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Zhishang Chemical

Polysorbate 20 CAS 9005-64-5

Molecular Formula: C26H50O10

Formula Weight: 522.6692

ZSpharmac: Methylglyoxal Miel Supplement

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Product Name: Polysorbate 20
CAS No: 9005-64-5
Purity: 99%

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Basic Info

Product Name:Polysorbate 20
Other Names:Tween(R) 20
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Amber Viscous Liquid
EINECS No.:500-018-3
Storage:Store Below +30°C.
Provide:Polysorbate 20 MSDS;
Polysorbate 20 COA

What is Polysorbate 20?

Polysorbate 20 (Tween 20), also known as polysorbate 20 (polysorbate20), is a non-ionic surfactant with strong hydrophilicity and chemical non-dissociation, and has good solubility for drugs It is often added in pharmaceutical preparations to increase the solubility of active ingredients; on the other hand, Polysorbate 20 can inhibit the automatic polymerization of macromolecular protein drugs and improve the stability of drugs. As a new type of non-ionic surfactant, Polysorbate 20 has high stability and is not easily affected by strong electrolytes, acids and alkalis. It can be mixed with other types of surfactants and has good compatibility. It can be used in various solvents. All have good solubility. Therefore, the consumption of Polysorbate 20 is also increasing. During use, wastewater containing Polysorbate 20 inevitably enters the water body, soil and other environments. Non-ionic surfactants are toxic to fish and aquatic organisms, affecting the migration and degradation of other co-existing organic matter in the environment, and their adsorption on soil/sediment can limit their application in the synergistic remediation of organic pollutants such as soil . And with the deepening of pharmacological research in recent years, it has been recognized that polysorbate surfactants have certain biological and pharmacological activities, which can induce degranulation of cells, cause the release of allergic active substances, and their own unsaturated fatty acids. It is also very easy to oxidize and degrade to produce a variety of toxic components, which are related to the adverse reactions such as dyspnea, nausea, vomiting, and rash in clinical medicine.

Polysorbate 20 Properties:

Melting point 98.9 °C (decomp)
Boiling point 100 °C
density 1.11 g/mL at 20 °C
vapor pressure <1.4 hPa (20 °C)
refractive index n20/D 1.468(lit.)
Fp >230 °F
storage temp. Store below +30°C.
solubility 100 g/L
form viscous liquid
color Amber
Specific Gravity1.090~1.130 (20/20℃)
PH6-8 (50g/l, H2O, 20℃)
PH Range7
Water Solubility 100 g/L


Polysorbate 20 Uses

  1. Polysorbate 20 is used as O/W kind food emulsifier, utilized alone or blended with Span-60, Span-65, Span-80. my nation specifies that it can be used in ice cream, as well as the maximum usage is 1.5 g/kg; the optimum usage in fruit juice drinks is 0.75 g/kg; the optimum usage in moon cakes is 0.5 g/kg.
  2. Polysorbate 20 is a nonionic surfactant.
  3. Polysorbate 20 can be used as a solubilizer, diffusing agent, stabilizer, antistatic representative, lubricating substance, and so on.
  4. Polysorbate 20 is an oil-in-water emulsifier that can be made use of as a solubilizer, diffusing agent, stabilizer, lubricating substance and antistatic representative.It is used as a solubilizer, penetrant and also dispersant for drugs and also cosmetics in medication as well as everyday chemicals.

Determination of Polysorbate 20

The method of spectrophotometric analysis of non-ionic surfactant Polysorbate 20 is realized by the following technical scheme:

1) Color reaction: Since the color of the aqueous solution of Polysorbate 20 is very light, it is necessary to select an appropriate reagent to react with it to generate colored compounds and then measure. As an electron acceptor, iodine can interact with the oxygen atom in the Polysorbate 20 molecule to form a yellow complex. Accurately weigh 1g l2 and 2g Kl, add distilled water to dissolve, and dilute to 100mL. Use the mixed solution of Kl-l2 as the developer. The prepared color developer should be stored at low temperature in the dark.

2) Color development conditions: the optimal pH range of the solution is 4-8, the amount of color developer is 0.25mL, the color development time is 20min, the best absorption wavelength is 486nm, and the reference solution is distilled water.

3) Standard curve: The purpose of making the standard curve is to establish the quantitative relationship between the measurement signal of the method and the concentration of the analyte Polysorbate 20. Accurately prepare standard solutions of Polysorbate 20 at different concentrations. Add 10 mL of standard solution of known concentration to the test tube, then add 0.25 mL of chromogenic reagent, shake well, and let stand for reaction for 20 min. Use a spectrophotometer at 486nm, use a 1cm cuvette, and use distilled water as a reference to measure the absorbance values ​​of each concentration of Polysorbate 20 and the color developer blank. The difference between the two is the absorbance value of the solution relative to the reagent blank at different concentrations. . A standard curve was obtained by plotting concentration versus absorbance.

4) Determination of Polysorbate 20 content: add 10 mL of polysorbate 20 solution of unknown concentration to the test tube, add 0.25 mL of color developer, shake well, and let stand for reaction for 20 min. Use a spectrophotometer at 486 nm and use a 1 cm cuvette to record the absorbance of the unknown concentration of Polysorbate 20. Substitute the absorbance into the standard curve equation established in step (3) to obtain the content of Polysorbate 20.

Difference Between Tween 80 and Polysorbate 20

Artificial raw material of Tween 80: It is created by the polymerization of sorbitan monooleate and also ethylene oxide.

The synthetic basic material of Polysorbate 20 is a combination of polyoxyethylene sorbitan monolaurate and also a part of polyoxyethylene disorbate monolaurate.

Use Tween 80: Tween 80 is a polyol type nonionic surfactant, which is the most frequently utilized polysorbate. It has exceptional resistance to electrolytes and strong hydrophilicity. It is commonly utilized in fluid, semi-solid as well as solid prep work as O/W emulsifier, solubilizer, moistening representative, dispersant as well as stabilizer.

Application of Polysorbate 20: It is the condensate of Span and also ethylene oxide. Due to the fact that there are much more hydrophilic groups – polyoxyethylene in its particle, it has solid hydrophilicity and is a non-ionic decontamination. representative. It is commonly used as an oil-in-water (O/W) emulsifier; it can be used in mix with various other emulsifiers such as salt lauryl sulfate or Span to increase the stability of the emulsion. It can likewise be made use of as a solubilizer for certain medicines.

Properties of Tween 80: The peroxide value of Tween 80 does not exceed 10, and it is a light yellow to orange-yellow viscous fluid; it has a slight odor. The taste is somewhat bitter as well as astringent, with a warm feeling. Soluble in water, ethanol, methanol or ethyl acetate, very somewhat soluble in mineral oil.

Characteristic of Polysorbate 20: Polysorbate 20 is a yellow or amber clear oily fluid with an unique smell and weak bitter preference. The family member density is 1.01, the boiling point is > 100 ℃, the flash point is 321 ℃, the refractive index is 1.472, and the viscosity (25 ℃) is 0.25 ~ 0.40 Pa · s.

There are many hydrophilic teams in the particle, it is miscible with water, ethanol, methanol and ethyl acetate, insoluble in fluid paraffin, non-volatile oil and also light petroleum, 1 part of this product can dissolve in 130 parts of cottonseed oil and 200 parts of cottonseed oil. In toluene, the pH of the 5% aqueous option is 5-7; the HLB value is 16.7.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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