(1) Application in emergency medicine
Pyridoxine Bnf is involved in amino acid metabolism and is related to the synthesis of central neurotransmitter γ-aminobutyric acid (GABA). It has certain detoxification and antispasmodic effects. On the basis of comprehensive treatment, the new therapy of high-dose vitamin B combined with 20AA compound amino acid has achieved good results in the treatment of bromadiolone, tetramine and other rodent poisoning and trauma-induced bleeding patients with coagulation disorders. Intravenous infusion of large doses of vitamin B6 can significantly improve the total effective rate of treatment of children with convulsions in children, so it is worthy of clinical promotion. Tuberculosis patients are treated with isoniazid. If vitamin B6 is not used at the same time, it may cause isoniazid poisoning, which is manifested as typical symptoms of pellagra, typical skin diseases and intestinal disease symptoms of common diseases; for acute and severe isoniazid poisoning, intravenous injection of large Dosage of vitamin B6 method of treatment. In addition, high-dose supplementation of vitamin B6 (50-100 mg/d) can improve the immune response level of critically ill patients.
(2) Application in cardiovascular diseases
Pyridoxine Bnf is beneficial for some patients with cardiovascular disease. Homocysteine (Hcy) is an intermediate metabolite of methionine metabolism. Abnormally elevated levels of Hcy in plasma can damage endothelial cells and blood vessels, and is a risk factor for various cardiovascular diseases. Vitamin B6 can promote the biosynthesis of nitric oxide (NO) in endothelial cells, reduce the level of Hcy in plasma, and is often combined with folic acid to treat homocysteinemia and the accompanying coronary heart disease, hypertension, and cerebral infarction A series of cardiovascular and cerebrovascular diseases.
(3) Application in gynecological diseases
Pyridoxine Bnf is a coenzyme synthesized by GABA and 5-hydroxytryptamine, which can reduce nerve excitability and relax uterine smooth muscle, so it can effectively treat female primary dysmenorrhea, and has the advantages of small side effects and low cost. Pyridoxine Bnf is also often combined with other drugs to form compound preparations, such as Diclegis (doxylamine succinate-pyridoxine hydrochloride, an oral sustained-release tablet) is effective for nausea and vomiting in pregnant women and has good tolerance sex. Large doses of vitamin B6 can also change the local circulatory disturbance, reduce the milk of lactating women, and can be used to return milk or relieve acute mastitis. In addition, vitamin B6 also has a certain therapeutic effect on gynecological diseases such as premenstrual syndrome, hyperprolactinemia, and perimenopausal syndrome.
(4) Treatment of Pyridoxine Bnf-dependent epilepsy
Pyridoxine Bnf-dependent epilepsy in children is vitamin B6 deficiency caused by congenital metabolic defects. The children are not sensitive to conventional antiepileptic drugs and need to take pharmacological doses of vitamin B6 for life. Children can take vitamin B6 25-200mg/d orally, and the maximum recommended dose is 500mg/d. For those vitamin B6-dependent epilepsy unresponsive to vitamin B6, can be treated with pyridoxal 5-phosphate.
It can still be seen that Pyridoxine Bnf is used to treat carpal tunnel syndrome, children’s autism, acne vulgaris, leukopenia and other diseases. Vitamin B6 can also prevent hand-foot syndrome caused by capecitabine.