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Pyrogallol CAS 87-66-1

Molecular Formula: C6H6O3

Formula Weight: 126.11

ZSpharmac: Pyrogallol Supplement

Product Name: Pyrogallol
CAS No: 87-66-1
Purity: 99%

Basic Info

Product Name:Pyrogallol
Other Names:Pyrogallol, 98+%
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:White Very Fine Crystalline Powder
EINECS No.:201-762-9
Storage:Store Below +30°C.
Provide:Pyrogallol MSDS;
Pyrogallol COA

What is Pyrogallol?

Pyrogallol is a kind of chemical reagent and chemical raw material with various uses. It is widely used in pharmaceutical synthesis, dyes, food, pesticides and electronic products, etc. Analytical reagents, etc., and cannot be replaced by other products in some fields. At present, the main raw material for producing Pyrogallol is gallic acid. Pyrogallol is obtained by hydrolysis of gall or tara, a forest product. Gallatia is a special product in my country, with good quality and large quantity (the output accounts for about 1/4 of the world’s output). Therefore, doing a good job in the deep processing of gall has great economic and social benefits.

Pyrogallol is an important organic fine chemical product, which is widely used in chemical industry, organic synthesis, printing and dyeing, analysis, food, medicine, pesticide and other fields. Mainly used in oxygen absorbers, photographic developers and heat-sensitive agents, radioactive element scavengers, dye mordants, metal salt reducing agents, neutral electroplating, chloroprene rubber vulcanization and PVC polymerization kettle additives, food packaging, synthetic resin additives Antioxidant. For example, the effect of propolis in inhibiting Helicobacter pylori was studied by using the method of Pyrogallol in the blood agar medium of heart-brain infusion, and the ideal effect was obtained, and the method has the advantages of convenient operation and low cost. Helicobacter pylori infection is a very common chronic bacterial infection, which is the main pathogenic factor of chronic gastritis and peptic ulcer. The method is low in cost and good in curative effect, which is in line with my country’s national conditions and people’s conditions, and has great application value.

Pyrogallol Properties:

Melting point 43-47 °C(lit.)
Boiling point 309 °C
density 1.112 g/mL at 25 °C(lit.)
vapor density 4.4 (vs air)
vapor pressure 10 mm Hg ( 167.7 °C)
refractive index n20/D 1.387
Fp >230 °F
storage temp. Store below +30°C.
solubility water: soluble
pkapK1:9.03(0);pK2:11.63(+1) (25°C)
form Very Fine Crystalline Powder
color White
PH4-5 (50g/l, H2O, 20℃)
Water Solubility 400 g/L (25 ºC)


Various Applications of Pyrogallol

This product is used as a polymerization inhibitor for styrene and polystyrene, and is also used for the preparation of metal colloidal solutions, shadow agents for film films, medicines and dyes. It is used as an oxygen absorber in gas analysis, and is used in cosmetic powders, hair conditioners, hair dyes, etc.

1. Application in Analysis The study found that pentavalent vanadium and Pyrogallol can form colored complexes in acetic acid buffer solution with pH value of 6.6, and the complexes can be adsorbed by anion exchange resin. On this basis, a method for the determination of vanadium by resin phase spectrophotometry was established. The relative standard deviation (RSD) (n = 5) of the assay results was less than 3%, and the recoveries ranged from 98.6% to 102.6%. When using liquid chlorine to synthesize hydrochloric acid, the lamp cap, sight glass short section and air cooling pipe of the hydrochloric acid synthesis furnace are seriously corroded. Analysis and research on liquid chlorine tail gas showed that it was caused by excessive oxygen content. During the analysis, potassium pyrogallate was used to determine the oxygen in the exhaust gas after sodium hydroxide absorption, and the maximum volume ratio of oxygen content could reach 20%. This helps a lot with antiseptics. The content of vitamin A, D3 and E in feed additives was determined simultaneously by filling nitrogen gas and leaving saponification overnight. Antioxidant Pyrogallol, ethanol and potassium hydroxide solution were added to the sample, then filled with nitrogen, placed under sealed and protected from light conditions for 24h for sufficient saponification, and then purified by high performance liquid chromatography for analysis. The method has the advantages of high recovery rate, good repeatability, accurate and reliable results, and relatively simple.

