Zhishang Chemical

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Zhishang Chemical

Polyglycol CAS 25322-68-3

Molecular Formula: N/A

Formula Weight: 0

ZSpharmac: Polyglycol Supplement

Product Name: Polyglycol
CAS No: 25322-68-3
Purity: 99%

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Basic Info

Product Name:Polyglycol
Other Names:Poly(ethylene glycol)
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Very Pale Yellow Waxy Solid
EINECS No.:500-038-2
Provide:Polyglycol MSDS;
Polyglycol COA

What is Polyglycol?

Polyglycol is referred to as “PEG”. A polymer compound formed by intermolecular dehydration condensation of ethylene glycol. The chemical formula is HOCH2(CH2OCH2)nCH2OH. where n is above 4. The average molecular weight is 200-7000. The numbers complying with business polyethylene glycols show average molecular weights. For example, Polyglycol-400 means that the typical molecular weight of the industrial Polyglycol is about 400.

Colorless viscous fluid or white solid. Reduced toxicity! Soluble in water and numerous organic solvents, quickly soluble in fragrant hydrocarbons, somewhat soluble in aliphatic hydrocarbons. It is not hydrolyzed for a long period of time, secure to warmth, as well as does not respond with lots of chemical reagents. Certain steel salts are soluble in Polyglycol at concerning 100 ° C and also continue to be steady at area temperature. It can be made use of as a plasticizer, softener, moistening representative, lubricant, solvent, adhesive, as well as can additionally be used to develop fragrances and be made use of as pharmaceutical prep work.

Polyglycol Property

Melting point 64-66 °C
Boiling point >250°C
density 1.27 g/mL at 25 °C
vapor density >1 (vs air)
vapor pressure <0.01 mm Hg ( 20 °C)
refractive index n20/D 1.469
Fp 270 °C
storage temp. 2-8°C
solubility H2O: 50 mg/mL, clear, colorless
form waxy solid
color White to very pale yellow
Specific Gravity1.128
PH5.5-7.0 (25℃, 50mg/mL in H2O)
Water Solubility Soluble in water.


Polyglycol Uses

Polyglycol and polyethylene glycol fat esters are thoroughly utilized in the cosmetic as well as pharmaceutical industries. As a result of the truth that polyethylene glycol has great deals of fantastic household or business buildings: water-solubility, non-volatile, physical inertness, mildness, lubricity, in addition to skin moisturizing, soft top qualities, satisfying after-feel, and so on. Various member of the family molecular weight portions of Polyglycol can be selected to transform the density, hygroscopicity as well as additionally tissue framework of the item. Lowered molecular weight polyethylene glycol (Mr<2000) is suitable for use as wetting agent and consistency regulator for cream, lotion, toothpaste and shaving cream, etc. It is also suitable for non-cleaning hair care products. Gives hair a silky shine. Polyglycol with high relative molecular weight (Mr>< 2000) appropriates for use as wetting agent as well as consistency regulatory authority for cream, cream, tooth paste and also cutting cream, etc. It is also appropriate for non-cleaning hair treatment items. Gives hair a smooth shine. Polyglycol with high loved one molecular weight (Mr > < 2000)is suitable for usage as wetting representative as well as uniformity regulatory authority for cream, lotion, toothpaste as well as reducing cream, and so on. It is in addition proper for non-cleaning hair treatment items. Provides hair a smooth luster. Polyglycol with high loved one molecular weight (Mr > 2000)appropriates for lipsticks, antiperspirant sticks, soaps, cutting soaps, frameworks as well as also sophistication cosmetics. In cleaning agents, polyethylene glycols are in addition made use of as postponing along with thickening representatives. In the pharmaceutical market, it is utilized as a base for creams, lotions, lotions, lotions as well as additionally suppositories. Easily used polyethylene glycols (such as Polyethylene Glycol NF, Dowchemical Co.) that appropriate for food in addition to pharmaceutical use are better for aesthetic usage. The application of methoxy polyethylene glycol and likewise polypropylene glycol is similar to that of Polyglycol.

Polyglycol is commonly made use of in various pharmaceutical solutions such as injections, topical formulas, ocular solutions, dental as well as also anal solutions. Solid qualities of polyethylene glycol can be contributed to fluid polyethylene glycols to change viscosity for topical lotions; Polyglycol blends can be made use of as suppository bases; aqueous polyethylene glycols can be utilized as postponing agents or to change various other suspension media density; polyethylene glycol along with different other emulsifiers are used in combination to enhance the protection of the solution. On top of that, Polyglycol is additionally made use of as a movie finish representative, a tablet lube, a controlled release product, and the like.

