Pyridoxine Bnf CAS 65-23-6

Molecular Formula: C8H11NO3

Formula Weight: 169.18

ZSpharmac: Pyridoxine Bnf Supplier

Product Name: Pyridoxine Bnf

CAS No: 65-23-6

Purity: 99%

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Basic Info

Product Name:	Pyridoxine Bnf
Other Names:	Pyridoxine
CAS:	65-23-6
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White to Off-White Solid
EINECS No.:	200-603-0
Storage:	Inert Atmosphere,2-8°C
Provide:	Pyridoxine Bnf MSDS； Pyridoxine Bnf COA

What is Pyridoxine Bnf?

Pyridoxine Bnf, also known as vitamin B6 or anti-pellagra vitamin, scientific name 2-methyl-3-hydroxy-4,5-dimethylolpyridine, common name pyridoxine hydrochloride, usually use its hydrochloride as preparation, white or Light yellow crystalline powder, melting point 204-206°C (decomposition). It has a sour and bitter taste, is stable in the air, and gradually deteriorates when exposed to sunlight, and is easy to sublime. The role of ferric chloride is reddish brown.

Pyridoxine Bnf Property

Melting point	214-215 °C(lit.)
Boiling point	298.46°C (rough estimate)
density	1.2435 (rough estimate)
refractive index	1.5100 (estimate)
storage temp.	Inert atmosphere,2-8°C
solubility	H₂O: 0.1 g/mL at 20 °C, clear, colorless
form	Solid
pka	pKa 5.00(H2O t = 25.0 I = 0.15 (mixed)) (Uncertain)
color	White to Off-White

Pyridoxine Bnf Uses

Pyridoxine Bnf can be made use of as an artificial additive. It can similarly be taken advantage of as an intermediate of pyrithione hydrochloride.
Pyridoxine Bnf handles the vigor of sweat glands and can be made use of in cleaning along with treatment products for face oil control. It can also be made use of in hair care products to enhance the condition of oily hair and healthy and balanced hair roots.

Clinical Application of Pyridoxine Bnf

(1) Application in emergency medicine
Pyridoxine Bnf is involved in amino acid metabolism and is related to the synthesis of central neurotransmitter γ-aminobutyric acid (GABA). It has certain detoxification and antispasmodic effects. On the basis of comprehensive treatment, the new therapy of high-dose vitamin B combined with 20AA compound amino acid has achieved good results in the treatment of bromadiolone, tetramine and other rodent poisoning and trauma-induced bleeding patients with coagulation disorders. Intravenous infusion of large doses of vitamin B6 can significantly improve the total effective rate of treatment of children with convulsions in children, so it is worthy of clinical promotion. Tuberculosis patients are treated with isoniazid. If vitamin B6 is not used at the same time, it may cause isoniazid poisoning, which is manifested as typical symptoms of pellagra, typical skin diseases and intestinal disease symptoms of common diseases; for acute and severe isoniazid poisoning, intravenous injection of large Dosage of vitamin B6 method of treatment. In addition, high-dose supplementation of vitamin B6 (50-100 mg/d) can improve the immune response level of critically ill patients.

(2) Application in cardiovascular diseases
Pyridoxine Bnf is beneficial for some patients with cardiovascular disease. Homocysteine (Hcy) is an intermediate metabolite of methionine metabolism. Abnormally elevated levels of Hcy in plasma can damage endothelial cells and blood vessels, and is a risk factor for various cardiovascular diseases. Vitamin B6 can promote the biosynthesis of nitric oxide (NO) in endothelial cells, reduce the level of Hcy in plasma, and is often combined with folic acid to treat homocysteinemia and the accompanying coronary heart disease, hypertension, and cerebral infarction A series of cardiovascular and cerebrovascular diseases.

(3) Application in gynecological diseases
Pyridoxine Bnf is a coenzyme synthesized by GABA and 5-hydroxytryptamine, which can reduce nerve excitability and relax uterine smooth muscle, so it can effectively treat female primary dysmenorrhea, and has the advantages of small side effects and low cost. Pyridoxine Bnf is also often combined with other drugs to form compound preparations, such as Diclegis (doxylamine succinate-pyridoxine hydrochloride, an oral sustained-release tablet) is effective for nausea and vomiting in pregnant women and has good tolerance sex. Large doses of vitamin B6 can also change the local circulatory disturbance, reduce the milk of lactating women, and can be used to return milk or relieve acute mastitis. In addition, vitamin B6 also has a certain therapeutic effect on gynecological diseases such as premenstrual syndrome, hyperprolactinemia, and perimenopausal syndrome.

