1. Hyaluronic acid
Purified Sodium Hyaluronate, also known as hyaluronic acid, is a disaccharide (disaccharide derivatives linked by N-acetyl-D-glucosamine and β-D-glucuronic acid through β-1,3-glycosidic bonds) as repeating Units of straight-chain polymer polysaccharides.
Purified Sodium Hyaluronate can be roughly divided into macromolecules, medium molecules, small molecules and ultra-low molecules. The skin feel, viscosity and efficacy are different among them, which can meet the needs of different application scenarios.
2. Hydrolyzed hyaluronic acid
Hydrolyzed hyaluronic acid (also called oligomeric hyaluronic acid) is a hyaluronic acid molecule with a very low degree of polymerization, usually with a molecular weight of less than 10,000 Da, such as HA-Oligo. HA-Oligo is made by cutting common hyaluronic acid with safe and non-allergic recombinant human hyaluronidase, and then through special processing technology to form activated biological mucopolysaccharide fragments.
HA-Oligo can penetrate deep into the skin through the pores and intercellular spaces to the dermis, exerting the effect of base repair. In addition, HA-Oligo also has physiological activity, which has the functions of repairing damaged skin cells, promoting skin nutrient absorption, removing superoxide free radicals, increasing water content of muscle bottom, increasing skin elasticity, and delaying skin aging.
HA-Oligo has a low molecular weight, so even high-concentration HA-Oligo products have limited viscosity. Therefore, it can be used in combination with ordinary molecular weight hyaluronic acid in formulas to increase the overall moisturizing ability of cosmetics and improve the skin feel of products.
3. Sodium acetylated hyaluronate
Acetylated sodium hyaluronate is obtained by acetylation of sodium hyaluronate, such as HymagicTM-AcHA (hereinafter referred to as AcHA).
High “absorbent” skin property: AcHA has excellent skin affinity, even after washing, it can be firmly adsorbed on the skin, exerting the effects of lasting moisturizing and softening the skin.
Double moisturizing power: AcHA can double the moisturizing power, and can quickly combine moisture in a short period of time to increase the moisture content of the skin and keep the skin moisturized for 12 hours.
Repair the skin barrier: AcHA can not only promote the proliferation of epidermal cells, but also repair damaged epidermal cells, enhance the barrier function of the epidermal stratum corneum, and improve the natural defense ability of the skin.
4. Sodium hyaluronate cross-linked polymer
Sodium hyaluronate cross-linked polymer is a cross-linked HA obtained by cross-linking technology, with a dense network structure. The cross-linking reaction makes HA macromolecules locally highly aggregated and folded, which can bind more water molecules to achieve film formation, hydration and protection on the skin surface; it can be used as a free radical scavenger to relieve pain and blisters after sun exposure; it can be applied to Cosmetics and hair products; can also be used as a delivery system for water-soluble or oil-soluble active substances. The cross-linked hyaluronic acid not only increases in relative molecular weight, but also in volume, forming a network structure; the form changes from sol to gel, and its structure and function are strengthened.
In the natural state, HA will be rapidly degraded in the body, and the dissociation of the structure will also lead to the loss of some of its unique physical and chemical properties and biological activities, which greatly limits its clinical application. Therefore, some scholars use specific cross-linking agents to modify the three most abundant functional groups of HA, hydroxyl, carboxyl, and acetamide, to obtain their derivatives. These derivatives retain the original physical and chemical properties of hyaluronic acid while increasing the molecular weight, and have low toxicity, good biocompatibility, and the ability to resist degradation by hyaluronidase, which can make HA persist in the body for a long time and play a stable role. Its unique physical and chemical properties.
5. Silanized hyaluronic acid
Experiments have proved that silicon mainly exists in the extracellular matrix (ECM), and is one of the components required for the glycosaminoglycan and related protein complexes in connective tissue to form a whole. Exogenous silanol (soluble silicone) mimics the form of natural silicon in the body, helping to rebuild connective tissue and promote fibroblast proliferation and collagen production. Silylated hyaluronate (SHAC) has a strong moisturizing effect, can eliminate sticky feeling on the skin surface, has strong stability at high temperature, and can prevent and repair skin damage.
6. Hydroxypropyltrimethylammonium Chloride Hyaluronic Acid
Hydroxypropyltrimethylammonium chloride hyaluronic acid is a cationic hyaluronic acid, which is mainly used in hair products. In addition to the moisturizing properties of hyaluronic acid, it also has good adsorption to skin and hair Sex and affinity, not easy to be washed off, can play a long-lasting and efficient moisturizing effect. As a moisturizing factor in shampoos and conditioners, it has a good conditioning effect, can enhance skin moisturizing efficiency, reduce irritation, and is compatible with cationic, nonionic, anionic and amphoteric systems.
There are many raw materials modified by hydroxypropyltrimethylammonium chloride, such as: hydroxypropyltrimethylammonium chloride honey, hydroxypropyltrimethylammonium chloride guar gum, hydroxypropyltrimethylammonium chloride Ammonium chloride hydrolyzed silk, hydroxypropyltrimethylammonium chloride hydrolyzed collagen, etc.
