Zhishang Chemical

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Zhishang Chemical

Phloretin CAS 60-82-2

Molecular Formula: C15H14O5

Formula Weight: 274.27

ZSpharmac: Phloretin Supplement

Product Name: Phloretin
CAS No: 60-82-2
Purity: 99%

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Basic Info

Product Name:Phloretin
Other Names:Phloretin, 98%
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Beige Soluble
EINECS No.:200-488-7
Provide:Phloretin MSDS;
Phloretin COA

What is Phloretin?

Phloretin is a plant polyphenol with a dihydrochalcone framework, named for its concentration in the origin bark of apple trees. Because of its unique framework, phloretin has a variety of biological tasks, which has actually come to be a research study hotspot recently. Studies have found that phloretin has different medicinal effects such as anti-oxidation, anti-tumor, anti-inflammatory, immunosuppression, and promotion of bone formation.

With the raising market share of practical cosmetics, as a cosmetic functional resources, phloretin has actually obtained comprehensive attention from researchers in the beauty sector. Phloretin is a flavonoid compound with dihydrochalcone structure, which has antioxidant, anti-inflammatory, whitening, sunscreen, antibacterial, moisturizing and also other results, and has been used in cosmetics. Although phloretin has a specific application in cosmetics, there are still several issues worthy of our comprehensive research.

1) Optimization of the preparation method of phloretin: the content of all-natural phloretin is low, the removal is tough, as well as the price is high, which restricts its vast application in cosmetics; 2) Further modification of phloretin: low tide solubility, low absorption in vivo, Issues such as unsteady homes restrict the application of phloretin in cosmetics and also other areas; 3) The synergistic effect of rational application of phloretin: the compound use phloretin with anti-oxidants, sun blocks and also other useful elements can synergize 4) Research and development of functional cosmetics: Phloretin has a range of impacts, yet it is hardly ever utilized in this brand name of cosmetics, and also further r & d is required.

In short, its standard research ought to be increased to enhance the usage rate of waste deposits from apple handling and also tree trimming, so regarding provide a strong academic basis for the development of new natural cosmetics. Phloretin has a range of effects as well as will have broad application leads in cosmetics, which deserves additional research study by residential scholars.

Phloretin Properties:

Melting point 

~260 °C

Boiling point 

337.26°C (rough estimate)


1.1827 (rough estimate)

refractive index 


storage temp. 



Acetonitrile (Slightly), Methanol (Slightly)






White to beige

Water Solubility 



Physiological Function and Application of Phloretin

Research studies have revealed that the phenolic hydroxyl groups in the framework of natural flavonoids can react with cost-free radicals to produce stable semi-quinone totally free radicals, therefore hindering the lipid peroxidation in the initial phase and ending the totally free extreme chain reaction. Phloretin is a flavonoid with dihydrochalcone framework, with 4 phenolic hydroxyl groups, and its unique structure determines its solid antioxidant activity Artificial insemination experiments show that phloretin has the ability to hinder mitochondrial lipid peroxidation and feed on DPPH free radicals as well as ABTS cost-free radicals.

Researches have revealed that phloretin has solid antioxidant activity, as well as the antioxidant mass focus of oil is 10.30 mg/L, which can scavenge free radicals in the skin. Phloretin not only has antioxidant result on its own, but can likewise be made use of in combination with existing antioxidants to boost the antioxidant impact. The study discovered that a combination of 34.9% ferulic acid, 35.1% phloretin, as well as 30% water-soluble V had a synergistic antioxidant effect. At the same time, scholars utilized O/W microemulsion modern technology and embedding innovation to fix the issues of poor water solubility and also stability of phloretin, which gave guidance for the application of phloretin in cosmetics. It can be seen that phloretin and its incorporation facility have a great impact of scavenging complimentary radicals, and have fantastic application potential customers in anti-aging cosmetics.

Artificial insemination studies have shown that phloretin can hinder the manufacturing of inflammatory elements, chemokines and differentiation factors, as well as has a certain anti-inflammatory impact. At the same time, the research study found that phloretin can hinder the phosphorylation of solitary Akt and also MAPK, so regarding accomplish anti-inflammatory result. In vivo research studies have actually additionally shown that phloretin has antioxidant and also anti-inflammatory results. The anti-inflammatory result of phloretin in vitro as well as in vivo indicates that it has a possible comforting effect as well as can be used in comforting skin care items.

