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Propanedioic Acid CAS 141-82-2

Molecular Formula: C3H4O4

Formula Weight: 104.06

ZSpharmac: Propanedioic Acid Supplier

Product Name: Propanedioic Acid
CAS No: 141-82-2
Purity: 99%

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Basic Info

Product Name:Propanedioic Acid
Other Names:Malonic Acid
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Liquid
EINECS No.:205-503-0
Storage:Sealed in Dry,Room Temperature
Provide:Propanedioic Acid MSDS;
Propanedioic Acid COA

What is Propanedioic Acid?

Propanedioic Acid is likewise called methane dicarboxylic acid, carrot acid, malic acid, beetroot acid. There are 3 crystal kinds, two of which are triclinic and additionally one is monoclinic. Those taken shape from ethanol are triclinic white crystals. The family member molecular mass is 104.06. The relative density is 1.631 (15 ° C). The melting point is 135.6 ° C. It decomposes right into acetic acid and also co2 at 140 ° C. It does not break down under vacuum cleaner of 1.067 × 103 ~ 1.333 × 103Pa, yet sublimes straight. Insoluble in benzene, soluble in water 61.1 (0 ° C), 73.5 (20 ° C), 92.6 (50 ° C), ethanol 57 (20 ° C), ether 5.7 (20 ° C), a little soluble in pyridine. In case of potassium permanganate, it will be broken down right into formic acid and additionally co2. Propanedioic Acid is a dibasic acid with the regular sensitivity of a dibasic acid. As an example, the methylene group of malonic acid is active along with can undergo responses such as enhancement, alkylation, amination, as well as halogenation; its 2 carboxyl groups are incredibly close, can be dried out; can be esterified with alcohol; decarboxylated by home heating; compressed with carbonyl substances; added to materials having active dual bonds. The hydroxyl groups in the two carboxyl groups of malonic acid are all replaced by ethoxy groups (see replacement response) and additionally the substance diethyl malonate is created. Diethyl malonate is a crucial resources for natural synthesis, used for dyes and also medicines synthesis. Due to the truth that the molecule has an active methylene team, it can originally react with salt alkoxide to create salt malonate, and after that react with different energetic halogenated compounds to develop replaced malonate, which can be hydrolyzed as well as decarboxylated to obtain different monovalent, dicarboxylic acids in addition to numerous other keto acids and other compounds. As an example, a generally utilized hypnotic barbiturate can be prepared by reacting changed malonate with urea.
Thinking About that Propanedioic Acid produces co2 and water after home heating, there is no contamination problem, so it can be directly made use of as a lightweight light weight aluminum area treatment agent; it is in addition a basic material for the production of chemical fungicide Fuji No. 1 as well as herbicide Kusida; the pharmaceutical market uses malonic acid to prepare diuretics Besulfazone, anti-inflammatory drug phenylbutazone, sedative drug bromoxine, and more. In addition, malonic acid and additionally its esters are thoroughly utilized as pharmaceutical intermediates, such as barbiturates, vitamins B1 as well as B6, and more. The esters of propanedioic acid are generally made use of in organic synthesis, as well as likewise are also made use of as adhesives, seasonings, Resin ingredients, electroplating gloss, welding changes, and so on.

Propanedioic Acid Property

Melting point 132-135 °C (dec.) (lit.)
Boiling point 140℃(decomposition)
density 1.619 g/cm3 at 25 °C
vapor pressure 0-0.2Pa at 25℃
refractive index 1.4780
Fp 157°C
storage temp. Sealed in dry,Room Temperature
solubility 1 M NaOH: soluble100mg/mL, clear to slightly hazy, colorless to faintly yellow
pka2.83(at 25℃)
form Liquid
color White
PH3.17(1 mM solution);2.5(10 mM solution);1.94(100 mM solution)
Water Solubility 1400 g/L (20 ºC)


Propanedioic Acid Uses

  1. Propanedioic Acid is mostly made use of in pharmaceutical intermediates, but also in seasonings, adhesives, resin additives, electroplating polishes, and so on.
  2. Propanedioic Acid is the intermediate of the fungicide rice blastin and also the intermediate of the plant development regulatory authority indyl ester.
  3. Propanedioic Acid is a complexing representative for the determination of beryllium and also copper. Calibration of standard alkaline remedy. biochemical study. Organic Synthesis. Create barbiturate salts. Gas Chromatographic Analysis Requirements.
  4. Propanedioic Acid is mostly made use of in spices, adhesives, resin ingredients, pharmaceutical intermediates, electroplating polishing agents, surge control representatives, heat welding fluxing additives, etc. Malonic acid is used as a light weight aluminum surface area treatment representative. Considering that only water and also carbon dioxide are created during thermal decomposition, there is no pollution issue. In this regard, it has actually terrific benefits compared to the acid-type therapy representatives such as formic acid made use of in the past.

