Zhishang Chemical

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Zhishang Chemical

Pyrithione Zinc Bar Soap CAS 13463-41-7

Molecular Formula: C10H8N2O2S2Zn

Formula Weight: 317.7

ZSpharmac: Pyrithione Zinc Bar Soap Supplement

Product Name: Pyrithione Zinc Bar Soap
CAS No: 13463-41-7
Purity: 99%

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Basic Info

Product Name:Pyrithione Zinc Bar Soap
Other Names:Zinc Pyrithione
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Non-Precipitating Emulsion
EINECS No.:236-671-3
Storage:Sealed in dry,Room Temperature
Provide:Pyrithione Zinc Bar Soap MSDS;
Pyrithione Zinc Bar Soap COA

What is Pyrithione Zinc Bar Soap?

Zinc pyrithione, additionally known as Pyrithione Zinc Bar Soap, Zinc Pyrithione, Zinc Omedin, this zinc complex was synthesized and also made use of as a topical antifungal or anti-bacterial agent as early as the 1930s. It is white to yellow crystalline powder at space temperature level. Somewhat particular smell. not soluble in water. creates insoluble speeds up with cationic and also nonionic surfactants, is unsteady to light and also oxidizing representatives, as well as is unpredictable to acids as well as bases at greater temperatures. It is incompatible with EDTA and is partly suspended by nonionic surfactants. In the presence of heavy metals, chelation or dechelation takes place, and also these chelates are inadequately soluble in water.
EEC and also GB7916-87 state that the optimum allowable concentration of Pyrithione Zinc Bar Soap in cosmetics is 0.5%, as well as it is only utilized in items that are gotten rid of after use. The usage concentration of one stage is 250-1000mg/ kg (active compound), which can be utilized in gel, lotion, cream, dusting powder as well as anti-dandruff hair shampoo, as well as in antiperspirant and also sanitation products.

Pyrithione Zinc Bar Soap Property

Melting point approximate 240℃
density 1.782 g/cm3(Temp: 25 °C)
storage temp. Sealed in dry,Room Temperature
Water Solubility Insoluble (<0.1 g/100 mL at 21 ºC)
Merck 14,7994


Pyrithione Zinc Bar Soap Uses

  1. Pyrithione Zinc Bar Soap is a hair shampoo for dandruff that prevents the development of Gram-positive and negative microorganisms and also mold. It can effectively look after the hair, delay the aging of the hair, as well as control the generation of grey hair as well as hair loss. Zinc pyrithione ZPT has strong eliminating power to fungis as well as bacteria, can efficiently kill the fungi that create dandruff, and also play an anti-dandruff effect. Zinc pyrithione ZPT is popular in the shampoo industry as a classic anti-dandruff representative and is utilized by many well-known brands. Zinc pyrithione ZPT is additionally used as an aesthetic chemical, oil, pulp, paint, and also bactericide, as well as is likewise extensively utilized.
  2. Pyrithione Zinc Bar Soap is made use of in cosmetics as an anti-dandruff as well as antiseptic as well as is extensively used to create anti-dandruff hair shampoos. Primarily utilized in cosmetics, shampoos, skin care, and can likewise be used in adhesives, coatings, paints, and so on.
  3. Pyrithione Zinc Bar Soap is also utilized as a cosmetic preservative, oil representative, paint biocide; as a bactericide for items such as finishes and plastics, it is also commonly used. Broad-spectrum fungicides as well as pollution-free marine biocides.

Pyrithione Zinc Bar Soap App

It is a complicated of pyrithione as well as zinc, which is extremely reliable, risk-free as well as broad-spectrum bactericidal. The compound has superb anti-scaling and also anti-sebum properties in the field of everyday usage, and can properly kill fungi that create dandruff; in the field of layers, it can be intensified and related to deliver anti-fouling coverings to efficiently prevent marine organisms Attached to the hull; in the field of chemicals, it is mainly made use of to regulate apple leaf curl and also scab.

Furthermore, the antifungal representative Pyrithione Zinc Bar Soap additionally has certain applications on textiles. There are experiments to research the antifungal agent zinc pyrithione on cotton materials as well as polyester/cotton textiles under the problems of various mass concentrations, baking time as well as baking temperature level. application, the maximum process conditions were identified by single element as well as orthogonal experiments. The anti-mildew process parameters of cotton material are: the mass concentration of zinc pyrithione is 0.04 g/L, the baking time is 3min, the cooking temperature level is 120 ° C, the moving price is 80%, and also the bathroom proportion is 1:25;: The mass concentration of zinc pyrithione is 0.03 g/L, the baking time is 3 minutes, the cooking temperature level is 130 ℃, the rolling proportion is 80%, as well as the bath proportion is 1 ∶ 25. Under this process problem, the antifungal agent zinc pyrithione can play the very best antifungal impact.