In addition, modern-day medicine has actually revealed that important factors associated with the pathogenesis of acne as well as the variables that activate swelling are often not isolated. External application of phloretin can stop carbohydrates from going into skin cells, prevent extreme secretion of skin glands, as well as deal with exuberant acne. At the same time, entering cells can significantly reduce the activity of COX-2 promoter, prevent the production of prostate E2, and also relieve acne-type skin. Swelling.

Studies have actually located that phloretin has a specific capability to soak up ultraviolet rays. Adding phloretin to the fundamental formula of cosmetics can improve the SPF and also day spa values of cosmetics. Additionally, the phloretin, V, and ferulic acid blend protects human skin from UV rays as well as gives photoprotection to human skin. Phloretin can not just directly absorb ultraviolet rays, yet likewise enhance the expression of nucleotide excision repair work genes, slow down the development of pyrimidine dimers, glutathione deterioration as well as cell death generated by UVB, and also decrease the damage of ultraviolet rays to keratinocytes.

Ultraviolet radiation can create cells to produce reactive oxygen species and cost-free radicals, which are extremely unsteady as well as vulnerable to a collection of oxidative chain reactions that ultimately damages cells. Phloretin has antioxidant activity as well as absorbs ultraviolet rays, as well as has possible application value in sun block cosmetics.

Phloretin is a lipophilic substance that passes through into the skin via intercellular lipids. Researches have actually revealed that phloretin can transform the membrane dipole potential of the phospholipid bilayer, impacting the user interface organization of the phospholipid bilayer and the osmotic-driven water circulation characteristics of water. Phloretin in phloretin cream has excellent transdermal residential or commercial properties.

At the same time, when phloretin was used as the tool, the transdermal absorption of lidocaine hydrochloride increased to 5.4 times, indicating that phloretin might affect the transport procedure moderated by the carrier as well as had a particular function of promoting transdermal absorption. Phloretin is a natural, safe as well as effective lipophilic substance with a certain effect of promoting infiltration. It can be included in cosmetics as a carrier of reliable active components to promote the transdermal absorption of active ingredients as well as make it play a far better function. impact.

Phloretin is a flavonoid substance with bacteriostatic task The research located that phloretin has a strong repressive result on Gram-positive microorganisms, particularly on Staphylococcus aureus (ATC6538, MIC= 7.81 mg/L), Listeria (ATCC 13932, MIC= 62.5 mg/L) and also Salmonella typhimurium (ATCC 13111, MIC= 125 mg/L). In addition to its bacteriostatic activity against pathogenic germs, phloretin also has an effect on typical germs on the skin. The MICs of phloretin to P. acnes and P. acnes granules were both 0.5 mg/L, and also the results of professional trials showed that whiteheads, blackheads, papules and sebum secretion were all boosted after topics used phloretin for 4 weeks. There was a considerable decrease, suggesting that phloretin has a possible acne-relieving result.

On the one hand, the repressive effect of phloretin on bacteria is to act upon the enzyme protein system inside the bacteria, which influences the energy metabolism of bacteria and the oxidative damage fixing of bacterial development;, ultimately leading to microbial death. In summary, phloretin has a specific bacteriostatic effect. With the extensive research study on the bacteriostatic result of phloretin, phloretin might be developed as a brand-new natural bacteriostatic agent to be included in cosmetics to change some chemical preservatives. At the same time, it can likewise be added to acne cosmetics as an useful resources.

The study discovered that phloretin can inhibit the activity of tyrosinase, and its Ic ∞ was 37.5 txmol/L. The restraint rate of 0.3% phloretin to tyrosinase is as high as 98.2%, as well as its inhibitory effect on tyrosinase is far better than that of typical bleaching representatives (kojic acid and also arbutin). The compounding of tyrosinase inhibitor can significantly improve its restraint price and attain 100% inhibition impact well. In addition, the incorporation complicated of hydroxypropyl cyclodextrin and also phloretin likewise has a great inhibitory impact on tyrosinase activity.

