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Zhishang Chemical

Polyhexamethylene Biguanide Hydrochloride CAS 32289-58-0

Molecular Formula: C10H23N5

Formula Weight: 213.32312

ZSpharmac: Polyhexamethylene Biguanide Hydrochloride Supplement

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Product Name: Polyhexamethylene Biguanide Hydrochloride
CAS No: 32289-58-0
Purity: 99%

Basic Info

Product Name:Polyhexamethylene Biguanide Hydrochloride
Other Names:Polyhexamethylene Biguanidine HCl
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Colorless or Light Yellow Transparent Liquid
EINECS No.:1308068-626-2
Storage:Inert atmosphere,Room Temperature
Provide:Polyhexamethylene Biguanide Hydrochloride MSDS;
Polyhexamethylene Biguanide Hydrochloride COA

What is Polyhexamethylene Biguanide Hydrochloride ?

For a long period of time, Polyhexamethylene Biguanide Hydrochloride has actually been extensively made use of in medicine for antiseptic and likewise anti-bacterial. As a clinical product, it is used for cleanliness of phone call lenses, eye decreases, as well as surgical treatments. As a result of the solid resistance of the eyes to Polyhexamethylene Biguanide Hydrochloride , it can be made use of as a drug for the treatment of acanthamoeba keratitis, avoidance along with therapy of various other eye problems. At the same time, Polyhexamethylene Biguanide Hydrochloride is additionally commonly used in cosmetics, personal treatment items, fabrics, food sector, and so on.With the development of scientific research and modern technology, polyhexamethylene biguanide hydrochloride has numerous new applications. For instance, it is made use of as a flocculant, as a bactericide and also algaecide in swimming pools as well as commercial water treatment, as a bactericide in oil manufacturing and injection water, and also can clean and eliminate hazardous materials on glasses and various other hard surface areas.

Polyhexamethylene Biguanide Hydrochloride Properties:

storage temp. Inert atmosphere,Room Temperature
solubility Water
CAS DataBase Reference32289-58-0(CAS DataBase Reference)


Application of Polyhexamethylene Biguanide Hydrochloride

(1 )For Damp Wipes
Its anti-bacterial impact is primarily by dissolving lipids, altering the permeability of bacterial cell membrane layers, and creating challenges to metabolic process in bacteria. It has a broad antibacterial range and works versus Gram-positive as well as negative germs and molds. It is colorless, odor free, non-irritating to the skin, non-toxic and non-corrosive. Consequently, the damp wipes treated with it can accomplish quick sanitation effect without mold, and the life span can be up to 2 years.

( 2) Unique Sterilizers For Houses And Also Public Places
It is suitable for family sanitation, and also can be made use of for sterilization and also cleaning of fruits and vegetables; it is made use of for sterilization and also cleansing of different fabrics such as apparel, towels, bed sheets, and so on; Sterilization of the location.

( 3 )For Aquaculture
This product can promptly eliminate unsafe germs such as Gram-negative bacteria, Drifting Vibrio, Vibrio parahaemolyticus, Vibrio alginolyticus in salt water, as well as is great for various conditions triggered by microorganisms in sea cucumber as well as other water items. precautionary and restorative effects.

( 4) Disinfectant For Skin And Also Wound Surface
The item is anemic, non-corrosive, as well as has a resilient result. It can be comfortably used for cleansing and disinfection of skin, injuries, obstetrics and gynecology, and also urology. Particularly for some medical products that can not be decontaminated by high temperature, only a remedy with a concentration of 1 ‰ is required. Saturating or spraying can achieve acceptable sterilization result quickly. The product can likewise be made use of for disinfection of air, wall surfaces and also floorings in wards.

( 5 )For Ladies’s Lotion
The lotion and gel anti-bacterial made by this item can be used for bacterial, fungal, trichomoniasis, senile and also non-specific swelling, cervicitis as well as various other diseases.

( 6 )For Hand Sanitizer
The product is splashed directly on the hands as a hand sanitizer, which can safely, properly and also conveniently get rid of pathogenic germs on the hands, no water as well as soap, as well as can develop an anemic layer on the hands. Transparent unseen film, maintain lasting restraint as well as sterilization effect.

( 7 ) Used in The Textile Sector As Well As Feminine Napkins, Sanitary Pads, Infant Diapers And Other Items
The item can develop anti-bacterial textiles, such as towels, underwear, child clothes, bed linens and so forth. Simply immerse the fabric in the product-specific remedy before the final finishing stage. When germs fall on the textiles dealt with by this item, a small amount of water liquifies the active substances consisted of in them, and kills bacteria swiftly. After examinations, appropriately dealt with fabrics are still antibacterial after washing up to 120 times in water.

The item can quickly develop different sorts of sterile and also antibacterial sanitary napkins, sanitary napkins, child diapers, etc, which reduces the price and also addresses the trouble of brief legitimacy duration of traditional sanitation methods. Due to the fact that the item can be equally linked with the fine fibers of the above items, a slim polymer layer of antibacterial representative is formed on the surface, which can keep the very best state after sanitation, and also the legitimacy duration can be up to 2 years.

( 8 )For Cleaning Up Supplies
At present, the cleaning products with sanitation feature are generally added with chlorine preparations as sanitation ingredients, which have defects such as corrosiveness to textiles, fading, short sterilization validity period, and can just be utilized for white fabrics. The product has the advantages of being soluble in water, non-toxic, colorless, odorless, non-corrosive, non-fading, non-irritating to skin and mucous membranes, as well as has a lengthy validity duration.

( 9) Made Use Of in Beer, Drink As Well As Food Processing Sectors
The item is used in the sanitation as well as sanitation of pipelines, containers and various other production centers and floorings in the manufacturing of beer, drink as well as food. It just needs to weaken the product to 10ppm and soak or purge the pipe to achieve the sanitation impact. If there are no unique needs for filling food containers, the use concentration can be increased to 250ppm to attain the impact of rapidly as well as totally killing germs.

Preparation of Polyhexamethylene Biguanide Hydrochloride

1) Preparation of hexamethylenediamine hydrochloride
To a three-necked flask equipped with a thermometer and a stirring rotor, ethanol was added as a solvent to weigh 1,6-hexanediamine, and hydrochloric acid was added dropwise with stirring, and the reaction was exothermic. Control the dropping rate, keep the temperature below 28°C during the dropwise addition until the pH value of the solution reaches 5, continue the reaction for 1 hour after the dropwise addition is completed to ensure that the reaction is complete, then reduce the temperature to 0°C, filter, and filter the obtained filter cake drying. Then pure hexamethylenediamine hydrochloride is obtained.

2) Preparation of antibacterial agent Polyhexamethylene Biguanide Hydrochloride
Weigh a certain amount of dicyandiamide and hexamethylenediamine hydrochloride, the molar ratio of the two is 1:1.1, add a certain amount of n-butanol as a solvent, stir and heat under reflux, the polymerization reaction temperature is 170 ° C, constant temperature After 12 hours, n-butanol was distilled off to obtain the product.

Antibacterial mechanism of Polyhexamethylene Biguanide Hydrochloride

Polyhexamethylene biguanide hydrochloride PHMB is a cell membrane active antibacterial agent, and its inhibitory effect on bacterial activity is higher than that on fungi. At the same time, the PHMB adsorbed on the surface of the microorganism acts on the phospholipid bilayer in the cytoplasm through transmembrane transport, and combines with the negatively charged phosphate group, thereby changing the selective permeability of the cell membrane and destroying the cell metabolism. , thereby killing microorganisms.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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