Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Close this search box.

Proanthocyanidine CAS 111-42-2

Molecular Formula: N/A

Formula Weight: 0

ZSpharmac: Proanthocyanidine Supplier

Product Name: Proanthocyanidine
CAS No: 111-42-2
Purity: 99%

Navigation Bar

Basic Info

Product Name:Proanthocyanidine
Other Names:Proanthocyanidines
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
Provide:Proanthocyanidine MSDS;
Proanthocyanidine COA

What is Proanthocyanidine?

Proanthocyanidine was originally classified as condensed tannins or flavanols. With the development of separation technology and identification technology, as well as in-depth research on such substances, it has now been classified as a class of substances and called proanthocyanidins. Proanthocyanidine is condensed from varying amounts of catechin or epicatechin. The simplest Proanthocyanidine is catechin or epicatechin or the dimer, trimer, tetramer, etc. to decamer formed by catechin and epicatechin. Among all kinds of proanthocyanidins, dimers are the most widely distributed and studied most, and are the most important class of proanthocyanidins. It is a polyphenolic mixture that exists widely in nature, and is a general term for the broad categories of polyphenolic compounds that are ubiquitous in the plant kingdom. It has anti-oxidative activity, anti-tumor and anti-radiation functions. It has a unique positive therapeutic effect on senile dementia, cancer and allergies. This substance is widely found in grape seeds, grape skins, black wolfberry, seabuckthorn, peanuts, rose hips, blue berries, birch trees, wild thorn sunflowers, custard apples, wild strawberries and other plants. But studies have found that grape seed and pine bark extracts have the highest levels of proanthocyanidins. At present, Proanthocyanidine has been widely used in the field of health food.

Application of Proanthocyanidine

Examples of Proanthocyanidine applications are as follows:

1) Prepare a whitening skin cream containing Proanthocyanidine. The raw materials and weight ratios in the formula are: 2 parts of stearic acid, 9 parts of lanolin, 3 parts of higher fatty alcohol, 3 parts of glyceryl monostearate, meat 2 parts of isopropyl myristate, 4 parts of white oil, 1 part of triethanolamine, 0.5 parts of proanthocyanidins, 2 parts of aloe extract, 2 parts of vitamin A, 0.2 parts of hyaluronic acid, 0.2 parts of amino acid, appropriate amount of essence, An appropriate amount of pigment and purified water are added to 100 parts. The dosage and physical and chemical properties of each raw material in the present invention produce a synergistic effect, thereby achieving the effects of deep whitening and purification and accelerating metabolism. The pH value of the invention is close to that of human skin, and has no irritation to the skin; after use, the skin feels comfortable, soft, and non-greasy, and has obvious effects of removing freckles, preventing wrinkles, repairing and beautifying the skin.

2) To prepare a cigarette filter that can effectively scavenge free radicals and reduce the toxicity of smoke. The filter tow contains Proanthocyanidine, which has a very outstanding scavenging effect on gas phase free radicals in cigarette smoke at low concentrations. At the same time, when anthocyanin is used in combination with vitamin C (Vc), it also has a relatively good scavenging effect on gas phase free radicals. The invention also provides a method for manufacturing the cigarette filter. The cigarette filter of the present invention does not change the original cigarette taste, and can significantly reduce the free radicals and toxicity produced by smoking. In addition, since the present invention can directly add the scavenger to the filter tow, there is no need to use a composite method to manufacture the filter. Therefore, it can be mass-produced without large-scale equipment investment and modification.

Preparation of Proanthocyanidine

A method for extracting Proanthocyanidine, comprising the following steps:

(1) After the raw material grape seeds or pine bark are pretreated, they are heated and extracted with a solvent, and concentrated under reduced pressure to obtain a concentrated solution; grape seeds contain a large amount of water-soluble impurities, such as sugars, proteins, etc., but these impurities are insoluble in Acetone, so use acetone to extract the raw materials to remove the impurities to the greatest extent, reduce the pollution to the macroporous resin, and achieve the purpose of improving the purity of the product. In step (1), the method of heating reflux with acetone is used to replace the conventional method of extracting with water or ethanol, and the above-mentioned solvent is acetone, an organic solvent, which is heated and refluxed, and then concentrated under reduced pressure to obtain concentrated solution I; in addition, in the above Add refining operation between step (1) and step (6), its step comprises:

(2) the concentrated solution I is cooled and precipitated;

(3) packing macroporous resin in the chromatographic column;

(4) Put the supernatant of concentrated solution I on the column, add ethanol into the chromatographic column for desorption, and collect the desorption solution;

(5) Concentrate the stripped solution under reduced pressure by heating, and extract the concentrated solution II. In the refining process, the supernatant of the concentrated solution I is put on the column, so that the macroporous resin can selectively adsorb substances to achieve further purification of the product.

