Zhishang Chemical

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Zhishang Chemical

Retinoic Acido CAS 302-79-4

Molecular Formula: C20H28O2

Formula Weight: 300.44

ZSpharmac: Retinoic Acido Supplement

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Product Name: Retinoic Acido
CAS No: 302-79-4
Purity: 99%

Basic Info

Product Name:Retinoic Acido
Other Names:Retinoic acid
CAS:302-79-4
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow Powder
EINECS No.:206-129-0
Storage:-20°C
Provide:Retinoic Acido MSDS;
Retinoic Acido COA

What is Retinoic Acido?

Retinoic Acido is a commonly used drug in dermatology. It is the metabolic intermediate product of vitamin A (vitamin methanol) in the body. It generally affects the growth of bone and also epithelial metabolism, can advertise the expansion and also revival of epithelial cells, as well as can inhibit the spreading and also differentiation of keratinocytes.It can restore the hyperkeratosis to normal, so it has a certain therapeutic effect on many diseases with complete keratinization, incomplete keratinization and hyperkeratosis, and can treat a variety of skin diseases. Topical application penetrates the skin quickly and can significantly increase epithelial cell turnover. This class of drugs has a strong and rapid inhibitory effect on the secretion of sebaceous glands, which can reduce the secretion of sebum. In addition, this product also has anti-tumor, promoting wound healing and anti-infection effects.

维A酸乳膏

Retinoic Acido Properties:

Melting point 180-181 °C (lit.)
Boiling point 381.66°C (rough estimate)
density 1.0597 (rough estimate)
refractive index 1.4800 (estimate)
storage temp. -20°C
solubility Practically insoluble in water, soluble in methylene chloride, slightly soluble in ethanol (96 per cent).
pka4.73±0.33(Predicted)
form powder
color yellow
Water Solubility insoluble

 

Retinoic Acido Uses

  1. Retinoic Acido (ATRA) is a ligand of retinoic acid receptor (RAR) and RetinoidX receptor (RXR), which binds to RAR and RXR as transduction factors to regulate the growth and differentiation of normal cells and tumor cells. Cytochrome P450s (CYPs) catalyze the hydroxylation of ATRA; retinoic acid guides the evolution of embryonic stem cells (embryonicstemcells) into neurons.
  2. Retinoic Acido is used in anti-keratosis drugs.
  3. Retinoic Acido, also known as retinoic acid, is the metabolic intermediate product of vitamin A in this strain, which mainly affects the growth of bone and the metabolism of epithelial cells, and has the effects of promoting epithelial cell proliferation and keratinolysis. It can also be used as an adjuvant therapeutic drug for psoriasis (psoriasis), and can also be used to treat multiple common warts and various skin diseases such as ichthyosis and keratosis follicles.

Retinoic Acido Drug Interactions

(1) There is a risk of increasing photosensitivity when used in combination with photosensitizers.
(2) Shared with detergents such as soaps, preparations containing desquamative drugs (such as benzoyl peroxide, rasocin, salicylic acid, sulfur, etc.), preparations containing ethanol, isotretinoin, etc., which may aggravate skin irritation or Dry, so it must be used with caution.
(3) Concomitant use with cimetidine, cyclosporine, diltiazem, verapamil, ketoconazole, etc., can cause an increase in the blood concentration of this product, and may lead to tretinoin poisoning.
(4) Combined use with pentobarbital, phenobarbital and rifampicin can cause the plasma concentration of this product to decrease.
(5) This item will impact the liver cytochrome P450 enzyme system, leading to adjustments in blood drug concentration.
(6) Taking oryzanol, vitamin B1, vitamin B6 and other drugs at the same time can reduce or disappear the adverse reactions such as headache caused by this product. Pharmacological effects, pharmacokinetics, pharmacodynamics, indications, drug interactions and side effects of retinoic acid commonly used in dermatology.

Pharmacological Effects of Retinoic Acid

This product can induce epidermal hyperplasia, thicken the granular layer and the spinous cell layer, and promote the epidermis by affecting K1 and K10 keratinase hydrolysis in the later stage of epidermal cell differentiation, affecting the process of filaggrin from filaggrin to filaggrin and the formation of cross-linked envelope. This product can significantly inhibit the formation of experimental acne, and remove the keratin plug by regulating the abnormal process of keratinization of the pilosebaceous epithelium, thereby preventing and eliminating acne lesions. In addition, retinoic acid can also affect the melanogenesis of melanocytes, and its effect is multi-site, and it has no effect on the activities of three types of catalytic enzymes such as tyrosine hydroxylase, dopa oxidase and dihydroxyindole oxidase. It has an inhibitory effect, thereby reducing melanin formation and skin pigmentation; it has no effect on normal human melanocyte tyrosinase activity and melanin composition.

Retinoic Acid Precautions

(1) Those who are allergic to this product, those who are allergic to vitamin A derivatives, patients with acute or subacute dermatitis, eczema-like skin diseases and pregnant women are prohibited.
(2) People with allergies should use with caution.
(3) Breastfeeding women should stop breastfeeding during the medication period, and pregnancy is strictly prohibited for women of childbearing age. Use with caution in children.
(4) This product should avoid contact with eyes and other mucous membranes (such as mouth, nose, etc.). It should not be used on skin folds and skin ulcers.
(5) If there is burning sensation, itching, redness, etc. at the medication site, the medication should be discontinued, the local medication should be washed, and a physician should be consulted if necessary.
(6) For the treatment of acne, it can be temporarily aggravated in the first few weeks, and the treatment should be continued for more than 6 weeks to achieve the maximum effect.
(7) This product is not suitable for large-scale application, and the daily dosage should not exceed 20g.
(8) Do not use other drugs, cosmetics or detergents that can cause skin irritation and damage during the medication, so as not to aggravate skin reactions, increase drug absorption and cause systemic adverse reactions.
(9) Sunlight can aggravate the irritation of retinoic acid to the skin and lead to the decomposition of retinoic acid. Animal experiments suggest that retinoic acid can enhance the carcinogenicity of ultraviolet rays. Therefore, this product is best applied at night and before going to bed. Sun exposure should be avoided during the treatment process. , or use shading measures.

Pharmacokinetics of Retinoic Acid

For external use, a small amount is absorbed by the skin, and the absorption is increased when applied to a large area. About 5% of the external dose is excreted in the urine. This product is well absorbed after oral administration, and reaches the peak plasma concentration after 3 hours. After oral administration of 1 mg/kg, the plasma concentration can reach 0.3-0.5 mg/ml. After oral absorption, it is widely combined with plasma proteins, with an average elimination half-life of 0.7 hours. After a single oral dose of 40 mg, the blood drug concentration reaches the endogenous metabolic level in 7 to 12 hours. There was no accumulation in the body after repeated oral administration, but the plasma concentration decreased significantly, which may be due to the induction of cytochrome P450 enzymes, which increased the elimination rate and decreased the bioavailability. Mainly metabolized in the liver, the metabolite is glucuronide. 60% is excreted by the kidneys, and can also be excreted through the bile. The half-life of metabolites is longer than that of this product.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Our Mission
Help China Chemicals to benefit the happiness of human life
Our Vision
Become the most trusted chemical supplier in the world
Our Business Philosophy
Striver – oriented, enrich employees, customer first, deep service, seek development
Our Values
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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