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Pyrithione Zinc Powder CAS 13463-41-7

Molecular Formula: C10H8N2O2S2Zn

Formula Weight: 317.7

ZSpharmac: Pyrithione Zinc Powder Supplier

Product Name: Pyrithione Zinc Powder
CAS No: 13463-41-7
Purity: 99%

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Basic Info

Product Name:Pyrithione Zinc Powder
Other Names:Zinc Pyrithione
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Orange to Green Powder
EINECS No.:236-671-3
Storage:Sealed in dry,Room Temperature
Provide:Pyrithione Zinc Powder MSDS;
Pyrithione Zinc Powder COA

What is Pyrithione Zinc Powder?

Zinc pyrithione is likewise called zinc pyrithione, zinc pyrithione, as well as zinc omadine. This zinc facility was manufactured as early as the 1930s as well as additionally used as an antifungal or anti-bacterial representative for external use. It is white to yellow crystalline powder at area temperature level. Slightly particular odor. Insoluble in water. Zinc pyrithione forms insoluble speeds up with cationic as well as likewise nonionic surfactants, is unpredictable to light as well as also oxidants, as well as is unsteady to acids and antacids at better temperature level degrees. It is not suitable with EDTA, and likewise non-ionic surfactants will partly inactivate it. In the presence of heavy metals, chelation or anti-chelation occurs, as well as these chelates are terribly soluble in water.
EEC and additionally GB7916-87 specify that the maximum permitted focus of zinc pyrithione in cosmetics is 0.5%, in addition to it is only used in products that are washed off after usage. The concentration of one stage is 250-1000mg/ kg (energetic compound), which can be utilized in gels, creams, creams, powders as well as likewise anti-dandruff shampoos, along with in antiperspirant and also sanitation items.

Pyrithione Zinc Powder Property

Melting point approximate 240℃
density 1.782 g/cm3(Temp: 25 °C)
vapor pressure 0Pa at 25℃
storage temp. Sealed in dry,Room Temperature
solubility almost transparency in Pyridine
form Powder
color White to Orange to Green
OdorMild Characteristic
Water Solubility Insoluble (<0.1 g/100 mL at 21 ºC)


Pyrithione Zinc Powder Uses

  1. Pyrithione Zinc Powder is made use of in shampoo to eliminate dandruff, as well as can hinder the development of Gram-positive and also adverse microorganisms and also mold. It can successfully care for hair, delay the aging of hair, and manage the event of grey hair and also loss of hair. Zinc pyrithione ZPT has strong eliminating power versus fungi and also microorganisms, as well as can efficiently kill dandruff-producing fungis and also play an anti-dandruff effect. Zinc Pyrithione ZPT is well known in the hair shampoo sector as an anti-dandruff representative with a lengthy history and is made use of by lots of popular brands. Zinc pyrithione ZPT is likewise widely made use of as an aesthetic preservative, oil agent, pulp, paint, as well as fungicide.
  2. Pyrithione Zinc Powder is utilized as an anti-dandruff representative as well as fungicide in cosmetics, and also is extensively made use of in the prep work of anti-dandruff shampoos. Mainly utilized in cosmetics, hair shampoo, skin care, but likewise in adhesives, layers, paints, etc.
  3. Pyrithione Zinc Powder is used in shampoo to get rid of dandruff, and can inhibit the development of Gram-positive and also negative microorganisms and also mold and mildew. It can successfully look after hair, delay the aging of hair, and also control the event of gray hair as well as hair loss. In addition, it is likewise utilized as an aesthetic chemical, oil representative, paint biocide; as a fungicide for paint and also plastic products, it is likewise extensively used. Broad-spectrum fungicide as well as pollution-free marine biocide.

Pyrithione Zinc Powder Application

Pyrithione Zinc Powder is a complex of pyrithione and zinc, which has high-efficiency, safe and broad-spectrum bactericidal properties. The substance has excellent anti-scaling and anti-grease properties in the field of daily use, and can effectively kill the fungus that produces dandruff; in the field of coatings, it can be compounded and applied to ship antifouling coatings to effectively prevent marine organisms Attached to the hull; in the field of pesticides, it is mainly used to prevent and control apple leaf curl and scab.

In addition, the antifungal agent Pyrithione Zinc Powder also has certain applications on fabrics. Some experiments have studied the effect of the antifungal agent pyrithione zinc on cotton fabrics and polyester/cotton fabrics under different mass concentrations, baking time and baking temperature conditions. For application, the optimal process conditions were determined by single factor and orthogonal experiments. The anti-mildew process parameters of cotton fabrics are: the mass concentration of zinc pyrithione is 0.04g/L, the baking time is 3min, the baking temperature is 120°C, the liquid extrusion rate is 80%, and the liquor ratio is 1:25; the anti-mold process parameters of polyester-cotton fabrics are : The mass concentration of zinc pyrithione is 0.03g/L, the baking time is 3 minutes, the baking temperature is 130°C, the liquid extrusion rate is 80%, and the liquor ratio is 1:25. Under this process condition, the antifungal agent zinc pyrithione can exert the best antifungal effect.

