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Pure Guanidine Hydrochloride CAS 50-01-1

Molecular Formula:CH5N3.ClH

Formula Weight: 95.53

ZSpharmac: Pure Guanidine Hydrochloride Supplement

Product Name: Pure Guanidine Hydrochloride
CAS No: 50-01-1
Purity: 99%

Basic Info

Product Name:Pure Guanidine Hydrochloride
Other Names:Guanidine Hydrochloride
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:White to Slightly Yellow Crystals
EINECS No.:200-002-3
Storage:Room Temp
Provide:Pure Guanidine Hydrochloride MSDS;
Pure Guanidine Hydrochloride COA

What is Pure Guanidine Hydrochloride?

Pure Guanidine hydrochloride, chemical name carbamidine hydrochloride, is a white or a little yellow swelling, almost insoluble in acetone, benzene as well as ether. It can be utilized as medication, pesticide, dye as well as other natural synthesis intermediates. It is a vital basic material for the manufacture of sulfadiazine, sulfamethazine, sulfamethazine and also other medicines as well as folic acid. It can also be made use of as an antistatic representative for artificial fibers.

Pure Guanidine Hydrochloride Properties:

Melting point 180-185 °C(lit.)
density 1.18 g/mL at 25 °C(lit.)
refractive index n20/D 1.465
storage temp. room temp
solubility H2O: 6 M, clear, colorless
form Crystals
color White to slightly yellow
PH4.5-5.5 (100g/l, H2O, 20℃)
PH Range4.5 – 6.0 at 573 g/l at 25 °C
Water Solubility 2280 g/L (20 ºC)


Pure Guanidine Hydrochloride Uses

  1. Pure guanidine hydrochloride is used as an intermediate in organic synthesis; as an antistatic agent for synthetic fibers; a strong chaotropic agent for protein denaturation and subsequent renaturation.
  2. Pure guanidine hydrochloride is made use of as a medicine intermediate and also a crucial resources for the manufacture of sulfadiazine, sulfamethazine, sulfamethazine and folic acid.

Purification Method of Pure Guanidine Hydrochloride

A method for purifying pharmaceutical grade guanidine hydrochloride, which comprises the following steps: (a) under normal pressure, add 500 g of water into the mixer, then add 1200 g of crude guanidine hydrochloride, stir at 60 ° C for 30 min, stir evenly and then pump into a coarse filter to remove mechanical impurities and incompletely dissolved solid particles to obtain Guanidine hydrochloride crude guanidine aqueous solution; (b) The crude guanidine hydrochloride aqueous solution obtained by removing mechanical impurities and incompletely dissolved solid particle impurities through a coarse filter is pumped into an ultrasonic crystallization system for continuous and cyclic treatment to obtain guanidine hydrochloride clear liquid to induce the precipitation of fine impurities (the ultrasonic crystallization system adopts Continuous treatment type, which has an internal circulation system to recycle the crude guanidine hydrochloride aqueous solution) to obtain guanidine hydrochloride clear liquid; the operation control parameters of the ultrasonic crystallization system are: temperature 60 ° C, pressure and normal pressure, hydraulic residence time 60min and The frequency of the ultrasonic power source is 20KHz; the above-mentioned ultrasonic crystallization system adopts self-developed equipment, as shown in Figure 2, including a static component 1, an ultrasonic-induced crystallization component 2 and a filter press 3. The ultrasonic-induced crystallization assembly 2 includes a liquid inlet pipe 22 for feeding the crude guanidine hydrochloride aqueous solution, and a plurality of ultrasonic crystallizers 21 (three in this embodiment, three in this embodiment, one end of the liquid inlet pipe 22 and a plurality of ultrasonic crystallizers 21 connected in series through the pipes. The specific number can be selected according to actual needs) and a liquid outlet pipe 23 with one end connected to the ultrasonic crystallizer 21 (the most downstream one, which is defined according to the flow direction of the crude guanidine hydrochloride aqueous solution); the static component 1 includes a static tank 10. The clear liquid outlet pipe 11 whose one end communicates with the upper end of the stationary tank 10, and the impurity enrichment liquid outlet pipe 12 whose one end is communicated with the lower end of the stationary tank 10, is installed in the stationary tank 10 and has one end connected to the lower end of the stationary tank 10. The liquid conduit 13 connected to the other end of the liquid outlet pipe 23 and the conical separator assembly 14 installed in the static tank 10 and matched with the liquid conduit 13 (the conical separator assembly 14 is arranged in the liquid conduit). The bottom of the other end of the tube 13 communicates with it, including a central tube and a conical baffle installed on the side wall of the central tube and communicated with it. The effluent of the component is buffered and then introduced into the stationary tank 10, so that impurities can be gradually enriched to the bottom of the stationary tank 10; at this time, the level of the guanidine hydrochloride clear liquid in the stationary tank 10 rises and passes The liquid outlet pipe 11 overflows or discharges); the filter press 3 is respectively connected with the other end of the impurity-enriched liquid outlet pipe 12 and the middle of the liquid inlet pipe 22 through the pipeline, and is used to filter the impurity-enriched liquid after pressure filtration. The filtrate is re-introduced into the liquid inlet pipeline 22 for recycling, and the filter cake produced by the pressure filtration can be outsourced; (c) Pump the guanidine hydrochloride clear liquid that has been induced to remove impurities by the ultrasonic crystallization system into the precision filter to remove the fine impurity grains not completely removed by the ultrasonic crystallization system; then pump the guanidine hydrochloride solution that has passed through the precision filter into the decolorizer , in order to remove the trace amount of cyanamide impurities dissolved in the solution to obtain a refined guanidine hydrochloride solution, the process conditions of the decolorizer are: temperature 60 ℃, pressure 0.15MPa (G) and hydraulic residence time 30min; (d) pumping the purified guanidine hydrochloride solution into the finished product crystallizer for crystallization and purification; separating the crystals and drying to obtain pharmaceutical grade guanidine hydrochloride; the yield is 85% (calculated as crude guanidine) and the purity is 99.7%.

Preparation Method of Pure Guanidine Hydrochloride

The preparation method of guanidine hydrochloride has the following technological process: A, melting, the weight ratio of 1: 1.27 of dicyandiamide and ammonium chloride is put into the reactor, and melting reaction is carried out at 170~230 ℃ to obtain guanidine hydrochloride crude product; b, dissolving, at normal temperature, the crude guanidine hydrochloride is dissolved in water at a ratio of 1:1, and the solution is added with the ammonium salt removal alkaloid whose dosage is determined according to the ammonium salt content in the crude guanidine hydrochloride; c, filter, remove raw material and reaction by-product by the method of filtration; D, dehydration, the mother liquor after filtration is dehydrated at high temperature; e. Crystallization, the supersaturated solution is cooled, concentrated and crystallized to obtain high-purity guanidine hydrochloride. f. The guanidine hydrochloride after step e is then added to dicyandiamide to enter the reactor, and the melting reaction is carried out at 170 to 230 ° C for 3 to 4 hours, and then through steps b, c, d, and e, higher purity guanidine hydrochloride is obtained. , and repeat this step as many times as necessary. g, the guanidine hydrochloride after the e step is passed through b, c, d, e steps again, wherein the ratio with water in the b step is 1.5: 1, obtains higher purity guanidine hydrochloride, and can repeat this many times as needed step.

Company Profile

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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