1. RBP and kidney disease
We know that when kidney disease occurs, due to the decline of glomerular filtration rate and renal tubular reabsorption disorder, RBP in serum and urine are significantly increased. When the glomerular filtration rate (GFR) or renal blood flow decreases due to diabetic nephropathy, hypertensive nephropathy, etc., the filtration rate of RBP also decreases accordingly, which leads to the accumulation of RBP in the blood and increases the concentration. In addition, tubular proteinuria in urine of other patients with chronic kidney disease can also cause elevated RBP in blood, which is more sensitive than creatinine and blood urea nitrogen in the early stage, and is not affected by dietary interference.
2. RBP and liver disease
In addition to the kidney, because RBP is synthesized in the liver, when the liver is damaged by various factors, the synthesis function of RBP decreases, which is reflected in the decrease of RBP level in the blood. At the same time, the half-life of RBP is shorter than that of prealbumin, so it can Sensitively reflect changes in the synthetic function and catabolism of the liver in the early stage.
3. RBP and nutritional status
Physiologically, RBP has a very short half-life (3-12 hours) and high biological specificity. Many clinical diseases can affect the microcirculation of RBP. Therefore, plasma RBP level is often used as an indicator of clinical nutritional status evaluation to specifically diagnose early nutritional status. bad.
4. RBP and epidemic hemorrhagic fever
Epidemic hemorrhagic fever is a common acute infectious disease caused by hantavirus, and the fatality rate of severe patients is high. Most patients have kidney damage, which affects the concentration of RBP in urine.
5. RBP and tumor diagnosis
The pathological changes of the body during the development of tumor diseases and the accumulation of some chemotherapy drugs in the course of treatment will cause varying degrees of damage to renal function, especially in patients with advanced tumors. Therefore, the serum RBP concentration will have a large fluctuation.
Therefore, as a sensitive detection index, RBP is not only widely used in the early diagnosis and curative effect observation of kidney diseases, but also has a high value in the diagnosis of human liver function, clinical nutritional status, epidemic hemorrhagic fever, tumor diagnosis and other diseases. Clinical significance, worthy of our extensive clinical use.