Zhishang Chemical

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Zhishang Chemical

Protocatechuic Acid Sigma CAS 99-50-3

Molecular Formula: C7H6O4

Formula Weight: 154.12

ZSpharmac: Protocatechuic Acid Sigma Supplement

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Product Name: Protocatechuic Acid Sigma
CAS No: 99-50-3
Purity: 99%

Basic Info

Product Name:Protocatechuic Acid Sigma
Other Names:Protocatechuic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Pharmaceutical Raw Materials
Appearance:Beige to Brown
EINECS No.:202-760-0
Storage:Store Below +30°C.
Provide:Protocatechuic Acid Sigma MSDS;
Protocatechuic Acid Sigma COA

What is Protocatechuic Acid Sigma?

Protocatechuic acid (PCA) is 3,4-dihydroxybenzoic acid. is a simple phenolic acid that is a precursor for the synthesis of other complex molecules such as anthocyanin 3-O-β-D-glucoside and vanillin. It is found in edible vegetables, fruits, nuts, brown rice, pecans, tea, hibiscus flowers, and some Chinese herbs.

Protocatechuic Acid Sigma Properties:

Melting point 197-200 °C (dec.) (lit.)
Boiling point 237.46°C (rough estimate)
density 1.54
refractive index 1.6400 (estimate)
storage temp. Store below +30°C.
solubility 20g/l
pka4.48(at 25℃)
form Fine Crystalline Powder
color Beige to brown
Water Solubility Soluble in hot alcohol and ether. Slightly soluble in water.


Protocatechuic Acid Sigma Uses

  1. Protocatechuic Acid is used as dyes, pharmaceutical intermediates, analytical reagents (for the determination of iron).
  2. Protocatechuic Acid can be used to study the effects of 4-coumaric acid and 3,4-dihydroxybenzoic acid on basal oxidative DNA damage in rat colonic mucosa in vivo. It can be used for derivatization of chitosan resin.
  3. Protocatechuic acid has a range of biological tasks against various molecular targets, and also it has anti-bacterial, antioxidant, anti-inflammatory, anti-hyperglycemic and also neuroprotective effects. In addition, protocatechuic acid has potential chemical protective effects. It inhibits chemical carcinogens in vitro and produces pro-apoptotic and anti-proliferative effects in various ways. Therefore, it is currently clinically used for the treatment of burns, infantile pneumonia, bacillary dysentery, acute pyelonephritis, acute pancreatitis and some ulcer diseases.

Pharmacological Effects of Protocatechuic Acid

Protocatechuic acid is a metabolite of complex polyphenols, such as anthocyanins and also proanthocyanidins, which are plentiful in plants and also fruits and can be absorbed by pets and also human beings. It is estimated that people take in even more anthocyanins than other Polyphenols are high, so the dietary value of protocatechuic acid is progressively identified. A multitude of experiments have confirmed that protocatechuic acid has a variety of biological tasks versus different molecular targets, as well as it has anti-bacterial, antioxidant, anti-inflammatory, anti-hyperglycemic and also neuroprotective impacts. In addition, protocatechuic acid has possible chemical It can prevent chemical health hazards in vitro as well as generate pro-apoptotic and anti-proliferative effects in different aspects.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Protocatechuic Acid Sigma Quotation