Zhishang Chemical

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Zhishang Chemical

Pure Collagen CAS 9007-34-5

Molecular Formula: NULL

Formula Weight: 0

ZSpharmac: Pure Collagen Supplement

Product Name: Pure Collagen
CAS No: 9007-34-5
Purity: 99%

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Basic Info

Product Name:Pure Collagen
Other Names:Collagen
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solution
EINECS No.:232-697-4
Provide:Pure Collagen MSDS;
Pure Collagen COA

What is Pure Collagen?

Pure Collagen (collagen), likewise called collagen, is the main element of the extracellular matrix, generally in the form of insoluble fibrin. It is commonly located in the bones, tendons, muscle mass sheaths, ligaments, sarcolemma, cartilage and also skin of animals. It is a very important protein in connective cells, making up 25% to 30% of the overall healthy protein in animals, as well as plays a sustaining role. It is likewise one of the most crucial practical healthy protein that constitutes the intercellular material. There are several types of collagen, generally type I collagen in skin and also bones, kind II collagen in cartilage, type III collagen in embryonic skin, and type IV collagen in cell cellar membrane layer. The structural attribute of collagen is three-way helix structure, and its distinct three-way helix framework makes the molecular framework extremely secure, and also has the characteristics of reduced immunogenicity and also excellent biodegradability. Collagen, as an all-natural biological source, has distinct biocompatibility and biodegradability unrivaled by today’s synthetic polymer materials, as well as other residential or commercial properties such as high tensile strength, reduced immunity, hemostatic homes, and also cell promotion. development and also other residential properties. Therefore, it is widely made use of in scientific medication, cosmetics, food, chemical basic materials and research as well as various other areas.
The nutrients that make up Pure Collagen are very rich. In addition to tryptophan and cysteine, it also contains hydroxyproline and pyroglutamic acid, which are rare in general proteins.
1. In addition to cystine and tryptophan, Pure Collagen is rich in 18 amino acids, including 7 essential amino acids for the maintenance of the human body.
2. The glycine content in Pure Collagen accounts for nearly 1/3.
3. Hydroxylysine and Hydroxyproline exist in Pure Collagen, which are lacking in other proteins.

Pure Collagen Property

storage temp. 2-8°C
solubility H2O: 5 mg/mL, hazy, colorless and viscous
form solution
color white to off-white
PH Range7.0 – 7.6
Water Solubility It is soluble in water.


Applications of Pure Collagen

Pure Collagen is mostly made use of as scaffold material, skin and bone in cells engineering. With the application of collagen in tissue engineering, the application of bioengineered membranes is also more considerable, such as vascular membranes, heart shutoffs as well as ligaments. Collagen has great biocompatibility and also naturally degradable security, can be broken down as well as absorbed, and has excellent adhesion, so it has a distinct skin repair feature, and it can be utilized to make skin grafting products after adjustment. Collagen can form the skeleton of the extracellular matrix, is a vital part of cells, plays an anchoring and also assistance duty for cells, and can supply an ideal microenvironment for cell expansion and also development, along with a good supply of nutrients. Therefore, whether collagen is used as the skeletal system of a brand-new tissue before being absorbed or taken in as well as taken in right into the host and becomes a part of the host cells, it has an excellent control impact with the matrix around the cells, which contributes to the proliferation as well as repair of epithelial cells, consequently advertising the wound surface area. It can be used for the repair work, treatment and treatment of burns as well as injuries, and also can decrease and alleviate the level of burns and also scalds. Collagen organic dressings have 2 benefits: one is the easy prep work technique, convenient sanitation, and very easy handling; the various other is that it has good attachment, is suitable for the development of granulation tissue and epithelial cells, can reduce wound contracture and antigenic reaction, and has hemostatic residential properties. Good, easy to take in tissue secretions and various other qualities. Collagen can also be used in the treatment of eye diseases as a result of its special residential or commercial properties. Pure Collagen can promote the repair service of corneal epithelial cell damage and cell growth, and also can be dissolved in tears, with the capacity to assist epithelial cells to sneak right into the flaw location. At the same time, its destruction items can be utilized by new cells to manufacture brand-new collagen and contribute in linking cells. For that reason, it is extensively utilized in the therapy of ocular diseases. Collagen can likewise be utilized as a carrier for eye administration, and has the functions of boosting medicine concentration, extending medication action time, as well as decreasing medicine systemic medication poisoning, and has broad growth potential customers. Collagen is likewise extensively utilized in clinical medicine for aesthetic orthopedics, gum condition treatment, hard tissue repair service, nerve repair work and also regeneration, gum nerve repair covering products, synthetic organs, cardiac pacemakers, and also the dental filling of human internal organs. Additions etc.

