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Pure Squalane CAS 7683-64-9

Molecular Formula: C30H50

Formula Weight: 410.72

ZSpharmac: Pure Squalane Supplier

Product Name: Pure Squalane
CAS No: 7683-64-9
Purity: 99%

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Basic Info

Product Name:Pure Squalane
Other Names:Squalene
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Light Yellow Liquid
EINECS No.:203-826-1
Storage:Sealed in Dry,2-8°C
Provide:Pure Squalane MSDS;
Pure Squalane COA

What is Pure Squalane?

Squalene is furthermore described as tricosahexaene or cod liver oilene. An often branched polyunsaturated olefin. In microorganisms, squalene is an intermediate in the synthesis of cholesterol in addition to a forerunner for the synthesis of tricyclic, tetracyclic, as well as pentacyclic triterpenes. Just recently, squalene was manufactured from pure trans-geranyl acetone by Wittig response.

Pure Squalane Property

Melting point −75 °C(lit.)
Boiling point 285 °C25 mm Hg(lit.)
density 0.858 g/mL at 25 °C(lit.)
refractive index n20/D 1.494(lit.)
Fp >230 °F
storage temp. Sealed in dry,2-8°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form liquid
color light yellow


Health Benefits of Pure Squalane

Promotes cardiovascular health
Studies have shown that olive oil as a part of “healthy diet” has a certain preventive effect on cardiovascular diseases, and squalene may be one of the important active ingredients in olive oil.

A study using the “isoproterenol-induced myocardial infarction in rats” model pointed out that dietary supplementation of squalene may have a certain effect on reducing the incidence of cardiovascular diseases: reflected in the continuous 45-day dietary supplementation of Pure Squalane ( Accounting for 2% of food content) has a significant protective effect on isoproterenol-induced myocardial infarction, including: ① Squalene inhibits the expression and activity changes of metabolic enzymes regulated by isoproterenol, myocardial hydroxyproline and free amino acids ②Isoproterenol reduces antioxidants such as vitamin C and vitamin E, as well as the content of various antioxidant enzymes in the body, and squalene prevents the occurrence of the above reactions; ③Isoproterenol changes Squalene can also inhibit the occurrence of these reactions; ④ Squalene inhibits the increase of cholesterol and triglycerides in rats during the above process.

Another experiment using rats showed that rats ingested 1000 mg/kg body weight of squalene daily for 4 weeks, and the blood pressure and blood sugar, cholesterol, triglyceride and leptin levels of rats in the experimental group were significantly reduced. The body weight was also significantly lower than that of the control group, indicating that Pure Squalane has a certain regulatory effect on the progress of cardiovascular and other metabolic diseases by regulating glucose and lipid metabolism. Since squalene is directly involved in cholesterol metabolism, whether dietary supplementation of squalene can regulate cholesterol has attracted much attention. Some studies have pointed out that ingested squalene can inhibit the synthesis of cholesterol by feedback inhibiting the activity of HMG CoA reductase. Based on the existing research results, it is currently believed that dietary supplementation with squalene has a certain regulatory effect on cholesterol, but a scientific consensus has not yet been formed. Clinically, squalene can be used in combination with cholesterol-lowering drugs to enhance the efficacy of the drug. For example, the combination of squalene (860mg/d) and cholesterol-lowering drug pravastatin (10mg/d) can significantly enhance the therapeutic effect of the drug in clinical practice.

An analysis of patients with sudden death showed that the content of squalene in the heart is very high, a large amount of squalene forms a complex with fatty acids in the phospholipid bilayer of the cell membrane, stabilizes the structure of the cell membrane, and is effective against myocardial damage caused by oxidative damage play a protective role.

The above experiments support the conclusion that dietary supplementation of squalene is beneficial to cardiovascular health from different angles.

Hypoxia tolerance
In recent years, a number of studies have pointed out that the intake of squalene has the effect of resisting hypoxia, and many research institutions at home and abroad have published relevant results one after another.

