Zhishang Chemical

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Zhishang Chemical

Retinaldehyde CAS 116-31-4

Molecular Formula: C20H28O

Formula Weight: 284.44

ZSpharmac: Retinaldehyde Supplier

Product Name: Retinaldehyde
CAS No: 116-31-4
Purity: 99%

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Basic Info

Product Name:Retinaldehyde
Other Names:Retinal
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Yellow Powder
EINECS No.:204-135-8
Provide:Retinaldehyde MSDS;
Retinaldehyde COA

What is Retinaldehyde?

Vitamin A aldehyde, also known as Retinaldehyde, is the closest component to A acid, which is produced by oxidative cleavage of β-carotene. Reduction gives retinol and oxidation gives retinoic acid. Retinaldehyde is the prosthetic group of rhodopsin. 11-cis-retinal and opsin in visual cells form visual pigment, 11-cis-retinal isomerizes to all-trans-retinal after absorbing light, which changes the conformation of rhodopsin and initiates the stimulation of the brain. Nerve impulses that form vision.

Retinaldehyde Property

Melting point 61-63°C
Boiling point 366.92°C (rough estimate)
density 1.0083 (rough estimate)
refractive index 1.4500 (estimate)
storage temp. -20°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form powder
color yellow
Water Solubility <70mg/L(25 ºC)


The Role of Retinaldehyde

Retinaldehyde is an essential signal transduction molecule in eyeball growth, as well as it plays a variety of important duties in vertebrate eyeball development. Myopia is a developmental disease. The active growth of the sclera of the nearsighted eye is an important mechanism for its elongation, and Retaldehyde may be the carrier particle that controls the prolongation of the speculative myopia. The relationship between retinal and also the occurrence and also development of speculative myopia Some progression has actually been made in the study of Retinaldehyde and its nuclear receptors, retinal adjustments in the retina, choroid, and sclera of experimental myopic eyes, as well as retinal as a messenger particle that sends eyeball elongation signals from the retina to the sclera research study progress.

Retinoic acid has a wide variety of impacts in skin diseases, yet its clinical application is restricted somewhat due to local irritability. Retinoic acid is an intermediate metabolite of natural retinoic acid, which has similar biological task to retinoic acid, as well as the skin’s resistance to it is dramatically far better than that of retinoic acid. The metabolic rate and biological activity of Retinaldehyde in the body and also skin as well as its application in dermatology are examined.

Although stopping smoking can greatly decrease the threat of lung cancer, their threat of creating this cancer is still twice as high as that of never smokers within 20 years of stopping smoking cigarettes. The research outcomes of American professionals reveal that for such ex-smokers, taking an appropriate quantity of Retinaldehyde (that is, by-products of vitamin A retinol and retinoic acid) can additionally efficiently minimize the possibility of lung cancer. The study record was recently released in the Journal of the American Institute for Cancer Cells Study. In this research study, Dr. JonathanM.Kurie of the M.D.Anderson Cancer Proving Ground at the College of Texas contrasted the effects of 2 different Retinaldehydes on the retinoic acid beta receptor (RARbeta) in the lung cells of 226 ex-smokers. The decrease of RARbeta receptors is normally taken into consideration to be a precursor to the incident of precancerous tumors. At the beginning of the experiment, about 60% of the volunteers had a decrease in the number of RARbeta receptors. After taking retinal 9-cisRA for three months (twice a day), it was discovered that the number of RARbeta receptors in this team of volunteers had been considerably raised, however those who took another kind of retinal were considerably more than those in the control team. No visible difference. Additionally, professionals believe that these impacts of Retinaldehyde may be different for those who are cigarette smoking.

Skin Care Benefits of Retinaldehyde

The application of big amounts of non-physiological dosages of exogenous Retinaldehyde can trigger overloading of retinoic acid-dependent paths in the skin, leading to unfavorable responses such as skin irritability. RAL is an all-natural metabolite of retinol and a straight precursor of retinoic acid, and has similar biological tasks to Retinaldehyde. Compared to Retinaldehyde, the benefit of RAL is its multi-directional metabolic rate, that is, excess RAL can be promptly lowered to retinol, and afterwards kept and inactivated in the form of retinol, and also this “reverse metabolism” does not exist in Retinaldehyde. After it is soaked up by the skin, a lot of it is converted into retinol vinegar and stored for sluggish release, and also a percentage of RAL is oxidized into retinoic acid by keratinocytes in a differentiation-dependent manner, and a very small amount of retinoic acid remains in Cells can play a considerable biological duty. This can prevent skin unfavorable reactions brought on by huge doses of Retinaldehyde. Medical observations additionally reveal that topical RAL lotions are much better tolerated than tretinoin and also can be applied to sensitive locations. RAL for external use is not absorbed right into human blood, and the levels of numerous Retinaldehydes in the blood are not affected.

