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Raspberry Ketone Pure CAS 5471-51-2

Molecular Formula: C10H12O2

Formula Weight: 164.2

ZSpharmac: Raspberry Ketone Pure Supplier

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Product Name: Raspberry Ketone Pure
CAS No: 5471-51-2
Purity: 99%

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Basic Info

Product Name:Raspberry Ketone Pure
Other Names:Raspberry Ketone
CAS:5471-51-2
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless Liquid
EINECS No.:226-806-4
Storage:Under Inert Gas (argon)
Provide:Raspberry Ketone Pure MSDS;
Raspberry Ketone Pure COA

What is Raspberry Ketone Pure?

Raspberry Ketone Pure (in addition called raspberry ketone) exists in natural raspberry juice, the internet content pertains to (0.1 ~ 0.2)× 10-6, it is an essential aroma element of raspberry important oil, as well as also it is a type of elegant Fruity scent, its chemical name is 4-p-hydroxyphenyl-2-butanone, it is shiny granular or needle-like white crystal, melting point is 83 ° C, boiling point is 161 ° C (0.67 kPa), soluble in alcohols and Oil, virtually insoluble in water. Raspberry ketone has wonderful monetary worth, has actually gotten considerable emphasis in the last couple of years, as well as its requirement has actually in addition enhanced year by year.

Raspberry Ketone Pure Property

Melting point 

81-85 °C (lit.)

Boiling point 

200°C

density 

1.0326 (rough estimate)

vapor pressure 

40Pa at 25℃

refractive index 

1.5250 (estimate)

storage temp. 

under inert gas (argon)

solubility 

95% ethanol: soluble50mg/mL, clear to slightly hazy, colorless to faint yellow or tan

form 

Liquid

pka

9.99±0.15(Predicted)

color 

Clear colorless

Water Solubility 

Insoluble in water.

 

 

Raspberry Ketone Pure App

Raspberry Ketone Pure is not only widely used in the prep work of food flavors and everyday flavors, however likewise utilized in the synthesis of medicines, energizers, cosmetics, cigarettes, dyes, etc. Additionally, raspberry ketone and also its acetyl compounds are fruit fly attractants and also can be synthesized Made use of as a chemical. At the same time, because the molecular framework of raspberry ketone has fragrant rings, hydroxyl groups as well as ketone teams, it has unique chemical task and is additionally a crucial fine chemical intermediate. With the more growth of the fragrance market as well as natural synthesis industry, the study worth of Raspberry Ketone Pure has also enhanced steadily. In addition to being made use of as a perfume, it is likewise widely used in other areas.

For example, Raspberry Ketone Pure and epicatechin gallate are used as a new nutritional supplement composition, mainly for the treatment or prevention of obesity, or obesity-related symptoms; raspberry ketone is used as raw material to synthesize ractopamine, which can be used as a Cardiotonic drugs, used for the treatment of congestive heart failure, obesity and muscle atrophy; in addition, the application of raspberry ketone in environmental protection, Chinese cigarettes and other fields has also been studied. With the in-depth research and continuous improvement of Raspberry Ketone Pure in the future, the application field of raspberry ketone will continue to expand.

Raspberry Ketone Pure Weight Loss Benefits

Raspberry Ketone Pure prevents high-fat diet-induced increase in body weight and visceral weight in mice by increasing norepinephrine-induced fat cell breakdown, and reduces liver triglyceride content; improves leptin resistance and insulin resistance by mediating glucose and lipid metabolism disorders and other comprehensive effects to reduce the body weight of obese rats. Japanese scholars have also conducted human experiments and found that raspberry ketone has a more obvious effect on reducing visceral fat than subcutaneous fat.

The body weight, Lee’s index and wet weight of perirenal fat of rats in different doses of Raspberry Ketone Pure group were significantly lower than those in the model group, indicating that raspberry ketone has a weight loss effect. Obesity is the result of an imbalance between energy intake and consumption, which will inevitably lead to disorders of glucose and lipid metabolism. Compared with the control group, high-fat diets can induce obesity in rats while causing significant changes in the levels of blood sugar, blood TG, TC, and LDL-C. Increased, HDL-C levels decreased significantly. The levels of blood glucose, blood TG, TC, and LDL-C in the raspberry ketone group were significantly lower than those in the model group, while the level of HDL-C was significantly increased. It shows that Raspberry Ketone Pure has the effect of lowering blood sugar and blood fat.

Current studies suggest that endogenous resistance to leptin is the basis of obesity. In the experiment, the serum leptin level of rats in the obesity model group was significantly higher than that in the control group, indicating the existence of leptin resistance. Leptin resistance and TNFα can produce and aggravate insulin resistance, while obese people tend to decompose visceral fat and produce excessive FFA. Increased FFA inhibits glucose oxidation and stimulates liver glycogen synthesis, which can further aggravate insulin resistance. In the experiment, the insulin and TNFα levels of rats in the obesity model group were significantly increased, while the FFA level and insulin index were significantly decreased, indicating the existence of insulin resistance. Compared with the model group, the levels of serum leptin, FFA and insulin index of the rats in the raspberry ketone group were significantly decreased, while the levels of insulin and TNFα were significantly increased. It shows that Raspberry Ketone Pure can improve the leptin resistance and insulin resistance of obese rats induced by high-fat diet, which is of great significance in the prevention and treatment of obesity.

