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Pine Bark Extract Powder CAS 133248-87-0

Molecular Formula:  

Formula Weight: 0

ZSpharmac: Pine Bark Extract Powder Raw Material Supplier

Product Name: Pine Bark Extract Powder
CAS No: 133248-87-0
Purity: 99%

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Basic Info

Product Name:Pine Bark Extract Powder
Other Names:Pine Bark Extract
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Dark Red Powder
EINECS No.:919-848-6
Provide:Pine Bark Extract Powder MSDS;
Pine Bark Extract Powder COA

What is Pine Bark Extract Powder?

The primary part of pine tree essence is extremely water-soluble oligomeric proanthocyanidins, which can feed on excess cost-free radicals in the body, improve the body’s immunity, and has solid antioxidant capability. It can be utilized as a cancer prevention, anti-mutation, prevention and therapy It is the major energetic ingredient of cardiovascular disease medications and is used as a risk-free and safe brand-new natural antioxidant, so it has a wide range of uses in medication, healthcare, cosmetics, food and various other fields.

Pine Bark Extract Powder Physical and Chemical Properties and Structure

Pine bark remove is removed from the bark of coastal pine trees (pinuspinaster) in the Landes region of southwest France, and its brand name is PyenonolÀ (Pycnogenol). Its background can be traced back to 1534, when a French traveler Jaequeo Caltier brought it back to France from the indigenous people of the North Atlantic after an exploration. Greater than 400 years later on, with the development of study on the task of flavonoids, it began to bring in people’s attention. Some people also call various other kinds of bark extracts Pycnogenol, which has actually come to be synonymous with various elements with antioxidant activity in bark removes.

The major part of want bark remove is incredibly water-soluble proanthocyanidin oligomers (60% to 65%). There are likewise more than 40 various other water-soluble components, the majority of which are natural acids, including caffeic acid and protocatechu. acid, vanillic acid, ferulic acid, gallic acid, and so on, along with sugar lipids and other bioactive active ingredients beneficial to the human body. The parts of pine bark essence under UV detection are received Number 1. The (somewhat) improved ache bark essence is a fluid fine powder, a little reddish-brown, aromatic, and slightly astringent in the mouth. It is very steady in a completely dry setting and can be stored in the dark for up to 5 years, with only 1% loss of proanthocyanidins.


Pine Bark Extract Powder Uses

  1. Reduced free of charge radicals in cigarette smoke: The effect of adding yearn bark remove to the filter to minimize the gas phase, bit stage and overall entirely complimentary radicals of cigarettes is much better than including it to shredded cigarette, and is likewise much better than consisting of the similar amount of grape seed remove making use of the same approach. Pine bark remove can be utilized to feed on cost-free radicals in cigarette smoke.
  2. Postpone skin aging: Pine Bark Extract Powder can get rid of wrinkles, boost skin drooping and sagging, and make skin younger.
  3. Neuron security result: Pine Bark Remove Powder may increase the antioxidant enzyme internet content of mind cells, improve the body’s antioxidant capacity, scavenge cost-free radicals, removed lipid peroxidation, and shield the sincerity of cell membrane layer framework and feature, thus fighting versus Rotenone causes a reduction in nigra-striatal dopamine, keeping striatal dopamine at regular degrees; blocking the irregular event of α-synuclein, decreasing the incident of autophagy, and impacting the number and morphology of neuronal cells. It has a beneficial advertising impact, restores the uniformity and stability of cell morphology, reduces cell apoptosis and the generation of cost-free radicals in the body, consequently decreasing pathological problems to mind cells and reducing the pathological procedure of Parkinson’s illness.

Pine Bark Extract Powder Preparation

1.1. Extraction: Include 8 times of 50-70% ethanol to the accumulated yearn bark, and remove the ache bark three times, the first time for 3 hours, the 2nd time for 2.5 hours, and the 3rd time for 2 hours. The removal temperature level is 70 degree, and then gather the extract.

1.2. Ethanol recuperation: Vacuum cleaner vaporize the removal fluid, recover ethanol, add water to the removal fluid and cool it for later on use.

1.3. Centrifugation: Centrifuge the remove via 3 levels at 1000 rpm, 4400 rpm, and 14000 rpm respectively. Collect the supernatant after centrifugation. Among them, the first-level centrifugation is generally to remove large bit impurities in the extraction liquid, the second-level centrifugation is mostly to eliminate little bit contaminations in the removal fluid, and the third-level centrifugation is primarily to get rid of tiny bit pollutants in the extraction fluid. Via the third-level centrifugation, it can It effectively eliminates strong contaminations and water-insoluble particle issue in the concentrated fluid, stopping the concentrated liquid from infecting the chromatography column and making it challenging to restore.

