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Pentapeptide CAS 214047-00-4

Molecular Formula: C39H75N7O10

Formula Weight: 802.05

ZSpharmac: Pentapeptide Supplier

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Product Name: Pentapeptide
CAS No: 214047-00-4
Purity: 99%

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Basic Info

Product Name:Pentapeptide
Other Names:Palmitoyl Pentapeptide
CAS:214047-00-4
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colorless Liquid
EINECS No.:606-757-9
Storage:2-8°C(Protect From Light)
Provide:Pentapeptide MSDS;
Pentapeptide COA

What is Pentapeptide?

Peptide is a little molecular healthy and also balanced healthy protein, furthermore referred to as polypeptide or peptide. It is composed of amino acids with a certain collection linked by amide bonds. 2 amino acids are called dipeptides, and also in addition 3 amino acids are called tripeptides. subsequently. Peptides play an essential responsibility in the advancement, development and additionally metabolic procedure of microbes. Nearly all physical procedures in the human body are controlled by polypeptides or healthy proteins composed of details amino acid series. In the process of natural skin aging as well as additionally treatment, peptides play a vital feature, such as cell dispersing, cell activity, swelling, angiogenesis, pigment growth, along with healthy and balanced healthy protein synthesis as well as likewise standard.

Pentapeptide Property

Boiling point 1120.1±65.0 °C(Predicted)
density 1.147
storage temp. 2-8°C(protect from light)

 

How Pentapeptide Works

1. Anti-sagging skin, Pentapeptide advertises skin adaptability. Such as palmitoyl dipeptide-5, palmitoyl tetrapeptide-7, hexapeptide-8 or hexapeptide-10, presently amongst one of the most often taken advantage of is palmitoyl tetrapeptide-7.

2. Anti-carbonylation, this sort of peptide can safeguard collagen from being damaged as well as likewise cross-linked by energetic carbonyl substances, as well as at the same time can eat free of charge radicals. Such as carnosine, tripeptide-1 as well as in addition dipeptide-4 as well as more.

3. Enhance eye edema, increase microcirculation, reinforce blood circulation, such as acetyl tetrapeptide-5 along with dipeptide-2.

4. Pentapeptide markets face taking care of solution, as well as palmitoyl hexapeptide-6 advertises fibroblast spreading in addition to link, collagen synthesis and additionally cell movement.

5. Lightening along with freckle elimination Peptides such as tetrapeptide-30, nonapeptide-1 along with hexapeptide-2 can hinder the job of tyrosinase.

6. Pentapeptide promotes the advancement of eyelashes (hair), such as myristoyl pentapeptide-17 and also myristoyl hexapeptide-16, which improve keratin genetics.

7. Breast enhancement, acetyl hexapeptide-38 can market the expense of breast fat improvement as well as accomplish the visual end result of breast enhancement.

8. Weight-loss as well as additionally slendering, acetyl hexapeptide-39 minimizes subepidermal fat accumulation by stopping the expression of PGC-1α.