For example, after mice ingested squalene by gavage, the normal pressure hypoxia time and sodium nitrite poisoning survival time of mice under different doses were significantly prolonged; under acute cerebral ischemic hypoxia conditions, the intake of Pure Squalane can Prolong the panting time of the tested animals. While achieving the above effects, no toxic side effects of squalene were found; for example, the research of the Fujian Provincial Center for Disease Control and Prevention also obtained similar results. Survival time and panting time were significantly increased in sodium and acute ischemic hypoxic conditions, respectively.

Based on the above results, squalene is also a widely used functional ingredient in hypoxia-resistant health food in the domestic market.

The role of dietary intake of Pure Squalane in assisting the prevention and control of tumors is mainly reflected in the following two aspects:

First, reduce the toxicity of carcinogens. A large number of animal experiments have shown that squalene reduces the toxicity of carcinogens. For example, supplementing squalene (1%) in the diet reduces the probability of colon cancer in mice induced by azomethane; adding 2% squalene to food, Significantly reduces the incidence of breast cancer induced by 4-(methylnitrosamino)-1-(3-pyridine)-1-butanone. The mechanism of squalene reducing the toxicity of carcinogens includes: ① regulating intracellular signals related to tumor progression, such as inhibiting the farnesylation of Ras, and inhibiting the conversion of HMGCoA to mevalonate by regulating endogenous cholesterol metabolism; Interfering with DNA synthesis and cell proliferation, etc.; ② Regulating the synthesis and activity of metabolic enzymes of heterologous toxic substances in the body, blocking the activation of these substances in the body; ③ Clearing free radicals generated by heterologous substances in the body, inhibiting the Carcinogenesis and cancer progression intensified.

Second, enhance the efficacy of tumor drugs and reduce drug toxicity. In vitro experiments show that squalene enhances the tumor-killing ability of anti-tumor drugs such as doxorubicin, 5-fluorouracil, bleomycin and cisplatin; in vivo experiments also show that squalene has the above effects: for example, using Pure Squalane Combined with the antineoplastic drug nimustine (ACNU) in the treatment of lymphocytic leukemia P388 in mice, the drug effect was significantly improved; for example, squalene significantly reduced the production of cisplatin drugs on bone marrow cells during the treatment of tumors. Toxicity, squalene is also used as an auxiliary drug to treat leukopenia caused by cancer radiotherapy and chemotherapy.

There are also a small number of reports that squalene has the ability to inhibit the growth of tumor cells and improve the body’s immunity to fight tumors. Through more mechanism analysis, it is expected to further clarify the anticancer effect of squalene.

Reduce the damage of toxic substances to the body
In addition to reducing the toxicity of certain carcinogens, squalene also has a certain resistance to other exogenous toxic substances, part of which can be attributed to the antioxidant capacity of Pure Squalane, and the mechanism of some experimental results remains to be elucidated. For example, squalene inhibits DNA damage in normal cells caused by exogenous oxidants; by detecting the activities of a series of antioxidant enzymes in rats, as well as the content of other antioxidants in the body, it was found that dietary supplementation of squalene in rats significantly reduced environmental Phosphoramides cause heart and red blood cell damage by inducing oxidative reactions in the body. In addition, studies have shown that squalene also helps the body excrete exogenous toxic and harmful substances. For example, mice in the experimental group were supplemented with squalene for 3 weeks, and their ability to excrete the exogenous poison hexachlorobenzene (HCB) was increased by 3 times, and the clearance time of hexachlorobenzene in the body was significantly shortened; other studies have shown that squalene Alkenes improve the efficiency of the body’s excretion of theophylline and alkaloids.