Preparation of Raspberry Ketone Pure

1. Extraction and synthesis of natural grade raspberry ketone
Due to the continuous strengthening of people’s awareness of environmental protection, in recent years, the international market has favored natural fragrance products. Using the natural plant raspberry as the starting material, the natural grade raspberry ketone is obtained through the steps of extraction, decolorization, concentration, and refining; using natural anisaldehyde and fermented acetone as the starting material, through the Claisen-Schmidt reaction and selective hydrogenation , demethylation reaction to obtain natural raspberry ketone, the total yield is 75.75% (calculated as anisaldehyde), the content is 98.65%, and the aroma is pure; natural anisaldehyde is used as raw material, and natural acetone produced by fermentation is condensed Anisecetone is obtained, and anisecetone is obtained by hydrogenation. Finally, anisecetone is subjected to demethylation reaction to obtain natural raspberry ketone, and its natural degree is determined to be over 98% by measuring isotope 14C.

In addition, such methods are also reported in many patents. At present, the synthesis process of natural grade raspberry ketone is relatively mature, but the cost is high and the yield needs to be improved. It is limited to the use of high-end products, and further exploration of lower cost and more effective synthesis methods is needed.

2. Synthesis of petrochemical-grade raspberry ketones
As the total demand for raspberry ketone in the world increases year by year, and the raw materials of natural-grade raspberry ketone are limited and expensive, which cannot meet the needs of ordinary consumers, so plant extraction is uneconomical; and raspberry ketone synthesized from petrochemical raw materials Due to the rich source of raw materials and low price, it is widely used in the field of daily chemical essence deployment and agriculture. At present, raspberry ketone mainly comes from synthesis. From the perspective of starting materials, petrochemical grade raspberry ketone mainly includes p-hydroxybenzaldehyde and acetone as raw materials, phenol and 4-butanol-2-one as raw materials, and phenol and methyl vinyl ketone as raw materials.

1) Using p-hydroxybenzaldehyde and acetone as raw materials

Under base catalysis, 4-p-hydroxyphenyl-3-buten-2-one was synthesized by Claisen-Schmidt condensation through orthogonal experiment optimization process (yield 88.4%), and continued hydrogenation under palladium-carbon catalysis to synthesize Basinone (yield 84.0%); using NaOH solution as the Claisen-Schmidt condensation catalyst to synthesize p-hydroxyphenyl-3-buten-2-one, and then using 5% Pd/C and nickel formate as the second step reaction Catalyst, the raspberry ketone yield that obtains is respectively 72.55% and 65.7%.

Research the condensation reaction conditions of 4-Hydroxybenzaldehyde and acetone with orthogonal test, obtain preferred process condition as: the amount ratio n (p-Hydroxybenzaldehyde) of material substance: n (acetone): n (NaOH)=1.0: 25: 25 (reaction at 30 ℃ for 5 h), and then conventional hydrogenation reduction, vacuum distillation, and mixed solvent recrystallization to obtain raspberry ketone (yield 61.8%); using p-hydroxybenzaldehyde and acetone as raw materials, using NaOH to catalyze Claisen -Schmid condensation reaction, then using nickel formate as catalyst and isopropanol as solvent, hydrogenation reduction to obtain raspberry ketone (yield 42.0%).

2) Using phenol and 4-butanol-2-one as raw materials

Using acetone and formaldehyde as raw materials to synthesize the intermediate 4-butanol-2-one, and then using concentrated sulfuric acid as a catalyst to make it condense with phenol, purify, and synthesize raspberry ketone in two steps (the yield is more than 70%) ; Adopt phenol and 4-butanol-2-ketone under the catalysis of strongly acidic solid acid, one-step synthetic raspberry ketone product (yield 92.5%, purity 99%); Take formaldehyde and acetone as raw material, immobilized base KF/ A12O3 was used as catalyst to synthesize butanone alcohol, then butanone alcohol was reacted with phenol, and ion exchange resin D218 was used as catalyst to synthesize crude raspberry ketone (yield 46.0%~71.0%).

A θ-ring stainless steel packed fixed bed reactor was used to synthesize butanone alcohol with formaldehyde and acetone as raw materials and NaOH as a catalyst, and then butanone alcohol and phenol were used as raw materials to adopt a fluidized bed reactor with ion exchange resin D218 as a catalyst. Synthesis of raspberry ketone; use phenol and 4-hydroxy-2-butanone as raw materials, carry out Claisen-Schmidt condensation reaction to synthesize 4-(4-hydroxyphenyl)-3-buten-2-one, and then in acid catalysis Under Friedel-Crafts alkylation reaction to obtain raspberry ketone.

3) Using phenol and methyl vinyl ketone as raw materials

Using phenol and methyl vinyl ketone as raw materials, the raspberry ketone is synthesized by condensation reaction of phenol and methyl vinyl ketone in an acidic catalyst; Raspberry ketone was synthesized by selective addition reaction using vinyl vinyl ketone as the starting material.

About Products:
If you need Raspberry Ketone Pure, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Raspberry Ketone Pure manufacturer and supplier, ZSpharmac will provide Raspberry Ketone Pure raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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