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Purified Sodium Hyaluronate CAS 9067-32-7

Molecular Formula: C14H22NNaO11

Formula Weight: 403.31

ZSpharmac: Purified Sodium Hyaluronate Supplier

Product Name: Purified Sodium Hyaluronate
CAS No: 9067-32-7
Purity: 99%

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Basic Info

Product Name:Purified Sodium Hyaluronate
Other Names:Sodium Hyaluronate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Cream Powder
EINECS No.:618-620-0
Provide:Purified Sodium Hyaluronate MSDS;
Purified Sodium Hyaluronate COA

What is Purified Sodium Hyaluronate?

Detoxified Salt Hyaluronate, additionally called salt hyaluronate, is a from a physical point ofview energised product frequently existing in the body. Remove the non-inflammatory substance in Detoxified Salt Hyaluronate, called Healon. When 10 mg of this item is liquified in 1 ml of routine saline, its density can be 200,000 times more than that of liquid wit or routine saline. The healthy and balanced protein product of Healon is less than 0.5%, as well as it is a tidy as well as sterile high-purity service.

Purified Sodium Hyaluronate Property

Melting point >209°C (dec.)
alpha D25 -74° (c = 0.25 in water): Rapport et al., J. Am. Chem. Soc. 73, 2416 (1951)
storage temp. -20°C
solubility H2O: 5 mg/mL, clear, colorless
form Powder
color White to cream
PHpH(2g/l,25℃) : 5.5~7.5
Water Solubility SOLUBLE


Function and Efficacy of Detoxified Salt Hyaluronate in Cosmetics

1. Moisturizing result. The hyaluronic acid of the skin starts to shed after the age of 25. At the age of 30, just 65% of the early stage is left, as well as at the age of 60, only 25% is left. The dampness of the skin will likewise be shed along with the hyaluronic acid. Loss of flexibility and also radiance, the aging sensation of wrinkles will appear after a long time. Making use of cosmetics having Detoxified Salt Hyaluronate can replenish and keep moisture in the skin, bring back and preserve the younger luster of the skin.

2. Repair harmed skin. After the skin is revealed to the sun, the ultraviolet rays in the sunlight will create erythema, dermatitis, peeling and other sensations caused by skin burns. Cleansed Sodium Hyaluronate advertises the expansion and also division of skin cells and also gets rid of oxygen complimentary radicals, can promote the regrowth of damaged skin.

3. Skin treatment after acid therapy. After acid treatment, the skin is dehydrated, sensitive, and flaky. The use of practical cosmetics will aggravate skin level of sensitivity. Hyaluronic acid can swiftly renew the skin, so after acid therapy, you can just select hyaluronic acid. acid skin treatment.

4. Thickening residential or commercial property: Cleansed Sodium Hyaluronate has a high thickness in aqueous service, as well as its 1% liquid remedy is in the type of gel, which can enlarge as well as support when included in cosmetics.

Brief Introduction of Six Purified Sodium Hyaluronate and Its Derivatives

1. Hyaluronic acid

Purified Sodium Hyaluronate, also known as hyaluronic acid, is a disaccharide (disaccharide derivatives linked by N-acetyl-D-glucosamine and β-D-glucuronic acid through β-1,3-glycosidic bonds) as repeating Units of straight-chain polymer polysaccharides.

Purified Sodium Hyaluronate can be roughly divided into macromolecules, medium molecules, small molecules and ultra-low molecules. The skin feel, viscosity and efficacy are different among them, which can meet the needs of different application scenarios.

2. Hydrolyzed hyaluronic acid

Hydrolyzed hyaluronic acid (also called oligomeric hyaluronic acid) is a hyaluronic acid molecule with a very low degree of polymerization, usually with a molecular weight of less than 10,000 Da, such as HA-Oligo. HA-Oligo is made by cutting common hyaluronic acid with safe and non-allergic recombinant human hyaluronidase, and then through special processing technology to form activated biological mucopolysaccharide fragments.

HA-Oligo can penetrate deep into the skin through the pores and intercellular spaces to the dermis, exerting the effect of base repair. In addition, HA-Oligo also has physiological activity, which has the functions of repairing damaged skin cells, promoting skin nutrient absorption, removing superoxide free radicals, increasing water content of muscle bottom, increasing skin elasticity, and delaying skin aging.

HA-Oligo has a low molecular weight, so even high-concentration HA-Oligo products have limited viscosity. Therefore, it can be used in combination with ordinary molecular weight hyaluronic acid in formulas to increase the overall moisturizing ability of cosmetics and improve the skin feel of products.

3. Sodium acetylated hyaluronate

Acetylated sodium hyaluronate is obtained by acetylation of sodium hyaluronate, such as HymagicTM-AcHA (hereinafter referred to as AcHA).

