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Zhishang Chemical

Pure L-Carnosine CAS 305-84-0

Molecular Formula: C9H14N4O3

Formula Weight: 226.23

ZSpharmac: Pure L-Carnosine Supplement

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Product Name: Pure L-Carnosine
CAS No: 305-84-0
Purity: 99%

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Basic Info

Product Name:Pure L-Carnosine
Other Names:L-Carnosine
CAS:305-84-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline
EINECS No.:206-169-9
Storage:-20°C
Provide:Pure L-Carnosine MSDS;
Pure L-Carnosine COA

What is Pure L-Carnosine?

Pure L-Carnosine is a dipeptide (dipeptide, 2 amino acids) typically discovered in the brain, heart, skin, muscle mass, kidney and also tummy as well as various other body organs and cells. Pure L-Carnosine triggers cells in the human body and battles maturing with 2 devices: hinders glycation as well as secures our cells from cost-free extreme damage, which results in unrestrained cross-linking of sugar molecules and healthy proteins (sugar particles will certainly adhere to proteins), loss of mobile function and incomplete hereditary mixes that speed up aging. Pure L-Carnosine additionally maintains cell membranes and also decreases mind lipid peroxidation, consequently stopping nerve and also brain degeneration.

Pure L-Carnosine Properties

Melting point 253 °C (dec.) (lit.)
alpha 20.9 º (c=1.5, H2O)
Boiling point 367.84°C (rough estimate)
density 1.2673 (rough estimate)
refractive index 21 ° (C=2, H2O)
storage temp. -20°C
solubility DMSO (Very Slightly), Water (Slightly)
pka2.62(at 25℃)
form crystalline
color White
Water Solubility almost transparency

 

Anti-Aging Mechanism of Pure L-Carnosine

The totally free radical theory is now acknowledged as the system of skin aging. Oxygen joins the breathing chain procedure of microorganisms, however it is also a source of reactive oxygen species (ROS) at the same time. With the boost old and also the decline of the task of antioxidant enzymes, the generation of oxygen totally free radicals boosts and the scavenging result damages, leading to extreme accumulation of ROS in the skin and also damages to cell membranes, healthy proteins as well as nucleic acids. ROS can trigger the mitogen-activated protein kinase (MAPK) pathway in the body and at some point damage the skin framework. The MAPK path includes 4 paths: extracellular signal-regulated protein kinase (ERK) ), c-Jun N-terminal kinase (JNK), extracellular signal-regulated protein kinase 5 (ERK5), p38 mitogen-activated healthy protein kinase (p38 mitogen-activated healthy protein kinase) healthy protein kinase, p38MAPK). Amongst them, JNK can activate triggered protein-1 (AP-1), which consequently stimulates the manufacturing of matrix metalloproteinases (MMPs). MMPs are a team of zinc-dependent endopeptidases that play intricate functions in several physical and pathological processes, consisting of skin aging. MMP-1 can weaken undamaged collagen and elastin in dermal tissue, and also at the same time, the activation of MAPK pathway can inhibit the manufacturing of procollagen DNA, which at some point causes the devastation of facial structure and the development of skin aging.

Telomeres are repeated DNA sequences at the ends of chromosomes. Telomere length is proportional to the variety of cellular division. Telomere size is longest at birth as well as progressively reduces with age. Normal human cells have a limited number of departments, so shortening of telomeres is believed to be connected with aging. Telomerase can lengthen telomeres. Shao et alia discovered that growth of fibroblasts in a tool consisting of 20 mmol/Pure L-Carnosine could slow down the shortening of telomeres and extend cell life expectancy. Consequently, it is thought that decreasing telomere reducing as well as telomere DNA damage is one of the devices through which carnosine can prolong life expectancy.

Protein glycosylation is among the crucial procedures of healthy protein post-translational adjustment. The aldehyde group-containing sugars as well as the amino deposits of healthy proteins are linked under non-enzymatic problems to very first form a Schiff base, and then after a duration of reformation, a reasonably secure early glycosylation item is created, that is, a ketone amino compound (amadori item), the amadori item undergoes dehydration and also reformation to form highly energetic carbonyl compounds such as malondialdehyde (MG), etc, and then reacts with the cost-free amino group of the healthy protein to develop extra secure with cyclization, oxidation and also dehydration. innovative glycosylation output (AGEs). This procedure is called the Maillard reaction. With age, AGEs additionally gather, creating damages to cells and also body organs. The dermis is mostly made up of collagen fibers, flexible fibers and extracellular matrix produced by fibroblasts. Elastin and also collagen take part in non-enzymatic glycosylation reaction to create AGEs, creating cross-linked products of collagen and elastin. Oxidized collagen can be deteriorated by collagenase at the start, and also as the cross-linking of collagen gradually increases, the dissolution of collagen Reduced permeability as well as the accumulation of insoluble collagen leads to a decline in tissue leaks in the structure, leading to challenges to the exchange of nutrients and metabolites in between cells, which eventually results in a decrease in skin flexibility and also the appearance of wrinkles. Pure L-Carnosine can respond with energetic compounds in the body to safeguard proteins from glycosylation, while carnosine can engage with already glycosylated healthy protein products to avoid more cross-linking of glycosylated healthy proteins.

As early as 1994, McFarland as well as Holliday experimentally observed the impact of carnosine on the development, morphology as well as lifespan of fibroblasts. They found that high focus of carnosine (20 to 50 mmol/L) could postpone aging and also invigorate currently senescent fibroblasts. In the visibility of carnosine, fibroblasts that have actually reached a number of divisions close to the Hayflick dividing line can assume a non-senescent morphology, and when these cells are moved to media without carnosine, they promptly return to senescence kind.

