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Zhishang Chemical

Pure Honokiol CAS 35354-74-6

Molecular Formula: C18H18O2

Formula Weight: 266.33

ZSpharmac: Pure Honokiol Supplement

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Product Name: Pure Honokiol
CAS No: 35354-74-6
Purity: 99%

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Basic Info

Product Name:Pure Honokiol
Other Names:Honokiol
CAS:35354-74-6
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Powder
EINECS No.:609-119-8
Storage:2-8°C
Provide:Pure Honokiol MSDS;
Pure Honokiol COA

What is Pure Honokiol?

Pure Honokiol is an isomer of magnolol, which is a dimer developed by the polymerization of the side chain of one phenylpropanoid as well as the benzene center of one more phenylpropanoid. It is called neolignan as well as is discovered in Lauraceae. It is the active component of Chinese medicine Magnolia officinalis, which is antibacterial as well as anti-inflammatory.
Pure Honokiol, a biphenolic substance, is among the main active components of Magnolia officinalis. The energetic ingredients of Magnolia officinalis are mostly phenolic substances (mostly magnolol and Pure Honokiol) drawn out from the origin bark and branch bark of Magnolia officinalis. The sloping area with an altitude of 800-1700m comes from the uncommon as well as endangered medicinal plants under the second-class nationwide security. According to medical records, Magnolia officinalis has the features of heating the center, advertising qi, drying wetness as well as removing phlegm.
International modern pharmacological tests have actually confirmed that honokiol has broad-spectrum antibacterial homes, has a special and long lasting relaxation impact on muscular tissues, and also has significant central restraint and anti-ulcer and anti-gastric acid secretion impacts, so it can be utilized for anti-bacterial, anti-ulcer, sedative Central nerve system, unwind muscular tissues. In the therapy of intestinal illness, Pure Honokiol additionally has a really high professional value.

Pure Honokiol Properties:

Melting point 86℃
Boiling point 400.1±40.0 °C(Predicted)
density 1.107±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 36 mg/mL
form powder
pka9.89±0.48(Predicted)
color White to Off-White

 

Pharmacology of Pure Honokiol

1. Anti-pathogenic microorganisms Magnolia decoction is effective against gram-positive bacteria such as Staphylococcus, hemolytic streptococcus, pneumococcus, bacillus pertussis, as well as bacillus anthracis, dysentery bacillus, typhoid bacillus, paratyphoid bacillus, vibrio cholerae , Escherichia coli, Proteus, Bacillus subtilis, Bacillus diphtheria and other Gram-negative bacteria have inhibitory effects, of which the inhibitory effect on Staphylococcus is the strongest. At a concentration of 15%, it has inhibitory effects on dermatophytes such as Bacillus microsporum, Trichophyton concentric, Trichophyton rubrum, and Trichophyton versicolor in experimental animals. Magnolia decoction has some effect on improving the substantive pathological damage of experimental viral hepatitis in mice. Honokiol has considerable antibacterial activity against Gram-positive germs and also acid-resistant bacteria; Pure Honokiol has an extremely substantial anti-caries result, with a minimum repressive concentration of 6.3 μg/ ml, and also its antibacterial task is stronger than that of the normal anti-bacterial alkaloid Berberis Base (MIC: 50 μg/ ml). Magnolia and also Magnolia volatile oil saturated aqueous option have particular antibacterial impacts on Staphylococcus aureus, Sarcinus and also Bacillus subtilis.

2. Impacts on the cardiovascular system Honokiol and Pure Honokiol inhibit the formation of thromboxane B2 under numerous problems, as well as the increase in intracellular Ca2+ brought on by arachidonic acid or collagen is additionally prevented by both. Pure Honokiol can hinder the task of CaM-stimulated cyclic nucleotide phosphodiesterase, and also honokiol can bind to webcam in the existence of Ca2+, thereby annoying its activation of phosphodiesterase. Furthermore, Pure Honokiol has a stimulating impact on the basal activity of CaM-dependent phosphodiesterase.

