Zhishang Chemical

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PHMB CAS 32289-58-0

Molecular Formula: C10H23N5

Formula Weight: 213.32312

ZSpharmac: PHMB Supplier

Product Name: PHMB
CAS No: 32289-58-0
Purity: 99%

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Basic Info

Product Name:PHMB
Other Names:Polyhexamethylene Biguanidine HCl
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance: Colorless Liquid
EINECS No.:1308068-626-2
Storage:Inert Atmosphere,Room Temperature
Provide:PHMB MSDS;

What is PHMB?

PHMB is acknowledged as the most safe and also most effective broad-spectrum antibacterial representative in the 21st century. It is colorless as well as unsmelling, has low repressive focus, broad-spectrum and also low poisoning, does not create organic antibodies, has rapid action rate, low foam volume, as well as can be used externally of items. Types a layer of cations that lasts for a long period of time anti-bacterial.

PHMB Property

storage temp. Inert atmosphere,Room Temperature
solubility Water


Application of PHMB

(1 ), Utilized for damp wipes
PHMB’s antibacterial impact is primarily via dissolving lipids, transforming the permeability of bacterial cell membrane layers, and preventing the metabolism in the bacteria. It has a large anti-bacterial spectrum and works versus Gram-positive as well as negative germs and also mold and mildews. It is colorless, odorless, non-irritating to the skin, safe, and non-corrosive. For that reason, the damp wipes dealt with by it can not just accomplish rapid sanitation result, yet also will certainly not generate mildew, and the service life can reach 2 years.

( 2 ), Made use of for household and also public areas special sterilization disinfectant
PHMB appropriates for home sanitation, as well as can be utilized for sterilization as well as cleansing of fruits and vegetables; it can be made use of for sterilization and also cleansing of different fabrics such as clothing, towels, and also bed sheets; it can be made use of for automobiles, trains, aircrafts, ships, going shopping malls, movie theaters, hotels, dining establishments, etc. Sanitation of public locations.

( 3 ), For tank farming
PHMB can rapidly kill dangerous bacteria such as gram-negative bacteria, drifting vibrio, parahaemolytic vibrio, and also alginolytic vibrio in salt water, and also it is very good for avoiding various illness caused by germs in sea cucumbers and various other marine items and therapeutic effect.

( 4 ), For skin, wound anti-bacterial
PHMB is anemic, non-corrosive, and also has resilient efficacy. It can be easily used for cleansing as well as sanitation of skin, injuries, obstetrics as well as gynecology, and urology. Especially for some clinical supplies that can not be sanitized by high temperature, it just requires to be taken in an option with a focus of 1 ‰ Or spraying, can accomplish acceptable sanitation result in a short time. This item can additionally be utilized for disinfection of air, walls and ground in wards.

( 5 ), For women’s lotion
The cream and also gel disinfectant made by PHMB can be utilized for bacterial, fungal, trichomonas, senescent and non-specific swelling, cervicitis and also other conditions.

( 6 ), Used for hand disinfectant
PHMB is straight sprayed on the hands as a hand sanitizer, anytime and also where, it can securely, properly and also easily remove pathogenic bacteria on the hands, without water as well as soap, and can develop a colorless and also transparent layer on the hands The undetectable movie maintains long-term repressive and antiseptic results.

( 7 ), Used in the fabric industry as well as sanitary napkins, sanitary napkins, baby diapers as well as other products
PHMB can establish anti-bacterial textiles, such as towels, undergarments, child garments, bedding, etc. It is sufficient to immerse the fabrics in this product-specific option before the last finishing phase. When the microorganisms fall on the textiles treated by this product, the energetic compound consisted of in the micro-moisture will certainly be dissolved out, as well as the bacteria will be killed rapidly. After testing, the textiles dealt with effectively still have anti-bacterial residential properties after being cleaned in water for 120 times.

This product can be conveniently turned into all sort of sterilized and anti-bacterial feminine napkins, sanitary pads, infant diapers, and so on, which reduces the cost as well as resolves the problem of short legitimacy duration of traditional sanitation methods. Because the item can be evenly related to the penalty fibers of the above-mentioned products, a slim polymer layer of anti-bacterial agent is formed on the surface, which can preserve the most effective state after sterilization, as well as the validity duration can get to 2 years.

( 8 ), Utilized for washing products
At present, washing items with sanitation feature normally include chlorine prep work as disinfection active ingredients, which have issues such as corrosion to materials, fading, brief sanitation duration, and also can just be used for white fabrics. The product has the advantages of being soluble in water, safe, colorless, unsmelling, non-corrosive, non-fading, non-irritating to skin as well as mucous membrane layers, as well as lasting legitimate.

( 9) Used in beer, beverage and food handling markets
PHMB is used in the sterilization and also sanitation of pipelines, containers and various other production facilities as well as premises in the manufacturing of beer, beverages as well as food. It only needs to weaken the item to 10ppm, saturate or wash the pipes, and also the sterilization impact can be achieved. If there is no special need for loading food cans, the use concentration can be boosted to 250ppm to accomplish the impact of rapidly as well as completely killing bacteria.

Characteristics of PHMB

PHMB has many superb residential or commercial properties.
1. Exceptional sanitation capability
PHMB is a broad-spectrum fungicide that has excellent efficacy versus Gram-negative microorganisms that are difficult to treat with basic fungicides, and also can accomplish excellent bactericidal impacts at reduced concentrations without making bacteria resistant; Sanitation speed is fast, after sterilization, due to the fact that PHMB cations are adsorbed externally of the post, it can hinder the growth of germs for a very long time. There are literary works revealing that when PHMB is utilized, the alkaline environment is conducive to the feature of the bactericidal group, and the bactericidal impact is better than that under acidic problems, yet it ought to be noted that the guanidine group is hydrolyzed right into ammonia gas under alkaline problems With urea, so the pH value of the ready PHMB service should not be too expensive.

2. Excellent security
Non-volatile, excellent water solubility, aloof to temperature level as well as light, very easy to store as well as transport.

3. Other benefits
No harmful and also adverse effects (PHMB itself is a high molecular polymer, not easy to be taken in by body cells), primarily no deterioration, reduced foam, simple to wash, etc. Additionally, compared to iodine and also other disinfectants, PHMB also has the advantage of not staining.

Preparation of PHMB

1) Preparation of hexamethylenediamine hydrochloride
Add ethanol as a solvent into a three-neck flask equipped with a thermometer and a stirring rotor to weigh 1,6-hexamethylenediamine, add hydrochloric acid dropwise under stirring, and the reaction is exothermic. Control the rate of addition, keep the temperature below 28°C during the dropping process, until the pH value of the solution reaches 5, continue the reaction for 1 hour after the dropwise addition, to ensure that the reaction is complete, then reduce the temperature to 0°C, filter, and filter the obtained filter cake drying. The pure hexamethylenediamine hydrochloride is obtained.

2) Preparation of antibacterial agent polyhexamethylene biguanide hydrochloride
Weigh a certain amount of dicyandiamide and hexamethylenediamine hydrochloride, the molar ratio of the two is 1:1.1, add a certain amount of n-butanol as a solvent, stir and heat under reflux, the polymerization reaction temperature is 170 ° C, constant temperature After 12 hours, n-butanol was distilled off to obtain the product.

About Products:
If you need PHMB as a cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced PHMB manufacturer and supplier, ZSpharmac will provide PHMB raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get PHMB Quotation