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Polyvinylpyrrolidone Cross-Linked CAS 25249-54-1

Molecular Formula: C6H9NO

Formula Weight: 111.14176

ZSpharmac: Polyvinylpyrrolidone Cross-Linked Supplier

Product Name: Polyvinylpyrrolidone Cross-Linked
CAS No: 25249-54-1
Purity: 99%

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Basic Info

Product Name:Polyvinylpyrrolidone Cross-Linked
Other Names:Crospovidone
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Powder
EINECS No.:607-660-4
Provide:Polyvinylpyrrolidone Cross-Linked MSDS;
Polyvinylpyrrolidone Cross-Linked COA

What is Polyvinylpyrrolidone Cross-Linked?

Pharmaceutical excipients are an important part of pharmaceutical preparations, so selecting appropriate excipients is one of the key factors for the efficacy of pharmaceutical preparations. Polyvinylpyrrolidone Cross-Linked is a high molecular water-insoluble polymer obtained by cross-linking N-vinyl 2-pyrrolidone. It is a white or near-white powder, odorless, tasteless, good fluidity, and insoluble in water and various solvents. It is also insoluble in strong acids or alkalis. And it has high capillary activity, hydration ability and large specific surface area, which can quickly absorb water into the preparation, so it is often widely used in pharmaceutical preparations as a super disintegrant. The crospovidone produced by different preparation methods has different swelling abilities in water, and presents a variety of forms, including soft gel, white powder or porous particles, which can meet different needs. In terms of structure, cross-linked povidone can be regarded as polyvinylpyrrolidone (PVP) molecular chains with a linear molecular structure cross-linked by physical or chemical methods, so cross-linked povidone can also be called cross-linked polyvinylpyrrolidone (PVP). linked PVP or insoluble PVP. Therefore, in addition to the excellent properties of PVP such as adsorption complexation and physiological compatibility, crospovidone also has properties such as water insolubility, water absorption and water retention. Many studies have shown that crospovidone has no teratogenic, mutagenic and carcinogenic effects, and is well tolerated by the skin and mucous membranes. Among them, Polyplasdone XL-10 (PVPPXL-10) is crospovidone with fine particle size, the particle size is only about 25-40 μm, and it has a popcorn-like structure. Compared with microcrystalline cellulose, it has a larger specific surface area and Porosity, so it has good water absorption and water retention capacity. These excellent properties of Polyvinylpyrrolidone Cross-Linked make it widely used in cosmetics, food, medicine and many other fields.

Polyvinylpyrrolidone Cross-Linked Property

Melting point ~165 °C (dec.)(lit.)
form powder
color White to off-white
Water Solubility Insoluble in water, acid and alkaline.


Application of Polyvinylpyrrolidone Cross-Linked

1. Used as a disintegrant

Polyvinylpyrrolidone Cross-Linked is one of the excellent new excipients developed in recent years. Due to its strong water absorption and excellent disintegration properties, it is also known as the three Great super disintegrant. The action principles of super disintegrants mainly include: wicking, heat of wetting, deforming recovery, particle-clear particle repulsion, swelling, In practical applications, it is often the result of a combination of multiple effects. Polyvinylpyrrolidone Cross-Linked rapidly exhibits high capillary activity and excellent hydration capacity with little tendency to form gels. It is mainly used as a disintegrating agent for tablets, and can also be used as a disintegrating agent and filler for pills, granules, and hard capsules. The concentration of crospovidone used in direct compression and dry or wet granulation is generally 2% to 5%. The disintegration time limit and dissolution effect of the tablet made by this product will not change with time. The bulk density of the granules decreased with the increase of the main drug dosage, but the density change was not obvious. The tablets obtained by using this product as a disintegrant have high hardness, smooth and beautiful appearance, short disintegration time limit and high dissolution rate. Using calcium carbonate as a model drug, the compression formability of 4 fillers and the disintegration of 8 disintegrants were compared using tensile strength and disintegration time as indicators. The disintegration effects of ketone, croscarmellose sodium, dry starch and carmellose calcium were better, and the disintegration time limit of different fillers was all within 2 minutes.