Promotes skin health
Studies have shown that the antioxidant capacity of squalene is stronger than that of other lipid molecules in the skin. Squalene in the skin can effectively inhibit the cascade amplification of lipid peroxidation, thereby helping the skin resist the damage caused by ultraviolet radiation and other oxidation reactions. damage. Many studies have also pointed out that in addition to anti-oxidation, squalene (and its derivative squalane) also have emollient and moisturizing effects. A population-based experiment investigated the relationship between squalene supplementation and skin health: 40 female subjects over the age of 50 were divided into two groups for 90 days, respectively consuming 13.5 g and 27 g of squalene daily,37 Volunteers finally completed the test. The facial wrinkles of the subjects in the high-dose group were significantly reduced, and the facial erythema and pigmentation were significantly improved in both groups. Some molecular indicators related to facial skin also had different degrees in the two groups. improvement.

On the basis of extensive research on topical Pure Squalane skin care, the skin care effects of dietary supplementation of squalene have also been gradually confirmed.

The above studies have clarified the health effects of Pure Squalane in promoting cardiovascular health, cancer prevention and anti-cancer, and hypoxia resistance from different perspectives, but relevant systematic clinical research is still relatively limited.

Structure, Distribution and Metabolism of Pure Squalane

In 1916, scientists isolated squalene from shark liver oil; in 1936, its chemical structure was resolved. Based on its high lipophilicity, squalene can easily enter cells through the cell membrane structure. Afterwards, researchers found that squalene is widely distributed in nature. In addition to high content in shark liver oil, squalene is also contained in many vegetable oils. Its content in vegetable oils is generally 0.002%-0.03%. The content of squalene in rice bran oil and tea seed oil is relatively high, especially in olive oil, the content of squalene is as high as 0.2%-0.7%.

The Pure Squalane in the body comes from two parts: one is the squalene produced during the body’s metabolism, and its synthesis comes from the conversion of acetyl-CoA into 3-hydroxymethylglutaryl CoA (HMGCoA), which undergoes a series of catalysis The reaction eventually forms squalene, which can be further transformed into cholesterol and other sterols; the second is through the intake of squalene-containing foods.

Dietary intake of Pure Squalane has a high absorption rate (60%-85%), and a part of it is usually combined with very low-density lipoprotein and distributed to various tissues of the human body. The content of squalene is the highest in adipose tissue and skin, lymph nodes and liver, etc. Organs also contain a certain amount of squalene. Another part of squalene is used for cholesterol synthesis. This part of squalene enters the liver after being absorbed, and finally forms cholesterol after demethylation and rearrangement of chemical bonds.

Squalene is essential for the body due to its important role in the synthesis of cholesterol. Subsequent studies have found that squalene may also have anti-tumor, hypoxia resistance and cell protection activities. In the past few decades, squalene has been widely used in the fields of medicine and cosmetics, and in recent years, the application of squalene in the field of functional foods has also continued to expand.

Production Method of Pure Squalane

Take 900g fresh whale shark liver, clean it, mince it, add pure water, and homogenize it for 2 mins. Then warm it in a water bathroom at concerning 80 ° C, and adjust the pH of the liver homogenate to concerning 9 with 1mol/L sodium hydroxide option, stir constantly, warmth for 1 hour, as well as centrifuge while it is warm to absorb the yellow oil in the upper layer. Wash with sodium solution for 2 to 3 times, and then clean with pure water up until the pH is neutral to obtain regarding 300 ml of petroleum. Take 170ml of crude oil for vacuum cleaner purification. When the interior temperature is 85-140 ° C and the vacuum level is 6-1.22 , the initial fraction begins to show up, which is a yellow oily substance, about 40ml. When the inner temperature level rose to 90-206 ° C and also the vacuum level was 0.8-0.4 , the 2nd portion was accumulated as light yellow oil, about 78ml. The second fraction went through fractional distillation under decreased stress. When the interior temperature is 190 ° C as well as the vacuum degree is 0.53 Pa, light yellow oil begins to show up, about 20ml. When the internal temperature level rises to 195-200 DEG C and the vacuum cleaner degree is 0.4-0.3 , an anemic and transparent oily issue, regarding 35ml, is gathered, which is the squalene ended up product.

About Products:
If you need Pure Squalane as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Pure Squalane manufacturer and supplier, ZSpharmac will provide Pure Squalane raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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