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Polyvinylpyrrolidone Cross-Linked CAS 25249-54-1

Molecular Formula: C6H9NO

Formula Weight: 111.14176

ZSpharmac: Polyvinylpyrrolidone Cross-Linked Raw Material Supplier

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Product Name: Polyvinylpyrrolidone Cross-Linked
CAS No: 25249-54-1
Purity: 99%

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Basic Info

Product Name:Polyvinylpyrrolidone Cross-Linked
Other Names:PVPP
CAS:25249-54-1
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:607-660-4
Storage:2-8°C
Provide:Polyvinylpyrrolidone Cross-Linked MSDS;
Polyvinylpyrrolidone Cross-Linked COA

What is Polyvinylpyrrolidone Cross-Linked?

Cross-linked povidone (PVPP) is a water-insoluble polymer obtained through the cross-linking reaction of N-vinyl 2-pyrrolidone. It is a white or nearly white powder with no odor or taste, good fluidity, and insolubility in water and various solvents, as well as in strong acids or alkalis. It also has high capillary activity, hydration capacity, and a large specific surface area, allowing for quick water absorption in preparations. Due to these properties, it is commonly used as a super disintegrant in pharmaceutical preparations.

The swelling abilities of cross-linked polyvinylpolypyrrolidone produced by different methods vary, resulting in soft gels, white powder, or porous particles, to meet different needs. Structurally, crospovidone can be seen as polyvinylpyrrolidone (PVP) molecular chains cross-linked through physical or chemical methods, hence it is also known as cross-linked PVP or insoluble PVP. In addition to the excellent properties of PVP such as adsorption complexation and physiological compatibility, crospovidone also possesses water insolubility, water absorption, and water retention properties.

Numerous studies have demonstrated that crospovidone does not have teratogenic, mutagenic, or carcinogenic effects and is well tolerated by the skin and mucous membranes. Its porosity allows for good water absorption and retention capabilities. These outstanding properties make crospovidone widely used in cosmetics, food, medicine, and various other fields.

Polyvinylpyrrolidone Cross-Linked Property

Melting point ~165 °C (dec.)(lit.)
form powder
color White to off-white
Water Solubility Insoluble in water, acid and alkaline.

 

Polyvinylpyrrolidone Cross-Linked Application

Crospovidone is a widely used pharmaceutical excipient that has gained recognition in the United States Pharmacopoeia, the German Pharmacopoeia, and other regions around the world. It is known for its excellent disintegration properties and is often referred to as a super disintegrant due to its strong water-absorbing swelling. This makes it suitable for use in tablets, pills, granules, and hard capsules as a disintegrant. The recommended concentration of crospovidone in various processes is 2% to 5%, and it has been found to maintain disintegration time and dissolution effect over time. It has also been used in traditional Chinese medicine extract tablets and dispersible tablets, showing significant improvement in disintegration time and dissolution rate.

In addition to its disintegrant properties, crospovidone is also used as a dissolution accelerator to improve the drug dissolution of solid preparations. It has been found to significantly increase the dissolution rate of drugs with poor water solubility and has been used in the preparation of dispersible tablets with strong fat solubility, poor water solubility, and low oral bioavailability, showing a significant improvement in in vitro dissolution and release. The dosage range of crospovidone is 3% to 6%, and its addition method can impact the dissolution and disintegration of tablets. Additionally, crospovidone has excellent reprocessability, making it convenient for rework production without affecting the dissolution rate.

In addition to its use as a disintegrant and dissolution accelerator, there are reports of crospovidone being used as adsorbents, fillers, and other applications in pharmaceutical formulations.

Polyvinylpyrrolidone Cross-Linked Preparation

Polyvinylpyrrolidone Cross-Linked is a polymer that is formed through the polymerization of NVP under specific conditions and is insoluble in water, strong acids, strong alkali, and general organic solvents. Its synthesis methods include copolymerization of NVP monomer and polyunsaturated compounds, NVP monomer self-crosslinking polymerization, and PVP cross-linking. The NVP self-crosslinking polymerization method can be used to obtain water-insoluble cross-linked povidone with a high degree of cross-linking, while the copolymerization method can be used to obtain cross-linked povidone with super water absorption and water retention capabilities. Cross-linked povidone synthesized using different methods will have different properties and application fields. An example of a preparation method is as follows:

A method for synthesizing cross-linked povidone involves controlling the polymerization reaction conditions to ensure full reaction of the reactants, thereby obtaining cross-linked povidone with higher purity. The method includes the following steps:

1) Dissolve anhydrous sodium sulfate, anhydrous disodium hydrogen phosphate, and polyvinylpyrrolidone K30 in purified water;
2) Add N-vinylpyrrolidone to the solution from step 1) and fill it with nitrogen as a reaction protective gas;
3) When the temperature of the solution reaches 50 to 80°C, add hydrogen peroxide solution and divinylbenzene to initiate the polymerization reaction. The polymerization reaction time is 3 to 9.5 hours.

Contact Us

About Products:
If you need the cosmetic raw material Polyvinylpyrrolidone Cross-Linked, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Polyvinylpyrrolidone Cross-Linked manufacturer and supplier, ZSpharmac will provide Polyvinylpyrrolidone Cross-Linked raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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