2. Applications in Synthesis The research uses Pyrogallol as raw material, which undergoes methyl etherification and Claisen rearrangement. The natural compound diarylbutane lignin was successfully synthesized by hydrogen iodide addition and Wurtz reaction, which was isolated from the stem of Porlieria Chilensis in Chile. substance. From the structure of Pyrogallol, it can be seen that it contains three electron-donating groups hydroxyl groups, which enhances the activity of the benzene ring and is easily acylated by an acylating agent. It is mainly used to synthesize polyhydroxybenzophenone products, which are an important class of organic intermediates and are widely used in plastics, resins, coatings, synthetic rubber, photosensitive materials, food, medicine and cosmetics. The application field and scope are also expanding, and the market demand is increasing rapidly. The representative products of polyhydroxybenzophenones that can be synthesized from pyrogallic acid are 2,3,4,4′-tetrahydroxybenzophenone, 2,3,4-trihydroxybenzophenone, Nanjing Longyuan Natural The polyphenol synthesis plant has industrialized the production of this product. Using Pyrogallol, monochloroethanol and sodium hydroxide as raw materials, using chloroform as solvent, and using ammonium tributylethyl sulfate as phase transfer catalyst, 1,2,3-tricarboxymethoxyl was synthesized benzene. The product is an excellent color developer with good selectivity. At present, the chemical products produced by Nanjing Longyuan Natural Polyphenol Synthesis Factory using Pyrogallol as raw materials include 1,2,3-trimethoxybenzene, 2,3,4-trimethoxybenzaldehyde, 2,3, 4-Trihydroxybenzaldehyde and other products. 2,3,4-Trimethoxybenzaldehyde is an important intermediate for the synthesis of lomerizine and other drugs for the treatment of cardiovascular diseases; 2,3,4-trihydroxybenzaldehyde is used for the synthesis of Parkinson’s syndrome An important intermediate of benserazide.

3. Applied medicine in medicine Pyrogallol is a strong reducing agent and has fungicidal effect. It is often formulated into ointment for the treatment of psoriasis, lupus vulgaris, various ringworms and other parasitic skin diseases. It is often made into 2% to 3%. Topical preparations for topical application. The adverse reaction is that a large area of skin or skin peeling surface is easily absorbed and poisoned, causing systemic poisoning. It is toxic to the kidneys and blood system, which can cause red blood cells to rupture, and a large amount of denatured hemoglobin is formed, and protein, red blood cells and casts appear in the urine. It is irritating to local skin and mucous membranes, and can be dyed brown after skin contact. When used, it should not be applied to large areas of skin and skin peeling surfaces to avoid absorption and poisoning. Not compatible with alkalis, heavy metal salts and oxidants.

4. Application in feed Pyrogallic acid has a significant effect on the feeding and growth and development of small silkworms, especially on the silkworm emergence rate and developmental uniformity of the third instar silkworm. After the oxygen in the atmosphere comes into contact with the feed, the fat, VA, VD, VE, VB, carotene, some amino acids, and proteins in the feed will be destroyed by oxygen to varying degrees, and trace amounts of copper, iron, zinc, and manganese in the feed will be destroyed. Elements will also accelerate oxidative rancidity, which will bring serious harm to the quality, nutritional value and safety of feed. The combination of citric acid, vitamin C and pyrogallic acid has strong antioxidant effect, has obvious growth-promoting effect on animals, is cheap, has no toxic side effects, and has great use value in feed.

5. Application in pesticides Rotenone is an insecticidal active substance extracted and isolated from Roten vines. It has excellent contact and stomach poisoning effects on pests, no pollution to the environment, and pests are not easy to develop resistance. It is an excellent insecticide. However, its efficacy is easily affected by environmental factors, is unstable in nature, and is prone to oxidative degradation and photolysis. The study found that using pyrogallic acid as an antioxidant and photoprotectant can prevent its degradation and prolong its efficacy, and the degradation rate is inversely proportional to the amount of Pyrogallol. It solves the problem that rotenone is unstable in the environment. Pyrogallol was reacted with 2,2-dimethylpropane, and then reacted with methyl isocyanate to prepare carboxycarb, and the total yield was 68%. Carbamate is a kind of carbamate heterocyclic insecticide which is used in health and agricultural production. It is a new variety of high-efficiency and low-residue pesticides. Resource pyrogallic acid, the process has high economic and social benefits.

6. Other applications The application of pyrogallic acid in other fields has also been reported. For example, Pyrogallol can be used as a raw material to synthesize liquid crystal ligands and some new imaging materials, and it is widely used as a flotation agent in metallurgy.

Pyrogallol Production Process

Chemical processing of forest products 1) Preparation of Pyrogallol with gallic acid as raw material: gallic acid is decarboxylated and purified to obtain Pyrogallol. At present, the decarboxylation methods commonly used in industry include: biological decarboxylation, atmospheric pressure catalytic decarboxylation and reduced pressure catalytic decarboxylation. The reaction formula is as follows: 2) One-step preparation of Pyrogallol using Tara as raw material: One-step preparation of Pyrogallol using Tara powder as raw material, the product can reach the reagent grade standard. Preparation process: The ratio of tara powder and water is 1:3 (g:mL), and the mass is about 20% calcium oxide of tara powder. Seal it, put it in an oven, slowly heat up to 200°C, keep the temperature for 3 hours, cool down after the reaction, add hydrochloric acid for decarboxylation, filter to remove residue, then extract with ethyl acetate, and evaporate the ester layer to dryness. The residue was extracted with xylene to obtain a crude product, which was then purified by decolorization to obtain white needle-like crystal Pyrogallol. The one-step method greatly shortens the process flow, is easy to operate, reduces investment, and has a short growth cycle. Moreover, the price of raw materials used is cheaper, and greater economic benefits can be obtained.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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