Poloxamer 188 CAS 9003-11-6

Molecular Formula: (C3H6O.C2H4O)x

Formula Weight: 102.1317

ZSpharmac: Poloxamer 188 Supplier

Product Name: Poloxamer 188

CAS No: 9003-11-6

Purity: 99%

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Basic Info

Product Name:	Poloxamer 188
Other Names:	Polyethylene-Polypropylene Glycol
CAS:	9003-11-6
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	Colorless Liquid
EINECS No.:	618-355-0
Storage:	2-8°C
Provide:	Poloxamer 188 MSDS； Poloxamer 188 COA

What is Poloxamer 188?

Poloxamer 188 (oloame) is a polyoxyethylene polyoxypropylene ether block copolymer, also referred to as polyether polyol, and its brand name is luromio. This is a brand-new kind of polymer nonionic surface energetic agent.

Poloxamer 188 Property

Melting point	57-61 °C
Boiling point	>200 °C(lit.)
density	1.095 g/mL at 25 °C
vapor density	>1 (vs air)
vapor pressure	<0.3 mm Hg ( 20 °C)
refractive index	n20/D 1.466
Fp	>230 °F
storage temp.	2-8°C
solubility	H₂O: at <70 °Csoluble
form	solution
color	APHA: ≤120, 50/50 in CH3OH
PH	5.0-7.5 (100g/L in H2O)
PH Range	5.0 – 7.5
Water Solubility	Miscible with water.

Poloxamer 188 Uses

Poloxamer 188 is a nonproprietary name for polyoxyethylene-polyoxypropylene copolymer. The brand name of the item generated by German BASF firm is Pluronic (Pluronic), wherein the polyoxyethylene chain has relative hydrophilicity, and the polyoxypropylene chain has loved one lipophilicity, so it is a type of non-ionic polymer surfactant. It is mainly used as emulsifier and also solubilizer in pharmaceutical prep work.
Poloxamer 188 can be utilized as nonionic surfactant, soft and also hard surface cleaner, finish as well as defoamer in water treatment. Lube for metalworking, defoaming aid and extender for linear and also crosslinked polyesters as well as polyurethanes.
Poloxamer 188 is utilized as an emulsifier, which can be used in the fermentation process according to the policies of our country, and also it needs to be utilized in an appropriate quantity according to the manufacturing requirements.

Assay of Poloxamer 188

The polymer of Poloxamer 188 usually binds to the matrix (such as protein, nucleic acid, polypeptide, plasmid, etc.) in biological preparations, resulting in poor accuracy of the method. At present, there are no mature determination methods in the pharmacopoeias and national standards of various countries . Since it is a polymer compound and has no good ultraviolet response group, the common detection method of poloxamer 188 is to use size exclusion chromatography (gel column chromatography) to separate it from other components, and combine evaporative light It is detected by scattering or differential detectors, etc. However, gel chromatographic columns are usually expensive and have a short service life; evaporative light scattering detection has poor parallelism and is prone to contamination; differential detectors have high environmental requirements and poor sensitivity, which makes the above methods unable to meet the needs of conventional QC release.

In view of the above problems, the researchers developed a quantitative analysis method for poloxamer 188 in biological preparations by using a more versatile C18 chromatographic column and a CAD detector. The method is simple, fast, economical, sensitive and stable. , which can meet the needs of a large number of testing work such as mass production and product release.

The detection method of poloxamer 188 in biological preparations developed based on reverse chromatography and CAD detector has the advantages of economy, high efficiency and high sensitivity, and can realize the accurate quantification of poloxamer 188. In addition, the method uses a C18 chromatographic column with an analysis time of 12 minutes, which has obvious advantages in cost and efficiency compared with size exclusion chromatographic columns, and is more suitable for the routine detection and release of poloxamer 188. In summary, this method can be used as a preferred solution for the determination of Poloxamer 188 in biological agents.

Production Method of Poloxamer 188

Potassium hydroxide and glycerin are heated and reacted in the polymerization kettle to form potassium glycerol; then, at 90-95°C and a pressure of 0.4-0.5 MPa, propylene oxide is continuously added for reaction; after the above reaction is completed, a certain amount of ethylene oxide is added, Continue to polymerize at the same temperature and pressure <0.3MPa; after the reaction, neutralize to neutral with oxalic acid, decolorize with activated carbon, and filter to obtain the finished product of Poloxamer 188.

About Products:
If you need Poloxamer 188, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Poloxamer 188 manufacturer and supplier, ZSpharmac will provide Poloxamer 188 raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.