Step 1: Select and remove 1500kg of cinnamon twigs, then coarsely crush them into 1cm-3cm to obtain 1342kg of cinnamon twig granules, and then put a part of them into the extraction tank, after compaction, let steam moisten them, and then continue feeding and compacting , until the mouth of the tank overflows, cover the lid of the extraction tank;
The second step: inject steam from the bottom of the tank, maintain the extraction temperature at 100°C to 108°C, and extract for 2.5 hours to 3 hours to obtain cinnamon oil/water mixed steam;
Step 3: Pure Cinnamon Oil/water mixed steam is condensed through the condenser to obtain milky white cinnamon oil/water condensate;
Step 4: Pure Cinnamon Oil water condensate is separated by 10 oil-water separators connected in series to obtain cinnamon crude oil;
Step 5: Pure Cinnamon Oil/water condensate separates cinnamon crude oil and cinnamon oil aromatic water is concentrated by vacuum concentration equipment. Cinnamon crude oil with higher cinnamic aldehyde content.
Step 6: Heat the Pure Cinnamon Oil in a thermal insulation tank, control the temperature at 70°C to 80°C, and heat for 30min to 40min. The water wrapped in the cinnamon crude oil was completely separated to obtain Pure Cinnamon Oil 24.15kg, with a yield of 1.80%.
A preparation method of Pure Cinnamon Oil microemulsion. It is a cinnamon oil microemulsion system composed of cinnamon oil, compound emulsifier, co-emulsifier, deionized water and other components. Each 100ml microemulsion contains 2-17 grams of Pure Cinnamon Oil, 20-35 grams of complex emulsifier, 10-15 grams of co-emulsifier, 2-18 grams of dispersant, and the rest is deionized water. Stir magnetically at 20-60°C to obtain microemulsion evenly, and then sterilize after packaging. The invention has the advantages of less emulsifier consumption, simple process, high oil loading capacity and good bioavailability of the prepared microemulsion. The particle size is between 25nm and 40nm, the drug loading is between 2% and 17%, and the encapsulation efficiency is 80%.
A compound Pure Cinnamon Oil nanoemulsion, consisting of vegetable oil, organic materials, deionized water and auxiliary materials, wherein the vegetable oil includes cinnamon oil, samara oil, and peppermint oil configured according to a weight ratio of 1:2:5, and the vegetable oil accounts for The weight percentage of nanoemulsion is 4.0%, and the organic material includes alkyl glycoside and 1,2-propanediol configured according to the weight ratio of 4:2. The weight percentage of organic material in nanoemulsion is 40%; deionized water accounts for the weight percentage of nanoemulsion 35%; excipients include caprylic/capric triglyceride, SCY, vitamin E, DermosoftEco1388 and citric acid, caprylic/capric triglyceride is 2.0% by weight of nanoemulsion, SCY is 0.8% by weight of nanoemulsion, Vitamin E accounts for 0.2% by weight of the nanoemulsion, Dermosoft Eco1388 accounts for 3.0% by weight of the nanoemulsion, and citric acid accounts for 15% by weight of the nanoemulsion.