Pure Collagen can be drawn out from pet skin. Along with collagen, pet skin likewise includes proteoglycans such as hyaluronic acid as well as chondroitin sulfate. They are all natural moisturizing variables and are essential substances for keeping skin dampness. of tyrosine right into melanin. Collagen is similar to the collagen framework in the skin and the stratum corneum of the skin. Collagen for skin can promote the spreading as well as fixing of epithelial cells, supplement nutrients such as amino acids, and boost the environment for skin cells to survive. Collagen for skin promotes the metabolic rate of skin tissue as well as improves flow. It can load as well as repair harmed as well as maturing skin, and also has good compatibility, fondness and also permeability with the skin, and can be totally absorbed by the skin, to ensure that the skin is plump and wrinkles are stretched, and also at the same time, it can enhance skin thickness and also produce stress. As A Result, Pure Collagen has the functions of pure natural moisturizing, whitening, blemish removal, as well as anti-wrinkle, and also can be widely made use of in the cosmetics sector Nowadays, numerous cosmetics such as face masks, eye creams, and skin creams marketed out there contain collagen.

Pure Collagen has two applications in food: one is function and also the various other is nutrition. Collagen peptides can be eaten directly as practical foods, such as chewable tablet computers, protein powders for athletes, and also enteral nutrition prep work. Individuals consume foods rich in collagen, along with properly delaying the aging of the body, reinforcing muscles and also bones, as well as improving physical fitness, it can additionally have healthcare results such as weight-loss, blood pressure, as well as calcium supplements. After collagen is treated with particular enzymes, it can destroy the hydrogen bonds in its particles, to make sure that its initial tight supercoiled structure is damaged, and the formed tiny molecular materials with loosened structure can enhance connective cells and rise healthy protein when included in meat products. Web content, taste excellent and also nutritious. The enzymatic hydrolysis item of collagen can additionally be used as an improver for frozen food, as a viscosity enhancer and has a low melting point, very easy to melt, as well as has the attributes of melting in the mouth. For that reason, collagen is extensively used in jelly, butyric acid, ham, tinned food, bread and other foods. Furthermore, as a result of the film-forming buildings of Pure Collagen, it can be utilized as a film product for incapacitating enzymes and meat food labels. Collagen can additionally be utilized as a food adhesive artificial fiber film and as a food safety layer, used as wrapping paper for meat, fish, and so on, as a food safety layer, it has antioxidant buildings as well as keeps the color of meat products bright.

With the continuous study on Pure Collagen, the application of collagen in various other fields is likewise increasing and has good development leads. As an example, the wastes left in the tanning process are abundant in collagen extracted, which can be made use of as pet protein sources for feed to recognize resource application. After denaturing collagen, it can boost its textile properties and be utilized in the fabric market. At the same time, in recent years, Pure Collagen has additionally been used more and more in light markets such as paper market, tanning market, daily chemical market and so forth. With the constant growth as well as development of research study innovation, the research study on collagen will remain to grow, as well as collagen will be extra extensively made use of.

