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Pyrrolidine CAS 123-75-1

Molecular Formula: C4H9N

Formula Weight: 71.12

ZSpharmac: Pyrrolidine Supplement

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Product Name: Pyrrolidine
CAS No: 123-75-1
Purity: 99%

Basic Info

Product Name:Pyrrolidine
Other Names:Methyl Pyrrolidine
CAS:123-75-1
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Colorless or Yellow Liquid
EINECS No.:204-648-7
Storage:Store Below +30°C.
Provide:Pyrrolidine MSDS;
Pyrrolidine COA

What is Pyrrolidine?

Pyrrolidine is a cyclic secondary amine, the chemical formula is C4H9N, it is a colorless or yellow fluid, with a special smell, easy to turn yellow when revealed to light or humid air, soluble in water, ethanol, destructive and simple to flammability. Pyrrolidine is extensively utilized in medication, food, pesticides, daily chemicals, layers, textiles, printing as well as dyeing, papermaking, photosensitive products, polymer materials, desulfurizers, zeolite layout materials and other areas.

Pyrrolidine Properties:

Melting point -63 °C
Boiling point 87-88 °C/760 mmHg (lit.)
density 0.852 g/mL at 25 °C (lit.)
vapor density 2.45 (vs air)
vapor pressure 128 mm Hg ( 39 °C)
FEMA 3523 | PYRROLIDINE
refractive index n20/D 1.443(lit.)
Fp 37 °F
storage temp. Store below +30°C.
solubility water: miscible
form Liquid
pka11.27(at 25℃)
PH12.9 (100g/l, H2O, 20℃)
explosive limit1.6-10.6%(V)
Water Solubility Miscible with alcohol, ether, chloroform and water.

 

Pyrrolidine Uses

  1. Pyrrolidine is utilized in pharmaceutical resources, natural synthesis, and unique natural solvents.
  2. Pyrrolidine is used in organic synthesis. Insecticide. fungicide. Epoxy hardener. Rubber accelerator. inhibitor.
  3. Pyrrolidine is made use of in the preparation of drugs, fungicides, insecticides, as well as a lot more.

Preparation of Pyrrolidine

1. 1,4-butanediol and ammonia are the gas-phase catalytic synthesis method of raw material
The process uses 1,4-butanediol and ammonia water as raw materials, and passes through a gas-phase fixed bed of a solid acid/rare earth metal compound supported catalyst. Pyrrolidine was synthesized under the condition of h-1, and the yield was about 95%. In this technology, a small amount of water is added during the synthesis process, which can reduce the difficulty of subsequent product separation. The process is safe and efficient, the production process is short, and the conversion rate of raw materials and product yields are high. At the same time, my country is a big producer of 1,4-butanediol, with a wide range of raw material sources and low prices. Therefore, this process technology is the future production of four A major route of hydrogen pyrrole.

2. Gas-phase catalytic synthesis method using Pyrrolidine and ammonia as raw materials
The process uses Pyrrolidine and ammonia gas as raw materials for gas-phase catalytic synthesis of tetrahydropyrrole, has high atomic utilization rate, and the reaction process is environmentally friendly and pollution-free. This process has been industrialized abroad, but due to the large gap between domestic catalyst performance levels and foreign countries, the product quality is poor and it is difficult to scale production. Therefore, the research on amination catalysts for this process should be the focus of future research and development. A new catalyst was synthesized by Yu Xu et al. Using Pyrrolidineand ammonia gas as raw materials, tetrahydropyrrole was synthesized under the conditions of HSZM-5 catalyst with a silicon-aluminum ratio of 70, reaction temperature of 240-280 °C, and gas-solid contact time of 60 g/h·mol. The conversion rate of Pyrrolidine was close to 100. %.

3. Gas-phase catalytic hydrogenation method using pyrrolidone as raw material
Inspired by the process route of preparing pyrrolidine and its alkyl derivatives by hydrogenation of pyrrolidone as raw material by Donald H. Champion et al., the synthesis of Pyrrolidine by gas-phase hydrogenation of pyrrolidone as raw material was realized by screening and preparing new catalysts. The process route, the yield of which is above 85%, has high practical significance, and is a major direction of synthesizing Pyrrolidine in the future.

4 Synthesis of pyrrole as raw material
The synthesis methods using pyrrole as raw materials are divided into gas-phase catalytic hydrogenation method and electrolytic reduction method.

1) Synthesis of Pyrrolidine by gas-phase catalytic hydrogenation of pyrrole as raw material: using catalysts with Pt and Ni as the main active components, the yield of gas-phase catalytic hydrogenation of pyrrole as raw material to synthesize Pyrrolidine is about 50%, which is practical in industrial production. It is not meaningful.