3. Anti-tumor effect Honokiol and its hydroxymethyl derivatives have obvious inhibitory effect on secondary skin tumors in mice. The three extract components of Magnolia officinalis, lignan, honokiol, Pure Honokiol and the monoterpene magnoliol, are 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr Antagonist of viral early antigen (EBv-EA) activation. Pure Honokiol, a methanol extract of Magnolia officinalis, has a significant inhibitory effect on mouse skin tumors induced by a phase II carcinogenic experiment in vivo.

Preparation method of Pure Honokiol

The first step: take 14.80 g of 4-allyl anisole into a 250 ml flask, slowly add an appropriate amount of pyridine perbromide as a brominating agent, add an appropriate amount of Zn as a catalyst, and react for 3 h. The fraction at 152°C was distilled off under reduced pressure, which was 2-bromo-4-allyl anisole.

The second step: take 18.70 g of 4-bromo-anisole, add ethyl magnesium chloride, 2,5-dimethylphenyl magnesium bromide, react at 40 ° C for 2 h, and then slowly add 12.10 g of allyl bromide, After the reaction for 5h, the fraction at 150°C was distilled off under reduced pressure, which was 4-bromo-2-allyl anisole.

The third step: Dissolve 2.38 g of nickel hexahydrate in 2 ml of water, add 5.25 g of triphenylphosphine, dissolve in 75 ml of glacial acetic acid, and react at room temperature for 24 h. Olive green microcrystals are precipitated in the reaction solution. Filter, wash with glacial acetic acid, and dry in a desiccator with sulfuric acid or potassium hydroxide in a vacuum to obtain dark blue crystals.

The fourth step: take 150 ml of anhydrous ether into a 250 ml flask, add 3.00 g of magnesium strips, soak for 1 h, and then slowly add the prepared 4-bromo-2-allyl anisole, reaction 3 h, make 4-bromo-2-allyl anisole into Grignard reagent, then add the prepared 2-bromo-4-allyl anisole into it, react for 12 h, distill out under reduced pressure Fractions below 150°C are obtained to obtain Pure Honokiol methyl ether, which is then hydrolyzed, finally extracted with ethyl acetate and water, concentrated to dryness under reduced pressure, and purified by silica gel column chromatography (ether:hexane=1:2) to obtain white crystals The product is Pure Honokiol.

Pure Honokiol Extraction Method

1. The manufacturing procedure of Magnolia officinalis essence (liquid remove) is to crush Magnolia officinalis, soak with ethanol for 12 hours, place it in a percolation cyndrical tube, penetrate with about 12 times the quantity of ethanol, accumulate the percolation liquid, and recuperate ethanol under decreased stress to the fullest., need to flow remove. The yield is about 9%, the strong content is 85.0%, the material of magnolol is more than 11.0%, and also the material of Pure Honokiol is more than 5.0%.

2. Extraction and splitting up of magnolol and Pure Honokiol Take the crude powder of Magnolia officinalis, include 1/5 amount (W/W) of quicklime powder, mix well, and infiltrate with 15-20 times the amount of pure water. Include hydrochloric acid to readjust the pH to 2-3, as well as allow it stand. Collect the precipitated precipitate, wash with pure water up until the pH value of the precipitate is 6-7, include alumina (1:10) after drying out, blend well, location in an extractor, and also remove with cycloethane. The cycloethane essence was concentrated and permitted to cool, white crystals were precipitated, as well as the crystals and also mommy alcohol were gotten by purification. The crystals were recrystallized with cyclohexane to get Pure Honokiol. After the mother alcohol is concentrated, crystals are precipitated, as well as cyclohexane is recrystallized to get colorless flake crystals, which are magnolol crystals. The return of honokiol was 85%, and also the yield of Pure Honokiol was 74%.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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