Preparation of Pentapeptide

1. Preparation of Fmoc-Ser(tBu)-WangResin
Put 1.71g Wang Resin into the reaction column, wash it once with DMF, and drain it; use an appropriate amount of dry dichloromethane to swell at room temperature, blow and stir with N2 for 30 minutes until the resin is fully swollen, and drain the liquid; wash it once with DMF, and drain it; re-evaporate DMF for washing Once, drain. Add 5ml of DMF/DCM (1:1) solution of 3.07gFmoc-Gly-OH, 1.30gHOBt, and 1.49ml DIC. After reacting for 5 minutes, 0.10 g of DMAP was added and reacted for 4 hours. After the reaction, the reaction solution was drained, washed with DMF three times and drained, and a little resin was taken out for substitution degree detection. Then add 200ml of blocking reagent (AC2O/pyridine (7:6, V:V)), react for 8-16h, wash twice with DMF; wash twice with anhydrous methanol (10min/time), and dry under vacuum to constant weight. The degree of substitution of Fmoc-Ser(tBu)-WangResin was measured to be 0.71mmol/g.
2. Preparation of Matrixyl-WangResin
1) In the Fmoc-Ser(tBu)-WangResin reaction column, add DCM to swell for 20-30min, then pump it off. Add DBLK solution (piperidine/DMF (V/V)=1:4) for deprotection twice (5+10min), add DMF to wash for 1min between two deprotections, and remove. After taking off the protection twice, wash it with DMF, methanol, DCM, and DMF once each, pick a little resin with a glass rod, check it with indene, and it turns dark purple, indicating that Fmoc has been removed and is ready to be fed. 2) In the process of deprotection, weigh 0.93g Fmoc-Lys(Boc)-OH and 0.81gHOBt into a beaker, add 2ml of refined DMF to dissolve, after the complete dissolution, put the beaker in an ice bath to cool for 2min, and then Add 0.93ml DIC to activate the solution for 8 minutes. If white flocculent foam appears, the activation is complete. Use a Buchner funnel to filter out the small white solid particles in the activation solution, pour the obtained clear filtrate into the reaction column, and then add DMF In the reaction column, adjust the N2 so that the resin is evenly blown up, put on a drying tube, and keep no wall hanging phenomenon during the reaction process, if there is wall hanging, use a little refined DMF to flush the resin on the wall to in the reaction solution. React at room temperature for 2 hours. After passing the indene test, the reaction solution can be removed and the next amino acid can be connected.
3. Cleavage of Matrixyl-WangResin
Put 0.10 g of Matrixyl Wang Resin dried to constant weight in a glass flask, add 4 ml of TFA-sulfide anisole-anisole-EDT (volume ratio 95:5:3:2) under stirring in an ice bath, react for 30 minutes, and gradually rise to to room temperature, reacted at room temperature for 2h. Filter, wash the resin with a little TFA, pour the filtrate into 40ml of anhydrous glacial ether, precipitate a white solid, centrifuge at 4000rpm for 4min, discard the supernatant, repeat twice, and dry in vacuum to obtain 46.6mg of crude peptide.
4. Analysis and identification of Matrixyl crude peptide
The crude Matrixyl was analyzed by RPHPLC. The HPLC-ESI-MS analysis of the purified Matrixyl showed that its m/z was 402.3{[M+H]2+}, and the molecular weight of Matrixyl was 802.05. The theoretical value was consistent with the actual value.

Beauty Pentapeptide and Pentapeptide

Class peptides can experience the dermis to elevate collagen, turning around the procedure of skin aging by rebuilding from the inside out.
Beauty pentapeptide is furthermore a charm peptide. The model of the peptide is Pentapeptide, commonly referred to as Pentapeptide, which can mimic the disabling result of botulinum toxin. It is a quick peptide item of 5 amino acids generated by peptide bonds, which resembles healthy protein in framework, however the peptide chain of protein is much longer, generally consisting of hundreds of amino acids. These polypeptides can be separated right into dipeptides (including 2 amino acids), tripeptides (including 3 amino acids), tetrapeptides (having 4 amino acids), and more according to the option of amino acids had in them. Due to the different type of amino acids had, There are numerous varieties of dipeptides, as well as the identical looks for tripeptides; at the same time, with the comparable a number of amino acids, the order (web web link) of each amino acid is different, along with dipeptides will definitely furthermore have numerous arrays. So there are polypeptides with various features along with names. Pentapeptide is composed of 6 amino acids (Pal-palmitic acid, Lys-lysine, Thr-threonine, Thr-threonine, Lys-lysine, Ser-serine).
Elegance pentapeptide remains in truth the C-terminal item of collagen I, which has the end result similar to laser surgical treatment. Promote the spreading of collagen, flexible fibers along with hyaluronic acid, improve the skin’s water internet material as well as water retention, rise skin thickness along with decrease fantastic lines; at the same time, a long-chain fat (palmitic acid) is included in raise the absorption influence. Contrasted to laser surgical treatment, Pentapeptide quantities being entirely integrated with the skin, changing the skin ecology as well as cell taking care of, as well as furthermore playing the feature of intracellular hormones as well as furthermore enzymes.

About Products:
If you need Pentapeptide as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Pentapeptide manufacturer and supplier, ZSpharmac will provide Pentapeptide raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Pentapeptide Quotation