Application of Polyglycol in Biomedical Field

Medical Polyglycol is also known as polyethylene oxide (PEO). Straight polyethers gotten by ring-opening polymerization of ethylene oxide. The major usages in the biomedical area are as adheres to:
1) Get in touch with lens solution. The viscosity of the liquid service of Polyglycol is sensitive to shear cost and microorganisms are not easily increased on polyethylene glycol.
2) Synthetic lubricating substances. Condensation polymer of ethylene oxide and also water. In order to prepare the cream base of water-soluble medications, it can also be used as a solvent for insoluble medicines such as acetylsalicylic acid as well as high levels of caffeine for the prep work of shots.
3) The company of medication consistent launch as well as also incapacitated enzyme. Using the liquid solution of Polyglycol to the outer layer of the pill can regulate the diffusion of the medication in the pill in the body to boost the effectiveness of the drug.
4) Area change of medical polymer products. Making use of polyglycol-containing amphiphilic copolymers to adsorb, intercept as well as also graft on the surface of clinical polymer products can enhance the biocompatibility of medical polymer items touching blood.
5) Making an alkanol contraceptive motion picture.
6) Making hydrophilic anticoagulant polyurethane.
7) Polyethylene glycol 4000 is an osmotic laxative, which can raise the osmotic tension in the digestive tract dental caries, absorb water, soften the stool, raise the amount, and additionally advertise peristalsis and likewise defecation.
8) Denture fixatives. Using the non-toxicity as well as gel-forming property or business residential or commercial properties of Polyglycol, it is used as a part of denture fixatives. 9) PEG4000 and also PEG6000 are normally made use of to advertise cell mix or protoplast combination as well as to aid in DNA uptake by microbes such as yeast in modification. PEG can take in water in solution, so it is additionally made use of to concentrate alternatives.

Polyglycol Identification Test

Solubility Polyglycol with an apparent molecular weight of 1000 (or above) is easily soluble in water. Polyethylene glycol is soluble in many organic solvents, including aliphatic ketones and aldehydes, chloroform, glycol ethers, esters and aromatic hydrocarbons; insoluble in ether and most aliphatic hydrocarbons. Solubility in water and organic solvents decreases with increasing molecular weight.
Apparent molecular weight Apparent molecular weight is 95.0%~105.0% of the declared value if the apparent molecular weight is lower than 1000; if the apparent molecular weight is 1000~7000, it is 90.0%~110.0% of the declared value; %~112.5%.
The method for measuring the apparent molecular weight is as follows.
Preparation of phthalic anhydride solution Take 49g of phthalic anhydride, put it in a brown bottle, and add 300ml of freshly distilled pyridine. Shake vigorously to dissolve and let stand overnight before use.
Preparation of liquid Polyglycol sample solution Carefully take 25ml of the above phthalic anhydride solution and put it in a clean, dry, heat-insulated pressure-resistant bottle. Accurately weigh a certain number of samples into the bottle, the amount is equivalent to the quotient of the expected apparent molecular weight divided by 160 (if the apparent molecular weight of the sample is 200, take 1.3 g of the sample, if the apparent molecular weight is 600 , then take 3.8g). Plug it, wrap it tightly, and put it in a cloth bag.
Preparation of solid Polyglycol sample solution Carefully take 25ml of the above phthalic acid solution and put it into a clean, dry, heat-insulated pressure-resistant bottle. Accurately weigh a certain number of samples that are pre-melted and put into the bottle, the amount is equivalent to the quotient of the expected apparent molecular weight divided by 160; however, due to its limited solubility, any sample should not exceed 25g. Add 25 mL of pyridine newly distilled from phthalic anhydride, shake to dissolve, add a stopper, wrap it tightly, and put it in a cloth bag.
Operation Immerse the sample bottle in a water bath at 96-100°C, and the immersion depth is the same as the liquid level of the material in the bottle. After heating in a water bath for 30-60min (apparent molecular weight ≥3000 is 60min). Take out and cool to room temperature. Carefully open the lid to remove the remaining pressure in the bottle, then take it out from the cloth bag, add 5 drops of 1% phenolphthalein in pyridine solution, and titrate with 0.5mol/L sodium hydroxide until pink appears, and maintain for 15s. At the same time, put 25ml of phthalic acid solution into the sample bottle, and carry out the blank test as above. Then calculate the apparent molecular weight of the sample as follows:
The kinematic viscosity of Polyglycol with different apparent molecular weights at 100°C (±0.3°C) is as follows:
The measuring instrument adopts Ubbelohde suspended level’ viscosimeter, see Fig. 11102. The volume of the ball B is 5ml on average. The upper and lower limits of the B ball are the highest and lowest standard lines of the liquid placed. For the material used to measure the viscosity of (300~600)×10-6m2/s, a No. 3 viscometer is used, and the capillary diameter is (2.00±0.04)mm. Before the measurement, it is necessary to make the instrument reach a constant temperature in a constant temperature bath, and then measure the time required for the liquid to drop from the T1 line to the T2 line. In order to obtain accurate results, it should be between 80 and 100s (accurate to 0.1s). The viscosity is calculated as follows:
In the formula, c is the viscosity constant measured by a viscometer with a certain oil of known viscosity;
v—Kinematic viscosity of the tested liquid, 1×10-6m2/s;
t1 – required flow time, s.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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