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Raspberry Ketones Solaray CAS 5471-51-2

Molecular Formula: C10H12O2

Formula Weight: 164.2

ZSpharmac: Raspberry Ketones Solaray Supplement

Product Name: Raspberry Ketones Solaray
CAS No: 5471-51-2
Purity: 99%

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Basic Info

Product Name:Raspberry Ketones Solaray
Other Names:4-(4-Hydroxyphenyl)-2-Butanone
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless Liquid
EINECS No.:226-806-4
Storage:Under Inert Gas (Argon)
Provide:Raspberry Ketones Solaray MSDS;
Raspberry Ketones Solaray COA

What is Raspberry Ketones Solaray?

Raspberry Ketones Solaray, also known as rubus ketone, raspberry ketone, chemical name is 4-p-hydroxyphenyl-2-butanone. It was discovered by the Japanese Nomura and Nozawa in 1918. In 1957, it was identified as the main aroma substance in raspberry, but the content in natural raspberry fruit is only 1-4 mg/kg.

Raspberry Ketones Solaray is a safe flavoring flavor approved by the Flavor Manufacturers Association of America (FEMA) and the Council of Europe (COE) with FEMA number 2588. GB 2760-1996 stipulates that the dosage of Raspberry Ketones Solaray as a food spice is 40~320 mg/kg, which can be used for raspberry, grape, pineapple, peach, plum, strawberry, red berry, jasmine, gardenia, tuberose and other fragrances It can also be used as a modifier or fixative in the preparation of flavors for daily use, food flavors, daily chemical flavors and tobacco flavors. It has become a spice with extremely high economic value after vanillin.

At the same time, it is also an important fine chemical intermediate. In the cosmetics industry, raspberry ketones can be added to whitening cosmetics because of their whitening effect, and because Raspberry Ketones Solaray is a natural fragrance, it can also play a role in fixing fragrance. In agriculture, raspberry ketone and its acetyl compounds are sex attractants for fruit flies, also known as sex pheromones. They are synthesized as pesticides, and their demand is increasing, far exceeding the amount used in food and cosmetics. . In the pharmaceutical industry, Raspberry Ketones Solaray can be added to medicines because of its anti-inflammatory properties; its combination with epicatechin gallate can be used to prevent, treat obesity or, for example, non-insulin-dependent diabetes mellitus and comprehensive Obesity-related symptoms such as schizophrenia; raspberry ketones and Schiff bases from primary amines are intermediates of the beta-adrenergic agonist dobutamine used to treat weakened myocardial contractility. In other applications: Raspberry Ketones Solaray is also used to make fishing lures.

Raspberry Ketones Solaray Property

Melting point 

81-85 °C (lit.)

Boiling point 



1.0326 (rough estimate)

refractive index 

1.5250 (estimate)

storage temp. 

under inert gas (argon)


95% ethanol: soluble50mg/mL, clear to slightly hazy, colorless to faint yellow or tan






Clear colorless

Water Solubility 

Insoluble in water.


Raspberry Ketones Solaray Uses

  1. Raspberry Ketones Solaray is an edible flavor that is permitted to be used in GB 2760-96. Mostly utilized to prepare raspberry, grape, strawberry as well as various other flavors.
  2. Raspberry Ketones Solaray is made use of in the prep work of food flavors, which has the effect of boosting flavor as well as sweetening, and can additionally be utilized in cosmetics and also soap tastes.
  3. Raspberry Ketones Solaray is a food flavor permitted by my nation’s “Hygienic Standards for making use of Food Additives”, and also is mainly utilized to prepare edible flavors for pineapple, peach, strawberry, plum as well as various other fruits.
  4. Raspberry Ketones Solaray is widely utilized in strawberry, raspberry, pineapple, peach and various other edible tastes, typically as a fixative in fruity tastes. In the daily chemical significance, it can be utilized in jasmine, jasmine, tuberose, and so on with .

Preparation of Raspberry Ketones Solaray

1. Extraction and synthesis of natural grade Raspberry Ketones Solaray
Due to the continuous strengthening of people’s awareness of environmental protection, in recent years, the international market prefers natural flavor products. Taking natural plant raspberry as the starting material, through the steps of extraction, decolorization, concentration, and refining to obtain natural grade raspberry ketone; using natural anisaldehyde and fermented acetone as the starting material, through Claisen-Schmidt reaction, selective hydrogenation , the demethylation reaction obtains natural grade raspberry ketone, the total yield is 75.75% (in anisaldehyde), the content is 98.65%, and the aroma is pure; with natural anisaldehyde as raw material, it is condensed with the natural acetone produced by fermentation method Anisylidene acetone is obtained, and then anisole acetone is obtained by hydrogenation. Finally, anisylacetone is demethylated to obtain natural Raspberry Ketones Solaray. The method of measuring isotope 14C is used to determine that its naturalness is more than 98%.

In addition, such methods are also reported in many patents. At present, the synthesis process of natural grade Raspberry Ketones Solaray is relatively mature, but the cost is high and the yield needs to be improved. It is limited to the use of high-end products. It is necessary to further explore lower cost and more effective synthesis methods.

