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Phenyl Ethyl Alcohol CAS 60-12-8

Molecular Formula: C8H10O

Formula Weight: 122.16

ZSpharmac: Phenyl Ethyl Alcohol Supplement

Product Name: Phenyl Ethyl Alcohol
CAS No: 60-12-8
Purity: 99%

Basic Info

Product Name:Phenyl Ethyl Alcohol
Other Names:Phenethyl Alcohol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Daily Chemical Raw Materials
Appearance:Clear Colorless Liquid
EINECS No.:200-456-2
Storage:Store Below +30°C.
Provide:Phenyl Ethyl Alcohol MSDS;
Phenyl Ethyl Alcohol COA

What is Phenyl Ethyl Alcohol?

Phenyl Ethyl Alcohol is one of the most widely used bulk spices. The current annual output in the world is estimated to be about 10,000 tons. Probably, except for vanillin, there are no other synthetic flavors close to the 10,000-ton level. There are two methods for large-scale industrial production of Phenyl Ethyl Alcohol. One uses benzene and ethylene oxide as raw materials, aluminum trichloride as catalyst, and is synthesized by Friedel-Crafts reaction method; the other uses styrene as raw material, which is converted into ethylene oxide through the stage of generating halohydrin, It is prepared by hydrogenation reaction with Raney nickel as catalyst.
Any production process method must ensure that the side reaction impurities that damage the aroma are removed to the maximum extent, and the fragrance-grade Phenyl Ethyl Alcohol products have high requirements for purity and aroma quality.Phenylethanol is widely used in daily fragrance formulations. Moreover, FEMA is also recognized as GRAS, and FDA has approved it to be edible, so it is also widely used in food flavors and tobacco flavors. The maximum amount of phenylethyl alcohol in the formula of daily chemical essence can reach 40%. IFRA has no restrictions.

Phenyl Ethyl Alcohol Properties:

Melting point -27 °C (lit.)
Boiling point 219-221 °C/750 mmHg (lit.)
density 1.020 g/mL at 20 °C (lit.)
vapor density 4.21 (vs air)
vapor pressure 1 mm Hg ( 58 °C)
refractive index n20/D 1.5317(lit.)
Fp 216 °F
storage temp. Store below +30°C.
solubility Miscible with chloroform.
form Liquid
color Clear colorless
Odorfloral odor of roses
PH6-7 (20g/l, H2O, 20℃)
explosive limit1.4-11.9%(V)
Water Solubility 20 g/L (20 ºC)


Phenyl Ethyl Alcohol Uses

  1. Phenyl Ethyl Alcohol is commonly made use of in the formula of soap and aesthetic fragrances.
  2. Phenyl Ethyl Alcohol is an edible flavor that is permitted to be utilized in my country, and the dosage is based upon regular production demands. Typically, it is 21-80mg/ kg in 13 gum tissues; 16mg/kg in baked products; 12mg/kg in candy; 8.3 mg/kg in cold beverages.
  3. Phenyl Ethyl Alcohol is GB 2760– 1996 specified as enabled to use edible seasonings. It is primarily utilized to prepare tastes such as honey, bread, peaches and berries.
  4. Phenyl Ethyl Alcohol is made use of to prepare rose-flavored flower essential oil and numerous flower-flavored significances, such as jasmine, clove, as well as orange bloom. In addition, different edible tastes can additionally be prepared, such as strawberry, peach, plum, melon, sugar, honey, cream and also other edible flavors.
  5. Phenyl Ethyl Alcohol is made use of in everyday chemicals as well as food tastes, and also is extensively made use of in formulating soap and also aesthetic flavors.

Phenyl Ethyl Alcohol Production Method

Phenyl Ethyl Alcohol normally exists in ylang-ylang oil, neroli oil, rose oil, hyacinth oil, and so on. The majority of the industrial products are prepared by synthetic method. First, benzene and light weight aluminum trichloride were contributed to the reaction pot and cooled down to 6 ° C, after that nitrogen (stress 40kPa) was introduced, and the blower was begun to circulate. The hydrogen chloride produced in the circulating gas is first cleaned with water, and afterwards cleaned with 20% NaOH service. The theoretically called for ethylene oxide was passed under stirring at 0 ~ 5 ° C, and then the response was mixed for 1 h. After the response was finished, the response blend was put into a sharp bottom container, and the benzene layer was separated. After home heating and steaming the benzene, the recurring fluid is subjected to vacuum purification, as well as the fraction at 110-120 ° C(2.67 kPa) is gathered, which is crude phenethyl alcohol. The crude item is reacted with boric acid to generate high-boiling triborate, and 5% to 10% of non-alcoholic pollutants are distilled off at 0.3 kPa. The remaining triborate is decomposed with water, and also after separation, drying, and vacuum cleaner purification, the ended up item of Phenyl Ethyl Alcohol is gotten.

37kg of styrene and 135kg of water were put into the activator with styrene as basic material, as well as heated up to 85 ~ 90 ° C with mixing, then sodium bromide service (40.5 kg of salt bromide was dissolved in 80kg of water) and also salt chlorate were consistently included dropwise respectively./ Sulfuric acid service (15kg of salt chlorate dissolved in 30kg of water, plus 95kg of 40% sulfuric acid), the dropwise addition was finished within 2h, and also the reaction was proceeded till the family member density of the reduced organic layer d420 > 1.430 (concerning 4h). Amazing, stand, as well as launch the reduced oily compound, which is crude bromophenethyl alcohol, concerning 68.5 kg.