2. Desorption on column
2.1. Second travel through the column
Pass the centrifuged extract through a macroporous resin chromatography column with a diameter-height ratio of 1:10. The macroporous material chromatography column needs to be cleansed beforehand to make sure cleanliness, i.e., material regeneration. First, utilize alkali washing, and after that wash with purified water. to nonpartisanship, then clean with acid up until the pH worth is ~ 4, and then wash with purified water till neutral. After the removal liquid is passed, wash with purified water via the column until the effluent is clear, and remove it in the macroporous material chromatography column. macromolecular materials, and after that use 5% to 15% ethanol, such as 5%, 10%, and 15% ethanol, to elute in sets till the eluate is clear to get rid of the molecular weight and macropores in the macroporous material chromatography column. For compounds with incompatible material pore dimensions, 70% ethanol is after that made use of to desorb the active ingredients in the macroporous resin chromatography column. After desorption is finished, the desorbed fluid is collected and the ethanol is recouped under lowered pressure.

2.2. Second go through the blog post
Pass the desorbed fluid that has gone through the column with a macroporous material chromatography column with a diameter-to-height proportion of 1:30, that is, a macroporous material chromatography column with a pore diameter of 500mm and an elevation of 15m. Resin chromatography columns and macroporous material chromatography columns require to be cleansed ahead of time to ensure that they are clean and have actually been restored. After cleaning, clean the column with detoxified water till the effluent is clear, and then use 30%, 50%, and 70 respectively. % ethanol, rinse 3 times (when with 30%, as soon as with 50%, as soon as with 70%), gather the desorbed liquid respectively, recover the ethanol under lowered pressure, concentrate it right into a thick paste, and dry it under vacuum to acquire Pine Bark Extract Powder. The macroporous resin chromatography column is very clean (without way too many impurities) after going through the column numerous times. Consequently, the material can be regenerated by cleaning it with 95% ethanol.

The Physiological Effects of Pine Bark Extract Powder on Different Groups of People

The anti-aging and antioxidant activities of want bark essence are average for everyone, as can be seen from the two classic experiments over. For special groups of individuals, pine bark remove additionally reveals special physiological impacts.
For females, along with its aesthetic impact, numerous fruit acids consisted of in ache bark essence can reduce spasm discomfort (anti-spasm) and can ease uterine spasm. The protective impacts of yearn bark extract on veins might additionally help better minimize menstrual discomfort. In a study, Dr. Takafumi Kohama and Nobutaka Suzuki of Kanazawa University Institution of Medicine in Japan asked some ladies to start taking 30 to 60 mg/d of pine bark essence 2 weeks prior to menstruation. After four weeks of taking it, 80% created endometriosis. 70% of ladies dealing with severe dysmenorrhea and 60% of females who had actually undergone gynecological surgical treatment had their discomfort reduced or completely disappeared.
For males, due to the antioxidant and complimentary extreme scavenging activity of want bark remove, it can enhance male the inability to conceive symptoms brought on by sperm irregularities. It is likewise reliable for people with impotence. Durackova et al. carried out a three-month experiment with 21 people with erectile dysfunction making use of ache bark remove and a sugar pill. In the experiment, impotence was measured by the worldwide identified IIEF-5 (Global Impotence Index). The greatest rating is 25, 21-25 is regular function, 16-20 is light disorder, 11-15 is moderate condition. Listed below 10 is a severe disability) for verification. The topics were aged from 22 to 69 years of ages, and the examination dosage was 12Omg/day, taken orally in three divided dosages. 3 months later, the subjects’ IIEF-5 index enhanced from the original standard of 12.6 ± 1.1 to 16.8 ± 0.8. The placebo did not boost the IIEF-5 index.
Pine bark essence can likewise inhibit platelet aggregation brought on by smoking, enhance the memory and learning ability of the elderly, and enhance the workout resistance of professional athletes. Because the major element of want bark remove is proanthocyanidins, which can shield cardiovascular systems, stop hypertension, avoid cancer, enhance human resistance, improve visual feature, etc, ache bark essence need to also have it. Pine bark extract has excellent solubility in water, is well absorbed after dental administration, takes effect promptly after getting in the body, and the result lasts for a long time.

About Products:
If you need the cosmetic raw material Pine Bark Extract Powder, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Pine Bark Extract Powder manufacturer and supplier, our company, ZSpharmac will provide Pine Bark Extract Powder raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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