2. Synthesis of Petrochemical Grade Raspberry Ketones Solaray
As the total demand for Raspberry Ketones Solaray in the world increases year by year, at the same time, the raw materials of natural grade raspberry ketones are limited and expensive, which cannot meet the needs of ordinary consumers, so plant extraction is not economical; and raspberry ketones synthesized from petrochemical raw materials Due to the abundant sources of raw materials and low prices, it is widely used in the preparation of daily chemical flavors and agriculture. At present, raspberry ketones are mainly derived from synthesis. Petrochemical grade raspberry ketone mainly includes p-hydroxybenzaldehyde and acetone as raw materials, phenol and 4-butanol-2-one as raw materials, and phenol and methyl vinyl ketone as raw materials.

1) Using p-hydroxybenzaldehyde and acetone as raw materials

4-p-hydroxyphenyl-3-buten-2-one (yield 88.4%) was synthesized by Claisen-Schmidt condensation under alkali catalysis, and the process was optimized by orthogonal experiment. Basin ketone (yield 84.0%); NaOH solution was used as Claisen-Schmidt condensation catalyst to synthesize p-hydroxyphenyl-3-buten-2-one, and then 5% Pd/C and nickel formate were used as the second reaction step. The obtained raspberry ketone yields were 72.55% and 65.7%, respectively.

The condensation reaction conditions of p-Hydroxybenzaldehyde and acetone are studied by orthogonal experiments, and the preferred process conditions are obtained: the ratio of material to substance is n(p-Hydroxybenzaldehyde): n(acetone): n(NaOH) = 1.0: 25: 25 (reaction at 30 ℃ for 5 h), and then through conventional hydrogenation reduction, vacuum distillation, mixed solvent recrystallization to obtain raspberry ketone (yield 61.8%); using p-hydroxybenzaldehyde and acetone as raw materials, NaOH catalyzed Claisen -Schmid condensation reaction, then using nickel formate as catalyst, isopropanol as solvent, hydrogenation reduction to obtain raspberry ketone (yield 42.0%).

2) Using phenol and 4-butanol-2-one as raw materials

Using acetone and formaldehyde as raw materials to first synthesize the intermediate 4-butanol-2-ketone, then use concentrated sulfuric acid as a catalyst to condense it with phenol, purify, and synthesize raspberry ketone by a two-step method (the yield is over 70%) ; Adopt phenol and 4-butanol-2-ketone under the catalysis of strong acid solid acid, one-step synthesis raspberry ketone product (yield 92.5%, purity 99%); Take formaldehyde and acetone as raw material, immobilized alkali KF/ A12O3 was used as the catalyst to synthesize butanone alcohol, then the butanone alcohol was reacted with phenol, and the crude Raspberry Ketones Solaray was synthesized by using the ion exchange resin D218 as the catalyst (yield 46.0%~71.0%).

A θ ring stainless steel packing fixed bed reactor was used to synthesize butanone alcohol with formaldehyde and acetone as raw materials and NaOH as a catalyst, and then using butanone alcohol and phenol as raw materials, a fluidized bed reactor was used, and ion exchange resin D218 was used as a catalyst. Synthesis of Raspberry Ketones Solaray; using phenol and 4-hydroxy-2-butanone as raw materials, the Claisen-Schmidt condensation reaction was carried out to synthesize 4-(4-hydroxyphenyl)-3-buten-2-one, and then acid-catalyzed Friedel-Crafts alkylation was carried out to obtain raspberry ketone.

3) Using phenol and methyl vinyl ketone as raw materials

Using phenol and methyl vinyl ketone as raw materials, Raspberry Ketones Solaray was synthesized by condensation reaction of phenol and methyl vinyl ketone in an acidic catalyst; Raspberry Ketones Solaray was synthesized by selective addition reaction using vinyl ketone as the starting material.

Detection of Raspberry Ketones Solaray

People have done a lot of research on the method of detecting Raspberry Ketones Solaray, and some studies have established a spectrophotometric method for raspberry ketone: Raspberry Ketones Solaray and Ni(NO3)2 form a stable complex with a coordination ratio of 1:1 , the coordination constant is 8.520, the standard curve obeys Lambert-Beer law in the range of (8.152~73.370) × 10 -6 mol/L, the correlation coefficient r = 0.996 6, the recovery rate is 102.80%, the relative standard deviation (RSD ) is 0.190%.

Another study has established a method for the rapid and accurate determination of the content of Raspberry Ketones Solaray reference substance by nuclear magnetic resonance internal standard method: using deuterated DMSO as solvent, benzoic acid as internal standard, measurement temperature of 25 °C and scanning 32 times under the conditions of collecting Raspberry Ketones Solaray The 1H NMR spectrum of the mixture of Ketones Solaray and benzoic acid, the proton signal peaks with chemical shift δ in Raspberry Ketones Solaray at 6.97 and chemical shift δ in benzoic acid at 7.95 are the quantitative peaks, and the peak area ratio y(As:Ar) is the same as The linear regression equation of the mass ratio x (ms mr) is y = 0.197x + 0.783, and the correlation coefficient r = 0.9970, where As is the integrated area of ​​the quantitative peak of the tested sample, Ar is the integrated area of ​​the quantitative peak of the internal standard substance, ms is the mass of the sample, and mr is the mass of the weighed internal standard substance. The RSD value of the assay repeatability experiment was 0.47% (n = 6), the RSD value of the stability was 0.58%, and the RSD value of the sample recovery was 1.18%.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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