Extraction Method of Pure Collagen

The approximate process of extracting Pure Collagen is to remove grease, remove impurity proteins, collagen precipitation, purification, etc. Its extraction methods are as follows: hot water extraction, acid extraction, alkali extraction and enzymatic extraction.
1. Hot water extraction method
The hot water extraction method is a method of directly extracting the denatured Pure Collagen or collagen hydrolyzate in hot water after the raw materials are subjected to pretreatment such as removing impurities. 40-42℃, 45℃.
2. Acid extraction method
Acid extraction method commonly used acids are: formic acid, acetic acid, hydrochloric acid, oxalic acid, citric acid, lactic acid, etc. Acids with low ionic concentrations can destroy intermolecular salt bonds and Schiff’s bases, causing collagen fibers to swell and dissolve. When using acid to extract collagen, a collagen hydrolyzate with uneven molecular weight can be obtained depending on the conditions such as acid concentration, hydrolysis temperature, and hydrolysis time. However, tryptophan will be completely destroyed, and serine and tyrosine will also be partially destroyed during the complete hydrolysis of isoconcentration acid. Therefore, acidity, temperature, time and other influencing factors should be accurately controlled for biomedical collagen dissolution by acid method.
3. Alkaline extraction method
Alkaline extraction usually uses sodium hydroxide, sodium carbonate, etc. Collagen is extracted under alkaline conditions, which can easily cause protein denaturation, such as hydrolysis of collagen peptide bonds, and all amino acids containing hydroxyl and sulfhydryl groups are destroyed; the obtained product has a low isoelectric point pH value , aspartamide and glutamine are converted into aspartic acid and glutamic acid respectively; if the hydrolysis is serious, a racemic mixture of D and L-type amino acids will be produced.If the material of D-type amino acid is more than that of L-type amino acid, after that It will certainly prevent the absorption of L-type amino acids, some D-type amino acids are poisonous, as well as some even have carcinogenic, teratogenic and also mutagenic results. Therefore, when extracting collagen with full framework and also risk-free usage, the alkaline method is rarely used to extract collagen.
4. Enzyme removal technique
Treating pigskin with protease can not only hydrolyze the terminal peptides of collagen fibrin and also boost the return of Pure Collagen, however likewise will certainly not damage the three-way helix structure of collagen and preserve its outstanding physical as well as biochemical homes. The generally made use of proteases are mostly neutral protease, bromelain, ficin, trypsin and pepsin. There are numerous elements that affect enzyme removal, such as enzyme focus, ratio of enzyme to substratum, enzymatic hydrolysis time, enzymatic hydrolysis temperature, pH worth, and material-to-liquid ratio. In practice, the majority of the collagen is drawn out by the chemical substance method.

Does Supplementing With Pure Collagen Actually Work?

There has been debate over whether or not Pure Collagen supplements work. There is a view that collagen is a macromolecular structure that needs to be broken down into amino acids by the digestive system before it can be absorbed by the body. It is uncertain whether these amino acids can synthesize collagen again, and how much collagen can be synthesized.

However, in April 2019, in the top international scientific journal “Nature”, scientists from Japan published a new research result and found that the key to keeping the skin young and intact lies in collagen. This research is the anti-aging effect of collagen. “Name”.

A number of clinical studies have also confirmed that after taking collagen for 8 weeks for women with aging skin, skin firmness increased by 20%, moisture increased by 12%, and crow’s feet at the corner of the eyes decreased by 11%. Various skin problems have been significantly improved.

In addition, Professor Cai Meiqin, deputy director of the Department of Nutrition, Shanghai Jiao Tong University School of Medicine, and vice chairman and secretary general of the Shanghai Nutrition Society, led the design of a questionnaire for collagen peptide products.

The survey was conducted by about 2,500 women in many places across the country who took the Yi Rijian collagen peptide products provided by Mary Kay, and shared the benefits of collagen to the skin in four aspects: “moisturizing”, “bright”, “bounce” and “powder”. change.

About Products:
If you need Pure Collagen, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Pure Collagen manufacturer and supplier, ZSpharmac will provide Pure Collagen raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Pure Collagen Quotation