Pure Collagen CAS 9007-34-5

Molecular Formula: NULL

Formula Weight: 0

ZSpharmac: Pure Collagen Supplier

Product Name: Pure Collagen

CAS No: 9007-34-5

Purity: 99%

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Basic Info

Product Name:	Pure Collagen
Other Names:	Collagen
CAS:	9007-34-5
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White to Off-White Solution
EINECS No.:	232-697-4
Storage:	2-8°C
Provide:	Pure Collagen MSDS； Pure Collagen COA

What is Pure Collagen?

Collagen, also referred to as collagen, is the major part of the extracellular matrix, generally in the form of insoluble fibrin. It widely exists in the bones, ligaments, muscle sheaths, tendons, sarcolemma, cartilage and also skin of animals. It is an exceptionally essential protein in connective cells, accounting for 25% to 30% of the total protein in animals, as well as plays a supporting function. It is likewise one of the most essential functional healthy protein that makes up the intercellular material. There are many types of Pure Collagen. Typically, type I collagen is discovered in skin and bones, type II collagen is discovered in cartilage material, kind III collagen is discovered in embryonic skin, and also kind IV collagen is located in cell basement membrane layers. The structural function of collagen is a three-way helix framework. Its distinct three-way helix structure makes the molecular structure really secure, and has the characteristics of low immunogenicity as well as excellent biodegradability. As a natural organic source, Pure Collagen’s unique biocompatibility as well as biodegradability are unequaled by today’s artificial polymer products. In addition, it has various other characteristics such as high tensile toughness, low resistance, hemostatic properties, and promoting cell regeneration. efficiency such as growth. Consequently, it is widely made use of in the fields of professional medicine, cosmetics, food, chemical basic materials and also research study.
The nutrients that make up collagen are extremely rich. In addition to tryptophan and cysteine, it likewise contains hydroxyproline and pyroglutamic acid, which are rare generally proteins.
1. Along with cystine as well as tryptophan, collagen is abundant in 18 kinds of amino acids, including 7 sort of amino acids needed to preserve the human body.
2. Glycine content in collagen accounts for almost 1/3.
3. There are hydroxylysine and also hydroxyproline in collagen, which are lacking in various other proteins.

Pure Collagen Property

storage temp.	2-8°C
solubility	H₂O: 5 mg/mL, hazy, colorless and viscous
form	solution
color	white to off-white
PH	7.0
PH Range	7.0 – 7.6
Water Solubility	It is soluble in water.

Application of Pure Collagen

1. Application in the medical and also health and wellness market
Pure Collagen is mostly used as scaffold product, skin and bone in tissue design. With the application of collagen in tissue engineering, the application of bioengineered membrane layers is also extra considerable, such as vascular membranes, heart shutoffs as well as tendons.
Collagen has great biocompatibility as well as biodegradable security, can be deteriorated as well as taken in, and has great adhesion, so it has an unique skin repair service feature. After adjustment, it can be made use of to make skin graft materials. Collagen can comprise the skeletal system of the extracellular matrix and also is a crucial component of cells, anchoring as well as supporting cells, offering a proper microenvironment for cell proliferation as well as development, as well as supplying a good supply of nutrients. As a result, whether collagen is used as the skeleton of brand-new cells prior to being taken in or absorbed as well as assimilated into the host to end up being a part of the host tissue, it has an excellent control effect with the matrix around the cells, which is conducive to the proliferation and also repair service of epithelial cells, therefore advertising injury healing. It can be utilized for the fixing, treatment and also nursing of burns and wounds, and can reduce and also ease the level of burns and also scalds. Collagen biological clothing has two benefits: the one is that the prep work method is easy, the sterilization is convenient, and also it is easy to procedure; Excellent, easy to absorb tissue secretions as well as various other features.
Pure Collagen can likewise be made use of in the therapy of eye illness due to its unique buildings. Collagen can advertise the fixing of corneal epithelial cell damages and cell development, and can be dissolved in splits, as well as has the capacity to direct epithelial cells to creep into the problem location. At the same time, its degradation products can be made use of by new cells to synthesize new collagen and contribute in attaching cells. As a result, it is widely made use of in the treatment of eye conditions. Collagen can also be used as a provider for eye management, which has the features of raising medication concentration, lengthening medicine activity time, and lowering systemic drug poisoning of medications, as well as has broad advancement potential customers.
Collagen is likewise commonly utilized in cosmetic orthopedics, gum disease treatment, hard cells repair work, nerve repair as well as regeneration, periodontal nerve repair work wrapping products, fabricated body organs, heart pacemakers, as well as filling of human interior body organs in clinical medicine. Include points and so on.

