Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Close this search box.

Phenyllithium Solution CAS 591-51-5

Molecular Formula: C6H5Li

Formula Weight: 84.05

Zhishang Chemical: Phenyllithium Solution Supplement

Product Name: Phenyllithium solution
CAS No: 591-51-5
Purity: 99%

Basic Info

Product Name:Phenyllithium Solution
Other Names:Phenyllithium, 1.0 M Solution in Ethyl Ether, J&KSeal
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Brown or Red Solution
EINECS No.:209-720-1
Storage:Store at +2°C to +8°C.
SigmaAldrich COA

What is Phenyllithium Solution?

Phenyllithium Solution or lithium benzene is an organometallic reagent with empirical formula C 6 h 5 li. It is most commonly used as a metallizing agent in organic synthesis and a substitute for Grignard reagent used to introduce phenyl in organic synthesis. Crystalline Phenyllithium Solution is colorless; However, according to the impurities in the solvent and solute used, the phenyllithium solution will show various shades of brown or red.

Phenyllithium Solution Properties:

Melting point 160-163 °C(Solv: benzene (71-43-2))
Boiling point 140-143 °C
density 0.835 g/mL at 25 °C
Fp 20 °C
storage temp. Store at +2°C to +8°C.
solubility Miscible with ether and hydrocarbons.
Water Solubility Severe reaction

Phenyllithium Solution Uses

  1. Phenyllithium Solution is an organometallic compound, which can be used as an important synthetic reagent and plays an important role in basic theoretical research and industrial synthesis.
  2. Phenyllithium Solution can be used as a metallation reagent for the preparation of alkyllithium, etc., as a dehydrohalogenation reagent for the preparation of vitamins and hormones, and the like.

Preparation of Phenyllithium Solution

A preparation method of Phenyllithium Solution, comprising the following steps:
1) Under the protection of inert gas, add sodium-lithium alloy and n-butyl ether into the system, and stir to obtain a sodium-lithium alloy dispersion; the mass fraction of sodium in the sodium-lithium alloy is 1-6%, the present invention Substituting metallic lithium in sodium-lithium alloys can promote the initiation of the reaction. The dosing mass ratio of sodium-lithium alloy and n-butyl ether is 1:10~30. The reaction process of sodium-lithium alloy and bromobenzene has relatively high requirements on moisture and air (such as oxygen and carbon dioxide). Before production, the air in the entire production system is replaced with an inert gas, and the inert gas is argon. , The density of argon is higher than that of air, and the anhydrous and oxygen-free conditions are easy to control, and the inert gas needs to be dried before use. The reaction between bromobenzene and sodium-lithium alloy is usually difficult to initiate, the success rate is low, and it is very sensitive to temperature. The reaction stops when the temperature is lower than 10 °C. Once the reaction stops, even heating and dropwise addition of bromobenzene cannot be rescued. At the same time, the temperature cannot be higher than 30°C, otherwise a large amount of coupling products will be produced.
(2) at 10~30 ℃, add bromobenzene dropwise to the sodium-lithium alloy dispersion liquid obtained in step (1) under stirring, control the temperature of the system at 10~30 ℃, after the dropping is completed, the insulation reaction is processed to obtain benzene base lithium solution. Dissolving bromobenzene in n-butyl ether and then dropping it into the system, the mass percentage concentration of the obtained bromobenzene n-butyl ether solution is 40-60%. In terms of active ingredients, the dosage of bromobenzene in the bromobenzene-n-butyl ether solution is 10 to 20 times the quality of the sodium-lithium alloy in the system. The dropwise addition of bromobenzene is completed within 6 to 8 hours. The purity of the product is closely related to the dropping rate of bromobenzene. If the dropping rate is too fast, a coupling product will be produced. During the dropwise addition of bromobenzene, the concentration of the product phenyllithium should be monitored in real time, and the dropwise addition of bromobenzene should be stopped when the product concentration does not increase. After the dropwise addition of benzene is completed, the reaction is continued for 1 to 2 hours under heat preservation.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Phenyllithium Solution Quotation