Tumor is inseparable from the event of aging. With the increase old, the incidence of tumor also increases dramatically, which may be related to the steady decrease of DNA damage repair work feature with age. At the same time, oncogenes can generate cell senescence. The scientists discovered that also in the visibility of oxygen, lump cells preferentially use sugar for aerobic glycolysis to create lactate to produce ATP, a sensation known as the Warburg effect. Therefore, it can be presumed that preventing the glycolytic task of growth cells can inhibit lump spreading. Ding et al. discovered that Pure L-Carnosine can substantially prevent the growth of tumor cells by measuring the survival price of human hepatoma cells, and this sensation was concentration-dependent. As well as it is inferred that carnosine may be made use of to inhibit the spreading of human lump cells in the future to accomplish the objective of anti-tumor.

Autophagy and also apoptosis are closely related to maturing and aging-related diseases. Autophagy is the self-digestion procedure of intracellular metabolites, such as abnormally modified proteins, healthy protein polymers and also harmed organelles, through lysosomes. As a result, autophagy can manage the quality of intracellular healthy proteins as well as organelles to keep the stability of the intracellular setting. Reduced autophagic actions has actually been observed in several models of aging, and up-regulation of autophagic activity by pharmacological as well as hereditary strategies can minimize the development of age-related illness, yet on the other hand, too much autophagy can increase aging.

Pure L-Carnosine is a rapamycin analog. Activation of the animal target of rapamycin (mTOR) path is the driving pressure bring about mobile senescence. Carnosine can improve mobile senescence by preventing the mTOR signaling path. Cycle apprehension to reduce the appearance of UVA-induced senescence phenotype in dermal fibroblasts. To summarize, the anti-aging device of carnosine is mostly anti-oxidation, hindering telomere reducing, hindering mitochondrial damage, anti-glycation, anti-tumor, and so on. It can not only prevent cell aging, yet also postpone the progression of some diseases connected to aging. advancement occurs. Although there are some research studies, there is not a great deal of research on Pure L-Carnosine’s anti-aging skin.

Pure L-Carnosine Clinical Study

Pure L-Carnosine was found by Russian medication shop Gurevich in addition to carnitine. Research studies in the UK, South Korea, Russia and various other nations have actually shown that carnosine has solid antioxidant ability and is beneficial to the body. Carnosine has actually been revealed to feed on responsive oxygen radicals (ROS) as well as α-β unsaturated aldehydes formed throughout oxidative stress and anxiety by overoxidizing fats in cell membranes.

Various research study studies have really located that N-Acetyl Carnosine has an exceptional effect in the prevention and also therapy of cataracts, among which showed that Pure L-Carnosine can improvecataracts brought on by guanidine direct exposure to rat lens opacities, although these claims Carnosine is sustained for cataract therapy and also various other hypothetical advantages to the eye, yet so far, it has not been totally sustained by the mainstream clinical neighborhood. As an example, the Royal University of Ophthalmology in the UK has stated that carnosine is neither risk-free nor effective for topical treatment of cataracts’s idea.

A 2002 study reported that Pure L-Carnosine might improve autistic kids’s social connections and also raise the vocabulary utilized by autistic children, however the enhancements asserted in the research may additionally be From maturation, sugar pill effect, or other factors not described in this study.

In pet experiments, carnosine supplements boosted corticosteroid degrees, which may explain the hyper signs and symptoms that sometimes accompany high doses of carnosine, yet the research studies described above involved shots of carnosine right into the ventricles of chickens as well as corticosteroids The phenomenon of raised levels has actually not yet shown up in human experiments. In animal experiments, carnosine has been found to postpone the development of cancer cells, secure against alcohol-induced oxidative stress and anxiety as well as alcohol-induced chronic liver damage, and in computer mouse experiments, carnosine’s neuroprotective system can avoid irreversible mind anemia.

Pure L-Carnosine can boost the Hayflick restriction of human fibroblasts and also the price at which telomere reducing takes place. The upkeep of telomeres might be beneficial to the development of some prospective cancers cells, so carnosine is also considered a safety agent.

It is usually thought that the regular vegetarian lacks Pure L-Carnosine, yet it is unidentified whether this will certainly cause negative impacts.

Preparation of Pure L-Carnosine

A) Preparation of hydrazinolysis reaction solution, in a 1000ml four-necked reaction flask, put into phthaloyl Pure L-Carnosine 50g (0.14mol), water 200ml, hydrazine hydrate (mass percent concentration is 80%) 10.8 as intermediate g (0.17mol), heated to reflux for 1.0h, added acetic acid to adjust the pH of the material to 5.5, filtered to remove by-products, and obtained a hydrazinolysis reaction solution;
B) To prepare Pure L-Carnosine, add 100 ml of dichloromethane and 9.6 g (0.09 mol) of benzaldehyde to the hydrazinolysis reaction solution obtained in step A). After stirring at room temperature for 12 h, the material is left to stand for stratification, and two The methyl chloride layer and the aqueous layer were washed twice with 50 ml of dichloromethane, then 3 g of activated carbon and 25 ml of ammonia water (18%) were added, decolorized at 60°C for 0.5 h, filtered to remove the activated carbon, the decolorized solution was concentrated in vacuo until a solid was precipitated, and 300 ml of methanol was added to crystallize , stirred for 2.0h, filtered, and the filter cake was dried at 100°C for 6h to obtain 28.6g of Pure L-Carnosine product. Hydrazine residues were not detected in the product.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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