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Procyanidin CAS 4852-22-6

Molecular Formula: C30H26O13

Formula Weight: 594.52

ZSpharmac: Procyanidin Supplier

Product Name: Procyanidin
CAS No: 4852-22-6
Purity: 99%

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Basic Info

Product Name:Procyanidin
Other Names:Proantho Cyanidins
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Red Brown Powder
EINECS No.:1806241-263-5
Provide:Procyanidin MSDS;
Procyanidin COA

What is Procyanidin?

Procyanidin is a big course of polyphenolic materials extensively existing in plants, which is similar in framework to anthocyanins, and is developed by the condensation of flavan-3-ol monomers. Structurally, proanthocyanidins are composed of various amounts of catechin or epicatechin. The simplest proanthocyanidins are catechin, or epicatechin, or dimers created by catechin and epicatechin, along with trimers, tetramers, etc as much as decamers. According to the degree of polymerization, two to pentamers are normally called oligomeric proanthocyanidins (OPC for short), and those with more than pentamers are called high-polymeric proanthocyanidins (pay per click for brief). Procyanidin has strong antioxidant task and has actually been commonly used in food, medication, cosmetics and other areas. Proanthocyanidins extracted from blueberry leaves can deal with liver disease C virus.

Procyanidin Property

solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form powder
color Red brown


The Role of Procyanidin

Blood circulation
In Europe, in order to boost blood circulation, deal with diabetic person retinopathy, lower edema and hinder varicose capillaries, etc, proanthocyanidins have actually been made use of in scientific therapy for years. Procyanidin can reinforce veins, arteries as well as blood vessels, so it has the result of reducing swelling and also tension. The decreased resistance as well as boosted permeability of veins make it simpler for cells to take in nutrients and remove waste. It is the feature of the blood circulatory system to transfer nutrients and also transport waste. The heart pumps the blood; the arteries and also capillaries carry the blood; as well as the capillaries transportation nutrients to cells and also waste products out. Proanthocyanidins can feed on water-soluble and fat-soluble complimentary radicals in cell membranes, therefore inhibiting the process of releasing certain enzymes to harm capillary walls.

Eye defense
Diabetic retinopathy, an indication of diabetes mellitus, is caused by microbleeds in the blood vessels of the eye as well as is a common reason for grown-up loss of sight. France has allowed the use of Procyanidin to treat this disease for several years. This method significantly minimizes capillary bleeding in the eye and boosts vision. Proanthocyanidins have actually also been used to stop difficulties after cataract surgical procedure in diabetic person individuals.

In 1998, professionals selected many people without eye conditions and eye injuries to perform experiments to explore whether proanthocyanidins can ease night blindness. Individuals were divided right into two teams, one group was vehicle drivers that drove at evening, and also the other group was people who spent the majority of their time with computer screens. Four weeks later on, their capability to endure loss of sight was inspected again, as well as 98% of the testers had actually improved.

Get rid of edema
Edema is caused by the infiltration of water, electrolytes, and so on in the blood right into the body cells, and also it is generally swelling in the damaged area. Healthy individuals who sit for as well long will certainly have edema, women will certainly have edema before menstruation, sporting activities injuries usually trigger edema, some operations might create edema, and also some illness can likewise trigger edema. Studies have actually revealed that taking anthocyanins once a day can significantly soothe edema. The University of Bordeaux in France conducted a medical trial as well as examined 40 patients with an average age of 60 and edema. The individuals were split right into 2 groups. The individuals took 300 mg of anthocyanins each day for 60 days, and all the signs were eased. After 30 days, swelling went away in 26% of people. After 60 days, the edema in the legs of 63% of the test subjects was healed.

Moisturize the skin
Europeans call Procyanidin youth nutrition, skin vitamins, oral cosmetics. Due to the fact that it brings back the vigor of collagen, making the skin smooth and also elastic. Collagen is the building block of skin and is the gel-like material that holds our body together. Vitamin C is an important nutrient for biochemical synthesis of collagen. Proanthocyanidins make more vitamin C reliable, which suggests that vitamin C can a lot more easily carry out all its features (consisting of collagen production). Proanthocyanidins are connected to collagen, which can avoid the damages of enzymes that ruin collagen. Proanthocyanidins not only assist collagen fibers create a cross-linked structure, however likewise aid bring back damages caused by extreme cross-linking caused by injuries and totally free radicals. Extreme cross-linking suffocates as well as solidifies connective cells, which wrinkles and too soon ages the skin. Anthocyanins also safeguard the body from sun damages and also advertise the healing of psoriasis as well as age areas. Proanthocyanidins are additionally ingredients to topically used skin creams.

Cholesterol is a vital component of cell membranes and plays a vital role in the production of hormones and also the transportation of fats. Nonetheless, too much cholesterol is a possibly negative indication. The mix of proanthocyanidins as well as vitamin C can disintegrate cholesterol into bile salts, which can then be eliminated from the body. Proanthocyanidins accelerate the disintegration as well as removal of damaging cholesterol. Here once more, the collaborating connection between vitamin C as well as anthocyanins was confirmed.

Cardioprotective representative
Proanthocyanidins not only aid recover skin flexibility, yet also help joints, arteries, and also other cells (such as the heart) preserve typical feature. The vascular system is responsible for blood circulation and also sends out blood to all cells as well as tissues. It can additionally hinder the manufacturing of histamine, decrease swelling, and help arteries stand up to the influence of those mutagenic factors that trigger cardiovascular disease.

Although the French generally eat even more high-fat foods than Americans, the French die from heart problem at a much lower rate than Americans. The French are popular for their love of alcohol, which is typically a have to with meals. The variety of French drinkers dealing with coronary heart problem is 30% to 40% lower than that of non-drinkers, due to the fact that French merlot consists of proanthocyanidins.

