Zhishang Chemical

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Zhishang Chemical

Resveracel CAS 501-36-0

Molecular Formula: C14H12O3

Formula Weight: 228.24

ZSpharmac: Resveracel Supplement

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Product Name: Resveracel
CAS No: 501-36-0
Purity: 99%

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Basic Info

Product Name:Resveracel
Other Names:Resveratrol
CAS:501-36-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Off-White Powder
EINECS No.:610-504-8
Storage:-20°C
Provide:Resveracel MSDS;
Resveracel COA

What is Resveracel?

Resveracel is an anthraquinone terpenoid, mostly originated from the root essence of Polygonum cuspidatum Sieb.etZucc. Polygonum cuspidatum: seasonal shrub-like herb, up to 1 meter or even more. Rhizomes lying underground, woody yellow-brown, nodes evident. Stems set up, round, surface glabrous, spread with many red spots, hollow. Simple fallen leaves alternative, generally ovate to virtually round, 7-12cm long, 5-9cm large, apex short acuminate, base rounded or cuneate; petiole 1-1.5 centimeters long, filmy, brown, caducous. The flowering duration is July-September, and also the fruiting duration is September-October. It can be dug deep into, cut, and sun-dried in springtime and also autumn. Mostly birthed in valleys, streams or coasts. Distributed to central as well as southern China, produced in Jiangsu, Zhejiang, Jiangxi, Fujian, Shandong, Henan, Shaanxi, Sichuan and also other places.

Resveracel is an all-natural antioxidant that decreases blood thickness, inhibits platelet coagulation and vasodilation, keeps blood streaming, protects against the incident as well as growth of cancer cells, has anti-atherosclerosis and also coronary heart disease, heart disease, Avoidance as well as therapy of hyperlipidemia. The tumor-inhibiting effect also has estrogen-like effects and also can be used to deal with conditions such as bust cancer. It can postpone aging, stop cancer cells and is located in high degrees in red grape skins, red wine and grape juice. Studies have actually revealed that the stability of chromosomes is damaged as people age, and Resveracel can turn on a healthy protein sirtuin that repairs chromosome wellness, therefore delaying aging.

Resveracel Property

Melting point 253-255°C
Boiling point 449.1±14.0 °C(Predicted)
density 1.359±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
form Powder
pka9.22±0.10(Predicted)
color Off-white
Water Solubility Soluble in water (3 mg/100mL), ethanol (50 mg/mL), DMSO (16 mg/mL), DMF (~65 mg/mL), PBS (pH 7.2) (~100µg/mL), methanol, and acetone (50 mg/mL).

 

Resveracel Uses

  1. Resveracel can prevent the oxidation of low-density lipoprotein, as well as has the potential to stop and deal with heart diseases, prevent cancer, anti-virus and immune regulation. Its result is primarily shown up in its antioxidant homes.
  2. Resveracel is made use of in cardio drugs, which can reduce blood lipids, stop heart disease, and has anti-AIDS effects.
  3. Resveracel is made use of as an antioxidant as well as has anti-inflammatory, antithrombotic, anticancer, anticancer, antihyperlipidemic, anti-bacterial and also other activities.
  4. Resveracel is used to delay aging, manage blood lipids, shield cardiovascular and cerebrovascular, and resist liver disease.
  5. Resveracel is a discerning prevention of COX? 1; a phenolic phytoalexin found in grape skins and various other plants with intracellular antioxidant task and also activation of SIRT1; an NAD+-dependent histone deacetylase consisted of in In mitochondrial biogenesis and also enhancing peroxisome gamma-activated proliferator co-activator-1α (PGC-1α) and also FOXO task; the antidiabetic, neuroprotective, and fat-suppressing behaviors of resveratrol may be Contributed by SIRT1 activation.

Benefits of Resveracel

Diabetes is the most common persistent condition, however it is likewise among the most convenient to stop. Due to this, individuals commonly take it gently. The most significant trouble with diabetes mellitus is arteriosclerosis. In addition to significantly enhancing the opportunities of coronary infarction as well as stroke, if it impacts Kidney microvascular, as well as more lead to kidney failure, so exactly how to manage blood sugar is deadly (in the United States alone, 70,000 individuals pass away every year from diabetes mellitus issues).

