Promotes cardiovascular health
Studies have shown that olive oil as a part of “healthy diet” has a certain preventive effect on cardiovascular diseases, and squalene may be one of the important active ingredients in olive oil.
A study using the “isoproterenol-induced myocardial infarction in rats” model pointed out that dietary supplementation of squalene may have a certain effect on reducing the incidence of cardiovascular diseases: reflected in the continuous 45-day dietary supplementation of Pure Squalane ( Accounting for 2% of food content) has a significant protective effect on isoproterenol-induced myocardial infarction, including: ① Squalene inhibits the expression and activity changes of metabolic enzymes regulated by isoproterenol, myocardial hydroxyproline and free amino acids ②Isoproterenol reduces antioxidants such as vitamin C and vitamin E, as well as the content of various antioxidant enzymes in the body, and squalene prevents the occurrence of the above reactions; ③Isoproterenol changes Squalene can also inhibit the occurrence of these reactions; ④ Squalene inhibits the increase of cholesterol and triglycerides in rats during the above process.
Another experiment using rats showed that rats ingested 1000 mg/kg body weight of squalene daily for 4 weeks, and the blood pressure and blood sugar, cholesterol, triglyceride and leptin levels of rats in the experimental group were significantly reduced. The body weight was also significantly lower than that of the control group, indicating that Pure Squalane has a certain regulatory effect on the progress of cardiovascular and other metabolic diseases by regulating glucose and lipid metabolism. Since squalene is directly involved in cholesterol metabolism, whether dietary supplementation of squalene can regulate cholesterol has attracted much attention. Some studies have pointed out that ingested squalene can inhibit the synthesis of cholesterol by feedback inhibiting the activity of HMG CoA reductase. Based on the existing research results, it is currently believed that dietary supplementation with squalene has a certain regulatory effect on cholesterol, but a scientific consensus has not yet been formed. Clinically, squalene can be used in combination with cholesterol-lowering drugs to enhance the efficacy of the drug. For example, the combination of squalene (860mg/d) and cholesterol-lowering drug pravastatin (10mg/d) can significantly enhance the therapeutic effect of the drug in clinical practice.
An analysis of patients with sudden death showed that the content of squalene in the heart is very high, a large amount of squalene forms a complex with fatty acids in the phospholipid bilayer of the cell membrane, stabilizes the structure of the cell membrane, and is effective against myocardial damage caused by oxidative damage play a protective role.
The above experiments support the conclusion that dietary supplementation of squalene is beneficial to cardiovascular health from different angles.
Hypoxia tolerance
In recent years, a number of studies have pointed out that the intake of squalene has the effect of resisting hypoxia, and many research institutions at home and abroad have published relevant results one after another.
For example, after mice ingested squalene by gavage, the normal pressure hypoxia time and sodium nitrite poisoning survival time of mice under different doses were significantly prolonged; under acute cerebral ischemic hypoxia conditions, the intake of Pure Squalane can Prolong the panting time of the tested animals. While achieving the above effects, no toxic side effects of squalene were found; for example, the research of the Fujian Provincial Center for Disease Control and Prevention also obtained similar results. Survival time and panting time were significantly increased in sodium and acute ischemic hypoxic conditions, respectively.
Based on the above results, squalene is also a widely used functional ingredient in hypoxia-resistant health food in the domestic market.
Antitumor
The role of dietary intake of Pure Squalane in assisting the prevention and control of tumors is mainly reflected in the following two aspects:
First, reduce the toxicity of carcinogens. A large number of animal experiments have shown that squalene reduces the toxicity of carcinogens. For example, supplementing squalene (1%) in the diet reduces the probability of colon cancer in mice induced by azomethane; adding 2% squalene to food, Significantly reduces the incidence of breast cancer induced by 4-(methylnitrosamino)-1-(3-pyridine)-1-butanone. The mechanism of squalene reducing the toxicity of carcinogens includes: ① regulating intracellular signals related to tumor progression, such as inhibiting the farnesylation of Ras, and inhibiting the conversion of HMGCoA to mevalonate by regulating endogenous cholesterol metabolism; Interfering with DNA synthesis and cell proliferation, etc.; ② Regulating the synthesis and activity of metabolic enzymes of heterologous toxic substances in the body, blocking the activation of these substances in the body; ③ Clearing free radicals generated by heterologous substances in the body, inhibiting the Carcinogenesis and cancer progression intensified.
Second, enhance the efficacy of tumor drugs and reduce drug toxicity. In vitro experiments show that squalene enhances the tumor-killing ability of anti-tumor drugs such as doxorubicin, 5-fluorouracil, bleomycin and cisplatin; in vivo experiments also show that squalene has the above effects: for example, using Pure Squalane Combined with the antineoplastic drug nimustine (ACNU) in the treatment of lymphocytic leukemia P388 in mice, the drug effect was significantly improved; for example, squalene significantly reduced the production of cisplatin drugs on bone marrow cells during the treatment of tumors. Toxicity, squalene is also used as an auxiliary drug to treat leukopenia caused by cancer radiotherapy and chemotherapy.
There are also a small number of reports that squalene has the ability to inhibit the growth of tumor cells and improve the body’s immunity to fight tumors. Through more mechanism analysis, it is expected to further clarify the anticancer effect of squalene.
Reduce the damage of toxic substances to the body
In addition to reducing the toxicity of certain carcinogens, squalene also has a certain resistance to other exogenous toxic substances, part of which can be attributed to the antioxidant capacity of Pure Squalane, and the mechanism of some experimental results remains to be elucidated. For example, squalene inhibits DNA damage in normal cells caused by exogenous oxidants; by detecting the activities of a series of antioxidant enzymes in rats, as well as the content of other antioxidants in the body, it was found that dietary supplementation of squalene in rats significantly reduced environmental Phosphoramides cause heart and red blood cell damage by inducing oxidative reactions in the body. In addition, studies have shown that squalene also helps the body excrete exogenous toxic and harmful substances. For example, mice in the experimental group were supplemented with squalene for 3 weeks, and their ability to excrete the exogenous poison hexachlorobenzene (HCB) was increased by 3 times, and the clearance time of hexachlorobenzene in the body was significantly shortened; other studies have shown that squalene Alkenes improve the efficiency of the body’s excretion of theophylline and alkaloids.
Promotes skin health
Studies have shown that the antioxidant capacity of squalene is stronger than that of other lipid molecules in the skin. Squalene in the skin can effectively inhibit the cascade amplification of lipid peroxidation, thereby helping the skin resist the damage caused by ultraviolet radiation and other oxidation reactions. damage. Many studies have also pointed out that in addition to anti-oxidation, squalene (and its derivative squalane) also have emollient and moisturizing effects. A population-based experiment investigated the relationship between squalene supplementation and skin health: 40 female subjects over the age of 50 were divided into two groups for 90 days, respectively consuming 13.5 g and 27 g of squalene daily,37 Volunteers finally completed the test. The facial wrinkles of the subjects in the high-dose group were significantly reduced, and the facial erythema and pigmentation were significantly improved in both groups. Some molecular indicators related to facial skin also had different degrees in the two groups. improvement.
On the basis of extensive research on topical Pure Squalane skin care, the skin care effects of dietary supplementation of squalene have also been gradually confirmed.
The above studies have clarified the health effects of Pure Squalane in promoting cardiovascular health, cancer prevention and anti-cancer, and hypoxia resistance from different perspectives, but relevant systematic clinical research is still relatively limited.
