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Phloretin Gel CAS 111-42-2

Molecular Formula: C4H11NO2

Formula Weight: 105.14

ZSpharmac: Phloretin Gel Supplier

Product Name: Phloretin Gel
CAS No: 111-42-2
Purity: 99%

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Basic Info

Product Name:Phloretin Gel
Other Names:Phloretin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Beige Powder
EINECS No.:200-488-7
Provide:Phloretin Gel MSDS;
Phloretin Gel COA

What is Phloretin Gel ?

Phloretin Gel belongs to the plant polyphenols of dihydrochalcone, which can be extracted from apple and grapefruit peels, and can protect plants from ultraviolet rays.

Phloretin Gel Property

Melting point 

~260 °C

Boiling point 

337.26°C (rough estimate)


1.1827 (rough estimate)

refractive index 


storage temp. 



Acetonitrile (Slightly), Methanol (Slightly)






White to beige

Water Solubility 



Phloretin Gel Effects and Applications


1. Inhibit the effect of tyrosinase, lighten the spots and whiten the skin;

2. Strong antioxidant capacity, can effectively delay skin wrinkles, aging and other aging symptoms;

3. It can prevent sugar components from entering epidermal cells, inhibit the excessive secretion of skin glands, and treat acne and acne;

4. Strong moisturizing effect.

Health products

1. Anti-oxidation and anti-free radical effects;

2. Anti-inflammatory and immunosuppressive effects.

Flavors, Spices

1. Inhibit bitterness and other unpleasant tastes in food and improve taste;

2. Reduce the odor of high-intensity sweeteners and cover up bad flavors;

3. Use with stevia as a taste regulator.

Biological Activity of Phloretin Gel

Antioxidant, anti-free extreme influence
The antioxidation activity of flavonoids has in fact been confirmed as early as the 1960s: countless flavonoids polyhydroxyl frameworks can have significant antioxidative residences by chelating with steel ions.

Phloretin Gel has strong anti-oxidant buildings, has anti-oxidant result on oil, and can eliminate free radicals in the skin.

Experiments reveal that when the last focus of the system is 13 μmol/ L, the restraint cost of phloretin to lipid peroxidation has to do with 53%; when the last focus of the system is 32 μmol/ L, the scavenging rate of phloretin to eliminate DPPH absolutely cost-free radicals Gotten to 74.6%.

Free radicals are compounds hazardous to the body produced by oxidation reactions, and are related to human degenerative conditions. Outside use of phloretin can quit sugar elements from getting in the skin cells, therefore preventing the excessive secretion of the skin, as well as also treating acne with exuberant secretion.

Lightening and also lightening outcome
Different research study outcomes show that the lightening tool of Phloretin Gel is primarily to prevent the task of tyrosinase in the body, thereby decreasing the production of melanin in the body.

We know that tyrosinase is an essential catalytic enzyme for the synthesis of melanin, and also phloretin has a high repressive job on tyrosinase, which is better than arbutin as well as kojic acid.

Additionally, the unification complex of hydroxypropyl-β-cyclodextrin in addition to phloretin also has an excellent effect of inhibiting tyrosinase task. Another study located that the mix of 34.9% ferulic acid, 35.1% phloretin as well as additionally 30% water-soluble VE has a teaming up anti-oxidative in addition to lightening outcome.

Enhanced transdermal absorption
Phloretin Gel is a lipophilic material that can travel through right into the skin with intercellular lipids, among the elements is that it can transform the membrane layer dipole ability of the phospholipid bilayer, affect the interfacial company of the phospholipid bilayer and also the infiltration of water to drive water circulation auto mechanics.

An extra research study situated that when phloretin was utilized as a medium for the transdermal absorption experiment of lidocaine hydrochloride, its absorption was 5.4 times that of the initial; In the absorption experiment of phenol as well as 1-naphthol, the results disclosed that phloretin as well as additionally phloridin can impede the impact of glucuronidation, promote the absorption of acetaminophen as well as likewise 1-naphthol in the small intestine, and also considerably boost their pharmacological activity

Anti-inflammatory task.
We know that when the skin barrier is damaged, the permeability of poisonous irritants will certainly elevate, as well as will certainly induce different cells to release pro-inflammatory aspects in addition to chemokines to manage the development of resistance and likewise swelling, consequently promoting the generation of delicate skin. Therefore, it is wrapped up that hindering the production of inflammatory facets as well as chemokines can prevent or lessen the damages of skin cells throughout the inflammatory action.

In the anti-inflammatory experiment of Phloretin Gel, artificial insemination research studies have actually revealed that phloretin can protect against the production of inflammatory aspects, chemokines along with distinction aspects; it can hinder the capability of monocytes to follow keratinocytes, as well as stop the signaling healthy protein kinase Phosphorylation of Akt as well as MAPK to achieve anti-inflammatory effects.

Not just that, contemporary medicine has actually revealed that the important aspects related to the pathogenesis of acne in addition to the elements that cause swelling are often not divided.

The outside use phloretin can avoid sugar aspects from getting in the skin cells, avoid the way too much secretion of the skin, as well as achieve the impact of handling acne with abundant secretion. At the same time, when phloretin enters the cell, it can considerably reduce the task of COX-2 promoter, hinder the production of prostate E2, and also alleviate the inflammatory comments of acne-type skin.

To summarize, Phloretin Gel is not just used in lightening along with anti-aging products, but also in acne-removing or soothing cosmetics.

Certainly, according to literary works records, phloretin also has the features of moisturizing, anti-hair loss, anti-bacterial and sun defense.

You can furthermore see great deals of items containing phloretin on the market, such as SkinCeuticals Bleaching Fixing Day Product, SkinCeuticals Phloretin CF, as well as Avon.

The Preparation Method of Phloretin Gel

Preparation of Phloretin by Chemical Method
Because the content of Phloretin Gel in natural plants is relatively low and the extraction cost is high, researchers try to prepare phloretin by semi-synthesis and total synthesis by chemical methods.

1.2.1 Semi-synthetic preparation

The preparation of phloretin by acid (usually hydrochloric acid or sulfuric acid) hydrolysis or enzyme (glucoside hydrolase) hydrolysis by phloridin is shown in Figure 1 .


Phloretin Gel is prepared from naringin by a two-step method[23]: naringin is widely found in the peel and pulp of grapefruit, tangerine and orange in Rutaceae, and is abundant in nature. Using naringin as raw material, naringin dihydrochalcone is obtained by catalytic hydrogenation reaction, and then hydrolyzed under acidic conditions to obtain phloretin. The reaction process is shown in Figure 2. new way.


1.2.2 Total synthesis preparation

Phloroglucinol and hydroxyphenylpropionic acid were used as raw materials to synthesize phloretin under the condition of BF3·Et2O as a catalyst[24]. The synthetic route is shown in Figure 3.


Using 2′-hydroxy-4′,6′-bis(methoxymethoxy)acetophenone and p-methoxybenzaldehyde as raw materials, undergo aldol condensation, catalytic hydrogenation, and dehydroxyl protecting group to obtain Phloretin Gel[25] . The synthetic route is shown in Figure 4.


Using diethyl malonate as a raw material, first synthesize the intermediate p-methoxyphenylpropionic acid; through acylation reaction and esterification reaction, synthesize the target intermediate tris-p-methoxypropionate trisphenol ester; Phloretin Gel was synthesized by Fries rearrangement reaction with AlCl3 as catalyst and nitrobenzene as solvent[26]. The main synthetic route is shown in Fig. 5.


About Products:
If you need Phloretin Gel, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Phloretin Gel manufacturer and supplier, ZSpharmac will provide Phloretin Gel raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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