RAL requires to be exchanged Retinaldehyde by enzymes in keratinocytes prior to it can function, so RAL has similar organic task to vitamin A acid. One of the indications of Retinaldehyde task is to generate the expression of cell retinoic acid binding healthy protein (CRABP-2). Exterior use RAL can obviously cause the expression of CRABP-2 mRNA and also protein. External use of all-natural retinoic acid can additionally induce the expression of nuclear retinoic acid receptors. Like Retinaldehyde, RAL likewise has the feature of regulating cell spreading and distinction. It can enhance epidermal DNA synthesis, increase epidermal thickness, generate 50kD keratin, and also decrease 7OkD keratin mRNA expression. Induce favorable keratinization, reduce 65kD keratin mRNA expression, rise filaggrin as well as loricrin mRNA expression. On top of that, RAL is additionally involved in the law of neovascularization in the skin, inhibiting the production of vascular endothelial development element by keratinocytes. Repair work UVA-induced elastic fiber and also collagen damage. RAL likewise has comedogenic as well as straight bactericidal action against P. acnes. All-natural retinoic acid plays a crucial duty in epidermal distinction, facial reconstruction and also skin inflammation. Retinaldehyde, as an essential intermediate metabolite of natural retinoic acid, not only has comparable biological activity to retinoic acid, yet additionally can be well tolerated by the skin, so it is widely utilized in cosmetics.

Clinical Application of Retinol Binding Protein

1. RBP and kidney disease
We know that when kidney disease occurs, due to the decline of glomerular filtration rate and renal tubular reabsorption disorder, RBP in serum and urine are significantly increased. When the glomerular filtration rate (GFR) or renal blood flow decreases due to diabetic nephropathy, hypertensive nephropathy, etc., the filtration rate of RBP also decreases accordingly, which leads to the accumulation of RBP in the blood and increases the concentration. In addition, tubular proteinuria in urine of other patients with chronic kidney disease can also cause elevated RBP in blood, which is more sensitive than creatinine and blood urea nitrogen in the early stage, and is not affected by dietary interference.

2. RBP and liver disease
In addition to the kidney, because RBP is synthesized in the liver, when the liver is damaged by various factors, the synthesis function of RBP decreases, which is reflected in the decrease of RBP level in the blood. At the same time, the half-life of RBP is shorter than that of prealbumin, so it can Sensitively reflect changes in the synthetic function and catabolism of the liver in the early stage.

3. RBP and nutritional status
Physiologically, RBP has a very short half-life (3-12 hours) and high biological specificity. Many clinical diseases can affect the microcirculation of RBP. Therefore, plasma RBP level is often used as an indicator of clinical nutritional status evaluation to specifically diagnose early nutritional status. bad.

4. RBP and epidemic hemorrhagic fever
Epidemic hemorrhagic fever is a common acute infectious disease caused by hantavirus, and the fatality rate of severe patients is high. Most patients have kidney damage, which affects the concentration of RBP in urine.

5. RBP and tumor diagnosis
The pathological changes of the body during the development of tumor diseases and the accumulation of some chemotherapy drugs in the course of treatment will cause varying degrees of damage to renal function, especially in patients with advanced tumors. Therefore, the serum RBP concentration will have a large fluctuation.

Therefore, as a sensitive detection index, RBP is not only widely used in the early diagnosis and curative effect observation of kidney diseases, but also has a high value in the diagnosis of human liver function, clinical nutritional status, epidemic hemorrhagic fever, tumor diagnosis and other diseases. Clinical significance, worthy of our extensive clinical use.

About That Product:
If you need Retinaldehyde as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Retinaldehyde, ZSpharmac will provide Retinaldehyde raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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