Phlorizin CAS 60-81-1

Molecular Formula: C21H24O10

Formula Weight: 436.41

ZSpharmac: Phlorizin Supplier

Product Name: Phlorizin

CAS No: 60-81-1

Purity: 99%

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Basic Info

Product Name:	Phlorizin
Other Names:	Phlorizin Hydrate
CAS:	60-81-1
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	Light Yellow to Tan Solid
EINECS No.:	200-487-1
Storage:	Room Temperature
Provide:	Phlorizin MSDS； Phlorizin COA

What is Phlorizin?

Phlorizin is the glucoside of phlorizin, the chemical name is 1-(2-(beta-D-glucopyranoseoxy)-46-dihydroxyphenyl)-3-(4-hydroxyphenyl)-propanone, which belongs to Dihydrochalcones in flavonoids. Phlorizin mainly exists in the root bark, stem, young leaves and apple fruit of apple trees, and also exists in a small amount in plants such as Compositae, Rhododendronaceae, Fabaceae, Fagaceae, Liliaceae and other plants. It has many important biological activities such as lowering blood sugar, improving memory, anti-allergic, anti-cancer, etc. It has potential utilization value in food, beauty and health care products industries.

Phlorizin Property

Melting point	113-114 °C(lit.)
Boiling point	468.89°C (rough estimate)
density	1.3178 (rough estimate)
refractive index	-54 ° (C=3.2, 95% EtOH)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	7.15±0.40(Predicted)
form	Solid
color	Light Yellow to Tan

Efficacy of Phlorizin

Antibacterial

Phlorizin is drawn out from apples, apple bark and leaves, etc. It is a phenolic material in the apple tree. Research studies have actually shown that phlorizin represent 95% of the overall material of phenolic substances in the apple tree. The web content is so high that its existing state can affect the general existing state of phenolic substances. Phlorizin is a glycoside developed by the combination of phloretin as well as glycosides as glucosides. The glycosyl is hydrolyzed to form sugar, as well as its high material is considered by numerous scholars to be a storage kind of carbohydrates. 4-deoxyphlorizin has actually also been widely researched as well as applied. Its deterioration item, phlorobark, can effectively hinder the activity of microbial tasks.

Anti-oxidation

All sort of flavonoids can get rid of cost-free radicals such as superoxide anion Oˉ2 · to a particular level. This antioxidant capacity originates from the hydrogen or electron donating capability of its phenolic hydroxyl team. Phlorizin is a glycoside by-product of dihydrochalcone phloretin. Dihydrochalcone is among the participants of flavonoids, which has particular antioxidant homes and antioxidant homes. Although the molecular framework of phlorizin deteriorates its antioxidant activity due to the 2′- hydroxyl glycosidation, its comprehensive antioxidant capacity is still higher than that of VC and also VE, as well as it has a distinct antioxidant system. Furthermore, phloridizin can be hydrolyzed to remove glycosides in the body to create phloretin, which has far better antioxidant capacity.

Phlorizin has anti-tumor task and has a healing result on skin cancer cells. It can be utilized in face products to prevent the formation of melanin, lighten the color of tea brownish, grey places and freckles.

Deal with diabetic issues

Current professional studies in the house and also abroad have actually shown that phlorizin has a good medicinal result in the treatment of diabetic issues. Numerous scientists make use of phlorizin when researching the pathogenesis of diabetes as well as checking out means to deal with diabetes mellitus, that makes the research study on diabetes therapy take place swiftly and also smoothly.

The young fallen leaves of Apple as well as Duosuike wonderful tea are rich in phloridzin. Recent researches have actually located that phloridzin has some unique features as well as has a great precautionary result on diabetic issues and also its complications. In order to provide some assistance for the growth and utilization of phlorizin.

Phlorizin especially and also competitively prevents the transport of glucose molecules by SGLT1 and SGLT2. It has actually been verified in a number of pet models that phlorizin can promote glucose secretion, lower fasting as well as postprandial blood glucose levels, and also do not create hypoglycemic side effects. Treating diabetic rats with phloridizin can recover normal insulin level of sensitivity and eliminate or reduce insulin resistance caused by glucose toxicity.

Boost memory

The task of the mind takes in a large quantity of power supplied by sugar. Several proofs have actually verified that the flowing blood sugar degree controls the procedure of discovering and memory. The impacts of many drugs that improve memory relate to the capability to release liver glycogen, rise brain blood glucose degrees and use of. Phlorizin prevents the entry of blood sugar right into the brain. Consequently, the system by which phlorizin improves the brain’s memory capability is evidently independent of blood glucose degrees or the brain’s ability to soak up sugar.