(4) Treatment of Pyridoxine Bnf-dependent epilepsy
Pyridoxine Bnf-dependent epilepsy in children is vitamin B6 deficiency caused by congenital metabolic defects. The children are not sensitive to conventional antiepileptic drugs and need to take pharmacological doses of vitamin B6 for life. Children can take vitamin B6 25-200mg/d orally, and the maximum recommended dose is 500mg/d. For those vitamin B6-dependent epilepsy unresponsive to vitamin B6, can be treated with pyridoxal 5-phosphate.

(5) Others
It can still be seen that Pyridoxine Bnf is used to treat carpal tunnel syndrome, children’s autism, acne vulgaris, leukopenia and other diseases. Vitamin B6 can also prevent hand-foot syndrome caused by capecitabine.

Preparation of Pyridoxine Bnf

Pyridoxine Bnf is the most widely distributed form of vitamin B6 compounds in nature, and it is also the main component of this series of vitamin medicines. At present, the industry mainly adopts the oxazole method to produce pyridoxine hydrochloride. However, a large amount of phosphorus pentoxide will be used in this method, which will easily cause equipment damage and safety accidents, and also bring serious three wastes problems. Therefore, chemists have carried out optimization research on this process, such as getting rid of phosphorus pentoxide, Preparation of N-ethoxyoxalylalanine ethyl ester (replacing N-formylalanine ethyl ester (1)) by synchronous esterification of alanine and oxalic acid, using phosgene-triethylamine system as cyclizing agent Production of important intermediate ethyl 4-methyl-5methoxy-2-oxazolecarboxylate (2). In 2009, the process reform was further carried out, so that the synthesis of 4-methyl-5-ethoxy oxazole (3) did not require high vacuum vacuum distillation operation, and Diels-Alder cycloaddition with diethyl maleate was carried out , aromatization, reduction to obtain the target product, the total yield can reach 56%. In the above processes, the biggest disadvantage is that highly toxic and carcinogenic benzene is used as the reaction solvent. In 2003, Roche (Shanghai) Vitamin Co., Ltd. completely broke the traditional production process and successfully built the first domestic Pyridoxine Bnf production line that does not use benzene as a solvent. This is a major breakthrough in the production process of Pyridoxine Bnf. important meaning.

Pyridoxine Bnf Precautions

Expecting women who get a large quantity of Pyridoxine Bnf can cause vitamin B6 reliance disorder in newborns; this product can trigger false positives in urobilinogen examinations.) Symptoms of Pyridoxine Bnf deficiency Vitamin B6 deficiency, involving the skin, cardiovascular system, stomach tract, blood system and nerve system. Signs of skin involvement include erythematous irritation, burning, blisters, vesicles, hyperpigmentation, as well as skin enlarging. Cardiovascular signs include atherosclerosis, coronary infarction, stroke, as well as persistent venous thromboembolism. Gastrointestinal symptoms include queasiness, diarrhea, stomach pain, as well as stomach pain. Hematological signs include anemia, frequently manifested as tiredness. Additionally, some clients also revealed basic fatigue and dizziness. Nerves damage brought on by Pyridoxine Bnf shortage includes main nerves damage and peripheral nerve damages. CNS signs include clinical depression, anxiousness, irritation, confusion, and white issue damages. Outer nerve damage can result in blended distal symmetrical polyneuropathy, materialized by bilateral distal extremity pins and needles or discomfort, and periodically distal limb weakness. Adults with neuropathy have reduced vibratory and also proprioceptive experiences, big fiber-related neurosensory ataxia, but regular discomfort and also temperature level feelings. In infants as well as infants, neurologic signs also consist of hypotension, uneasyness, bilateral focal electric motor seizures or myoclonic seizures, and also infantile spasms. Clients might also experience mental deterioration, disorientation, strength, as well as primitive reflexes.

About Products:
If you need Pyridoxine Bnf this cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Pyridoxine Bnf, our company, ZSpharmac will provide Pyridoxine Bnf raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.