For the main excipients of immediate-release solid preparations (domestic microcrystalline cellulose, Avicel PH102 microcrystalline cellulose, lactose, croscarmellose sodium starch, croscarmellose sodium, Polyvinylpyrrolidone Cross-Linked, low-substituted hydroxypropyl Preliminary research on the basic properties of cellulose) has been carried out. The test results show that the water absorption of crospovidone is the smallest, but its water absorption rate is the fastest. For tablets with high hardness, the rapid water absorption behavior of crospovidone can make water quickly enter the interior of the tablet through the “oil lamp oil wick” effect, causing the tablet to disintegrate quickly. Traditional Chinese medicine extract tablets contain a large amount of extracts, have high viscosity and hardness, are sticky when exposed to water, and are not easy to disintegrate. It is often unsatisfactory to use general disintegrants. Microcrystalline cellulose or crospovidone should be used as disintegrants for the preparation of dispersible tablets from the extract of Scutellaria baicalensis, and four kinds of disintegrants except microcrystalline cellulose can be used for the preparation of dispersible tablets with rhubarb extract. When preparing dispersible tablets from sub-extracts, the joint application of several disintegrants or reducing the proportion of extracts in dispersible tablets should be considered. Taking fenoveline as a model drug, the effects of different concentrations of disintegrants crospovidone, croscarmellose sodium and carboxymethyl starch sodium on the disintegration time were studied. Finally, when using the optimal concentration of crospovidone and other excipients, the fenoveline fast-disintegrating tablets prepared by direct compression method have low friability, acceptable taste and short disintegration time.

2. Used as a dissolution enhancer

Polyvinylpyrrolidone Cross-Linked is also used as a dissolution rate enhancer, which greatly improves the drug dissolution rate of solid preparations. Taking telmisartan with poor water solubility as a model drug, and adding cross-linked povidone as an excipient to prepare telmisartan immediate-release tablets, by testing the physicochemical properties and in vitro dissolution of granules and tablets, it was found that cross-linked polymer The immediate-release tablets made of vitamin ketone have suitable hardness and disintegration time, and the dissolution rate is also significantly increased. Compared with starch, crospovidone can significantly improve the dissolution rate of paracetamol in Qiangli Yinqiao tablets, and it does not change with storage time. When preparing ganciclovir dispersible tablets with strong fat solubility, poor water solubility and low oral bioavailability, crospovidone was selected as the disintegrant, and it was found that the cumulative dissolution rate of the prepared dispersible tablets could reach more than 90% after 6 minutes , the conclusion that the in vitro dissolution and drug release of ganciclovir dispersible tablets is obviously better than that of ordinary tablets and capsules is drawn. The usage and dosage of crospovidone can be determined according to the main drug, auxiliary materials and production process. The test shows that the optimal dosage range of crospovidone is 3% to 6%. The dissolution rate of tablets has a significant impact, and internal addition or mixed addition is suitable; in addition, Polyvinylpyrrolidone Cross-Linked has excellent reprocessability, which is especially important in rework production. No additional disintegrant is needed, and the dissolution rate is not affected, which is convenient for production .

In addition, there are also reports for use in adsorbents, fillers, and the like.