Additionally, Has been widely used in the day-to-day chemical market. It is typically utilized in hair shampoos to eliminate dandruff, inhibit the development of Gram-positive and also negative germs as well as molds, and can additionally be utilized as a chemical for cosmetics. Nevertheless, its application in latex paint has just begun in the last few years, and it is not really considerable. It is still in the exploratory phase. Some experiments have actually executed research study on the mold resistance as well as algae resistance of zinc pyrithione in latex paint. The results show that Pyrithione Zinc Bar Soap and other worsened anti-mildew and also anti-algae agents can provide detailed anti-mildew and anti-algae results to the product and also keep the top quality of the item. Nevertheless, zinc pyrithione has special benefits in terms of environmental protection and also sterilization durability, as well as has lasting application potential customers in the future of continuous environmental management of latex paint.

Pyrithione Zinc Bar Soap Preparation

Method 1: The preparation principle is that ZnSO4 · 7H2O reacts with SPT to create ZPT and sodium sulfate. Evaluate an appropriate quantity of zinc sulfate heptahydrate as well as prepare zinc sulfate solutions of 0.25 mol/L and 0.50 mol/L specifically. Measure an appropriate amount of sodium pyrithione remedy and also prepare 0.5 mol/L and 1.0 mol/L salt pyrithione remedy specifically. The technological problems of the response procedure are controlled, as well as the two are swiftly included in a three-necked flask for response at a certain quantity ratio to get Pyrithione Zinc Bar Soap crystals, which are then suction filteringed system, washed, and also vacuum-dried to get zinc pyrithione powder.

Technique 2: Using pyridine as raw material, after 30% H2O2 oxidation, N-oxidative-2-hydroxypyridine was synthesized in the system of dimethyl sulfoxide, toluene and also sulfur powder, and lastly complexed with Zn2+ to develop a salt, although this technique Simple, readily available and low-cost resources, yet the overall yield is incredibly reduced, only about 17%.

Method 3: Making Use Of 2-carboxypyridine as the raw material, the reaction conditions are reasonably severe, and stimulants such as NaH as well as LiCl are utilized in the response process, which is expensive and also has a high risk variable, and large-scale industrialization is challenging.

Technique 4: Using 2-chloropyridine as a raw material, making use of a catalytic oxidation system composed of maleic anhydride and also acetic acid, and also better controlling the mercaptolation reaction through a Na2S-NaSH barrier system, zinc pyrithione is gotten with a return of regarding 75%.

1) Synthesis of 2-chloro-N-oxypyridine (1): In a 250 mL four-necked flask equipped with mechanical stirring, a condenser tube, a constant-pressure dropping funnel, and a thermometer, 20.0 g (0.18 mol) of 2-chloropyridine was added Pyridine, 1.3 g (0.013 mol) maleic anhydride, 5.0 mL of 50% H2O2 and 50 mL of ethyl acetate were stirred to dissolve all of them. After the temperature was raised to 80 °C, 9.5 mL of H2O2 was added dropwise, and the dropwise addition was completed in 15 min. Reaction 4 h, TLC to determine the reaction endpoint. The product was washed with water and distilled under reduced pressure to obtain a pale yellow liquid.

2) Synthesis of 2-mercapto-N-oxypyridine (2): Add NaOH solution to compound 1, adjust to pH 9.0~11.0, heat up to 50 °C, protect with N2, and dropwise add 100 ℃ through a constant pressure dropping funnel The buffer solution composed of 17.6 g (0.31 mol) NaSH and 9.4 g (0.12 mol) Na2S was added dropwise for about 30 min. During the process, attention was paid to controlling the pH change, and the temperature was raised to 90 °C for 2 h. After the reaction, it was lowered to room temperature, and 1 mol/L HCl solution was added to adjust the pH to 2, and a large amount of white precipitates were produced, which was filtered and dried to obtain the product.

3) Synthesis of 2-mercapto-N-oxypyridine sodium salt (3): Add NaOH solution to compound 2, adjust to pH 6 (± 0.5), and dissolve it with slight heat to form a transparent yellow solution.

4) Synthesis of Pyrithione Zinc Bar Soap (4): Weigh 14.0 g (0.05 mol) of ZnSO4 7H2O solid, dissolve it in 150 mL of distilled water, and slowly add it dropwise to compound 3 at 50 °C through a constant pressure dropping funnel. A large amount of white precipitate formed, and stirring was continued for 2 h. Suction filtration, washed twice with water, washed with cyclohexane, and dried to obtain 22.9 g of white solid with a total yield of 68%.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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