In a small research study, resveratrol (150 mg per day for 1 month, a DSM patented ingredient resVida) was located to improve blood glucose levels (4.2%) as well as insulin degrees (decreased by 4.2%) in obese individuals. 13.7%).

A current meta-analysis additionally discovered that (including 11 research studies, a total amount of 388 individuals), for clients with diabetic issues, Resveracel can boost not eating blood sugar, insulin, glycosylated hemoglobin. The research likewise kept in mind that these enhancements in blood sugar markers were not found in non-diabetic people.

According to the World Health And Wellness Company, 2.3 billion people are overweight (over 15 years of ages) as well as 700 million are obese.

Dangers associated with weight problems consist of: Type 2 diabetes, heart disease, high blood pressure, high blood lipids, and also enhanced rates of numerous cancers cells.

Larger monitorings (with a 10-year follow-up duration of 500,000 men and women) located that being obese was connected with a 20% to 40% enhanced mortality price, a couple of times that of normal-weight people.

A systematic literary works evaluation (Systematic Evaluation, including 7 research studies with an overall of 208 participants) suggested that in overweight topics, dental Resveracel had no significant result on weight administration, adipose tissue reduction, as well as abdominal weight problems (however, the only The favorable result was that resveratrol minimized an inflammatory marker (IL-6).

The scientists believe that weight reduction is a steady process, taking into account the constraints of small example dimension, diversification, and also short experimental period (mainly less than 90 days), which still requires to be further validated in the future.

Heart disease, typically called cardiovascular disease, is generally triggered by insufficient blood flow to the heart tissue because of lack of oxygen. The reason that cardiovascular disease is awful is that the majority of the time there are no signs and symptoms, and as soon as it occurs, it has a death price of up to 30%, which is unexpected.

Amongst them, coronary cardiovascular disease (ie angina pectoris and also coronary infarction) is the most typical one. It prevails in men in between the ages of 40 and 60, and also most ladies occur after the age of 50. It is the primary cause of premature death (regarding 70% of all fatalities from heart problem). In a 6-month research study of 34 individuals with metabolic disorder, taking Resveracel (100 mg everyday) enhanced vascular wellness markers: endothelial cell relaxation, compared to sugar pill However other blood worths were the same.

In addition, in a double-blind controlled research (example variety of 75 individuals, experimental period of one year), taking resveratrol can not just substantially boost a range of inflammatory factors, including C-reactive healthy protein (CRP), tumor necrosis variable (TNF-α), can additionally decrease the aspects that trigger embolism: plasminogen activator inhibitor type I (PAI-1), which might be made use of as a gold element in the prevention of cardiovascular disease.

Usually, the brain will certainly have more than one aging path. After entering old age, if the physical as well as mental problems are typical, under normal aging, cognitive feature typically begins to decline after the age of 80. An additional path is connected to mental deterioration, which is defined by the destruction of mind cells, which can easily lead to memory as well as cognitive impairment in time, as well as also become incapable to care for themselves.

The most typical in senile dementia is: the major pathological function of Alzheimer’s disease is the accumulation of beta-amyloid protein outside the afferent neuron, leading to abnormal cell feature as well as necrosis, as well as the tangle of nerve fibers formed by the extreme buildup of tau protein.

In animal experiments, it has been discovered that providing Resveracel to experimental computer mice can not just lengthen the typical life expectancy, however also reduce the aggregation of beta-amyloid as well as tau healthy protein, which can protect afferent neuron and decrease cognitivedeterioration. validated. In a tiny research (in overweight middle-aged adults between the ages of 50 and 75), taking resveratrol (200 mg daily for 26 weeks) not only enhanced blood glucose metabolic process and body fat, yet likewise Assists improve memory performance (recall a lot more words heard 30 minutes ago) and hippocampal connectivity/an important location for forming long-term memory.

Choroidal neovascularization is one of the most complicated complication of macular degeneration (wet pathology), these brand-new unusual blood vessels usually cause macular edema, retinal pigment epithelium degeneration and even retinal detachment, and if left unattended, one of the most major cause is loss of sight. Vascular endothelial growth factor VEGF inhibitors are presently the main therapy for the treatment of wet macular deterioration, which can slow down unusual angiogenesis as well as vision damage.