High “absorbent” skin property: AcHA has excellent skin affinity, even after washing, it can be firmly adsorbed on the skin, exerting the effects of lasting moisturizing and softening the skin.

Double moisturizing power: AcHA can double the moisturizing power, and can quickly combine moisture in a short period of time to increase the moisture content of the skin and keep the skin moisturized for 12 hours.

Repair the skin barrier: AcHA can not only promote the proliferation of epidermal cells, but also repair damaged epidermal cells, enhance the barrier function of the epidermal stratum corneum, and improve the natural defense ability of the skin.

4. Sodium hyaluronate cross-linked polymer

Sodium hyaluronate cross-linked polymer is a cross-linked HA obtained by cross-linking technology, with a dense network structure. The cross-linking reaction makes HA macromolecules locally highly aggregated and folded, which can bind more water molecules to achieve film formation, hydration and protection on the skin surface; it can be used as a free radical scavenger to relieve pain and blisters after sun exposure; it can be applied to Cosmetics and hair products; can also be used as a delivery system for water-soluble or oil-soluble active substances. The cross-linked hyaluronic acid not only increases in relative molecular weight, but also in volume, forming a network structure; the form changes from sol to gel, and its structure and function are strengthened.

In the natural state, HA will be rapidly degraded in the body, and the dissociation of the structure will also lead to the loss of some of its unique physical and chemical properties and biological activities, which greatly limits its clinical application. Therefore, some scholars use specific cross-linking agents to modify the three most abundant functional groups of HA, hydroxyl, carboxyl, and acetamide, to obtain their derivatives. These derivatives retain the original physical and chemical properties of hyaluronic acid while increasing the molecular weight, and have low toxicity, good biocompatibility, and the ability to resist degradation by hyaluronidase, which can make HA persist in the body for a long time and play a stable role. Its unique physical and chemical properties.

5. Silanized hyaluronic acid

Experiments have proved that silicon mainly exists in the extracellular matrix (ECM), and is one of the components required for the glycosaminoglycan and related protein complexes in connective tissue to form a whole. Exogenous silanol (soluble silicone) mimics the form of natural silicon in the body, helping to rebuild connective tissue and promote fibroblast proliferation and collagen production. Silylated hyaluronate (SHAC) has a strong moisturizing effect, can eliminate sticky feeling on the skin surface, has strong stability at high temperature, and can prevent and repair skin damage.

6. Hydroxypropyltrimethylammonium Chloride Hyaluronic Acid

Hydroxypropyltrimethylammonium chloride hyaluronic acid is a cationic hyaluronic acid, which is mainly used in hair products. In addition to the moisturizing properties of hyaluronic acid, it also has good adsorption to skin and hair Sex and affinity, not easy to be washed off, can play a long-lasting and efficient moisturizing effect. As a moisturizing factor in shampoos and conditioners, it has a good conditioning effect, can enhance skin moisturizing efficiency, reduce irritation, and is compatible with cationic, nonionic, anionic and amphoteric systems.

There are many raw materials modified by hydroxypropyltrimethylammonium chloride, such as: hydroxypropyltrimethylammonium chloride honey, hydroxypropyltrimethylammonium chloride guar gum, hydroxypropyltrimethylammonium chloride Ammonium chloride hydrolyzed silk, hydroxypropyltrimethylammonium chloride hydrolyzed collagen, etc.

Purified Sodium Hyaluronate Production Method

It is a salt formed by the carboxyl group of hyaluronic acid and metal sodium ions. Hyaluronic acid is ubiquitous in animals and humans, such as skin, muscle, cartilage, brain, cockscomb, arterial and venous walls, etc. Commonly used raw materials for extraction include rooster comb, umbilical cord, bull’s eye, etc. The preparation method of taking cockscomb as raw material is as follows.
1. Extraction: wash fresh chicken combs with acetone, dehydrate and pulverize, add distilled water to soak and extract for 24 hours, repeat 3 times, and combine the filtrates.
2. Protein removal and precipitation: the extract was mixed with an equal volume of chloroform and stirred for 3 hours, the water phase was separated, and 2 times the amount of ethanol was added, the precipitate was collected, dehydrated with acetone, and vacuum-dried to obtain crude hyaluronic acid.
3. After enzymatic hydrolysis, complexation, dissociation, and precipitation, high-quality hyaluronic acid is obtained. Then it forms a salt with metal sodium ions.

About Products:
If you need Purified Sodium Hyaluronate this cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced Purified Sodium Hyaluronate manufacturer and supplier, ZSpharmac will provide Purified Sodium Hyaluronate raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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