In addition, Pyrithione Zinc Powder has been widely used in the daily chemical industry. It is often used in shampoos to remove dandruff, can inhibit the growth of Gram-positive and negative bacteria and molds, and can also be used as a preservative for cosmetics. However, its application in latex paint has only started in recent years, and it is not very extensive. It is still in the exploratory stage. Some experiments have carried out research on the anti-mold and anti-algae properties of zinc pyrithione in latex paint. The results show that pyrithione Zinc and other compound anti-mold and anti-algae agents can provide comprehensive anti-mold and anti-algae effects for the product and maintain the quality of the product. However, zinc pyrithione has unique advantages in environmental protection and sterilization persistence, and has a long-term application prospect in the future of continuous environmental protection of latex paint.

Pyrithione Zinc Powder Preparation

Technique 1: The prep work concept is that ZnSO4 · 7H2O responds with SPT to generate ZPT and sodium sulfate. Consider a proper amount of zinc sulfate heptahydrate to prepare 0.25 mol/L and also 0.50 mol/L zinc sulfate services respectively. Step an appropriate quantity of salt pyrithione remedy, as well as prepare 0.5 mol/L and 1.0 mol/L salt pyrithione services respectively. The process conditions of the reaction process are regulated, and also both are rapidly added into a three-necked flask at a certain volume ratio for response to acquire pyrithione zinc crystals, which are after that suction filtered, cleaned, and vacuum-dried to get Pyrithione Zinc Powder.

Approach 2: Making use of pyridine as raw material, after 30% H2O2 oxidation, synthesize N-oxide-2-hydroxypyridine in a system of dimethyl sulfoxide, toluene, and sulfur powder, and ultimately form a salt with Zn2 +, although this method Simple, easy to get and also economical basic materials, but the total return is very reduced, only about 17%.

Method 3: 2-carboxypyridine is used as the raw product, the response problems are fairly extreme, and also catalysts such as NaH as well as LiCl are used in the reaction procedure, which is pricey and also has a high threat factor, and also large industrialization is hard.

Approach 4: Using 2-chloropyridine as raw material, utilizing a catalytic oxidation system made up of maleic anhydride and acetic acid, and also better managing the mercaptolation response with the Na2S-NaSH buffer system, Pyrithione Zinc Powder was gotten with a yield of concerning 75%.

1) Synthesis of 2-chloro-N-oxypyridine (1 ): Include 20.0 g (0.18 mol) 2-chloro Pyridine, 1.3 g (0.013 mol) maleic anhydride, 5.0 mL 50% H2O2 as well as 50 mL ethyl acetate were stirred to liquify them all. After the temperature was elevated to 80 ° C, 9.5 mL H2O2 was added dropwise, and also the dropwise addition was finished within 15 minutes. Reaction 4 h, tender loving care to establish the reaction endpoint. The product was washed with water as well as distilled under lowered stress to get a light yellow fluid.

2) Synthesis of 2-mercapto-N-oxypyridine (2 ): add NaOH solution to compound 1, adjust to pH 9.0 ~ 11.0, raise the temperature to 50 ° C, safeguard with N2 and also decrease 100 The barrier service including 17.6 g (0.31 mol) NaSH and 9.4 g (0.12 mol) Na2S in mL was added dropwise in about thirty minutes. Take note of regulate the adjustment of pH throughout the process, raise the temperature to 90 ℃, as well as react for 2 hours. After the reaction was completed, it was decreased to space temperature, and 1 mol/L HCl service was contributed to change the pH to 2. There was a large amount of white precipitate, which was filteringed system by suction and also dried out to acquire the product.

3) Synthesis of 2-mercapto-N-oxypyridine sodium salt (3 ): add NaOH solution to substance 2, adjust to pH 6 ( ± 0.5), and also a little heat to dissolve it completely, creating a clear yellow option.

4) Synthesis of zinc pyrithione (4 ): Weigh 14.0 g (0.05 mol) of ZnSO4 · 7H2O solid, dissolve it in 150 mL of pure water, as well as slowly add it dropwise to intensify 3 at 50 ° C via a constant stress dropping funnel. A huge quantity of white precipitate developed, and also stirring was continued for 2 h. Suction filtering, cleaning two times with water, cleaning with cyclohexane, as well as drying out to obtain 22.9 g of white solid with a complete return of 68%.

About Products:
If you need Pyrithione Zinc Powder, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Pyrithione Zinc Powder, ZSpharmac will provide Pyrithione Zinc Powder raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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