In a preliminary study, it was located that Resveracel inhibits the vascular endothelial development element VEGF to slow choroidal neovascularization (generated by the inflammatory hormonal agent TGF-β or tissue hypoxia), which may enhance the disease process of macular deterioration.

In addition, other small research studies have likewise located that Resveracel (after 1 hour of taking it) aids enhance choroidal thickness (increases blood circulation, which reduces the chance of macular degeneration) contrasted to placebo. But until now, no researches have directly validated the partnership between resveratrol and also age-related macular deterioration, so additional verification is needed.

So far, the scientific area thinks that one of the most reliable way to lengthen human lifespan is with calorie restriction, that is, restricting 20-40% of day-to-day calorie consumption, yet under the condition of balanced nourishment, in many studies, calorie constraint Diverse species have additionally been revealed to increase life-span significantly (approximately 60%), and also while long-term research studies in people have not yet been released, initial proof recommends that the outcomes must be consistent.

In a 6-month human research study, complying with a calorie-restricted diet was discovered to decrease a range of lifespan-related worths, including insulin levels, body temperature, DNA damage, and also help reduce metabolic syndrome, heart disease, as well as cancer. Rate. In some studies, resveratrol has actually been located to generate disease resistance and also life expansion comparable to the effect of calorie constraint (can activate the sirtuin 1 durability genetics).

Consequently, in a controlled pet research study (both teams were fed a high-calorie diet plan), the speculative mice consumed Resveracel substantially enhanced the survival price and also decreased the death price by 31% (in addition to boosting insulin level of sensitivity, lowering blood sugar, raising granule However, the life-extending effect of resveratrol on humans has not been conclusive, so it stays to be confirmed by more massive and also properly designed studies in the future.

Ulcerative colitis is a kind of inflammatory digestive tract illness. The main professional signs are bloody diarrhea, abdominal aches and other signs. It is a persistent swelling caused by immune disorder (intestinal tract mucosa is the major damaged part), and Clients likewise have a greater occurrence of bowel cancer cells. Currently, it is thought that oxidative stress and also totally free radicals play an essential role in the reason and aggravation of illness, and also Resveracel has actually become the target of lots of looks into because of its outstanding reactive oxygen types scavenging capability.

A double-blind controlled research study (6 weeks in 56 people with moderate to modest ulcerative colitis) found that taking resveratrol (500 mg daily) along with The greater the focus of the item after the body is struck by totally free radicals, the greater the oxidative stress and anxiety, the higher the concentration of the body’s total antioxidant capability and the focus of superoxide dismutase (SOD, a sort of anti-oxidant). Furthermore, illness task and also lifestyle were dramatically boosted in the Resveracel-treated group (contrasted to the placebo-controlled group).

Toxic Activity of Resveracel

Hormonal as well as genotoxic activity of Resveracel: Resveratrol-induced cytotoxicity, micronucleus and metaphase chromosomal translocation were observed in L5178Y mouse lymphoma. Induction of micronuclei was additionally observed in Chinese hamster V79 cells. Micronucleus centromere signaling and cell cycle analysis recommend that resveratrol does not straight interfere with tubulin polymerization released by mitotic cells. Research studies have actually revealed that resveratrol has no straight effect on microtubule assembly. The device of securing mitochondrial function: some scholars studied mitochondria isolated from rat brain tissue with a hypoxia-reoxygenation rat version, and found that resveratrol totally obstructed the release of cytochrome C in a concentration-dependent way. The formation of oxide anions can be substantially minimized at 1 nmol. Hypoxia-reoxygenation-induced disruption of the mitochondrial protective membrane layer was approximately 70% shielded at 0.1 μmolar concentrations of Resveracel. In the visibility of NADH and also cytochrome C, a reduced 50% efficient focus of resveratrol of 18.34 pm can obstruct mitochondrial oxygen consumption. 3 significant devices of resveratrol securing mitochondria: antioxidant properties, the function of complex III as well as cell membrane stabilization. Peripheral anti-pain impact: confirmed with a 1% formalin examination, the results showed that resveratrol opened up large as well as small conductance Ca2+-turned on potassium ion networks, however not ATP-sensitive K+ networks, resulting in experimentally created Anti-pain result, it is confirmed that the anti-pain impact of Resveracel is related to K+ network. Voltage-dependent K+ channels might likewise be involved.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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