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Rhapontin CAS 155-58-8

Molecular Formula: C21H24O9

Formula Weight: 420.41

ZSpharmac: Rhapontin Raw Material Supplier

Product Name: Rhapontin
CAS No: 155-58-8
Purity: 99%

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Basic Info

Product Name:Rhapontin
Other Names:Rhaponiticin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Brown Prwder
EINECS No.:205-845-0
Provide:Rhapontin MSDS;
Rhapontin COA

What is Rhapontin?

Rhaponitin, also known as poniticin, is a chemical compound with the molecular formula C21H24O9. It is a derivative of stilbene and belongs to the group of stilbene glycosides. While the Chinese Pharmacopoeia 2005 Edition does not mention rhaponitin, recent studies have demonstrated its various pharmacological activities.

Some of the reported benefits of rhaponitin include antibacterial properties, improved microcirculation, reduced blood lipids and blood sugar levels, anti-tumor effects, inhibition of allergic reactions, modulation of the immune system, anti-thrombotic properties, and antioxidant effects. Additionally, its metabolites, such as lefacidin, have shown a range of pharmacological activities.

Lefacidin, a metabolite of rhaponitin, has been found to act as an agonist of PPAR-γ, which helps in reducing blood glucose levels and treating diabetes. Its efficacy in lowering blood sugar levels is comparable to that of the drug pioglitazone, a thiazolidinedione. This makes lefacidin a promising candidate for the development of a highly effective diabetes drug with minimal side effects, derived from natural sources.

Rhapontin Property

Melting point 236-240 °C
alpha D32 -59.5° (acetone)
Boiling point 457.61°C (rough estimate)
density 1.2828 (rough estimate)
refractive index 1.6230 (estimate)
storage temp. 2-8°C
solubility Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
color Brown
Water Solubility slightly soluble in water


Rhapontin Uses

A study conducted by various medical institutions including Gansu Provincial People’s Hospital, Air Force Lanzhou Hospital, and Lanzhou Railway Central Hospital has confirmed the effectiveness of Lepangting tablets in treating hyperlipidemia. This includes conditions such as hypertriglyceridemia, hypercholesterolemia, and hyperlipoproteinemia in 30 clinical cases.

Furthermore, research carried out by the Geriatric Medicine Research Group at Tongji Medical University involved 92 elderly individuals who took Lepangting tablets at a dosage of 20mg three times a day for three months. The study found a significant 28.10% reduction in lipid peroxide levels compared to before taking the medication.

In another study by the same research group, 124 subjects aged 50-70 years old underwent various tests to assess their physical and cognitive abilities. After three months of taking Lepangting tablets at a dosage of 20mg three times a day, improvements were observed in tests measuring flexibility, balance, and memory. Patients with conditions such as coronary heart disease and hypertension also reported positive effects, including reduced chest tightness, fewer angina attacks, and stabilized blood pressure.

Overall, clinical trials and observations have shown that Lepangting tablets have anti-aging properties, leading to improvements in lipid levels, immunity, and overall health in middle-aged and elderly individuals.

Rhapontin Preparation

The roots and rhizomes of Hetao rhubarb are crushed and extracted with 95% (v/v) ethanol aqueous solution in a weight to volume ratio of 1:3. The extraction process is carried out three times using flash extraction for 1.5 minutes each time. The extracts are then filtered and combined to obtain the total extract of rhubarb.
The extract is then suspended in water and extracted three times with petroleum ether/ethyl acetate (2:1, v/v) to separate the lipids from the soluble components. The aqueous phase, containing the soluble components, is reserved.
The remaining aqueous phase, after filtering out the fat-soluble components, contains the crude Rhapontin filter cake.
The crude Rhapontin is recrystallized using 75% (v/v) ethanol aqueous solution and then vacuum freeze-dried to obtain the pure Rhapontin product.

Contact Us

As a company specializing in the production and supply of Rhapontin raw materials, we are committed to providing customers with high-quality products and preferential prices. We have rich experience and technology to ensure product quality and stable supply. No matter where you are, we can provide you with the Rhapontin raw materials you need to support your production and research and development.

We always adhere to the principle of honest operation, strictly control product quality, and serve every customer with a customer-first attitude. Over the years, we have established good cooperative relationships with customers at home and abroad and won their trust and praise.

If you have needs or are interested in our products, please contact our service staff directly, we will wholeheartedly provide you with the best quality services and products. Looking forward to cooperating with you and developing together!

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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