The Progress of the Preparation Method of Polyvinylpyrrolidone Cross-Linked

As early as the 1930s, Walter Reppe and others just synthesized the water-soluble homopolymer of NVP, but until the 1950s, people began to prepare insoluble polymer PVPP. Since then, relevant literature has successively reported various methods for preparing Polyvinylpyrrolidone Cross-Linked, including radiation crosslinking, photocrosslinking and chemical crosslinking. Polyvinylpyrrolidone Cross-Linked is insoluble in water, strong acid, strong alkali and various organic solvents, and only has different degrees of swelling in the above solutions. Polyvinylpyrrolidone Cross-Linked prepared by different methods has different swelling ability and adsorption ability, and its appearance can be soft gel, white powder, or porous particles, so it is suitable for many application fields.
Crosslinked polymers of NVP can be prepared by crosslinking linear PvP. Utilize ultraviolet light or gamma ray to irradiate PVP aqueous solution, all can generate cross-linked PVP. Use various catalysts to synthesize the method of cross-linked polyvinylpyrrolidone mainly to contain following three kinds, now divide as follows:
1, Schildkneeht used NaZSZO in 1953:, KZSZO: Etc. persulfate treatment PVP aqueous solution generated cross-linked PVP gel. In order to obtain moderately strong gels, the required concentration of persulfate is large, generally twice the concentration of PVP. The exact mechanism of persulfate cross-linked PVP is not clear, and possible explanation is: persulfate is thermally cracked into sulfate ion free radicals and radical free radicals in aqueous solution, and they can take a hydrogen atom from polymer molecule, Macromolecular free radicals are generated, and these macromolecular free radicals can form stable covalent crosslinks through molecular or chain segment diffusion.
2. Hort and Grosse: use hydrogen peroxide and iodine to treat PVP aqueous solution for cross-linking reaction. In the PVP aqueous solution, hydrogen peroxide and navel were gradually added in a molar ratio of 2:1, and after reacting at 50°C for 3 hours, a cross-linked PVP gel was obtained. The product can be used as thickener, flocculant and protective colloid.
3. In the presence of peroxide, Merijan uses a. A diene crosslinked PVP solution. The cross-linking reaction is to mix 1molPVP and 0.02-0.3mol of a certain a. A diene such as 1,7-octadiene, and an organic solvent to form a reaction solution, wherein each mole of a, co-diene contains 0.5-1.omol peroxide, and the temperature is constant within the temperature range of 100-200 °C React for 1-30 hours, and then vacuum distill off the organic solvent to obtain the cross-linked product. The reaction solvent should use a. A general solvent for diene and PVP, various alcohols such as methanol, ethanol and 1,4-butanediol are applicable. Since the reaction temperature is high, if an organic solvent with a low boiling point is used, the reaction needs to be pressurized. Any alpha-diene with a molecular weight between 68 and 280 can be used as a crosslinking agent. By changing the relative concentration and reaction time of α-diene, various products with different degrees of solubility can be obtained, from cross-linked PVP with different solubility to completely water-insoluble PVP gel.
Cross-linked PVP can also be prepared by copolymerization of NVP monomers with a cross-linking agent. Field et al carried out precipitation polymerization of NVP and an appropriate amount of cross-linking agent and free radical initiator in an aqueous electrolyte solution, and the resulting product was a porous granular NVP cross-linked polymer after filtration, washing and drying. Commonly used crosslinking agents in polymerization systems include the following multifunctional compounds: alkylene bisacrylamide such as N, N’-methylenebisacrylamide, etc.; divinyl aromatic compounds such as divinylbenzene, divinyl Ethylbenzene, etc. Free radical initiators commonly used in vinyl polymerization are suitable for this reaction, including peroxide initiators such as dibenzophthalein peroxide, ditertbutyl peroxide, etc., and azo compounds such as azobisiso Ding Jing and so on. Because the NVP monomer can only be partially dissolved in the aqueous electrolyte solution, when the NVP dosage exceeds its saturation in the aqueous electrolyte solution, the heterogeneous polymerization system can be maintained by mechanical stirring. In the reaction system, a buffer solution such as disodium hydrogen phosphate is often added to make the reaction solution neutral or weakly alkaline.
Shih et al. used organic solvents to replace the aqueous electrolyte solution in the above-mentioned precipitation polymerization reaction system to prepare white powdery cross-linked PVP. The organic solvent adopted in the reaction system includes aliphatic hydrocarbons, such as cyclohexane, heptane, etc.; aromatic hydrocarbons such as toluene, etc. The solubility of PVP in these organic solvents does not exceed 1% at room temperature. The amount of solvent used in the reaction is such that the copolymerized precipitate can still be stirred near the end of the polymerization reaction. The cross-linked polymer prepared by this method has a higher degree of swelling in aqueous solution. To prepare highly cross-linked cross-linked PVP, popcorn flower polymerization or propagation polymerization can be used. In 1960, Grosser and Plainfield proposed to use alkali metal or alkaline earth metal compounds, such as their oxides, hydroxides or alkoxides, as catalysts to heat NVP monomers under anhydrous conditions to prepare white powdery insoluble NVP crosslinking polymerization. The reaction has a longer induction period, ranging from 4 to 24 hours. This is the first application of popcorn flower polymerization on NVP monomer. Subsequently, many researchers have done a lot of research work in this area.

Market prospect of Polyvinylpyrrolidone Cross-Linked

About Products:
If you need Polyvinylpyrrolidone Cross-Linked as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Polyvinylpyrrolidone Cross-Linked manufacturer and supplier, ZSpharmac will provide Polyvinylpyrrolidone Cross-Linked raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


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We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

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Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

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Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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