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Pure Tryptophan CAS 73-22-3

Molecular Formula: C11H12N2O2

Formula Weight: 204.23

ZSpharmac: Pure Tryptophan Supplier

Product Name: Pure Tryptophan
CAS No: 73-22-3
Purity: 99%

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Basic Info

Product Name:Pure Tryptophan
Other Names:L-Tryptophan
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Yellow-White Powder
EINECS No.:200-795-6
Provide:Pure Tryptophan MSDS;
Pure Tryptophan COA

What is Pure Tryptophan?

L-Tryptophan is a neutral fragrant amino acid containing indole groups. It is white or rather yellow leaf-like crystal or powder. The solubility in water is 1.14 g (25 ° C). It is soluble in thin down acid or antacid. It is fairly steady in lye as well as disintegrates in solid acid. A little soluble in ethanol, insoluble in chloroform as well as likewise ether.

Pure Tryptophan Property

Melting point 289-290 °C (dec.)(lit.)
alpha -31.1 º (c=1, H20)
Boiling point 342.72°C (rough estimate)
density 1.34
refractive index -32 ° (C=1, H2O)
storage temp. 2-8°C
solubility 20% NH3: 0.1 g/mL at 20 °C, clear, colorless
form powder
pka2.46(at 25℃)
color White to yellow-white
PH5.5-7.0 (10g/l, H2O, 20℃)
Odorwh. cryst. or cryst. odorless powd., sl. bitter taste
optical activity[α]20/D 31.5±1°, c = 1% in H2O
Water Solubility 11.4 g/L (25 ºC)


The Role of Pure Tryptophan

Pure Tryptophan is among the necessary amino acids in human as well as animal life activities. It plays a crucial function in the development, growth as well as metabolic process of people as well as pets. It is called the second essential amino acid as well as is widely utilized in medication, food and also feed.

In medication, Pure Tryptophan can synthesize hormones such as hydroxytryptamine and from a physical standpoint active materials such as pigments, alkaloids, coenzymes, and also plant hormones in the body, which can protect against as well as treat pellagra. As an aromatic amino acid, L-tryptophan has the attributes of deriving other biologically energetic materials. As a precursor of neurotransmitters and also hormonal agents, it takes part in the guideline of neurophysiological activities in pets. The derivative of L-tryptophan, 5-HT, is a central neurotransmitter that plays a vital function in regulating pet behavior (consuming, exhaustion, stress and anxiety). Melatonin (originated from 5-HT) secreted by the pineal gland regulates the body clock of pets. Psychological rhythm, enhance sleep impact and other effects. Because serotonin receptors likewise exist in the intestinal system, there are clinical records that L-tryptophan is made use of to boost stomach health and wellness. After taking L-tryptophan to individuals dealing with stomach acid reflux, gastritis as well as duodenal abscess, the patient’s gastrointestinal function was recovered. Loss of metabolic rate of L-tryptophan can cause diabetic issues as well as neurological disorders. For that reason, amino acid injections or compound amino acid prep work made of L-tryptophan as the major basic material are generally used in medication as restorative drugs for diabetes, neurological problems, and also niacin deficiency.

In regards to food and also feed, Pure Tryptophan can be utilized as human nutritional supplements, nutritional supplements for pregnant women, unique milk powder for babies as well as kids, and antioxidants. Furthermore, due to the fact that L-tryptophan is an amino acid that is reasonably doing not have in some plant proteins, using it to reinforce food and also make feed additives plays a crucial role in improving the application of plant healthy proteins. It is the third biggest feed additive amino acid after methionine as well as lysine. As a feed additive, it can promote food intake for animals, weaken stress and anxiety feedbacks, enhance pet sleep, increase fetal and also young antibodies, improve lactation of dairy products animals, reduce the quantity of top quality protein in the diet regimen, as well as conserve feed costs.

Six Physiological Functions of Pure Tryptophan

1. The specificity of amino acid transport in animals
As a macronutrient, changes in plasma and tissue levels of tryptophan have different effects than other amino acids.

It is the only amino acid in animals that binds to serum albumin through non-covalent bonds (McMenemy et al., 1958). This binding is related to its molecular configuration: L-tryptophan mainly binds to serum albumin at one site with high stereospecificity, while the binding force of D-tryptophan to serum albumin is very small, only 1% of that of L-tryptophan (McMenemy et al., 1958). In addition, it is also affected by changes in the concentration of some other macromolecular neutral amino acids and free fatty acids in plasma. When this binding state changes, the metabolism of tryptophan in the body will change (such as affecting the synthesis of serotonin in the brain), and even cause some diseases, such as hepatic coma.

2. Tryptophan can regulate the synthesis of animal liver protein
Sidransky et al. (1980) proved that L-tryptophan can affect the metabolism of liver RNA and protein. It can significantly promote the accumulation of polyribosomes in the liver, the synthesis of cytoplasmic poly(A)-RNA, the release of nuclear-labeled RNA, and the activity of nuclear membrane nucleoside triphosphatase; The activity of NADPH-cytochrome c reductase and NADH-cytochrome b5 reductase in microsomal protein increases liver microsomal protein content (Takahashi, 1991). In addition, Cortamira et al. (1991) believe that tryptophan increases muscle and liver protein synthesis by stimulating insulin release. Therefore, tryptophan is a special amino acid. It is not only one of the amino acid components of protein, but also participates in the regulation of protein synthesis. As for the detailed mechanism of this regulation function, further research is required.

Production Method of Pure Tryptophan

1. indole and propylene glycol are mixed by the ratio of 2:8 and indole solution is made, with indole solution: the mixed amino acid conversion solution of L-serine: high-activity Pure Tryptophan synthetase is sent in the retort after the impurity is filtered out by the ratio of 1:6:3, stir evenly, adjust temperature between 36~48 ℃, react more than 24 hours.

2. Cool the reaction solution to room temperature, and separate the transformation products by isoelectric point crystallization (the principle is: there is the following equilibrium in the amino acid solution. In a solution with a certain pH value, the number of positive ions and negative ions is equal and the concentration is very low, while the dipole concentration is the highest. At this time, the electrolysis exists in the form of dipole ions, and the amino acid does not move. At this time, the pH value of the solution is the isoelectric point of the amino acid. At its isoelectric point, the solubility of various amino acids is the smallest, and they will crystallize into solids. Point is the method of adjusting the pH value, which can make a certain amino acid crystallize, while other amino acids are still in liquid state to achieve the purpose of separating amino acids. The isoelectric point pH value of L-tryptophan is 5.9.) Use 10% dilute sodium hydroxide aqueous solution or dilute hydrochloric acid to adjust the pH value at about 5.9.

3. Wash Pure Tryptophan crystals successively with 65% and 95% ethanol to remove impurities (because L-tryptophan is basically insoluble in ethanol) and send it to a vacuum dryer for 8 hours to obtain the finished product of L-tryptophan.

The invention has the beneficial effects of providing an enzymatic production process for Pure Tryptophan, which has the advantages of simple process, wide source of raw materials, easy operation and low production cost.

About Products:
If you need Pure Tryptophan as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Pure Tryptophan, ZSpharmac will provide Pure Tryptophan raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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