1) Anti-aging: The effect of rhodiola rosea extract—rhodiola, a medicinal plant, on the culture of human embryonic lung diploid fibroblasts (2BS) and rat liver in vitro was investigated by combining in vitro and in vivo research methods , Observed the effect of Rhodiola on the growth and proliferation of 2BS cells, as well as the changes in the morphology and histochemistry of rat liver cells and the changes of lipid peroxide (LPO) and liver serum superoxide dismutase (SOD) in liver tissue. The result of the experiment is that rhodiola can promote the growth and proliferation of 2BS cells, reduce the content of LPO in rat liver tissue and lipofuscin in liver cells, and the activity of acid phosphatase (ACPase). The results prove that Rhodiola has the effect of delaying cell aging and anti-degeneration.
2) Anti-senile dementia: In an experiment, D-galactose was injected intraperitoneally for 6 consecutive weeks, and Aβ140 was injected bilaterally into the hippocampus to create an AD rat model. The learning and memory behavior of rats was detected by Y-maze and one-time passive avoidance test, the content of lipofuscin in cerebral cortex, the fluidity of mitochondrial membrane, SOD activity and MDA content in hippocampus were measured, and the ultrastructure of hippocampus was observed by electron microscope. Results Rhodiola can significantly improve the learning and memory impairment of dementia rats, significantly reduce the hippocampal SOD activity, MDA content and cortical lipofuscin content of dementia rats, and inhibit the degeneration and apoptosis of hippocampal neurons. Therefore, rhodiola may have a certain preventive effect on senile dementia rats by affecting the level of free radicals
3) Effect of Rhodiola on biochemical indicators such as blood sugar in diabetic rats. Of 25 SD rats, 5 were randomly selected as the blank control group, and the remaining 20 were treated with alloxan-induced diabetes. After successful modeling, they were randomly divided into an experimental group (10 rats) and a control group (10 rats). The experimental group used the extract of Rhodiola angustifolia——Rhodiola rosea, and injected it into the rats of the experimental group through the tail vein every 3 days. On the 32nd day, the blood was taken by cutting off the head, and the blood sugar, transaminase, urea nitrogen and blood routine indicators of each rat were measured. . Results Rhodiola had no significant (P>0.05) effect on blood glucose, BUN, MCV, MCH, MCHC, PLT in diabetic rats; but compared with the control group, GPT, RBC, HCT, HGB, RDW, WBC were significantly A significant (P<0.05) increase occurred. Therefore Rhodiola can alter the normal physiological function of the liver.
4) Anti-tumor: The effect of rhodiola on liver cancer was explored by combining the research method of in vitro cultured liver cancer cells (7721) and transplanted liver cancer (H22) in mice. The experimental results show that rhodiola can inhibit the growth and proliferation of 7721 and H22 liver cancer cells, reduce DNA synthesis, increase glycogen content, improve the quality of life of tumor-bearing mice and prolong their survival period. According to the results of flow cytometry, rhodiola can inhibit the S phase (DNA synthesis phase) of liver cancer cells cultured in vitro. It is suggested that rhodiola has a certain inhibitory effect on 7721 and H22 liver cancer cells.