2. Application in cosmetics
Pure Collagen can be removed from animal skins. In addition to collagen, animal skins also contain proteoglycans such as hyaluronic acid and chondroitin sulfate. They are 100% natural moisturizing variables as well as are very important compounds for keeping skin dampness. The role of tyrosine right into melanin. Collagen is similar to the collagen structure in the skin and the follicle of the skin. It can promote the proliferation and repair of epithelial cells, supplement amino acids as well as various other nutrients, enhance the living environment of skin cells, advertise the metabolic rate of skin tissue as well as improve circulation, to ensure that damages and also aging The skin is filled up and also repaired, and also has excellent compatibility, affinity and also leaks in the structure with the skin, and can be completely soaked up by the skin, to ensure that the skin is plump, creases are stretched, and at the same time, it can increase skin thickness and also produce stress. As a result, collagen has all-natural hydrating, bleaching, anti-freckle, anti-wrinkle and various other impacts, and can be widely used in the cosmetics industry Nowadays, lots of cosmetics such as facial masks, eye lotions, and also skin lotions sold in the marketplace consist of collagen.

3. Application in food industry.
Pure Collagen has 2 applications in food: one is feature, as well as the various other is nourishment. Collagen peptides can be straight consumed as functional foods alone, such as chewable tablet computers, protein powder for professional athletes, as well as enteral nutrition preparations. Individuals consume foods rich in collagen, which can not only properly delay the aging of the body, strengthen muscles and bones, and enhance fitness, however likewise have wellness effects such as weight reduction, blood pressure reduction, and calcium supplements. After collagen is treated with specific enzymes, the hydrogen bonds in its molecules can be ruined, as well as its original tight superhelical framework is destroyed, as well as the little molecular materials developed with a fairly loose framework can be contributed to meat items to enhance connective cells as well as boost healthy protein. Material, taste excellent and also nutritious. The enzymatic hydrolysis product of collagen can also be utilized as an improver for frozen food, as a thickener with a reduced melting point, very easy to melt, and also has the qualities of melting in the mouth. For that reason, collagen is commonly utilized in jelly, yogurt, pork, canned food, bread and other foods. In addition, benefiting from the film-forming buildings of collagen, it can be used as a movie product for immobilized enzymes as well as meat food labels. Collagen can likewise be utilized as a food adhesive, synthetic fiber film and also as a food security layer, made use of as covering paper for meat, fish, and so on, as a food defense layer, it has antioxidant homes as well as maintains the shade of meat items brilliant.

4. Application in other fields
With the constant study on Pure Collagen, the application of collagen in other fields is additionally raising and has an excellent growth possibility. As an example, removing the rich collagen from the waste left over from the tanning process can be made use of as pet healthy protein resources for feed to understand resource use. After the denaturation treatment of collagen, its textile efficiency can be enhanced as well as used in the textile sector. At the same time, in recent years, collagen has actually additionally been made use of more and more in light sectors such as papermaking industry, leather industry, and daily chemical market. With the constant development as well as renovation of study technology, the study on collagen will certainly continue to deepen, and Pure Collagen will certainly be more extensively utilized.

