Zhishang Chemical

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Zhishang Chemical

Poloxamer 188 CAS 9003-11-6

Molecular Formula: C5H10O2

Formula Weight: 102.1317

ZSpharmac: Poloxamer 188 Supplier

Product Name: Poloxamer 188
CAS No: 9003-11-6
Purity: 99%

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Basic Info

Product Name:Poloxamer 188
Other Names:Poloxamer
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colorless to Yellow Transparent Liquid
EINECS No.:618-355-0
Provide:Poloxamer 188 MSDS;
Poloxamer 188 COA

What is Poloxamer 188?

Poloxamer 188 is a polyoxyethylene polyoxypropylene ether block copolymer, and also its brand is luromio. This is a brand-new kind of high molecular nonionic surfactant. The polyoxyethylene material is 81.8 +19%. Poloxamer 188 is comfortably soluble in water or ethanol, liquified in outright ethanol, ethyl acetate, chloroform, almost insoluble in ether or oil ether, as well as has a particular frothing building. The pH worth of the 2.5% fluid solution is in between 5.0 and also 7.5, in addition to the pH well worth of the injection is 6.0 to 7.0. The liquid solution is rather stable airborne, as well as the pH worth will definitely go down when revealed to light. This item is safe and secure to acid-base liquid service along with steel ions.

Poloxamer 188 Property

Melting point 57-61 °C
Boiling point >200 °C(lit.)
density 1.095 g/mL at 25 °C
vapor density >1 (vs air)
vapor pressure <0.3 mm Hg ( 20 °C)
refractive index n20/D 1.466
Fp >230 °F
storage temp. 2-8°C
solubility H2O: at <70 °Csoluble
form solution
color APHA: ≤120, 50/50 in CH3OH
PH5.0-7.5 (100g/L in H2O)
PH Range5.0 – 7.5
Water Solubility Miscible with water.


Poloxamer 188 Uses

1. As an emulsifier as well as stabilizer: Poloxamer 188 (Pluronic F68), as an oil-in-water emulsifier, is one of the really few synthetic emulsifiers presently used in intravenous emulsions. The dosage is 0.1% ~ 5%. The emulsion prepared by this item has couple of milk fragments, normally less than 1 μm, as well as has high absorption rate. Secure physical buildings, able to hold up against autoclaving and low temperature level cold.
Application example: Fat solution infusion for injection, Lipomul prescription: 150g cottonseed oil, 12g soybean lecithin, 3g Pluronic F68, 40g sugar, add water for shot to 100ml.

2 Poloxamer 188 as a solubilizer: Taking salicylic acid as an instance, salicylic acid can be solubilized in 2 Pluronic types, Pluronic L65 and Pluronic F68, each mole of Pluronic L65 can solubilize 1.3 mol of salicylic acid, and also each mole of Pluronic F68 can solubilize 0.93 mol of salicylic acid, showing the steady solubility of salicylic acid in different concentrations of pluronic. The solubility of salicylic acid in pluronic per minute (mg/mlx10000). The solubility of salicylic acid in F68 progressively increased with the boost of active representative concentration, yet in L65 with the rise of focus, the solubility enhanced quickly to the optimum, but after that slowly lowered.

3 Poloxamer 188 is utilized as an absorption booster: on the one hand, due to the fact that this product reduces digestive peristalsis, the house time of the medication in the gastrointestinal system increases, as well as the absorption rises.

4 Poloxamer 188 as a sustained-release product: a strong product with a huge molecular weight, used as a binder, finish material, etc to prepare tablets, capsules, gels, etc.Gel, and so on, to accomplish the objective of sustained release, managed launch, and have actually achieved acceptable results. The dose is 5% ~ 15%.

5 Poloxamer 188 as a solid dispersant: Pluronic strong model products, can be utilized as a provider for strong dispersions, This product is not only soluble, yet additionally can promote the absorption of drugs, as well as it can likewise be utilized as a matrix for sustained launch.

Production Process of Poloxamer 188

one. Pretreatment of raw materials: In the ring-opening polymerization reaction, in order to ensure the reaction speed and molecular weight control of Poloxamer 188 synthesis, as well as the color and unsaturation of the product, the polymerization monomer should be purified first, and the catalyst and initiator should also be removed Trace impurities such as water, aldehydes, oxygen, and polyhydroxy sugars are brought into the same reaction system.

2. Ring-opening polymerization reaction: The ring-opening polymerization reaction with epoxy as raw material is an exothermic reaction, so condensed water is used to remove the heat of reaction in time during the reaction process. In addition, oxygen will oxidize and inhibit the polymerization reaction, so the air in the reactor must be exhausted with a vacuum pump before the reaction to ensure that the reaction is carried out in the absence of oxygen. At the same time, in the process of the reaction, also Vacuuming should be done continuously so that high quality Poloxamer 188 can be produced.

3. Post-treatment process: The crude Poloxamer 188 produced by the polymerization reaction must be post-processed. Post-processing work mainly includes neutralization, adsorption, dehydration, filtration, rectification and other units. Poloxamer 188 undergoes a series of post-treatments, not only to neutralize and filter out the remaining catalyst impurities, but also to remove other harmful impurities through adsorption, dehydration and distillation processes to obtain low water content, light color and no peculiar smell , Good performance, uniform polyether products. The basic refining methods can be roughly divided into the following categories:

(1) Use inorganic acid or organic acid to neutralize in the polymerization reaction of producing Poloxamer 188. For systems that use alkaline metal hydroxides as catalysts (such as calcium hydroxide, barium hydroxide, strontium hydroxide, etc.), inorganic acids are rarely used as neutralizers during neutralization. For the use of alkali metal hydroxides as catalyst systems. It is recommended to use inorganic acids as neutralizers, such as hydrochloric acid, phosphoric acid, dilute sulfuric acid, etc.

(2) Adsorption, the adsorption operation is to remove residual catalyst plasma and colored substances in Poloxamer 188. Commonly used adsorbents include magnesium silicate, aluminum silicate, activated clay, activated carbon, molecular sieve, diatomaceous earth, medium charcoal, etc., therefore, The adsorption operation temperature is generally around 100°C.

(3) Ion exchange. In industrial production, the neutralization adsorption method is often used, but the special polyether with high requirements can also be treated by the ion exchange method. This method can not only effectively remove the metal ions in Poloxamer 188, but also It can also remove colored and toxic substances in polyether.

(4) Filtration. The purpose of filtration is to remove the salt generated after the catalyst is neutralized. Now most of the advanced rotary screen filter equipment is used. during the filtering process. According to the molecular weight and functionality of the polyether produced, suitable filter aids should be added appropriately to reduce the viscosity of the system material, improve the filtration efficiency and reduce the residual amount of the product in the filter cake.

(5) Rectification and adjustment. In order to obtain polyether products with low impurity content, light color and relatively narrow molecular weight distribution, rectification and adjustment procedures are also required. The rectification of polyether is carried out under reduced pressure at about 100°C, using a falling film evaporator, adding 0.05%-0.5% di-tert-butyl p-cresol and other antioxidants, as well as butylated hydroxytoluene and Complexes such as amine antioxidants (such as phenothiazine, etc.), remove trace moisture and other impurities in polyether.

About Products:
If you need Poloxamer 188, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Poloxamer 188 manufacturer and supplier, ZSpharmac will provide Poloxamer 188 raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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