Pure Honokiol CAS 528-43-8

Molecular Formula: C18H18O2

Formula Weight: 266.33

ZSpharmac: Pure Honokiol Supplier

Product Name: Pure Honokiol

CAS No: 528-43-8

Purity: 99%

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Basic Info

Product Name:	Pure Honokiol
Other Names:	Magnolol
CAS:	528-43-8
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White to Almost White Neat
EINECS No.:	610-903-7
Storage:	Sealed in Dry,2-8°C
Provide:	Pure Honokiol MSDS； Pure Honokiol COA

What is Pure Honokiol?

Magnolia officinalis is an energetic substance removed from the completely dry bark, branch bark and likewise root bark of Magnolia officinalis Rehd. et Wils. as well as also Magnolia officinalis Rehd. et Wils. var. biloba Rehd. et Wils., anti-inflammatory, anti-tumor, anti-endomycin, muscle recreation, eliminate intense inflammatory pain, and so on. In relation to anti-bacterial result, magnolol has significant anti-bacterial activity versus Gram-positive bacteria, acid-resistant germs, and likewise filamentous fungis, as well as additionally has an extra significant antibacterial result on Streptococcus mutans, and has the toughest repressive influence on Staphylococcus. Scientifically, it is normally made use of to eliminate volume in the breast as well as stomach area, calm the main nerve system, unwind the muscle mass of athletes, anti-fungal, anti-ulcer as well as other medicines.
Environment along with distribution It commonly expands mixedly in the different timberlands at the foot of hills as well as also roadside streams at an elevation of 800-1700 meters. It is a light-loving mesophytic tree types; it suches as an awesome as well as damp atmosphere. It is a great idea to make use of somewhat acidic or neutral dirt with deep, productive, loose, humus-rich, as well as well-drained soil. It is primarily generated in Enshi, Jianshi, Badong, Yichang, Lichuan, as well as Chengkou, Kaixian, Wuxi, Wushan, Shizhu, Wulong, and Fengjie of Chongqing City in Hubei Area.
Plant kind Deciduous tree, 7-15m high. The bark is purple-brown, the wintertime buds are covered by stipules, and also the stipules diminish after opening. Alternating single fallen leaves, gathered at the top of branchlets, elliptic obovate leaves, 20-45cm long, 10-25cm large, pinnacle obtuse or brief pointed, base cuneate or round, entire or bumpy, the back is beige when young Short hairs, white powder when old. Blossoms as well as additionally leaves open at the same time, singular branch top, white, aromatic, regarding 15cm in size, pedicel thick, covered with brown hairs; perianth markets 9-12; stamens great deals of; pistils countless carpels, organized on the substantial receptacle.

Pure Honokiol Property

Melting point	101.5-102°
Boiling point	180°C/1mmHg(lit.)
density	1.107±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	ethanol: soluble1mg/mL
form	neat
pka	9.49±0.43(Predicted)
color	White to Almost white

Application of Pure Honokiol

Magnolia honokiol is a mixture of phenols drawn out from the typical Chinese medication Magnolia officinalis. It has numerous organic features such as anti-virus, antibacterial, anti-inflammatory and also anti-diarrhea. An important basis for finding out functions.

1) Pure Honokiol has anti-bacterial and anti-hemolytic effects on Staphylococcus aureus. In order to examine the antibacterial task as well as anti-infection device of overall magnolol versus mastitis pathogens (mainly Staphylococcus aureus), the minimum inhibitory focus of overall magnolol against Staphylococcus aureus was identified by brew dilution technique first of all, The impacts of total magnolol on the pathogenicity of Staphylococcus aureus were verified from various levels and angles by hemolysis examination, Western blot test, fluorescent measurable PCR test and also LDH launch examination. The outcomes showed that complete magnolols had certain anti-bacterial task against Staphylococcus aureus, and the minimum inhibitory concentration variety for Staphylococcus aureus was 8-16 μg · mL-1. Additionally, the results of this study show that magnolol at subinhibitory concentration can hinder the expression of α-hemolysin to minimize the pathogenicity of Staphylococcus aureus, and can significantly ease the cell spreading mediated by Staphylococcus aureus α-hemolysin. damages impact.

2) The impact of Pure Honokiol on the contractile function of test subject isolated tracheal smooth muscular tissue. Making use of the separated guinea pig tracheal strip approach, the straight impact of magnolol on the isolated test subject bronchial strip and also the enmity to the tightening triggered by high potassium, histamine as well as acetylcholine were observed. Outcomes: Overall magnolol had no considerable impact on the basal tension of test subject bronchial strips. It can inhibit the tightening of tracheal smooth muscular tissue induced by potassium chloride, acetylcholine, as well as phosphate histamine, and also its result is dose-dependent. 3 × 10-5g/ mL magnolol can inhibit the contraction generated by KCl, Ach, and also His respectively (95.96 ± 3.02 )%, (93.98 ± 4.62)%, (92.15 ± 5.66) %. Final thought: Magnolol has a substantial relaxing impact on tracheal smooth muscular tissue, as well as its device is related to the voltage-dependent calcium network on the cell membrane layer as well as the release of intracellular calcium.

Preparation of Pure Honokiol

A method for preparing high-purity total magnolol from Magnolia bark bark, the method comprises the following processing steps:

1) Dry the magnolia bark, crush the magnolia bark and set aside;

2) Extract the crushed Magnolia officinalis bark above to obtain an oily extract, the crude extract A of total phenols of Magnolia officinalis, and set aside;

3) Weigh the silica gel with 20%~50% weight of the total magnolophenol crude extract A, stir it evenly with the magnolo total phenol crude extract A, and then add the magnolototal phenol silica gel to stir the weight ratio to be 3~6 times the amount n-hexane, heating to a temperature of 60-80°C for extraction, filtering the n-hexane extract, and repeating the extraction of the filter residue 1-3 times, combining the n-hexane extract to obtain n-hexane extract B, which is set aside;

4) Concentrate the n-hexane extract B in vacuum, place it in cold storage to crystallize, control the crystallization temperature at 2°C-5°C, and then suction-filter the n-hexane crystals of total magnolol phenols to obtain white total magnolol phenol crystals C;

5) Add the total magnolol phenol crystal C to petroleum ether with a boiling point of 60-90°C, the weight ratio of petroleum ether to the total magnolol phenol crystal C is 10-30 times the amount, heat it in a water bath to a temperature of 60-90°C, and keep it round Slightly boil the petroleum ether in the bottom flask, completely dissolve the magnolol total phenol crystal C, pour out the petroleum ether to dissolve the supernatant, refrigerate and crystallize the poured petroleum ether solution, control the crystallization temperature at 2°C-5°C, and crystallize well after completion The total magnolol phenols were filtered by suction to obtain the total magnolol phenols crystal D, and the refined total magnolol phenols were obtained.

About Products:
If you need Pure Honokiol, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Pure Honokiol manufacturer and supplier, ZSpharmac will provide Pure Honokiol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.