Allergy inflammation
Procyanidin not only helps slow down cardio inflammation, but also helps treat numerous diseases, such as allergic reactions, asthma, bronchitis, hay fever, rheumatoid arteritis, sporting activities injuries, stress abscess, etc. When the human body is inflamed, it releases a compound called histamine, which can induce different symptoms of the above diseases. Anthocyanins inhibit the enzymes needed to produce histamine, protecting against the production of histamine, therefore minimizing inflammation. Proanthocyanidins are widely known preventions of histamine, but it does not obstruct various other enzymes. Our bodies are loaded down with chemicals as well as contaminants from our food, alcohol consumption water, air, as well as plants and also pets such as pollen. Consequently, allergic reactions are a very typical illness. The anti-allergic as well as anti-inflammatory abilities of proanthocyanidins have actually been recorded in several literary works. Professional athletes appreciate anthocyanins since they make joints adaptable, repair service collagen in connective cells, as well as minimize edema. It has actually also been reported that proanthocyanidins improve joint inflammation in many individuals.

Varicose veins
Symptoms of varicose capillaries can consist of pain, itching, shedding, as well as fatigue. Serious varicose veins can cause heart problem, stroke, thrombophlebitis, lung blood clot, etc. Dr. Haake carried out clinical research in Hamburg, Germany, and found that Procyanidin is beneficial to people with varicose capillaries. Of the 110 clients taking part in the trial, 41 had calf bone pains. People took 90 mg of anthocyanins by mouth each day, and 77% of the testers had substantial improvement. Additionally, 93% of individuals with calf aches disappeared.

Brain feature
Procyanidin can aid enhance memory, reduce aging and also the risk of stroke. The reality that proanthocyanidins can help boost memory and brain feature also after a stroke has been confirmed by professional studies. For example, hyperactivity disorder (or ADHD) in children is typically treated with a western medication called Ritilan. This type of western medicine has the side effect of preventing the development of children. People may end up being depending on it. Once they stop taking it, people will certainly have symptoms such as raised cravings, clinical depression as well as sleepiness. Some reports suggest that changing Ritilan with proanthocyanidin all-natural supplements is both reliable and also secure.

Improve hypoxia
Hypoxia describes the lasting absence of oxygen, which has incurable damages to the body. Absence of oxygen in the senior might trigger psychological as well as physical issues, such as Alzheimer’s disease. Elderly individuals frequently have inadequate blood circulation. Proanthocyanidins scavenge complimentary radicals, hinder capillary rupture and also damage to bordering tissues. Proanthocyanidins also enhance the state of veins as well as improve blood flow to the mind, so the brain can get even more oxygen.

Procyanidin Determination Method

1. Benzylthiol (or phloroglucinol) acid degradation method
In the presence of benzyl mercaptan, phloroglucinol and other nucleophiles, Procyanidin was subjected to acid hydrolysis before determination.
2. Butanol-hydrochloric acid degradation method
The principle is that proanthocyanidins are degraded in the presence of inorganic acids and heated to produce red anthocyanins, which have a maximum absorption at 550nm. This method is specific and selective.
3. High performance liquid chromatography
Reversed-phase high-performance liquid chromatography (RP-HPLC) has been proven to be an effective method for analyzing phenolic substances. It can better separate monomers, dimers and a small amount of trimers of proanthocyanidins, and is often used to analyze low molecular weight Proantho Cyanidins.
4. Vanillin method
The flavonoid ring of Procyanidin reacts with aromatic aldehydes in a strong acid medium to form a colored adduct for determination, which can simultaneously determine the total content of monomers and polymers, usually using catechin as a standard substance.

Procyanidin Preparation Method

1. Plant extraction approach
1.1 Removal
At present, the frequently made use of procedure is to degrease initially, consisting of pressing approach, solvent method, and supercritical carbon dioxide extraction approach. Among them, supercritical carbon dioxide removal technique is the very best, not only has a high oil removal rate, yet also has the least damaging impact on proanthocyanidins and lower top quality. good.
1.2 Separation
Purification of Procyanidin monomer is typically separated by column chromatography, amongst which polyamide, SephadexLH-20 and additionally ToyopealHW-40 are the most effective fillers. For substances that are testing to different or require a small amount, semi-preparative reversed-phase high-performance fluid chromatography (RP-HPLC) along with normal-phase high-performance liquid chromatography (NP-HPLC) can be used for prep work. As the degree of polymerization increases, the number of isomers of proanthocyanidins increases geometrically, in addition to it is really challenging to various and detoxify such macromolecular monomers. For polymers, they can be fractional according to their molecular weight (degree of polymerization). Today, the well-known category approaches consist of solvent rainfall in addition to various chromatographic approaches, such as slim layer chromatography, regular phase high performance fluid chromatography, gel size exclusion chromatography, in addition to countercurrent chromatography.
2. Biosynthesis
The major product of the decrease of (2R,3 R)-dihydro-3 ′,4 ′,3,5,7-pentahydroxyflavan by salt borohydride as lowering rep is 2,3- The trans-3,4-trans isomer, while the decrease thing of the enzyme is the 2,3-trans-3,4-cis isomer. Under a little acidic conditions, the 3,4-trans isomer could be partly converted to the 3,4-cis isomer. The 3,4-cis isomer is far more acidic than the 3,4-trans isomer and easily responds with thiol along with diol reductases. The problems required for enzyme synthesis are rather severe, as well as there is additionally a problem of cis-trans isomers. Today, this approach is not yet fully grown.

About Products:
If you need Procyanidin as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Procyanidin manufacturer and supplier, ZSpharmac will provide Procyanidin raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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