Pure Collagen Biological Properties

1. Low immunogenicity
As a medical biomaterial, the most important feature of collagen is its low immunogenicity. Collagen has three types of antigen molecules, the first type is the non-helical telopeptide of the collagen peptide chain, the second type is the conformation of the triple helix of collagen, and the third type is the amino acid sequence of the a-chain helical region. The second type of antigenic factors only exist in natural collagen molecules, the third type only in denatured collagen, and the first type of antigenic factors exist in both natural and denatured collagen.
2. Biocompatibility
Biocompatibility refers to the good interaction between collagen and host cells and tissues. Whether it is used as the skeleton of a new tissue before being absorbed, or absorbed and assimilated into the host to become a part of the host, they all have a good interaction with the matrix around the cells, showing the coordination of mutual influence, and become the normal physiological structure of cells and tissues. part of a functional whole.
3. Biodegradability
Collagen can be degraded by specific proteases, that is, biodegradable. Because collagen has a tight and firm helical structure, most proteases can only cut off its side chains, and only specific proteases can degrade collagen under certain conditions, and the collagen peptide bonds will be broken. Once the peptide bond of collagen is broken, its helical structure is destroyed immediately, and the broken collagen polypeptide is completely hydrolyzed by protease.

Pure Collagen Extraction Method

The general process of extracting collagen is to remove oil, remove impurities, collagen precipitation, purification, etc. Its extraction methods are as follows: hot water extraction, acid extraction, alkali extraction and enzyme extraction.
1. Hot water extraction method
The hot water extraction method is to extract the denatured collagen or collagen hydrolyzate directly in hot water after the raw materials are pre-treated by removing impurities, etc. The temperature used is 100°C boiling water bath, 60-70°C, 40-42°C, 45°C.
2. Acid extraction method
Acids commonly used in acid extraction are: formic acid, acetic acid, hydrochloric acid, oxalic acid, citric acid, lactic acid, etc. Acids with low ionic concentration can destroy intermolecular salt bonds and Schiff’s bases, causing collagen fibers to swell and dissolve.
When acid is used to extract collagen, collagen hydrolyzate with uneven molecular weight can be obtained according to different conditions such as acid concentration, hydrolysis temperature, and hydrolysis time. However, tryptophan will be completely destroyed in the process of complete hydrolysis with equal concentration of acid, and serine and tyrosine will also be partially destroyed. Therefore, it is necessary to accurately control the acidity, temperature, time and other influencing factors for the dissolution of biomedical collagen by acid method.
3. Alkaline extraction method
Alkaline extraction usually uses sodium hydroxide, sodium carbonate, etc. Extracting collagen under alkaline conditions can easily cause protein denaturation, such as collagen peptide bond hydrolysis, all amino acids containing hydroxyl and sulfhydryl groups are destroyed; the resulting product has a low isoelectric point pH value , asparagine and glutamine are converted into aspartic acid and glutamic acid respectively; if the hydrolysis is severe, a racemic mixture of D and L amino acids will be produced, and if the content of D amino acids is higher than that of L amino acids, then It can inhibit the absorption of L-type amino acids, some D-type amino acids are toxic, and some even have carcinogenic, teratogenic and mutagenic effects. Therefore, when extracting collagen with complete structure and safe use, the alkaline method is rarely used to extract collagen.
4. Enzyme extraction method
Treating pigskin with protease can not only hydrolyze the terminal peptides of collagen fibrils and increase the yield of collagen; it will not destroy the triple helical structure of collagen and maintain its excellent physical and biochemical properties. Commonly used proteases mainly include neutral protease, bromelain, ficin, trypsin and pepsin. There are many factors affecting enzyme extraction, such as enzyme concentration, ratio of enzyme to substrate, enzymatic hydrolysis time, enzymatic hydrolysis temperature, pH value, and solid-liquid ratio. In actual operation, most of Pure Collagen are extracted by enzyme complex method.

About Products:
If you need Pure Collagen as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Pure Collagen manufacturer and supplier, ZSpharmac will provide Pure Collagen raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.