Zhishang Chemical

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Zhishang Chemical

Pure Tryptophan CAS 73-22-3

Molecular Formula: C11H12N2O2

Formula Weight: 204.23

ZSpharmac: Pure Tryptophan Supplier

Product Name: Pure Tryptophan
CAS No: 73-22-3
Purity: 99%

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Basic Info

Product Name:Pure Tryptophan
Other Names:L-Tryptophan
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Yellow-White Powder
EINECS No.:200-795-6
Provide:Pure Tryptophan MSDS;
Pure Tryptophan COA

What is Pure Tryptophan?

Pure Tryptophan is a neutral aromatic amino acid containing indolyl, white or slightly yellow leaf-like crystals or powder, solubility in water 1.14g (25°C), soluble in dilute acid or dilute alkali, relatively weak in lye Stable, decomposed in strong acid.

Pure Tryptophan Property

Melting point 289-290 °C (dec.)(lit.)
alpha -31.1 º (c=1, H20)
Boiling point 342.72°C (rough estimate)
density 1.34
refractive index -32 ° (C=1, H2O)
storage temp. 2-8°C
solubility 20% NH3: 0.1 g/mL at 20 °C, clear, colorless
form powder
pka2.46(at 25℃)
color White to yellow-white
PH5.5-7.0 (10g/l, H2O, 20℃)
optical activity[α]20/D 31.5±1°, c = 1% in H2O
Water Solubility 11.4 g/L (25 ºC)


The Role of Pure Tryptophan

Pure Tryptophan In cosmetics and personal care products, L-Tryptophan is mainly used as a hair conditioner and skin conditioner – among others.

In medicine, Pure Tryptophan can synthesize hormones such as hydroxytryptamine and physiologically active substances such as pigments, alkaloids, coenzymes, and plant hormones in the human body, which can prevent and treat pellagra. As an aromatic amino acid, Pure Tryptophan has the characteristics of deriving other biologically active substances. As a precursor of neurotransmitters and hormones, it participates in the regulation of neurophysiological activities in animals. The derivative of L-tryptophan, 5-HT It is a central neurotransmitter that plays an important role in regulating animal behavior (feeding, fatigue, anxiety). Melatonin (derived from 5-hydroxytryptamine) secreted by the pineal gland regulates the circadian rhythm of animals. Melatonin It is considered to be related to the function of initiating sleep, so it has the effects of eliminating mental tension, regulating mental rhythm, and improving sleep effects. Since there are also receptors for serotonin in the gastrointestinal tract, there are clinical reports of using L-tryptophan to improve the health of the gastrointestinal tract. In patients suffering from acid reflux, gastritis and duodenal ulcers, L-tryptophan is administered. – After tryptophan, the patient’s gastrointestinal function was restored. Metabolism failure of Pure Tryptophan can cause diabetes and neurological disorders. Therefore, amino acid injections or compound amino acid preparations made of L-tryptophan as the main raw material are commonly used in medicine as therapeutic drugs for diabetes, neurological disorders, and niacin deficiency.

In terms of food and feed, Pure Tryptophan can be used as human nutritional supplements, nutritional supplements for pregnant women, special milk powder for infants and young children, and antioxidants. In addition, since Pure Tryptophan is an amino acid that is relatively lacking in some plant proteins, using it to fortify food and make feed additives plays an important role in improving the utilization of plant proteins. It is the third largest feed addition after methionine and lysine As a feed additive, amino acids can promote food intake, weaken stress response, improve animal sleep, increase the antibody of fetus and young, improve lactation of dairy animals, reduce the amount of high-quality protein in rations, and save feed costs.

Production Method of Pure Tryptophan

1. Indole and propylene glycol are mixed by the ratio of 2:8 to make indole solution, and indole solution: the mixed amino acid conversion solution of L_serine: high-activity Pure Tryptophan synthetase is filtered by the ratio of 1:6:3 Send in the reaction tank after removing impurity, stir, adjust temperature between 36~48 ℃, react more than 24 hours.

2. Cool the reaction solution to normal temperature, and separate the conversion product by isoelectric point crystallization (the principle is: there is the following equilibrium in the amino acid solution, in a certain pH solution, the number of positive ions and negative ions is equal and the concentration is very low , and the dipole concentration is the highest. At this time, the electrolysis exists in the form of dipole ions, and the amino acid does not move. At this time, the pH value of the solution is the isoelectric point of the amino acid. When various amino acids are at their isoelectric point, the solubility is the smallest, and the The crystallization is solid. Since the isoelectric points of various amino acids are different, the method of adjusting the isoelectric point, that is, adjusting the pH value, can make a certain amino acid crystallize, while other amino acids are still in liquid state to achieve the purpose of separating amino acids. The isoelectric point pH value of Pure Tryptophan is 5.9.) Use 10% dilute sodium hydroxide aqueous solution or dilute hydrochloric acid to adjust the pH value at about 5.9. The crude product of L-tryptophan was obtained after liquid.

3. Wash Pure Tryptophan crystals successively with 65% and 95% ethanol to remove impurities (because L-tryptophan is basically insoluble in ethanol) and send it to a vacuum dryer for 8 hours to obtain the finished product of L-tryptophan.

The invention has the beneficial effects of providing an enzymatic production process for Pure Tryptophan, which has the advantages of simple process, wide source of raw materials, easy operation and low production cost.

Six Physiological Functions of Pure Tryptophan

About Products:
If you need L-Tryptophan as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced L-Tryptophan manufacturer and supplier, ZSpharmac will provide L-Tryptophan raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Pure Tryptophan Quotation