(6) carry out drying treatment;

For production, specific process steps can be selected according to needs. For example, when the above step (1) is heated and refluxed in acetone, it can be carried out twice, and the first time is heated and refluxed for 3 hours. After extracting the leaching solution, the residue Add acetone again and heat to reflux for 2 hours, and extract the leachate for the second time; then combine the leachate extracted twice. In the step (1), the dosage of the acetone aqueous solution is 3 to 5 times (V/W) of the amount of the plant material. The concentration of acetone is 60-75%, the optimum concentration is 65-70%; the heating temperature is 55-70°C, the optimum temperature is 60-65°C. During the desorption process with ethanol, the volume ratio of ethanol to resin is 3:1 (V/W), and the ethanol concentration is 60-75% according to different requirements of different products.

And in the process of step (5) heating and concentrating under reduced pressure, the concentrating heating temperature is 60-80°C, preferably 65-70°C. According to different raw materials, the ratio of acetone to raw materials also changes accordingly, for example: for using grape seeds as raw materials, the volume ratio of raw materials to acetone in the step (1) is 1:3. And take pine bark as raw material, the volume ratio of raw material and acetone in the described step (1) is 1: 5.

Proanthocyanidine, the Difference Between Anthocyanin and Proanthocyanidin

Proanthocyanidine is a family members of bioflavonoids, a kind of polyphenols; referred to as PCA, this substance widely exists in plants, and can be claimed to be a second metabolite of plants. Nonetheless, Proanthocyanidine is not a single compound, yet a collection of substances. Make-up, including huge molecular weight and also small molecular weight substances, little molecular weight are: catechin (catechin and epicatechin), dimer (procyanidin B collection), trimer (procyanidin C series); big molecular weight is tannin (condensed tannins) as well as polymers (polyhydroflavan-3-ol).

Procyanidin, referred to as PC, is a bioflavonoid combination with a special molecular framework, and also its oligomer: oligomeric proanthocyanidin (OPC) is currently internationally acknowledged as a reliable natural antioxidant for scavenging free radicals in the human body. It is usually a reddish-brown powder with a minor gas and also astringent preference, soluble in water and most natural solvents. Research studies have actually shown that blueberry fallen leave remove proanthocyanidins can protect against liver disease C virus replication. It is a bioflavonoid with a special molecular framework, and also it is an efficient natural anti-oxidant that can feed on complimentary radicals in the human body. Generally grape seed essence or French maritime pine bark extract. Proanthocyanidins (grape seed remove) is a brand-new type of high-efficiency anti-oxidant with strong in vivo task. Experiments have actually verified that the anti-free extreme oxidation capability of oligomeric proanthocyanidins OPC is 50 times that of vitamin E as well as 20 times that of vitamin C, and it can be soaked up promptly and also totally. It can reach the highest possible blood concentration in 20 minutes after oral administration, as well as the metabolic half-life can get to 7 hours.

Anthocyanin, in addition called anthocyanin, referred to as OPC, is a type of water-soluble natural pigment widely present in plants in nature, and likewise is a colored back aspect gotten by hydrolysis of anthocyanin. A lot of the primary coloring products in fruits, vegetables and also flowers associate with it. Under the conditions of various pH worths of plant cell vacuoles, anthocyanins make flowers reveal dynamic shades. It is comprehended that there are greater than 20 sort of anthocyanins, as well as likewise there are 6 important ones in food, especially geranium pigments, cyanidin pigments, delphinium pigments, peony pigments, morning elegance pigments in addition to mallow pigments. The anthocyanins in the natural state exist in the form of glycosides, called anthocyanins, as well as there are really number of cost-free anthocyanins. Anthocyanins are mostly made use of in food coloring, in addition to can likewise be used in dyes, medication, cosmetics, etc.

About Products:
If you need Proanthocyanidine as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Proanthocyanidine manufacturer and supplier, ZSpharmac will provide Proanthocyanidine raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Proanthocyanidine Quotation