Preparation of Propanedioic Acid

1. Preparation of malonic acid aqueous remedy

The cyanoacetate is hydrolyzed with antacid under slight negative pressure to acquire sodium malonate. After the hydrolysis is finished, the spin-offs ammonia and methanol are removed, recouped, and also utilized to make glycine, and so on. The reaction service was acidified by adding hydrochloric acid to get a blended option of Propanedioic Acid and also sodium chloride.

Micro-negative stress refers to a stress slightly lower than typical pressure, normally at a stress of 0.95-0.99 ambiences.

2. Removal of Propanedioic Acid

Pick an ester solvent extractant consisting of ethyl formate, ethyl acetate, propyl acetate, methyl propionate or ethyl propionate, the extraction conditions include: water/organic phase quantity ratio 1:1 -8, removal temperature 30 -100 ° C, each removal time is 10-20min, and also the variety of removals is 3-9 times.

3. Concentration

The essence is focused by vacuum cleaner purification to obtain solid Propanedioic Acid with a web content of more than 99.5%, and also the extractant is recovered and recycled at the same time.

4. Salt recovery

Remove the inorganic salts in the staying water phase, concentrate by distillation, filter and dry to get the spin-off sodium chloride.

The technique for the ester solvent extraction as well as purification of malonic acid, the removal agent is ideally ethyl formate in the step 2, the water/organic stage quantity ratio is preferably 1:4 -7, and the extraction temperature level is preferably 35-60 ° C.

In the step 4, the not natural salt sodium chloride in the remaining water phase is extracted for crystallization, which can be made use of as an industrial raw material.

Beneficial impact

A brand-new procedure was suggested, a brand-new technique of preparing malonic acid by hydrolysis of cyanoacetate, especially methyl cyanoacetate. The process is easy and the investment is tiny; as well as the propanedioic acid with really high pureness can be obtained via ester removal, which can fulfill the prep work and use of the existing industrial pharmaceutical intermediates. The entire procedure assurances high purity, safety and security as well as environmental management, as well as has high theoretical and practical worth.


Propanedioic Acid Best Practices

Sodium hydroxide solution is added in the methyl cyanoacetate, the system is brought slight negative pressure, starts to heat up to 105-115 ℃ of insulation 3 hours, stops hydrolysis when almost no ammonia is released. Sodium malonate solution is obtained; the temperature of the sodium malonate solution is lowered to below 50 degrees, hydrochloric acid is slowly added therein, the acidification temperature is strictly controlled below 50 degrees, and the temperature is kept at this temperature for 0.5 hours after adding the hydrochloric acid. Propanedioic Acid mixed solution is obtained, and the content of malonic acid is determined. The calculated malonic acid production rate was 92%.

The malonic acid aqueous solution prepared above, the extraction aqueous solution is the water phase (W), and the ethyl formate (0) is the organic phase, which is extracted by intermittent stirring. In a three-necked flask equipped with a stirrer, a thermometer and a condenser, add 25mL of aqueous solution and 25mL of ethyl formate, control the extraction temperature, stir, and make the extractant ethyl formate contact with the malonic acid aqueous solution. Compared with 0/W=1, the extraction temperature was 38°C, and the extraction time was 15 minutes. After phase separation, the organic phase was distilled under reduced pressure to obtain solid Propanedioic Acid, and the yield of malonic acid in one extraction was 35%. After continuous extraction for 5 times, solid malonic acid was obtained by concentration and combined. The yield is 90%. After drying, the content is 99.6%.

About Products:
If you need Propanedioic Acid, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Propanedioic Acid manufacturer and supplier, ZSpharmac will provide Propanedioic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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