Synthesis of Phlorizin

The synthetic path of phlorizin is a little various from that of various other flavone dihydrochalcones. In the research outcomes of Gosch C et al., malonyl-CoA and also p-coumaroyl-CoA are the key in the procedure of synthesizing phlorizin precursor substances. The response has 2 pathways, An as well as B. The A path generates flavonoids, and the B pathway produces the target product phlorizin.

The primary step of the A pathway: 3 molecules of malonyl-CoA and P-coumaroyl-CoA are militarized by chalcone synthase (CHS) to create naringenin chalcone; the second step: the response likewise Will additionally produce other flavonoids. The first step of path B: three molecules of malonyl-CoA and also p-dihydrocoumaroyl-CoA are militarized by CHS to produce phloretin, and the second action: phloretin is catalyzed by glycosyltransferase A glycosylation reaction happens, and a particle of glucose is connected to the No. 2 placement to generate the target product phlorizin. Amongst them, P-coumaroyl-CoA as well as p-dihydrocoumaroyl-CoA can be transformed right into each other in numerous ways. The study outcomes of Dare A P et al. discovered that the enoyl reductase comparable genetics ENRL-3 and ENRL-5 are likely to be the key genetics that promote the synthesis of phlorizin, as well as the entire synthesis pathway of phlorizin needs the engagement of numerous enzymes to play a role with each other. effect.

Extraction and Separation and Purification of Phlorizin

1. Removal of phlorizin Phloridin is insoluble in water however conveniently soluble in natural solvents. Most of the conventional methods are the application of natural solvent extraction, as well as currently the majority of them are ultrasonic-assisted extraction, microwave-assisted extraction and also various other techniques. Utilizing apple branches as resources, phlorizin was extracted twice with 10 times the quantity of water as solvent, complied with by open macroporous resin chromatography and also gradient elution with ethanol. The crudely extracted phlorizin was incorporated as well as made use of for medium and also low pressure preparative chromatography, ODS was made use of as a filler, as well as methanol and also water (3:7) were used for elution, and also the concentrated items were incorporated for recrystallization to acquire a pure item.

Contact HPLC chromatography, the result reveals that sample pureness gets to greater than 98%. Xu Kai et al. contrasted different techniques such as ultrasonic method as well as microwave approach, as well as lastly figured out the optimum extraction procedure using L16 (43) orthogonal experiment testing: utilize red Fuji apple as basic material, 40% ethanol service as extraction solvent, and the product The liquid proportion was 1:30, as well as the reflux extraction was performed for 1 hour, as well as the best removal result was gotten. In the study results of Feng Jinyu et al., it was located that when ultrasonic-assisted extraction of phlorizin was executed, the extraction temperature was 45 ° C, the extraction solvent was 70% ethanol solution, and also 30 times the quantity of solvent was included for 35 mins to draw out the most effective effect. Due to the fact that the content of removed phlorizin is typically reduced, additional contamination elimination and also separation and filtration processes are needed to acquire phlorizin with higher pureness.

2. Separation and also filtration of phlorizin Some literature mentions that the reason the purity of phloridzin is really low is that there are a lot more flavonoids and flavonoids in the plant of Polyacae, and also its structure is complicated, as well as the by-products are relatively low. Several, Yang Dajian and others have identified 3 main dihydrochalcones in pleasant tea, which are phlorizin, trilobatin, as well as 3-hydroxyphloridin in turn. Presently, in the existing literary works, it can be ended that the splitting up techniques of phlorizin include macroporous material adsorption method, chitosan flocculation method, high performance centrifugal partition chromatography (HPCPC), polyamide column separation, removal approach and more. Li Shenghua and others showed that D101 macroporous material has the very best separation and purification result on phlorizin, and also its purity can get to 95.6%.

In the study of Sun L et al., X-5 and polyamide material were used to divide epicatechin, hyperoside as well as phlorizin successively. The splitting up pureness can get to more than 95%. This technique is not just practical as well as reduced in expense, but also minimizes the danger of migration. kind. Wang Huiying used the chitosan flocculation method to get a mass fraction of phlorizin of 21.7%, which is close to the confirmation examination outcomes. Chitosan does not need heating as well as conserves sources and also is better for massive commercial use. For the first time, Li Rongtao and also others used HPPCC chromatography to divide and also purify the ethanol extract of apple branches, and gotten phlorizin with a purity of 91.2%. High-efficiency centrifugal partition chromatography has the advantages of high performance, rapidity, high healing price and also high loading ability. Normally speaking, various methods can divide and also purify phlorizin with higher pureness, and the approach can be picked according to one’s own scenario to attain the experimental purpose.

About Products:
If you need Phlorizin, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Phlorizin manufacturer and supplier, ZSpharmac will provide Phlorizin raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.