Zhishang Chemical

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Zhishang Chemical

R Serine CAS 302-84-1

Molecular Formula: C3H7NO3

Formula Weight: 105.09

ZSpharmac: R Serine Supplier

Product Name: R Serine
CAS No: 302-84-1
Purity: 99%

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Basic Info

Product Name:R Serine
Other Names:DL-Serine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline Powder
EINECS No.:206-130-6
Storage:Store Below +30°C.
Provide:R Serine MSDS;
R Serine COA

What is R Serine?

Serine is a non-essential amino acid that plays a role in fat and fatty acid metabolism and muscle growth, as it aids in immune hemoglobin and antibody production. R Serine is also required to maintain a healthy immune system. R Serine plays a role in the manufacture and processing of cell membranes, muscle tissue, and the synthesis of the sheath that surrounds nerve cells.

R Serine Property

Melting point 240 °C (dec.) (lit.)
Boiling point 197.09°C (rough estimate)
density 1.53
refractive index 1.4368 (estimate)
storage temp. Store below +30°C.
solubility H2O: soluble
form Crystalline Powder
pka2.19(at 25℃)
color White
Water Solubility 50.23 g/L (25 ºC)


R Serine Uses

  1. R Serine, along with being used as a resources for protein synthesis as well as offering a carbon skeletal system in the synthesis of essential materials such as purine, thymine, methionine as well as choline, it is required for the make-up of the active center of some enzymes as well as the procedure of the glycolic acid path in plants. join.
  2. R Serine has special wettability, so it is made use of as an aesthetic additive for creams (humectants) to keep the moisture of the stratum corneum as well as preserve the gentleness of the skin; artificial additive, utilized as dietary supplements; pharmaceutical resources as well as mixtures.

Preparation Method of R Serine

R Serine can be prepared by:
1. Extraction method. The protein containing more serine is hydrolyzed, and then extracted and purified with ion exchange resin.
2. Using glycolaldehyde, hydrocyanic acid and ammonia as raw materials to synthesize, after obtaining amino nitrile, it can be obtained by hydrolysis.
3. Fermentation method. Using glucose as carbon source and glycine as precursor, it can be obtained by fermentation with Corynebacterium glycineophilus or Sarcina albicans. Or it can be prepared by fermentation with methanol as the carbon source, using Pseudomonas 3ab or Pseudomonas MS31.
4. Using acrylonitrile as raw material, chlorinated to generate α,β-dichloropropionitrile, and then ammoniated to generate α-chloro-β-aminopropionitrile, and then aziridine-2-carboxyl is generated in alkaline solution Sodium, through strong acid cation exchange resin, can obtain R Serine.
5. Using chloroacetaldehyde as raw material, reducing it with sodium bisulfite and then reacting with alkali to generate α-amino-β-chloroethane sulfonate sodium, which is further cyanated with sodium cyanide to obtain α-amino-β- Chloropropionitrile, and finally obtained by the acrylonitrile method.
6, α-Isocyanoacetamide reacts with formaldehyde to generate quinazoline intermediate, which can be directly hydrolyzed.
7. Electrolytic reduction method. First, ethyl propionamic acid is oxidized to the corresponding oxime, and then lithium chloride is used as the supporting electrolyte, and the two poles are lead and platinum, respectively, and electrolytic reduction can be performed.
8. Using ethanolamine as raw material, it is oxidized with hydrogen peroxide under the action of catalyst sodium tungstate, and then cyanated by sodium cyanide to generate amino nitrile, and finally hydrolyzed in hydrochloric acid to obtain R Serine.

Amino Acid Composition of Mulberry Leaf Protein and Silkworm Body Protein

The amino acid composition of mulberry leaf protein and silkworm body protein is different, mainly because the content percentage of six kinds of alanine, methionine, glycine, tyrosine, phenylalanine and proline in silkworm body protein is higher than that of mulberry leaf protein. , especially methionine, which is an essential amino acid, the protein of silkworm body is 2.7 times higher than that of mulberry leaf, and must be accumulated from eating a large amount of food. Other non-essential amino acids can be generated in silkworm except from mulberry leaves. The cocoon silk protein produced in the silkworm body is different from the silkworm body protein. The content of non-essential amino acids such as glycine, alanine, serine and tyrosine is significantly larger. The total of these four amino acids reaches 79.68%, while the silkworm body protein It only accounted for 43.26%, especially the increase of serine was the largest. It can be seen that the production of cocoon silk protein is not derived from silkworm body protein, but is directly synthesized in silk gland cells using free amino acids in blood as materials.
The increased alanine and glycine in silkworm can transfer amino groups from another amino acid (glutamic acid or aspartic acid) to pyruvic acid or glyoxylic acid, respectively, with the participation of transaminase. Alanine can be generated under the sequential action of glutamic aminotransferase, oxaloacetate decarboxylase and alanine aminotransferase. It can also be generated by ornithine aminotransferase (Xu Tingsen et al., 1980). Silk gland tissue can use ketomalonic acid as an amino acceptor to undergo transamination to generate aminomalonic acid, and then generate glycine under the catalysis of aminomalonic acid decarboxylase (Zou Boxiang et al., 1979). Glycine can be interconverted with serine, glucose can also generate serine through 3-phosphate hydroxypyruvate, and serine can generate alanine through pyruvate. Tyrosine can be generated from phenylalanine, and cystine can be converted from methionine but not the other way around, so phenylalanine and methionine are both essential amino acids. When the feed is rich in tyrosine and cystine, the requirement of phenylalanine and methionine can be reduced.

About Products:
If you need R Serine, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced R Serine manufacturer and supplier, ZSpharmac will provide R Serine raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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