2) Synthesis of Pyrrolidine by electrolytic reduction of pyrrole: take 10% H2SO4 pyrrole and Ni catalyst solution as cathode solution, Cu tube as cathode; 10% H2SO4 solution as anode solution, Pb plate as anode, electrify for 6~8h to obtain The yield of Pyrrolidine is 15%~20%, which has no practical guiding significance in industrial production.

Hepatotoxicity of Chinese Herbal Medicines Containing Pyrrolidine Alkaloids

Mechanism of PA-induced hepatotoxicity
PA is widely distributed in various plant groups in nature. According to statistics, about 3% of flowering plants (about 6,000 species in total) contain PA, mainly distributed in Lithaceae, Compositae, Leguminosae, Orchidaceae, etc. Most PAs are formed by the condensation of two parts, an amino alcohol with a double-fused pyrrolidine ring (crack base) and an organic acid (crack acid). PA with a double bond at the 1, 2 position of the double-fused pyrrolidine ring is hepatotoxic, such as lilybase and senilin. So far, more than 120 hepatotoxic PAs have been isolated from plants, and it is one of the most important plant hepatotoxic components currently known [2|.

After ingesting Chinese herbal medicines containing PA, pyrrole alkaloids can be metabolized in the liver through two metabolic pathways: one is to form N monoxide through a mixed-function oxidase system, and the other is to form dehydrogenation through cytochrome P450 dehydrogenation. Alkaloids or pyrroles. PA itself and its conventional hydrolysis products are not toxic to the body, but when they reach the liver. Under the catalysis of cytochrome P450, it is first oxidized to unstable dehydropyrrolidine alkaloid (DHP), which can be further hydrolyzed to dehydrogenase (DHN). DHP and DHN have strong electrophilicity and can combine with macromolecules in the liver such as DNA/RNA to affect protein synthesis and cell division. The two can react with glutathione (GSH) or cysteine ​​to form Less toxic or non-toxic products. When GSH content is reduced, the formation of toxic substances increases, resulting in cell damage [3]. Hepatocytes in zone III of the hepatic lobule are rich in cytochrome P450, but the content of GSH is low. Cells are vulnerable to damage from toxic substances [H]. Some studies have found that monocrotaline, which belongs to the PA class, is metabolized by cytochrome P450 in the liver to the alkylating agent dehydro monocrotaline, which inhibits the activity of NADH dehydrogenase in the respiratory chain complex I, thereby causing animal and human inflammation. Liver injury, the mechanism may be related to the conformational change of respiratory chain complex I caused by the modification of cysteine ​​sulfhydryl by metabolites.

Research status of experimental detection methods for PA
At present, the existing methods for detecting the hepatotoxicity of Chinese herbal medicines containing PA include in vitro and in vivo methods. The in vitro approach is to extract total alkaloids from suspected toxic herbs, and then use liquid chromatography-mass spectrometry (HPLC/MS) and other chromatographic analysis methods to determine whether they contain PA components, in order to provide an indirect diagnostic basis for the diagnosis of HVOD [7] ]. The in vivo approach is to detect the patient’s blood or urine and other biological samples, and apply chromatographic analysis methods to analyze and identify the PA components and their content in the blood samples.

During the analysis of PA metabolism in vivo, it was found that DHP and DHN generated by liver cytochrome P450 metabolism also entered the blood circulation and combined with the sulfhydryl group of cysteine ​​residues in plasma proteins. Since the in vivo half-life of PA metabolites can be significantly prolonged after binding to plasma proteins, if the specific changes in plasma proteins after the interaction with PA metabolites can be found, it may be used as an ideal detection marker for detecting the hepatotoxicity of PA-containing herbs. Recent studies have reported [1 5|, after treating horse blood with PA active ingredient monocrotaline in vitro, panorama analysis by proteomics method found that a high molecular weight protein polymer appeared in horse serum protein spectrum; The main components of fibrinogen, serum albumin and transferrin were confirmed to be fibrinogen, serum albumin and transferrin, which cross-combined with PA metabolites to form high molecular weight protein polymers. Detection of this high-molecular-weight protein polymer present in blood may serve as a marker for horses eating PA-containing plants. Therefore, it is believed that in rodents and human-related diseases, PA can also change the binding state of plasma proteins. Using technical means such as proteomic panoramic analysis, it is possible to find its specific structural changes, in order to detect PA. In vivo biochemical markers.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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