70kg thick bromophenethyl alcohol and also 77kg 20% NaOH service (computed by the saponification value of bromophenethyl alcohol) are gone down right into the reactor. The temperature was heated up to 35-45 ° C, as well as the reaction was stirred up until 420 < 1.0781 (regarding 1 h). The layers were delegated stand, and also the top natural layer was washed when with water to acquire about 42 kg of crude ethylene oxide. Fractional purification under reduced stress, accumulate 30kg of fractions at 60 ~ 65 ℃ (400 ~ 533Pa), refractive index nD201.535, family member density d16161.055.

Include prior ethylene oxide 20kg, ethanol 15kg, Raney nickel 250g and also 450g 20% NaOH remedy in the 60L activator, include hydrogen at area temperature as well as 0.98 ~ 1.96 MPa pressure, up until inhaling the theoretical amount of hydrogen. The catalyst was filtered off, the filtrate was counteracted with acid, and then the ethanol was first distilled to recover ethanol, and after that fractionated to take 99-99.5 ℃ (1.33 kPa) portions to acquire about 27 kg of finished phenethyl alcohol with a refractive index of nD201.530-1.533 and a family member thickness of 25251.018.

Research status of Phenyl Ethyl Alcohol

Phenyl Ethyl Alcohol exists in many plants, especially flowers, such as the essential oils of hyacinth, jasmine, narcissus, lily, etc., but its content is too low to be extracted. The only exception is rose essential oil, from which some species of rose essential oil can obtain Phenyl Ethyl Alcohol in concentrations of more than 60%. However, the production cycle of extracting natural phenylethyl alcohol from roses is long and the cost is high, and large-scale industrial production cannot be carried out to meet the needs of the market.

At present, the vast majority of Phenyl Ethyl Alcohol is chemically synthesized from benzene or styrene, and its raw materials are carcinogens, which are harmful to human health and the environment. In addition, chemical synthesis port-Phenyl Ethyl Alcohol often contains some by-products that are difficult to remove, which seriously affects the product quality.

Synthesis by using microorganisms as production strains can overcome the above shortcomings. Many foods produced by microbial fermentation contain Phenyl Ethyl Alcohol, such as cocoa, coffee, bread, beer, cheese, etc. In particular, Ehrlich (Ehrlich) found that adding phenylalanine (L-Phe) to yeast culture can greatly improve the yield of Phenyl Ethyl Alcohol.

Most microorganisms, especially yeast, can produce Phenyl Ethyl Alcohol through normal metabolic pathways. Phenyl Ethyl Alcohol is produced by yeast by converting phenylalanine in the fermentation broth during the fermentation process. As for the metabolic pathway, phenethyl alcohol can also be synthesized de novo through the shikimate pathway as shown in Figure 2-7. Glucose produces phosphoenolpyruvate through the glycolytic pathway (EMP) and 4-phosphate erythrose through the pentose phosphate pathway (HMP), both in 2-keto-3-deoxy-D-arabinoheptulose. Under the action of acid-7-phosphate synthase (DAHP synthase), shikimic acid is formed through the intermediate DAHP. Shikimic acid passes through the intermediates chorismic acid and prebenzoic acid to form phenylpyruvate under the action of chorismate mutase and prebenzoic acid dehydratase. On the one hand, phenylpyruvate can generate phenylethyl alcohol through phenylacetaldehyde, and on the other hand. In one aspect, L-Phe can also be formed by transamination with L-glutamic acid. DAHP synthase and prephenate dehydratase in the metabolic pathway are feedback-inhibited by L-Phe. L-Phe forms phenylpyruvate through the action of transaminase, which is decarboxylated by phenylpyruvate decarboxylase to form phenylacetaldehyde, which is then catalyzed by alcohol dehydrogenase to generate phenylethyl alcohol. Ehrlich also pointed out that there is a close relationship between the amount of added L-Phe and the final yield of phenethyl alcohol when describing this approach. This pathway is currently the main way to use microbial transformation to produce phenylethanol.

A variety of yeasts have the ability to synthesize JB-Phenyl Ethyl Alcohol de novo. For example, when Kluyveromyces marxianus is fermented for 5 days, it can produce a concentration of 400 mg/L of Phenyl Ethyl Alcohol III. Fermentation of Pichia fermentans for 16h can form Phenyl Ethyl Alcohol with a concentration of 505.5mg/L. In addition, there are Saccharomyces vini, Toru-lopsis utilis, Cladosporium cladosporioides, Kluyveromyces lactis, Saccharomyces cerevisiae, abnormal Hansenula Yeast (Hansenula anomala), etc. can synthesize a certain amount of phenethyl alcohol M 6I de novo during the growth process. This pathway exists widely in microorganisms, but because the metabolic pathway is too long, there are too many branches, and there are various inhibitory effects, the final yield of Phenyl Ethyl Alcohol is very low.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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