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Polyoxyethylene Stearate CAS 9004-99-3

Molecular Formula: C34H70O9

Formula Weight: 622.91

ZSpharmac: Polyoxyethylene Stearate Supplement

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Product Name: Polyoxyethylene Stearate
CAS No: 9004-99-3
Purity: 99%

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Basic Info

Product Name:Polyoxyethylene Stearate
Other Names:PEG-10 Stearate
CAS:9004-99-3
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Waxy Solid
EINECS No.:618-405-1
Storage:2-8°C
Provide:Polyoxyethylene Stearate MSDS;
Polyoxyethylene Stearate COA

What is Polyoxyethylene Stearate?

Polyoxyethylene stearate is a non-ionic surfactant approved as food additive E431 No. E.

Polyoxyethylene Stearate Properties:

Melting point 47 °C
Fp 39 °C
storage temp. 2-8°C
Hydrophilic-Lipophilic Balance (HLB)18.8

Polyoxyethylene Stearate Uses

  1. Polyoxyethylene stearate is used as an emulsifier for oils and esters during liquid or paste emulsification in lubricating oil production. It can also be used as a thickener and stabilizer in paper powder coating, a lubricant and softener for textiles, a lubricant for multiple transmission wires in cable ducts, and a lubricant for paper sizing.
  2. Polyoxyethylene stearate is used in cosmetics, pharmaceutical emulsifiers, soap-based thickeners, conditioners, emulsion stabilizers, and so on.

Polyoxyethylene Stearate Identification Test

Solubility Soluble in ethanol, methanol, acetone, ether, ethyl acetate and dioxane; dispersible in warm water; soluble in mineral oil and turbid. Determined by OT-42 method.
Freezing point 27 ~ 29 ℃.
Determined by conventional methods.
Take 5ml of 5%W/V) sample solution, add 10ml of ammonium thiocyanate cobaltate solution (reconstituted with 37.5g of cobalt nitrate and 150g of ammonium thiocyanate to 100ml with water, freshly prepared) and 5ml of chloroform, shake well and make it Separate the layers; a blue color should develop in the chloroform layer.
About 44g of fatty acids and 59g of polyols can be produced after saponification of 100g sample with alkali.
Take 20g of sample (accurate to 0.01g), carry out alkaline hydrolysis with potassium hydroxide ethanol solution (TS-190), and heat under reflux for 2h at the same time. The amount of calculation exceeds 100%. After hydrolysis, water is added and the ethanol is evaporated on a steam bath to convert the soapy ethanolic solution into an aqueous solution. The fatty acid is freed by acidifying the hot aqueous soapy solution with sulfuric acid. The acid solution was extracted with 3 parts petroleum ether to separate out the fatty acids. The petroleum ether extract was evaporated on a steam bath and the residue was dried to constant weight under vacuum at 75°C to recover fatty acids. Multiply the recovered fatty acid weight by 100/w to obtain the fatty acid yield in a 100 g sample (where w is the weight of the sample). Fatty acids can be identified by measuring physical and chemical constants (eg saponification temperature), or by gas-liquid chromatography.
The polyol aqueous solution after fatty acid removal was neutralized to pH 7 with potassium hydroxide test solution (TS-189). Evaporate on a steam bath to a moist residue and extract the polyol with 3 parts of hot absolute ethanol. After evaporating off the ethanol on a steam bath, the residue was dried to constant weight under vacuum at 75°C to obtain the polyol part in the sample. Multiplying the recovered polyol weight by 100/W is the yield of the polyol obtained in the 100 g sample (where W is the sample weight).

Polyoxyethylene Stearate Biological Activity

In vitro: Polyoxyethylene Stearate has actually been advised as an additive to radiolabeled 7H12 Middlebrook TB medium and also has consequently been shown to advertise the growth of mycobacteria in the contaminated BACTEC Rapid Society System. Polyoxyethylene Stearate produces the greatest increase in detection of M. consumption growth and polyoxyethylene (30) stearate as well as polyoxyethylene (JL) stearate on development of mycobacterial varieties other than M. consumption effect and also lower the time called for. Polyoxyethylene stearate prevents P-gp-mediated efflux in a concentration-dependent fashion mostly by modulating substrate-stimulated P-gp ATPase activity. Polyoxyethylene 40 Stearate reduces vinblastine sulfate efflux. The cytotoxicity of vinblastine to K562/ADR cells was considerably improved when cells were co-treated with 100 or 150 μg/ mL polyoxyethylene 40 stearate. In vivo: Polyoxyethylene stearate can be utilized as a pharmaceutical active ingredient to increase the dental bioavailability of co-administered P-gp substratums and also particular CYP isoform substrates. The mean growth quantity as well as imply lump weight were dramatically smaller in the polyoxyethylene 40 stearate + vinblastine team. The inhibition rate of lump growth enhanced from 0.06 (vinblastine team) to 0.84 (vinblastine + polyoxyethylene 40 stearate group). The mean lump volume as well as suggest tumor weight were significantly smaller in the polyoxyethylene 40 stearate + vinblastine team. The restraint price of tumor growth increased from 0.06 (vinblastine team) to 0.84 (vinblastine + polyoxyethylene 40 stearate team). The mean lump volume and mean tumor weight were significantly smaller sized in the polyoxyethylene 40 stearate + vinblastine group. The inhibition rate of tumor growth increased from 0.06 (vinblastine group) to 0.84 (vinblastine + polyoxyethylene 40 stearate group).

Effects of Polyoxyethylene Stearate (POES) on Radiation

Polyoxyethylene stearate (POES) is a nonionic emulsifier. Such representatives have been revealed to improve the development of mycobacteria artificial insemination. POES (POE( JL) S) has actually been suggested as an additive to radiolabeled 7H12 Middlebrook TB medium as well as has for that reason been shown to promote the growth of mycobacteria in the contaminated BACTEC Rapid Society System. We examined the growth-promoting impact of 6 previously untested POEs (POE( 8 )S to POE( 100 )S) whose spreading properties (hydrophilic-lipophilic balance-HLB) are understood. The purpose of this research was to establish which POES had the best capacity to promote the growth of different mycobacterial types as well as the connection in between the HLB of each POES and also its impact on the growth of each varieties. We located that POE( 50 )S had the best growth-promoting result, which in identifying the moment needed for M. tuberculosis development and POE( 30 )S and POE( JL) S for mycobacteria aside from M. tuberculosis Variety (MOTT). To contrast the effect of POES with its HLB (in BACTEC 7H12 medium),.
We suggest four variables that may affect the growth-promoting ability of each POES:.
1 its dispersing impact on bacteria (serving as an emulsifier);.
2 has a solubilizing result on bacterial cells;.
3 The result of POES on the dispersion of radiolabeled fatty acids made use of as substratums in media to create radiolabeled carbon monoxide 2;.
4 mycobacteria can metabolize POES. s (in BACTEC 7H12 medium).
We propose four variables that may affect the growth-promoting capability of each POES:.
1 its spreading effect on germs (functioning as an emulsifier);.
2 has a solubilizing impact on bacterial cells;.
3 The effect of POES on the dispersion of radiolabeled fatty acids made use of as substrates in media to create radiolabeled CO 2;.
4 mycobacteria can metabolize POES. s (in BACTEC 7H12 medium).
We recommend 4 elements that may influence the growth-promoting capability of each POES:.
1 its spreading effect on bacteria (working as an emulsifier);.
2 has a solubilizing effect on bacterial cells;.
3 The impact of POES on the dispersion of radiolabeled fats made use of as substrates in media to create radiolabeled CO 2;.
Four mycobacteria can metabolize POES.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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