hepatoma cells cultured in vitro. It is suggested that salidroside has a certain inhibitory effect on 7721 and H22 hepatoma cells.

Preparation of Rhodiolin

Rhodiolin is prepared by CO2 liquid-phase supercritical extraction process. The technical solution is to wash the Rhodiola rhizomes, dry them in the sun, and pulverize them into granules for later use. The extraction kettle, separation kettle I, and separation kettle II are heated or cooled respectively (the set temperature is: extraction kettle 30 °C, separation kettle I 65 °C, separation kettle II 40 °C), open the CO2 gas cylinder (the flow rate is 10-10-100 per 1Kg of raw materials 20Kg.h-1), pressurize the system at the same time, when the set pressure is reached (the set pressure is: extraction kettle 20Mpa, separation kettle I 12Mpa, separation kettle II 6Mpa), close the gas cylinder, and after 150 minutes of constant temperature and constant pressure cycle extraction , decompress and recover the gas, and take out Rhodiolin powder from the separation kettle. Rhodiola powder can be directly mixed with water to make a pure Chinese medicine mask, or can be made into pure natural Rhodiolin skin cream and skin lotion by adding deionized water and emulsified by vacuum homogenization. It can also be used as a natural component of other different functional cosmetics. If the finished product is required to be pure white or transparent, Rhodiolin must also be decolorized.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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