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RHEGF CAS 62253-63-8

Molecular Formula: C270H401N73O83S7

Formula Weight: 6221.96724

ZSpharmac: RHEGF Supplier

Product Name: RHEGF
CAS No: 62253-63-8
Purity: 99%

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Basic Info

Product Name:RHEGF
Other Names:Epidermal Growth Factor
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Liquid
EINECS No.:810-845-4

What is RHEGF?

Skin development aspect, complete name RHEGF, is a tiny peptide, composed of 53 amino acid residues, belongs to the EGF (skin growth aspect) family members, a multifunctional growth aspect: both in vivo and also in vitro Tissue cells have a solid mitogenic result.Numerous experimental studies have shown that EGF can stimulate the proliferation of various cells, mainly epidermal cells and endothelial cells. It is used for the repair and healing of corneal injuries, burns, and surgical wounds, and has achieved good results. Professors Montalcini and Cohen were awarded the Nobel Prize in Physiology and Medicine in 1986 for their discovery of epidermal growth factor and analysis of its structure and mechanism of action.
RHEGF has a wide range of biological effects and can strongly promote the growth of various epidermal tissues. It has been used in the treatment of burns, ulcers, various traumas and corneal injuries in medicine. EGF can also promote the metabolism of normal epidermal cells, and adding it to beauty and skin care products can achieve the effects of whitening, anti-wrinkle, and anti-aging.

RHEGF Property

storage temp. -20°C
form powder
color white


The Role of RHEGF in Beauty

1. Skin rejuvenation

RHEGF can promote different cells derived from ectoderm and endoderm, such as corneal epithelial as well as endothelial cells, epidermis, dermis cells (such as fibroblasts), mammary acinus as well as interstitial cells, and so on, to make them proliferate and also move, as well as increase metabolic process. Attain skin restoration effect.

2. Hydrate the skin

RHEGF can advertise the biosynthesis of DNA, RNA and also functional healthy proteins, can promote the synthesis of extracellular macromolecules (such as hyaluronic acid, elastin, etc), raise the water web content of the skin, and after that increase the elasticity of the skin as well as moisturize the skin.

3. Remove creases

RHEGF advertises the active transportation of mobile nutrients from extracellular to intracellular, boosting intracellular nourishment. Promote the secretion of facial cells to manufacture functional molecules such as collagen fibers, polysaccharides, and also glycoproteins, so that the subcutaneous dermal tissue is plump and also the muscle fibers are arranged neatly and also snugly, thus reducing and also eliminating wrinkles.

4. Repair wounds

By binding to the RHEGF receptor, it stimulates skin cells (consisting of epithelial cells from various tissues and various mesenchymal cells) to enter the cellular division cycle, and also starts the activation, expression, and secretion of some essential useful genes in the cells, such as biologically energetic healthy proteins. Advertise the linear plan of collagen fibers, the fast and regular growth of skin cells as well as cover the wound in time. Considerably accelerate the healing of wounds after plastic surgery, plastic surgery as well as various other skin injuries, and also maintain the wound surface area smooth, minimize or disappear scars and also reduce coloring

5. Stop coloring.

RHEGF has a strong promo result on the spreading of skin cells. After usage, the epidermal cells come to be younger, which makes the buildup of pigment as well as dead cells much less in the epidermal tissue, making the skin tender and also remarkable, removing areas and also Unusual skin manifestations such as hyperpigmentation. Using EGF in the treatment duration and healing period of blemish can efficiently curb the reappearance of pigmentation.

RHEGF≠Human Oligopeptide-1

On January 10, 2019, the State Drug Management clearly explained in [Frequently Asked Questions on Cosmetics Supervision as well as Management (1)] that RHEGF and also human oligopeptide 1 (skin growth variable, EGF) are not the same substance.

RHEGF is consisted of in my nation’s “Brochure of Names of Cosmetic Raw Products Used” (2015 Edition), and is usually used as a skin conditioning representative. However, human oligopeptide-1 is not included in the catalog and is usually used a lot more in the medical area. Presently, EGF is mostly utilized as a medical outside prep work for the therapy of skin burns and scalds (superficial 2nd level to deep 2nd level burns and scalds), residual wounds, skin benefactor website wounds as well as chronic abscess wounds, or for microneedle, laser Wait for postoperative repair work treatment. These damaged skins are used under the advice of a doctor’s medical diagnosis, and also there is no worry.

It is not recommended for typical skin, because the skin is challenging to take in. We understand that particles smaller than 500-800 Daltons can be easily soaked up by the skin. The molecular weight of this EGF is 6200, so the skin can not absorb it.

Because of its large molecular weight, EGF is hard to be absorbed under typical skin obstacle conditions. When the skin obstacle feature is insufficient, it might cause other prospective safety and security troubles. Based on considerations of performance and safety, EGF can not be used as an aesthetic raw material.

As a result, unlike RHEGF, human oligopeptide-1 (EGF) can not be utilized as a cosmetic raw material. It is a prohibited item to add or claim to include human oligopeptide-1 or EGF in the formula.

Why Use RHEGF After Laser Surgery?

RHEGF has a similar structure and purity to natural epidermal growth factor. In recent years, it has been mainly used clinically to promote various wound repairs and control scar formation. The use of recombinant human epidermal growth factor after fractional laser treatment can promote the synthesis of DNA, RNA and hydroxyproline in the process of skin wound tissue repair, induce the reverse transformation of differentiated and mature epidermal cells into epidermal stem cells, and accelerate the formation and regeneration of wound granulation tissue. The proliferation of epithelial cells can effectively promote the absorption of wound inflammation and accelerate the growth and development of cells, thereby shortening the healing time of wounds and improving the quality of wound repair.

Recombinant human epidermal growth factor combined with fractional laser in the treatment of acne scars has the advantages of quick onset and quick recovery, and can further improve the clinical efficacy.

About Products:
If you need RHEGF as a cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced RHEGF manufacturer and supplier, ZSpharmac will provide RHEGF raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get RHEGF Quotation