The 4 hydroxyl groups consisted of in the phloretin particle can develop hydrogen bonds with water molecules to take in water as well as have a potential moisturizing result Consequently, phloretin can likewise be made use of as a natural moisturizer in moisturizing cosmetics.

Researches have shown that phloretin can inhibit the activity of soybean lipoxygenase, consequently lowering hair loss due to premature aging, suggesting that phloretin has a prospective anti-hair loss effect, as well as can be utilized as an anti-hair loss basic material to be added to shampoo and hair care. in the component.

The study found that phloretin generates growth cell apoptosis by inhibiting the transport of sugar in lump cells. Studies have located that phloretin can prevent the spreading of cancer cells as well as induce their apoptosis in a concentration- and time-dependent fashion. Phloretin can block the cell cycle in the G1 phase. Calcium balance to induce cancer cells cell apoptosis.

The phloretin group and the higher choline group can substantially lower the product levels of complete cholesterol, triacylglycerol, alanine aminotransferase, aspartate aminotransferase, endothelin-1 as well as thromboxane A2, and substantially antagonize the degrees of prostacyclin as well as NO in serum. level, improve vascular endothelial feature. In addition, phloretin can enhance the activities of superoxide dismutase and glutathione peroxidase in the liver as well as decrease the level of malondialdehyde, as well as histopathological experiments likewise verified the protective impact of phloretin on the liver.

Another study revealed that phloretin can act upon ion channels in cells, inhibit the increase of calcium ions or hinder the release of calcium ions from the endoplasmic reticulum induced by phosphoinositide 3 through potential-dependent calcium channels, therefore affecting the aorta. tightening as well as shield blood vessels.

Phloretin is a lipophilic substance, and also phloretin has a particular result on the cell membrane, which can affect the carrier-mediated transportation procedure. Research studies have shown that phloretin can prevent the task of melanocytes, has a lightening effect on different skin pigmentation, and also has an excellent inhibitory impact on tyrosinase. It is an extremely secure and effective freckle bleaching agent. In vitro tyrosinase Activity experiments revealed that phloretin prevented tyrosinase task in a competitive as well as dose-dependent manner.

Preparation of Phloretin

The preparation methods of phloretin mainly include ultrasonic extraction method, immersion method, thermal reflux method, enzymatic method and biological enzymatic transformation method. The ultrasonic extraction method is simple, the extraction speed is fast, but the extraction efficiency is low. The ultrasonic extraction method cannot extract phloretin from apple flesh and apple peel, while the content of phloretin extracted from the leaves of Begonia is only the highest in the total. 0.55% of active ingredients. The dipping method is easy to operate, but the extraction efficiency is greatly affected by the solvent.

The yield of phloretin was low when extracted with a single solvent (ethanol, NaOH solution or methanol), and the yield was 36.60 g/g when extracted with acidic methanol, while the mixed solvent of methanol, ethanol, acetone, ethyl acetate and chloroform could extract the root bark. The prime yield was increased to 78%, and it can be seen that the mixed solvent contributed to the improvement of the extraction efficiency of the impregnation method. The extraction of phloretin by thermal reflux method has the advantages of high extraction efficiency and reduced solvent volatilization.

In Vitro Studies of Phloretin

Phloretin is a dihydrochalcone found in the bark of pears (Pears), apples, cherries and other fruits. Phloretin hinders the active transport of glucose right into cells by means of SGLT1 as well as SGLT2, although less so than its sugar ligand phloretin. Dental phloretin is entirely transformed to phloretin by hydrolases in the small intestine. An essential duty of this procedure is inhibition of glucose absorption by the small intestine and inhibition of renal glucose reabsorption. Phloretin additionally hinders various urea transporters. When incorporated with a high-protein diet regimen, it causes a reduction in urea as well as has a diuretic effect.Phloretin is a dihydrochalcone located in the bark of pears (Pears), apples, cherries as well as various other fruits. Phloretin prevents the energetic transportation of glucose right into cells via SGLT1 and SGLT2, although much less so than its sugar ligand phloretin. Oral phloretin is completely transformed to phloretin by hydrolases in the small intestine. A vital duty of this process is restraint of sugar absorption by the small intestine as well as restraint of kidney sugar reabsorption. Phloretin also hinders different urea transporters. When combined with a high-protein diet regimen, it causes a reduction in urea and also has a diuretic effect.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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